Formation d'émulsions multiples stimulables en une seule étape d'émulsification : effet du sel et évolution vers des architectures biocompatibles

Marine Protat 1
1 LIONS - Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : We studied stimuli-responsive multiple emulsions formed in a one-step mechanical emulsification process. These emulsions are stabilized by amphiphilic copolymers synthesized by atom transfer radical polymerization. Depending on pH, ionic strength and temperature, different emulsion types can be obtained, including water-continuous (W/O/W) and oil-continuous (O/W/O) multiple emulsions. These emulsions are stable during several months. We formed W/O/W emulsions with two entirely biocompatible systems using a poly(dimethylsiloxane)-b-poly(dimethylaminoethyl methacrylate) copolymer. Water/Miglyol® 812/water emulsions formulated with this copolymer enable the encapsulation and controlled release of hydrophilic species with the three stimuli: pH, ionic strength and temperature. Furthermore, we studied the formation conditions of multiple water – toluene – polystyrene-b-poly(styrene-st-dimethylaminoethyl methacrylate) emulsions. We probed the conformation of the polymer adsorbed at the water – oil interface using neutron reflectivity. Our results show an existing correlation between emulsion type and polymer conformation. Moreover, the formation of multiple emulsions is promoted by a decrease in the curvature of the microemulsions formed in water, which was assessed by cryo transmission electron microscopy and small angle neutron scattering. Finally, we settled predictive criteria for the formation of multiple emulsions. These criteria are based on interfacial tension and polymer partitioning measurements.
Keywords : Emulsions
Document type :
Theses
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https://tel.archives-ouvertes.fr/tel-01488470
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Submitted on : Monday, March 13, 2017 - 4:32:28 PM
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  • HAL Id : tel-01488470, version 1

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Marine Protat. Formation d'émulsions multiples stimulables en une seule étape d'émulsification : effet du sel et évolution vers des architectures biocompatibles. Matériaux. Université Pierre et Marie Curie (Paris 6), 2016. Français. ⟨tel-01488470⟩

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