The origin of glucocorticoid hormone oscillations Individual variation in glucocorticoid stress responses in animals Molecular mechanisms and cellular effects of glucocorticosteroids, PLoS Biol General and Comparative Endocrinology General and Comparative Endocrinology Immunol Allergy Clin North Am, vol.104, issue.25, pp.45-58, 2002. ,
Glucocorticoid-Mediated Inhibition of Angiogenic Changes in Human Endothelial Cells Is Not Caused by Reductions in Cell Proliferation or Migration Public Library of Science On the retinal toxicity of intraocular glucocorticoids The glucocorticoid receptor: pivot of depression and of antidepressant treatment, Biochem Pharmacol Psychoneuroendocrinology, vol.57, issue.36, pp.1878-86, 2010. ,
Mechanisms involved in the side effects of glucocorticoids, Pharmacology & Therapeutics, vol.96, issue.1, pp.23-43, 1983. ,
DOI : 10.1016/S0163-7258(02)00297-8
Preventing local regeneration of glucocorticoids by 11??-hydroxysteroid dehydrogenase type 1 enhances angiogenesis, Proceedings of the National Academy of Sciences, vol.102, issue.34, pp.12165-70, 2005. ,
DOI : 10.1073/pnas.0500641102
Inhibition of Proliferation, Migration and Proteolysis Contribute to Corticosterone-Mediated Inhibition of Angiogenesis, PLoS ONE, vol.7, issue.10, p.46625, 2012. ,
DOI : 10.1371/journal.pone.0046625.s002
Glucocorticoids induce apoptosis in human monocytes: potential role of IL- 1 beta, J Immunol, vol.163, pp.3484-90, 1999. ,
Evaluation of the Toxicity of Triamcinolone Acetonide and Dexamethasone Sodium Phosphate on Human Lens Epithelial Cells (HLE B-3), Journal of Ocular Pharmacology and Therapeutics, vol.27, issue.3, pp.265-71, 2011. ,
DOI : 10.1089/jop.2010.0120
Glucocorticoid-Induced Apoptosis in CNS Microvascular Pericytes, Developmental Neuroscience, vol.25, issue.6, pp.436-482, 2003. ,
DOI : 10.1159/000075669
Inhaled Corticosteroids, Journal of Allergy and Clinical Immunology, vol.112, issue.3, pp.1-40, 2003. ,
DOI : 10.1016/S0091-6749(03)01859-1
[Pathological changes of the blood vessels in rabbit femoral head with glucocorticoidinduced necrosis], Nan Fang Yi Ke Da Xue Xue Bao, vol.26, pp.785-792, 2006. ,
Cibles r??tiniennes d???action des m??dicaments, Annales Pharmaceutiques Fran??aises, vol.69, issue.2, pp.124-154, 2011. ,
DOI : 10.1016/j.pharma.2011.01.003
Early Effects of Intravitreal Triamcinolone on Macular Edema, Ophthalmology, vol.113, issue.11, pp.2048-53, 2006. ,
DOI : 10.1016/j.ophtha.2006.05.037
Effects of triamcinolone acetonide on vessels of the posterior segment of the eye, Mol Vis, vol.15, pp.2634-2682, 2009. ,
Triamcinolone Reduces Neovascularization, Capillary Density and IGF-1 Receptor Phosphorylation in a Model of Oxygen-Induced Retinopathy, Investigative Opthalmology & Visual Science, vol.47, issue.11, pp.4975-82, 2006. ,
DOI : 10.1167/iovs.06-0450
?? L???arbre vasculaire, les nouvelles voies de la gu??rison ??, Revue des Maladies Respiratoires, vol.26, issue.9, 2008. ,
DOI : 10.1016/S0761-8425(09)73343-1
Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration, Cochrane Database Syst Rev, vol.1, p.5022, 2013. ,
SCORE Study Report #11, Ophthalmology, vol.118, pp.1364-72, 2011. ,
DOI : 10.1016/j.ophtha.2010.11.020
URL : http://doi.org/10.1016/j.ophtha.2010.11.020
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012, Cell Death and Differentiation, vol.94, issue.1, pp.107-127, 2012. ,
DOI : 10.1083/jcb.200712051
HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line, Journal of Investigative Dermatology, vol.99, issue.6, pp.683-90, 1992. ,
DOI : 10.1111/1523-1747.ep12613748
Simplified methods for consistent and selective culture of bovine retinal endothelial cells and pericytes, Invest Ophthalmol Vis Sci, vol.31, pp.1738-1782, 1990. ,
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, Journal of Immunological Methods, vol.65, issue.1-2, pp.55-63, 1983. ,
DOI : 10.1016/0022-1759(83)90303-4
An Assay for DNA Fragmentation in Apoptosis without Phenol/Chloroform Extraction and Ethanol Precipitation, Analytical Biochemistry, vol.246, issue.1, pp.155-158, 1997. ,
DOI : 10.1006/abio.1997.2018
Apoptosis induced by Na+/H+ antiport inhibition activates the LEI/L-DNase II pathway, Cell Death and Differentiation, vol.10, issue.5, pp.548-57, 2003. ,
DOI : 10.1038/sj.cdd.4401195
Involvement of DNase II in Nuclear Degeneration during Lens Cell Differentiation, Journal of Biological Chemistry, vol.270, issue.48, pp.28579-85, 1995. ,
DOI : 10.1074/jbc.270.48.28579
URL : https://hal.archives-ouvertes.fr/inserm-00769967
-induced cell death, Biochemical Journal, vol.396, issue.3, pp.419-448, 2006. ,
DOI : 10.1042/BJ20051696
Different biocompatibility of crystalline triamcinolone deposits on retinal cells in vitro and in vivo, Experimental Eye Research, vol.85, issue.1, pp.44-53, 2007. ,
DOI : 10.1016/j.exer.2007.03.003
LC3 conjugation system in mammalian autophagy, The International Journal of Biochemistry & Cell Biology, vol.36, issue.12, pp.2503-2521, 2004. ,
DOI : 10.1016/j.biocel.2004.05.009
Conformational Modification of Serpins Transforms Leukocyte Elastase Inhibitor into an Endonuclease Involved in Apoptosis, Molecular and Cellular Biology, vol.27, issue.11, pp.4028-4064, 2007. ,
DOI : 10.1128/MCB.01959-06
URL : https://hal.archives-ouvertes.fr/inserm-00140748
Nuclear Translocation of a Leukocyte Elastase Inhibitor/Elastase Complex during Staurosporine-Induced Apoptosis: Role in the Generation of Nuclear L-DNase II Activity, Experimental Cell Research, vol.254, issue.1, pp.99-109, 2000. ,
DOI : 10.1006/excr.1999.4737
Endogenous Cortisol and TGF-?? in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function, The Journal of Immunology, vol.186, issue.1, pp.305-316, 2011. ,
DOI : 10.4049/jimmunol.1001450
Effects of dexamethasone and sex hormones on cytokine-induced cellular adhesion molecule expression in human endothelial cells, Eur J Dermatol, vol.12, pp.445-453, 2002. ,
Aldosterone Modulates Endothelial Permeability and Endothelial Nitric Oxide Synthase Activity by Rearrangement of the Actin Cytoskeleton, Hypertension, vol.61, issue.2, pp.501-509, 2013. ,
DOI : 10.1161/HYPERTENSIONAHA.111.196832
The effects of triamcinolone crystals on retinal function in a model of isolated perfused vertebrate retina, Experimental Eye Research, vol.87, issue.1, pp.22-31, 2008. ,
DOI : 10.1016/j.exer.2008.04.005
Glucocorticoids induce retinal toxicity through mechanisms mainly associated with paraptosis, Mol Vis, vol.13, pp.1746-57, 2007. ,
The Lack of Toxicity of Intravitreally Administered Triamcinolone Acetonide, American Journal of Ophthalmology, vol.91, issue.6, pp.785-788, 1981. ,
DOI : 10.1016/0002-9394(81)90013-1
Toxicity of Triamcinolone Acetonide on Retinal Neurosensory and Pigment Epithelial Cells, Investigative Opthalmology & Visual Science, vol.47, issue.2, pp.722-730, 2006. ,
DOI : 10.1167/iovs.05-0772
INTRAVITREAL TOXICITY OF THE KENALOG VEHICLE (BENZYL ALCOHOL) IN RABBITS, Retina, vol.26, issue.3, pp.339-383, 2006. ,
DOI : 10.1097/00006982-200603000-00014
The Toxic and Stress Responses of Cultured Human Retinal Pigment Epithelium (ARPE19) and Human Glial Cells (SVG) in the Presence of Triamcinolone, Investigative Opthalmology & Visual Science, vol.44, issue.12, pp.5293-300, 2003. ,
DOI : 10.1167/iovs.03-0490
Understanding uveitis: The impact of research on visual outcomes, Progress in Retinal and Eye Research, vol.30, issue.6, pp.452-470, 2011. ,
DOI : 10.1016/j.preteyeres.2011.06.005
Treatment of acute anterior uveitis in the community, as seen in an emergency eye centre. A lesson for the general practitioner?, European Journal of General Practice, vol.49, issue.1, pp.26-35, 2012. ,
DOI : 10.3109/13814788.2011.618221
Molecular mechanisms of topical anti-inflammatory effects of lipoxin A(4) in endotoxin-induced uveitis, Mol Pharmacol, vol.74, pp.154-161, 2008. ,
New Developments in Corticosteroid Therapy for Uveitis, Ophthalmologica, vol.224, issue.1, pp.46-53, 2010. ,
DOI : 10.1159/000318021
Current approach in diagnosis and management of anterior uveitis, Indian Journal of Ophthalmology, vol.58, issue.1, pp.11-19, 2010. ,
DOI : 10.4103/0301-4738.58468
Uvéites et médecine interne Stratégiesdiagnostique et thérapeutique. La Revue de médecine interne, pp.492-500, 2009. ,
Corticosteroid Intravitreal Implants, Dev Ophthalmol, vol.51, pp.122-133, 2012. ,
DOI : 10.1159/000336330
Suppression of experimental uveitis by a recombinant adenoassociated virus vector encoding interleukin-1 receptor antagonist, Molecular Vision, vol.15, pp.1542-1552, 2009. ,
Jun N-terminal kinase in rheumatoid arthritis, J Pharmacol Exp Ther, vol.291, issue.1, pp.124-130, 1999. ,
Activation of stress-activated protein kinase in osteoarthritic cartilage. Evidencefor nitric oxide dependence, Osteoarthritis Cartilage, vol.9, issue.4, pp.294-299, 2001. ,
D-JNKI1, a Cell-Penetrating c-Jun-N-Terminal Kinase Inhibitor, Protects Against Cell Death in Severe Cerebral Ischemia, Stroke, vol.35, issue.7, pp.1738-1743, 2004. ,
DOI : 10.1161/01.STR.0000131480.03994.b1
A peptide inhibitor of c-jun Nterminal kinase for the treatment of endotoxin-induced uveitis, Invest Ophthalmol Vis Sc, vol.51, pp.4683-4693, 2010. ,
Endotoxin-induced uveitis in rats as a model for human disease, Nature, vol.84, issue.5773, pp.611-613, 1980. ,
DOI : 10.1038/286611a0
Involvement of superoxide generated by polymorphonuclear leukocytes in endotoxin-induced uveitis, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.238, issue.4, pp.359-365, 2000. ,
DOI : 10.1007/s004170050365
Iontophoresis of Dexamethasone in the Treatment of Endotoxin-Induced-Uveitis in Rats, Experimental Eye Research, vol.65, issue.4, pp.533-545, 1997. ,
DOI : 10.1006/exer.1997.0364
Signal transduction by the c-Jun N-terminal kinase (JNK) ??? from inflammation to development, Current Opinion in Cell Biology, vol.10, issue.2, pp.205-219, 1998. ,
DOI : 10.1016/S0955-0674(98)80143-9
A Cholinergic Agonist Attenuates Endotoxin-Induced Uveitis in Rats, Investigative Opthalmology & Visual Science, vol.48, issue.6, pp.2719-2725, 2007. ,
DOI : 10.1167/iovs.06-0644
The JNK Inhibitor XG-102 Protects against TNBS-Induced Colitis, PLoS ONE, vol.98, issue.3, p.30985, 2012. ,
DOI : 10.1371/journal.pone.0030985.t001
Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of ??-Cell Death, Diabetes, vol.50, issue.1, pp.77-82, 2001. ,
DOI : 10.2337/diabetes.50.1.77
High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection, American Journal of Ophthalmology, vol.128, issue.2, pp.192-197, 1999. ,
DOI : 10.1016/S0002-9394(99)00129-4
Dexamethasone Concentration in Vitreous and Serum After Oral Administration, American Journal of Ophthalmology, vol.125, issue.5, pp.673-679, 1998. ,
DOI : 10.1016/S0002-9394(98)00003-8
Peribulbar Corticosteroid Injection: Vitreal and Serum Concentrations After Dexamethasone Disodium Phosphate Injection, American Journal of Ophthalmology, vol.123, issue.3, pp.358-363, 1997. ,
DOI : 10.1016/S0002-9394(14)70131-X
ACTH is a potent regulator of gene expression in human adrenal cells, Journal of Molecular Endocrinology, vol.45, issue.1, pp.59-68, 2010. ,
DOI : 10.1677/JME-10-0006
Thomas Addison and the Background to Cortisone, BMJ, vol.2, issue.4747, pp.1535-1541, 1951. ,
DOI : 10.1136/bmj.2.4747.1535
Cortisone, its effects on rheumatoid arthritis, rheumatic fever, and certain other conditions, Merck Rep, vol.59, pp.9-14, 1950. ,
Histoire de la corticoth??rapie, La Revue de M??decine Interne, vol.34, issue.5, pp.258-263, 2013. ,
DOI : 10.1016/j.revmed.2012.12.009
Histoire contemporaine des médicaments, 2002. ,
Hormonal regulation of P450scc, J Clin Endocrinol Metab, vol.201717, issue.63, pp.22-450, 1986. ,
The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Muller glial cells, The FASEB Journal, vol.24, issue.9, pp.3405-3415, 2010. ,
DOI : 10.1096/fj.09-154344
How circulating cytokines trigger the neural circuits that control the hypothalamic???pituitary???adrenal axis, Psychoneuroendocrinology, vol.26, issue.8, pp.761-788, 2001. ,
DOI : 10.1016/S0306-4530(01)00064-6
STEROIDOGENIC PATHWAYS AND TROPHIC RESPONSE TO ADRENOCORTICOTROPHIN OF CULTURED ADRENOCORTICAL CELLS IN DIFFERENT STATES OF DIFFERENTIATION, Journal of Endocrinology, vol.69, issue.3, pp.385-394, 1976. ,
DOI : 10.1677/joe.0.0690385
StAR Protein and the Regulation of Steroid Hormone Biosynthesis, Annual Review of Physiology, vol.63, issue.1, pp.193-213, 2001. ,
DOI : 10.1146/annurev.physiol.63.1.193
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation, N Engl J Med, vol.332, pp.1351-1362, 1995. ,
Brain angiotensin II modulates sympathoadrenal and hypothalamic pituitary adrenocortical activation during stress receptor phosphorylation in a model of oxygen-induced retinopathy, J Neuroendocrinol Invest Ophthalmol Vis Sci, vol.10, issue.47, pp.67-72, 1998. ,
Different biocompatibility of crystalline triamcinolone deposits on retinal cells in vitro and in vivo, Experimental Eye Research, vol.85, issue.1, pp.44-53, 2007. ,
DOI : 10.1016/j.exer.2007.03.003
Angiostatic Steroids, Annals of Surgery, vol.206, issue.3, pp.374-383, 1987. ,
DOI : 10.1097/00000658-198709000-00016
Glucocorticoid-Induced Apoptosis in CNS Microvascular Pericytes, Developmental Neuroscience, vol.25, issue.6, pp.436-446, 2003. ,
DOI : 10.1159/000075669
[Pathological changes of the blood vessels in rabbit femoral head with glucocorticoidinduced necrosis], pp.785-787, 2006. ,
Programmed cell death???V. Cytolytic enzymes in relation to the breakdown of the intersegmental muscles of silkmoths, Journal of Insect Physiology, vol.11, issue.7, pp.831-844, 1965. ,
DOI : 10.1016/0022-1910(65)90186-1
Heterogeneity of Cell Death, Cytogenetic and Genome Research, vol.139, issue.3, pp.164-173, 2013. ,
DOI : 10.1159/000348679
Caspase-independent cell death, Nature Medicine, vol.12, issue.7, pp.725-730, 2005. ,
DOI : 10.1038/sj.jcbfm.9600080
Caspase-independent cell death in T lymphocytes, Nature Immunology, vol.4, issue.5, pp.416-423, 2003. ,
DOI : 10.1038/ni0503-416
Recherches sur l'auto-initiation de la Mort cellulaire à la fin du XIXe siècle, In Gesnerus, vol.64, pp.193-218, 2007. ,
Cell death in normal development, Archives de Biologie, vol.76, pp.419-437, 1965. ,
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics, British Journal of Cancer, vol.26, issue.4, pp.239-257, 1972. ,
DOI : 10.1038/bjc.1972.33
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012, and Kroemer, G. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012, pp.107-120 ,
DOI : 10.1083/jcb.200712051
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009, Cell Death and Differentiation, vol.4, issue.1, pp.3-11, 2009. ,
DOI : 10.1242/dev.00933
URL : https://hal.archives-ouvertes.fr/hal-00407686
Conversation between apoptosis and autophagy: ???Is it your turn or mine????, Apoptosis, vol.11, issue.4, pp.321-333, 2011. ,
DOI : 10.1007/s10495-011-0589-x
Diversity in the Mechanisms of Neuronal Cell Death, Neuron, vol.40, issue.2, pp.401-413, 2003. ,
DOI : 10.1016/S0896-6273(03)00601-9
Autophagic vacuolar myopathies, Current Neurology and Neuroscience Reports, vol.57, issue.1, pp.64-69, 2003. ,
DOI : 10.1007/s11910-003-0040-y
Autophagy and cell death, Autophagy, vol.8, issue.8, pp.1250-1251, 2012. ,
DOI : 10.4161/auto.20669
Inhibition of Macroautophagy Triggers Apoptosis, Molecular and Cellular Biology, vol.25, issue.3, pp.1025-1040, 2005. ,
DOI : 10.1128/MCB.25.3.1025-1040.2005
Autophagy delays apoptotic death in breast cancer cells following DNA damage, Cell Death and Differentiation, vol.109, issue.3, pp.500-510, 2007. ,
DOI : 10.1093/emboj/18.9.2330
Characterization of stress response in human retinal epithelial cells, Journal of Cellular and Molecular Medicine, vol.6, issue.1, pp.103-115, 2013. ,
DOI : 10.1111/j.1582-4934.2012.01652.x
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD, Nature, vol.391, pp.43-50, 1998. ,
Endonuclease Activation and Chromosomal DNA Fragmentation during Apoptosis in Leukemia Cells, International Journal of Hematology, vol.156, issue.1, pp.31-37, 2006. ,
DOI : 10.1007/BF03342699
Trashing the genome: the role of nucleases during apoptosis, Nature Reviews Molecular Cell Biology, vol.18, issue.9, pp.677-688, 2005. ,
DOI : 10.1038/nrm1715
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis, Cell, vol.94, issue.4, pp.491-501, 1998. ,
DOI : 10.1016/S0092-8674(00)81590-1
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors, Cell, vol.94, issue.4, pp.481-490, 1998. ,
DOI : 10.1016/S0092-8674(00)81589-5
Poly(ADPribose ) signaling in cell death, 2013. ,
Gain-offunction of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis, J Cell Sci, vol.114, pp.3771-3778, 2001. ,
Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis: EVIDENCE FOR INVOLVEMENT OF CASPASE-7, Journal of Biological Chemistry, vol.274, issue.40, pp.28379-28384, 1999. ,
DOI : 10.1074/jbc.274.40.28379
Proteolysis of Poly(ADP-Ribose) Polymerase by Caspase 3: Kinetics of Cleavage of Mono(ADP-Ribosyl)ated and DNA-Bound Substrates, Radiation Research, vol.150, issue.1, pp.3-10, 1998. ,
DOI : 10.2307/3579638
Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication, Mol Cell Biochem, vol.193, pp.137-148, 1999. ,
DOI : 10.1007/978-1-4419-8740-2_20
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets, Molecular Cell, vol.39, issue.1, pp.8-24, 2010. ,
DOI : 10.1016/j.molcel.2010.06.017
The BCL-2 protein family: opposing activities that mediate cell death, Nature Reviews Molecular Cell Biology, vol.94, issue.1, pp.47-59, 2008. ,
DOI : 10.1038/nrm2308
BH3-only proteins and their roles in programmed cell death, Oncogene, vol.14, pp.128-136, 2008. ,
DOI : 10.1101/GAD.897601
The crystal structure of the mouse apoptosis-inducing factor AIF, Nature Structural Biology, vol.9, issue.6, pp.442-446, 2002. ,
DOI : 10.1038/nsb793
Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis, FEBS Letters, vol.401, issue.3, pp.118-123, 2000. ,
DOI : 10.1016/S0014-5793(00)01731-2
AIF: Not Just an Apoptosis-Inducing Factor, Annals of the New York Academy of Sciences, vol.63, issue.1, pp.2-11, 2009. ,
DOI : 10.1111/j.1749-6632.2009.04681.x
Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF), Biochemical and Biophysical Research Communications, vol.396, issue.1, pp.95-100, 2010. ,
DOI : 10.1016/j.bbrc.2010.02.163
AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX, The EMBO Journal, vol.42, issue.9, pp.1585-1599, 2010. ,
DOI : 10.1101/gad.1199904
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876946
Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death, Cell Death and Differentiation, vol.6, issue.6, pp.516-524, 1999. ,
DOI : 10.1038/sj.cdd.4400527
Life with or without AIF, Trends in Biochemical Sciences, vol.35, issue.5, pp.278-287, 2010. ,
DOI : 10.1016/j.tibs.2009.12.008
Outer Mitochondrial Membrane Localization of Apoptosis-Inducing Factor: Mechanistic Implications for Release, ASN Neuro, vol.103, issue.5, 2009. ,
DOI : 10.1042/AN20090046
Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells, Cancer Letters, vol.321, issue.2, pp.137-143, 2012. ,
DOI : 10.1016/j.canlet.2012.01.030
Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion, Basic Research in Cardiology, vol.18, issue.3, pp.397-407, 2011. ,
DOI : 10.1007/s00395-011-0164-1
Molecular characterization of mitochondrial apoptosis-inducing factor, Nature, vol.397, pp.441-446, 1999. ,
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis, Oncogene, vol.23, issue.8, pp.1514-1521, 2004. ,
DOI : 10.1038/sj.onc.1207279
Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans, Science, vol.298, issue.5598, pp.1587-1592, 2002. ,
DOI : 10.1126/science.1076194
Apoptosis-inducing factor (AIF) and leukocyte elastase inhibitor/l-DNase II (LEI/LDNaseII), can interact to conduct caspase-independent cell death, Apoptosis, vol.88, issue.9, pp.1048-1059, 2013. ,
DOI : 10.1007/s10495-013-0862-2
Ubiquitous Calpains Promote Both Apoptosis and Survival Signals in Response to Different Cell Death Stimuli, Journal of Biological Chemistry, vol.281, issue.26, pp.17689-17698, 2006. ,
DOI : 10.1074/jbc.M601978200
The calpains: modular designs and functional diversity, Genome Biology, vol.8, issue.6, p.218, 2007. ,
DOI : 10.1186/gb-2007-8-6-218
Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle), Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1765, issue.2, pp.101-125, 2006. ,
DOI : 10.1016/j.bbcan.2005.11.003
URL : https://hal.archives-ouvertes.fr/inserm-00172288
Lysosomes and autophagy in cell death control, Nature Reviews Cancer, vol.24, issue.11, pp.886-897, 2005. ,
DOI : 10.1016/S0092-8674(01)00421-4
Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1833, issue.10, pp.2244-2253, 2013. ,
DOI : 10.1016/j.bbamcr.2013.05.019
Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D, Neurochemistry International, vol.57, issue.3, pp.278-287, 2010. ,
DOI : 10.1016/j.neuint.2010.06.006
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration in rats, Neuroscience Letters, vol.367, issue.2, pp.205-209, 2004. ,
DOI : 10.1016/j.neulet.2004.06.004
URL : https://hal.archives-ouvertes.fr/inserm-00143906
Granzymes, Genome Biol, vol.2, p.3014, 2001. ,
DOI : 10.1006/rwei.1999.0266
DNases and apoptosis, Biochemistry and Cell Biology, vol.78, issue.4, pp.405-414, 2000. ,
DOI : 10.1139/o00-051
URL : https://hal.archives-ouvertes.fr/inserm-00129402
L-DNase II, a Molecule That Links Proteases and Endonucleases in Apoptosis, Derives from the Ubiquitous Serpin Leukocyte Elastase Inhibitor, Molecular and Cellular Biology, vol.18, issue.6, pp.3612-3619, 1998. ,
DOI : 10.1128/MCB.18.6.3612
Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein, J Biol Chem, vol.267, pp.6576-6583, 1992. ,
Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family, Cellular and Molecular Life Sciences, vol.65, issue.16, pp.2541-2553, 2008. ,
DOI : 10.1007/s00018-008-8049-7
Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis, Cellular and Molecular Life Sciences (CMLS), vol.61, issue.3, pp.301-325, 2004. ,
DOI : 10.1007/s00018-003-3240-3
Conformational Modification of Serpins Transforms Leukocyte Elastase Inhibitor into an Endonuclease Involved in Apoptosis, Molecular and Cellular Biology, vol.27, issue.11, pp.4028-4036, 2007. ,
DOI : 10.1128/MCB.01959-06
URL : https://hal.archives-ouvertes.fr/inserm-00140748
Leukocyte Elastase Inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1783, issue.10, pp.1755-1766, 2008. ,
DOI : 10.1016/j.bbamcr.2008.06.018
Proteinase inhibitors: another new fold, Structure, vol.2, issue.7, pp.575-576, 1994. ,
DOI : 10.1016/S0969-2126(00)00059-9
The serpin superfamily of proteinase inhibitors: structure, function, and regulation, J Biol Chem, vol.269, pp.15957-15960, 1994. ,
Role of the M-loop and Reactive Center Loop Domains in the Folding and Bridging of Nucleosome Arrays by MENT, Journal of Biological Chemistry, vol.278, issue.44, pp.43384-43393, 2003. ,
DOI : 10.1074/jbc.M307635200
Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition, Molecular and Cellular Biology, vol.25, issue.5, pp.1737-1748, 2005. ,
DOI : 10.1128/MCB.25.5.1737-1748.2005
Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies, Annual Review of Biochemistry, vol.78, issue.1, pp.147-176, 2009. ,
DOI : 10.1146/annurev.biochem.78.082107.133320
On the use of Zn2+ to discriminate endonucleases activated during apoptosis, Biochimie, vol.79, issue.7, pp.435-438, 1997. ,
DOI : 10.1016/S0300-9084(97)86153-6
URL : https://hal.archives-ouvertes.fr/inserm-00770541
Nuclear export of LEI/L-DNase II by Crm1 is essential for cell survival, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1783, issue.6, pp.1068-1075, 2008. ,
DOI : 10.1016/j.bbamcr.2008.02.012
Involvement of DNase II in Nuclear Degeneration during Lens Cell Differentiation, Journal of Biological Chemistry, vol.270, issue.48, pp.28579-28585, 1995. ,
DOI : 10.1074/jbc.270.48.28579
URL : https://hal.archives-ouvertes.fr/inserm-00769967
Involvement of L-DNase II in Nuclear Degeneration during Chick Retina Development, Experimental Eye Research, vol.72, issue.4, pp.443-453, 2001. ,
DOI : 10.1006/exer.2000.0969
Differential involvement of DNases in HeLa cell apoptosis induced by etoposide and long term-culture, Cell Death and Differentiation, vol.6, issue.3, pp.234-244, 1999. ,
DOI : 10.1038/sj.cdd.4400486
Effect of apoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level, International Journal of Molecular Medicine, vol.11, pp.737-742, 2003. ,
DOI : 10.3892/ijmm.11.6.737
Apoptosis induced by Na+/H+ antiport inhibition activates the LEI/L-DNase II pathway, Cell Death and Differentiation, vol.10, issue.5, pp.548-557, 2003. ,
DOI : 10.1038/sj.cdd.4401195
Nuclear Translocation of a Leukocyte Elastase Inhibitor/Elastase Complex during Staurosporine-Induced Apoptosis: Role in the Generation of Nuclear L-DNase II Activity, Experimental Cell Research, vol.254, issue.1, pp.99-109, 2000. ,
DOI : 10.1006/excr.1999.4737
L-DNase II associated with active process during ethanol induced cell death in ARPE-19, Mol Vis, vol.10, pp.65-73, 2004. ,
TP53 and MTOR crosstalk to regulate cellular senescence, Aging, vol.2, issue.9, pp.535-537, 2010. ,
DOI : 10.18632/aging.100202
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984599
BCL-2 Modifying Factor (BMF) Is a Central Regulator of Anoikis in Human Intestinal Epithelial Cells, Journal of Biological Chemistry, vol.286, issue.30, pp.26533-26540, 2011. ,
DOI : 10.1074/jbc.M111.265322
Mechanisms of ploidy increase in human cancers: a new role for cell cannibalism, Cancer research 72, pp.1596-1601, 2012. ,
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos, Experimental Neurology, vol.218, issue.2, pp.193-202, 2009. ,
DOI : 10.1016/j.expneurol.2009.03.020
Parthanatos, a messenger of death, Frontiers in Bioscience, vol.Volume, issue.14, pp.1116-1128, 2009. ,
DOI : 10.2741/3297
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality, Cell Death and Differentiation, vol.73, issue.4, pp.581-588, 2011. ,
DOI : 10.1038/cdd.2011.1
The cornified envelope: a model of cell death in the skin, Nature Reviews Molecular Cell Biology, vol.1529, issue.4, pp.328-340, 2005. ,
DOI : 10.1038/nrm1619
Intravitreal Steroids for Macular Edema: The Past, the Present, and the Future, Survey of Ophthalmology, vol.53, issue.2, pp.139-149, 2008. ,
DOI : 10.1016/j.survophthal.2007.12.005
Glucocorticoids induce retinal toxicity through mechanisms mainly associated with paraptosis, Mol Vis, vol.13, pp.1746-1757, 2007. ,
Cooperativity and complementarity: Synergies in non-classical and classical glucocorticoid signaling, Cell Cycle, vol.282, issue.15, pp.2819-2827, 2012. ,
DOI : 10.4161/cc.21018
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, Journal of Immunological Methods, vol.65, issue.1-2, pp.55-63, 1983. ,
DOI : 10.1016/0022-1759(83)90303-4
Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo, British Journal of Ophthalmology, vol.89, issue.6, pp.745-747, 2005. ,
DOI : 10.1136/bjo.2004.052563
Triamcinolone acetonide concentration after filtration of the solvent agent, American Journal of Ophthalmology, vol.139, issue.4, pp.712-713, 2005. ,
DOI : 10.1016/j.ajo.2004.09.059
Freeman???Sheldon syndrome: case report and review of the literature, International Ophthalmology, vol.7, issue.4, pp.405-407, 2011. ,
DOI : 10.1007/s10792-011-9467-3
Mechanisms Underlying Benzyl Alcohol Cytotoxicity (Triamcinolone Acetonide Preservative) in Human Retinal Pigment Epithelial Cells, Investigative Opthalmology & Visual Science, vol.52, issue.7, pp.4214-4222, 2011. ,
DOI : 10.1167/iovs.10-6058
Vehicle of triamcinolone acetonide is associated with retinal toxicity and transient increase of lens density, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.44, issue.12, pp.1152-1159, 2006. ,
DOI : 10.1007/s00417-005-0251-9
Mesures et analyses biomécaniques des interactions macrocirculation/microcirculation sanguines, 20ème Congrès Français de Mécanique, pp.28-30, 2011. ,
Blood-eye barriers in the rat: Correlation of ultrastructure with function, The Journal of Comparative Neurology, vol.44, issue.4, pp.566-576, 1994. ,
DOI : 10.1002/cne.903400409
Interactions between macrocirculation and microcirculation in shock, R??animation, vol.15, issue.2, pp.191-195, 2013. ,
DOI : 10.1007/s13546-013-0663-1
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light., Proceedings of the National Academy of Sciences, pp.11249-11253, 1992. ,
DOI : 10.1073/pnas.89.23.11249
Endogenous Cortisol and TGF-?? in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function, The Journal of Immunology, vol.186, issue.1, pp.305-311, 2011. ,
DOI : 10.4049/jimmunol.1001450
The presence of biologically significant concentrations of glucocorticoids but little or no cortisol, 1994. ,
Ocular distribution and toxicity of intravitreal injection of triamcinolone acetonide in normal equine eyes, Veterinary Ophthalmology, vol.26, pp.15-19, 2008. ,
DOI : 10.1111/j.1463-5224.2008.00636.x
Cortisol Inactivation by 11??-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.4, pp.1443-1450, 2009. ,
DOI : 10.1210/jc.2008-1879
Corticosteroid Suppression of VEGF-A in Infantile Hemangioma-Derived Stem Cells, New England Journal of Medicine, vol.362, issue.11, pp.1005-1013, 2010. ,
DOI : 10.1056/NEJMoa0903036
Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity, Journal of Controlled Release, vol.151, issue.1, pp.10-17, 2011. ,
DOI : 10.1016/j.jconrel.2010.11.031
Glucocorticoids Suppress Tumor Angiogenesis and In vivo Growth of Prostate Cancer Cells, Clinical Cancer Research, vol.12, issue.10, pp.3003-3009, 2006. ,
DOI : 10.1158/1078-0432.CCR-05-2085
Toward an Understanding of Angiogenesis: Search and Discovery, Perspectives in Biology and Medicine, vol.29, issue.1, pp.10-36, 1985. ,
DOI : 10.1353/pbm.1985.0049
Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease, British Journal of Pharmacology, vol.44, issue.2, pp.689-712, 2009. ,
DOI : 10.1111/j.1476-5381.2008.00047.x
Glucocorticoids, osteocytes, and skeletal fragility: The role of bone vascularity, Bone, vol.46, issue.3, pp.564-570, 2010. ,
DOI : 10.1016/j.bone.2009.06.030
Corticosteroids as an Antiangiogenic Agent for Histoplasmosis-Related Subfoveal Choroidal Neovascularization, Journal of Ocular Pharmacology and Therapeutics, vol.15, issue.5, pp.425-428, 1999. ,
DOI : 10.1089/jop.1999.15.425
Modulation of Endothelial Cell Expression of ICAM-1, E-Selectin, and VCAM-1 by ??-Estradiol, Progesterone, and Dexamethasone, Cellular Immunology, vol.167, issue.1, pp.79-85, 1996. ,
DOI : 10.1006/cimm.1996.0010
Effect of Prenatal Glucocorticoids on Cerebral Vasculature of the Developing Brain * Supplemental Methods, Stroke, vol.41, issue.8, pp.1766-1773, 2010. ,
DOI : 10.1161/STROKEAHA.110.588400
Influence of triamcinolone intravitreal injection on retinochoroidal healing processes, Experimental Eye Research, vol.84, issue.6, pp.1081-1089, 2007. ,
DOI : 10.1016/j.exer.2007.01.024
Selective Inhibition of Angiogenesis in Small Blood Vessels and Decrease in Vessel Diameter throughout the Vascular Tree by Triamcinolone Acetonide, Investigative Opthalmology & Visual Science, vol.49, issue.3, pp.1184-1190, 2008. ,
DOI : 10.1167/iovs.07-1329
Cibles r??tiniennes d???action des m??dicaments, Annales Pharmaceutiques Fran??aises, vol.69, issue.2, pp.124-130, 2011. ,
DOI : 10.1016/j.pharma.2011.01.003
Endotoxin-induced uveitis in rats as a model for human disease, Nature, vol.84, issue.5773, pp.611-613, 1980. ,
DOI : 10.1038/286611a0
Iontophoresis of Dexamethasone in the Treatment of Endotoxin-Induced-Uveitis in Rats, Experimental Eye Research, vol.65, issue.4, pp.533-545, 1997. ,
DOI : 10.1006/exer.1997.0364
Targeting JNK for therapeutic benefit: from junk to gold?, Nature Reviews Drug Discovery, vol.2, issue.7, pp.554-565, 2003. ,
DOI : 10.1038/nrd1132
D-JNKI1, a Cell-Penetrating c-Jun-N-Terminal Kinase Inhibitor, Protects Against Cell Death in Severe Cerebral Ischemia, Stroke, vol.35, issue.7, pp.1738-1743, 2004. ,
DOI : 10.1161/01.STR.0000131480.03994.b1
The ciliary smooth muscle electrotransfer: basic principles and potential for sustained intraocular production of therapeutic proteins, The Journal of Gene Medicine, vol.43, issue.11, pp.904-919, 2010. ,
DOI : 10.1002/jgm.1517
Protein delivery for retinal diseases: From basic considerations to clinical applications, Progress in retinal and eye research, pp.443-465, 2010. ,
DOI : 10.1016/j.preteyeres.2010.04.001
Influence of Drug Solubility and Lipophilicity on Transscleral Retinal Delivery of Six Corticosteroids, Drug Metabolism and Disposition, vol.39, issue.5, pp.771-781, 2011. ,
DOI : 10.1124/dmd.110.037408
Post-transcriptional and Nongenomic Effects of Glucocorticoids, Proceedings of the American Thoracic Society, vol.1, issue.3, pp.255-263, 2004. ,
DOI : 10.1513/pats.200402-015MS
dry eye disease; CLSO, confocal laser scanning ophthalmoscope; UHPLC?MS/MS, ultra high pressure liquid chromatography coupled with triple quadrupole mass spectrometer; d 12 CsA, deuterated CsA; IS, internal standard; PBS, phosphate buffer solution; CS, calibration standard; STT, Schirmer tear test ,
Dry eye disease: pathophysiology, classification, and diagnosis, Am. J. Manag. Care, vol.14, pp.79-87, 2008. ,
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca, Clin. Ophthalmol, vol.3, pp.57-67, 2009. ,
Changes in the tear film and ocular surface from dry eye syndrome, Progress in Retinal and Eye Research, vol.23, issue.4, pp.449-474, 2004. ,
DOI : 10.1016/j.preteyeres.2004.04.003
Utility assessment among patients with dry eye disease, Ophthalmology, vol.110, issue.7, pp.1412-1419, 2003. ,
DOI : 10.1016/S0161-6420(03)00462-7
URL : http://doi.org/10.1016/s0161-6420(03)00462-7
Cyclosporine A delivery to the eye: A pharmaceutical challenge, European Journal of Pharmaceutics and Biopharmaceutics, vol.56, issue.3, pp.56-307, 2003. ,
DOI : 10.1016/S0939-6411(03)00138-3
Uses and safety profile of ciclosporin in ophthalmology, Expert Opinion on Drug Safety, vol.69, issue.1, pp.79-89, 2008. ,
DOI : 10.1097/01.ico.0000151507.49565.6e
Molecular targets for existing and novel immunosuppressive drugs, Expert Reviews in Molecular Medicine, vol.2, issue.04, pp.1-23, 2000. ,
DOI : 10.1017/S1462399400001769
Mechanisms of action of cyclosporine, Immunopharmacology, vol.47, issue.2-3, pp.119-125, 2000. ,
DOI : 10.1016/S0162-3109(00)00192-2
Molecular effects of cyclosporine and oncogenesis: a new model, Medical Hypotheses, vol.63, issue.4, pp.647-652, 2004. ,
DOI : 10.1016/j.mehy.2004.03.030
Cyclosporin A Increases Tear Fluid Secretion via Release of Sensory Neurotransmitters and Muscarinic Pathway in Mice, Experimental Eye Research, vol.68, issue.5, pp.541-546, 1999. ,
DOI : 10.1006/exer.1998.0619
Effect of Cyclosporin A Eyedrops on Tear Secretion in Rabbit, Japanese Journal of Ophthalmology, vol.42, issue.3, pp.168-173, 1998. ,
DOI : 10.1016/S0021-5155(98)00003-3
Side effects of systemic cyclosporine in patients not undergoing transplantation, The American Journal of Medicine, vol.77, issue.4, pp.77-654, 1984. ,
DOI : 10.1016/0002-9343(84)90356-5
Clarke's Isolation and Identification of Drugs, 1986. ,
Cyclosporin A prodrugs: design, synthesis and biophysical properties, The Journal of Peptide Research, vol.9, issue.2, pp.63-147, 2004. ,
DOI : 10.1111/j.1399-3011.2003.00111.x
Conversion of cyclosporine A prodrugs in human tears vs. rabbits tears, Eur, J. Pharm. Biopharm, pp.59-51, 2005. ,
A novel water-soluble cyclosporine A prodrug: Ocular tolerance and in vivo kinetics, International Journal of Pharmaceutics, vol.295, issue.1-2, pp.295-302, 2005. ,
DOI : 10.1016/j.ijpharm.2004.12.015
A water-soluble prodrug of cyclosporine A for ocular application: A stability study, European Journal of Pharmaceutical Sciences, vol.26, issue.1, pp.124-129, 2005. ,
DOI : 10.1016/j.ejps.2005.05.003
Biological conversion of a water-soluble prodrug of cyclosporine A, Eur, J. Pharm. Biopharm, pp.67-555, 2007. ,
Application of in vivo confocal microscopy to the objective evaluation of ocular irritation induced by surfactants, Int, J. Pharm, vol.207, pp.89-98, 2000. ,
Recent advances in confocal microscopy for studying drug delivery to the eye: Concepts and pharmaceutical applications, European Journal of Pharmaceutics and Biopharmaceutics, vol.74, issue.1, pp.74-107, 2010. ,
DOI : 10.1016/j.ejpb.2009.09.002
Contribution à la validation d'un test de tolérance oculaire sur la souris, 1994. ,
Cyclosporin A on Human Corneal Endothelium, Cornea, vol.3, issue.4, pp.272-277, 1984. ,
DOI : 10.1097/00003226-198404000-00008
Novel microemulsion in situ electrolytetriggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results, Int. J. Pharm, pp.365-143, 2009. ,
Ocular Pharmacokinetics and Safety of Ciclosporin, a Novel Topical Treatment for Dry Eye, Clinical Pharmacokinetics, vol.18, issue.3, pp.247-261, 2005. ,
DOI : 10.2165/00003088-200544030-00003
Efficacy and safety of cyclosporin a ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease, Ophthalmology, vol.107, issue.5, pp.967-974, 2000. ,
DOI : 10.1016/S0161-6420(00)00035-X
Ocular tolerance of absorption enhancers in ophthalmic preparations, AAPS PharmSci, vol.4, issue.1, p.2, 2002. ,
DOI : 10.1208/ps040102
Evaluation of primary ocular irritation: alternative to the Draize test Ocular Therapeutics and Drug Delivery: A Multidisciplinary Approach, pp.489-525, 1996. ,
A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation, Analytica Chimica Acta, vol.656, issue.1-2, pp.8-35, 2009. ,
DOI : 10.1016/j.aca.2009.10.004
Coupling ultra-high-pressure liquid chromatography with mass spectrometry, TrAC Trends in Analytical Chemistry, vol.29, issue.1, pp.29-44, 2010. ,
DOI : 10.1016/j.trac.2009.09.008
Lachrymal Determinations: Methods and Updates on Biopharmaceutical and Clinical Applications, Ophthalmic Research, vol.36, issue.4, pp.183-194, 2004. ,
DOI : 10.1159/000078776
Laboratory findings in tear fluid analysis, Clinica Chimica Acta, vol.369, issue.1, pp.17-28, 2006. ,
DOI : 10.1016/j.cca.2005.12.035
Animal Models of Dry Eye: A Critical Assessment of Opportunities and Limitations, Investigative Opthalmology & Visual Science, vol.45, issue.6, pp.1641-1646, 2004. ,
DOI : 10.1167/iovs.03-1055
Ocular pharmacokinetics/pharmacodynamics, European Journal of Pharmaceutics and Biopharmaceutics, vol.44, issue.1, pp.71-83, 1997. ,
DOI : 10.1016/S0939-6411(97)00064-7
Ocular Penetration of Cyclosporine A in the Rat Eye, Archives of Ophthalmology, vol.108, issue.4, pp.584-587, 1990. ,
DOI : 10.1001/archopht.1990.01070060132063
Intraocular penetration of topically applied cyclosporine, Transplant. Proc, vol.20, pp.650-655, 1988. ,
A novel cyclosporin A aqueous formulation for dry eye treatment: in vitro and in vivo evaluation ,
Challenges and obstacles of ocular pharmacokinetics and drug delivery, Advanced Drug Delivery Reviews, vol.58, issue.11, pp.1131-1135, 2006. ,
DOI : 10.1016/j.addr.2006.07.027
Ocular penetration of cyclosporin A. III: The human eye., British Journal of Ophthalmology, vol.74, issue.6, pp.74-350, 1990. ,
DOI : 10.1136/bjo.74.6.350
Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs, Current Eye Research, vol.33, issue.7, pp.91-103, 1999. ,
DOI : 10.1076/ceyr.18.2.91.5381
Topical cyclosporin a in the treatment of acute graft rejection: a randomised controlled trial, Clinical & Experimental Ophthalmology, vol.113, pp.36-415, 2008. ,
DOI : 10.1111/j.1442-9071.2008.01784.x
Drug transport in corneal epithelium and blood???retina barrier: Emerging role of transporters in ocular pharmacokinetics, Advanced Drug Delivery Reviews, vol.58, issue.11, pp.58-1136, 2006. ,
DOI : 10.1016/j.addr.2006.07.024
Ocular penetration of cyclosporin A. The rabbit eye, Invest. Ophthalmol. Vis. Sci, pp.31-1362, 1990. ,
Distribution of Cyclosporin A in the Cornea After Topical or Oral Administration, Journal of Ocular Pharmacology and Therapeutics, vol.18, issue.1, pp.83-88, 2002. ,
DOI : 10.1089/108076802317233243
Pharmacokinetic of topical cyclosporin A in the rabbit eye, Invest. Ophthalmol. Vis. Sci, vol.27, pp.519-524, 1986. ,
Cyclosporine A formulation affects its ocular distribution in rabbits, Pharmaceutical Research, vol.19, issue.1, pp.108-111, 2002. ,
DOI : 10.1023/A:1013671819604
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease11Reprint requests to: Linda Lewis, 575 Anton Blvd, Suite 900, Costa Mesa, CA 92626., Ophthalmology, vol.107, issue.4, pp.631-639, 2000. ,
DOI : 10.1016/S0161-6420(99)00176-1
Pilot Trial of Cyclosporine 1% Ophthalmic Ointment in the Treatment of Keratoconjunctivitis Sicca, Cornea, vol.12, issue.4, pp.315-323, 1993. ,
DOI : 10.1097/00003226-199307000-00007
Topical Use of Cyclosporine in the Treatment of Vernal Keratoconjunctivitis, American Journal of Ophthalmology, vol.110, issue.6, pp.110-641, 1990. ,
DOI : 10.1016/S0002-9394(14)77061-8
Topical Cyclosporine in High-risk Corneal Transplants, Ophthalmology, vol.96, issue.8, pp.1144-1150, 1989. ,
DOI : 10.1016/S0161-6420(89)32756-4
URL : http://doi.org/10.1016/s0161-6420(89)32756-4
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, The Journal of Cell Biology, vol.119, issue.3, pp.493-501, 1992. ,
DOI : 10.1083/jcb.119.3.493
Trashing the genome: the role of nucleases during apoptosis, Nature Reviews Molecular Cell Biology, vol.18, issue.9, pp.677-688, 2005. ,
DOI : 10.1038/nrm1715
DNases and apoptosis, Biochemistry and Cell Biology, vol.78, issue.4, pp.405-414, 2000. ,
DOI : 10.1139/o00-051
URL : https://hal.archives-ouvertes.fr/inserm-00129402
L-DNase II, a molecule that links proteases and endonucleases in apoptosis, derives from the ubiquitous serpin leukocyte elastase inhibitor, Mol Cell Biol, pp.18-3612, 1998. ,
Conformational Modification of Serpins Transforms Leukocyte Elastase Inhibitor into an Endonuclease Involved in Apoptosis, Molecular and Cellular Biology, vol.27, issue.11, pp.27-4028, 2007. ,
DOI : 10.1128/MCB.01959-06
URL : https://hal.archives-ouvertes.fr/inserm-00140748
Activation of DNA-degrading enzymes during apoptosis, European Journal of Histochemistry, vol.47, issue.3, pp.47-185, 2003. ,
DOI : 10.4081/826
Glucocorticoids induce retinal toxicity through mechanisms mainly associated with paraptosis, Mol Vis, pp.13-1746, 2007. ,