A. Bermejo, I. Barrachina, E. Estornell, and D. Cortes, Acetogenins from Annonaceae: recent progress in isolation, synthesis and mechanisms of action, Nat. Prod. Rep., vol.5, issue.2, pp.269-303, 2005.
DOI : 10.1039/B500186M

C. Liaw, T. Wu, F. Chang, and Y. Wu, Historic Perspectives on Annonaceous Acetogenins from the Chemical Bench to Preclinical Trials, Planta Medica, vol.76, issue.13, pp.76-1390, 2010.
DOI : 10.1055/s-0030-1250006

M. Höllerhage, A. Matusch, P. Champy, A. Lombès, M. Ruberg et al., Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies, Experimental Neurology, vol.220, issue.1, pp.133-142, 2009.
DOI : 10.1016/j.expneurol.2009.08.004

A. H. Schapira, Complex I: Inhibitors, inhibition and neurodegeneration, Experimental Neurology, vol.224, issue.2, pp.331-335, 2010.
DOI : 10.1016/j.expneurol.2010.03.028

D. Caparros-lefèbvre and J. Steele, Atypical parkinsonism on Guadeloupe, comparison with the parkinsonism???dementia complex of Guam, and environmental toxic hypotheses, Environmental Toxicology and Pharmacology, vol.19, issue.3, pp.407-413, 2005.
DOI : 10.1016/j.etap.2004.12.052

P. Champy, G. U. Höglinger, J. Féger, C. Gleye, A. Laurens et al., Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe, Journal of Neurochemistry, vol.99, issue.1, pp.63-69, 2004.
DOI : 10.1046/j.1471-4159.2003.02138.x

E. S. Yamada, G. Respondek, S. Müssner, A. De-andrade, M. Höllerhage et al., Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice, Experimental Neurology, vol.253, pp.113-125, 2014.
DOI : 10.1016/j.expneurol.2013.12.017
URL : https://hal.archives-ouvertes.fr/inserm-00974704

P. Champy, V. Guérineau, and O. Laprévote, MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption, Molecules, vol.14, issue.12, pp.5235-5246, 2009.
DOI : 10.3390/molecules14125235
URL : https://hal.archives-ouvertes.fr/hal-00467420

J. , L. Ven, I. Schmitz-afonso, G. Lewin, O. Laprévote et al., Comprehensive characterization of Annonaceous acetogenins within a complex extract by HPLC-ESI-LTQ-Orbitrap ® using post-column lithium infusion, J.Mass Spectrom, pp.47-1500, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00758261

J. , L. Ven, I. Schmitz-afonso, G. Lewin, A. Brunelle et al., Identification of the environmental neurotoxins Annonaceous acetogenins in an Annona cherimolia Mill. alcoholic beverage using HPLC-ESI-LTQ-Orbitrap ®, J. Agric. Food Chem, vol.62, pp.8696-8704, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01059147

P. Champy, A. Melot, M. Ruberg, A. Lannuzel, O. Laprévote et al., Quantification of acetogenins in Annona muricata linked to atypical Parkinsonism in Guadeloupe, Mov. Disorder, vol.20, pp.893-896, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00017267

L. F. Potts, F. A. Luzzio, S. C. Smith, P. Hetman, I. Champy et al., Annonacin in Asimina triloba fruit: Implication for neurotoxicity, NeuroToxicology, vol.33, issue.1, pp.53-58, 2012.
DOI : 10.1016/j.neuro.2011.10.009

R. A. Levine, K. M. Richards, K. Tran, R. Luo, A. L. Thomas et al., ) Fruit by LC-HRMS, Journal of Agricultural and Food Chemistry, vol.63, issue.4, pp.1053-1056, 2015.
DOI : 10.1021/jf504500g

. Bonneau, Agence Franç aise de Sécurité Sanitaire des Aliments (French food safety agency) Avis de l'Agence franç aise de sécurité sanitaire des aliments relatif N, J. Chromatogr. B, pp.1004-1050, 2015.

M. P. Torres, S. Rachagani, V. Purohit, P. Pandey, S. Joshi et al., Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism, Cancer Letters, vol.323, issue.1, pp.29-40, 2012.
DOI : 10.1016/j.canlet.2012.03.031

H. Feng, Y. Dang, L. Zhang, C. Zhu, and C. Hu, In situ absorption in rat intestinal tract of solid dispersion of Annonaceous acetogenins, Gastroenterol. Res. Pract, issue.879676, p.2012, 2012.

]. Y. Chen, J. Chen, S. Liu, C. Xu, H. Xu et al., Determination of bullatacin in rat plasma by liquid chromatography???mass spectrometry, Journal of Chromatography B, vol.897, pp.94-97, 2012.
DOI : 10.1016/j.jchromb.2012.03.044

A. European-medicines, Guideline on Bioanalytical Method Validation, 2011.

J. Allegrand, I. Schmitz-afonso, V. Guérineau, A. Giuliani, J. Le-ven et al., Structural study of acetogenins by tandem mass spectrometry under high and low collision energy, Rapid Communications in Mass Spectrometry, vol.23, issue.24, pp.3602-3608, 2010.
DOI : 10.1002/jms.1787
URL : https://hal.archives-ouvertes.fr/hal-00538931

O. Laprévote, Structural study of acetogenins by tandem mass spectrometry under high and 323 low collision energy, Rapid Communications in Mass Spectrometry, vol.24, pp.3602-3608, 2010.

A. Bermejo, B. Figadère, M. C. Zafra-polo, I. Barrachina, E. Estornell et al., Acetogenins 326 from Annonaceae: Recent progress in isolation, synthesis and mechanisms of action, Natural 327 Products Reports, pp.269-303, 2005.

O. Laprévote, A. Brunelle, D. Touboul, and P. Champy, Annonaceous acetogenins as 330 environmental neurotoxins: Human exposure from edible Annona fruits, Planta Medica, vol.78, pp.25-331, 2012.

N. Bonneau, I. Schmitz-afonso, A. Brunelle, D. Touboul, and P. Champy, Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC???MS/MS and application to a pharmacokinetic study, Journal of Chromatography B, vol.1004, pp.46-52, 2015.
DOI : 10.1016/j.jchromb.2015.09.039

D. Caparros-lefèbvre and A. Elbaz, Possible relation of atypical parkinsonism in the French West 337, 1999.

A. Delacourte and C. Duyckaerts, Guadeloupean parkinsonism: A cluster of progressive 341 supranuclear palsy-like tauopathy, Brain, vol.125, pp.801-811, 2002.

G. Angibaud, C. Gaultier, and O. Rascol, Atypical parkinsonism and Annonaceae consumption in New 348, 2004.

S. Bharti and R. Roy, Quantitative 1H NMR spectroscopy, TrAC Trends in Analytical Chemistry, vol.35, pp.5-26, 2012.
DOI : 10.1016/j.trac.2012.02.007

N. Bonneau, L. Ven, J. Schmitz-afonso, I. Guérineau, V. Bajin-ba-ndob et al., Annonaceous acetogenins as environmental 355 neurotoxins: Human exposure from edible Annona fruits, Planta Med, vol.78, p.25, 2012.

A. Camilleri and N. Vassallo, The centrality of mitochondria in the pathogenesis and treatment of 357, 2014.

A. Cavé, D. Cortes, B. Figadère, L. A. Pettit, and G. , Acetogenins from Annonaceae, Progress 359, 1997.
DOI : 10.1007/978-3-7091-6551-5_2

A. Laurens and R. Hocquemiller, Quantification of acetogenins in Annona muricata linked to 363 atypical parkinsonism in Guadeloupe, Movement Disord, vol.20, pp.1629-1633, 2005.

D. Gromek, R. Hocquemiller, and A. Cavé, Qualitative and quantitative evaluation of annonaceous acetogenins by high performance liquid chromatography, Phytochemical Analysis, vol.53, issue.3, pp.133-140, 1994.
DOI : 10.1002/pca.2800050309

Z. Gu, D. Zhou, N. Lewis, J. Wu, H. Johnson et al., Quantitative evaluation of Annonaceous acetogenins in monthly samples of paw paw (Asimina triloba) twigs by liquid chromatography/electrospray ionization/tandem mass spectrometry, Phytochemical Analysis, vol.53, issue.1, pp.32-38, 1999.
DOI : 10.1002/(SICI)1099-1565(199901/02)10:1<32::AID-PCA433>3.0.CO;2-D

M. Hollerhage, T. Rosler, M. Berjas, R. Luo, K. Tran et al., Neurotoxicity of dietary supplements from 374, 2015.

U. Holzgrabe, Quantitative NMR spectroscopy in pharmaceutical applications, Progress in Nuclear Magnetic Resonance Spectroscopy, vol.57, issue.2, 2010.
DOI : 10.1016/j.pnmrs.2010.05.001

A. Lannuzel, G. Höglinger, S. Verhaeghe, L. Gire, S. Belson et al., Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes?, Brain, vol.130, issue.3, pp.816-827, 2007.
DOI : 10.1093/brain/awl347

L. Ven, J. Schmitz-afonso, I. Lewin, G. Brunelle, A. Touboul et al., Mill. Alcoholic Beverage Using HPLC-ESI-LTQ-Orbitrap, Journal of Agricultural and Food Chemistry, vol.62, issue.34, pp.8696-8704, 2014.
DOI : 10.1021/jf501174j
URL : https://hal.archives-ouvertes.fr/hal-01059147

R. Levine, K. Richards, K. Tran, R. Luo, A. Thomas et al., ) Fruit by LC-HRMS, Journal of Agricultural and Food Chemistry, vol.63, issue.4, pp.1053-1056, 2015.
DOI : 10.1021/jf504500g

G. Pauli, T. Gödecke, B. Jaki, and D. Lankin, H NMR. Development and Potential of an Analytical Method: An Update, Journal of Natural Products, vol.75, issue.4, pp.834-851, 2012.
DOI : 10.1021/np200993k

L. Potts, F. Luzzio, S. Smith, M. Hetman, P. Champy et al., Annonacin in Asimina triloba fruit: Implication for neurotoxicity, NeuroToxicology, vol.33, issue.1, pp.53-58, 2012.
DOI : 10.1016/j.neuro.2011.10.009

A. Schapira, Complex I: Inhibitors, inhibition and neurodegeneration, Experimental Neurology, vol.224, issue.2, pp.331-396, 2010.
DOI : 10.1016/j.expneurol.2010.03.028

J. Shoolery, Encyclopedia of Magnetic Resonance, 2007.

C. Simmler, J. Napolitano, J. Mcalpine, S. Chen, and G. Pauli, Universal quantitative NMR analysis of complex natural samples, Current Opinion in Biotechnology, vol.25, pp.51-59, 2014.
DOI : 10.1016/j.copbio.2013.08.004

T. Machado, A. Lage, G. , D. Silva-medeiros, F. et al., Total 401 ?,?-unsaturated-?-lactone acetogenins in Annona muricata by proton NMR spectroscopy, 2015.
DOI : 10.1007/s00723-014-0620-9

G. Webster and S. Kumar, Expanding the Analytical Toolbox: Pharmaceutical Application of Quantitative NMR, Analytical Chemistry, vol.86, issue.23, pp.11474-11480, 2014.
DOI : 10.1021/ac502871w

J. Allegrand, D. Touboul, I. Schmitz-afonso, V. Guérineau, A. Giuliani et al., Structural study of acetogenins by tandem mass spectrometry under high and low collision energy, Rapid Communications in Mass Spectrometry, vol.23, issue.24, pp.3602-3608, 2010.
DOI : 10.1002/jms.1787
URL : https://hal.archives-ouvertes.fr/hal-00538931

A. Colom, O. Neske, A. Chahboune, N. Zafra-polo, M. C. Bardón et al., , as a Potent Inhibitor of Mitochondrial Complex I, Chemistry & Biodiversity, vol.35, issue.3, pp.335-340, 2009.
DOI : 10.1002/cbdv.200800102

G. Angibaud, C. Gaultier, and O. Rascol, Atypical parkinsonism and Annonaceae consumption in New Caledonia, Movement Disorders, vol.17, issue.5, pp.603-604, 2004.
DOI : 10.1002/mds.20104

E. Apartis, B. Gaymard, S. Verhaeghe, E. Roze, M. Vidailhet et al., Predominant cortical dysfunction in Guadeloupean parkinsonism, Brain, vol.131, issue.10, pp.2701-2709, 2008.
DOI : 10.1093/brain/awn219

M. Arzoumanian, Prospection botanique : immersion en Grenade et à la Dominique à la recherche de plantes dont l'usage est jugé significatif par TRAMIL. Doctorat d'Etat en Pharmacie, 2013.

I. Bajin-ba-ndob, P. Champy, C. Gleye, G. Lewin, and B. Akendengué, Annonaceous acetogenins: Precursors from the seeds of Annona squamosa, Phytochemistry Letters, vol.2, issue.2, pp.72-76, 2009.
DOI : 10.1016/j.phytol.2008.11.006

S. A. Banack, S. J. Murch, and P. A. Cox, Neurotoxic flying foxes as dietary items for the Chamorro people, Marianas Islands, Journal of Ethnopharmacology, vol.106, issue.1, pp.97-104, 2006.
DOI : 10.1016/j.jep.2005.12.032

J. W. Banning, N. J. Uretsky, P. N. Patil, and J. L. Beal, Reticuline: A dopamine receptor blocker, Life Sciences, vol.26, issue.24, pp.2083-2091, 1980.
DOI : 10.1016/0024-3205(80)90593-7

I. Barrachina, I. Royo, H. A. Baldoni, N. Chahboune, F. Suvire et al., New antitumoral acetogenin ???Guanacone type??? derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone, Bioorganic & Medicinal Chemistry, vol.15, issue.13, pp.4369-4381, 2007.
DOI : 10.1016/j.bmc.2007.04.039

M. F. Beal, Energetics in the pathogenesis of neurodegenerative diseases, Trends in Neurosciences, vol.23, issue.7, pp.298-304, 2000.
DOI : 10.1016/S0166-2236(00)01584-8

M. F. Beal, Experimental models of Parkinson's disease, Nature Reviews Neuroscience, vol.55, issue.5, pp.325-334, 2001.
DOI : 10.1056/NEJM199810153391603

A. Bermejo, B. Figadère, M. C. Zafra-polo, I. Barrachina, E. Estornell et al., Acetogenins from Annonaceae: recent progress in isolation, synthesis and mechanisms of action, Nat. Prod. Rep., vol.5, issue.2, pp.269-303, 2005.
DOI : 10.1039/B500186M

N. Bonneau, I. Schmitz-afonso, A. Brunelle, and D. Touboul, Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC???MS/MS and application to a pharmacokinetic study, Journal of Chromatography B, vol.1004, pp.46-52, 2015.
DOI : 10.1016/j.jchromb.2015.09.039

B. Borroni, C. Agosti, E. Magnani, D. Luca, M. Padovani et al., Genetic Bases of Progressive Supranuclear Palsy: The MAPT Tau Disease, Current Medicinal Chemistry, vol.18, issue.17, pp.2655-60, 2011.
DOI : 10.2174/092986711795933722

I. Boulogne, L. Germosén-robineau, H. Ozier-lafontaine, M. Fleury, and G. Loranger-merciris, TRAMIL ethnopharmalogical survey in Les Saintes (Guadeloupe, French West Indies): A comparative study, Journal of Ethnopharmacology, vol.133, issue.3, pp.1039-1050, 2011.
DOI : 10.1016/j.jep.2010.11.034

M. G. Brandão, M. Pignal, S. Romaniuc, C. F. Grael, and C. W. Fagg, Useful Brazilian plants listed in the field books of the French naturalist Auguste de Saint-Hilaire (1779???1853), Journal of Ethnopharmacology, vol.143, issue.2, pp.488-500, 2012.
DOI : 10.1016/j.jep.2012.06.052

J. Bruch, H. Xu, A. De-andrade, and G. Höglinger, Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation, PLoS ONE, vol.10, issue.11, 2014.
DOI : 10.1371/journal.pone.0113070.t003
URL : http://doi.org/10.1371/journal.pone.0113070

M. Buraud, Ethnopharmacologie appliquée à la Guadeloupe dans le cadre du programme TRAMIL. Doctorat d'Etat en Pharmacie, 2010.

D. J. Burn and A. J. Lees, Progressive supranuclear palsy: where are we now?, The Lancet Neurology, vol.1, issue.6, pp.359-369, 2002.
DOI : 10.1016/S1474-4422(02)00161-8

A. Camilleri and N. Vassallo, The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease, CNS Neuroscience & Therapeutics, vol.28, issue.Suppl 2, pp.591-602, 2014.
DOI : 10.1111/cns.12264

A. Camuzat, M. Romana, A. Dürr, J. Feingold, A. Brice et al., H1 subhaplotype in Guadeloupean atypical Parkinsonism, The PSPassociated MAPT H1 subhaplotype in Guadeloupean atypical Parkinsonism, pp.2384-2391, 2008.
DOI : 10.1002/mds.22297

D. Caparros-lefèbvre and A. Elbaz, Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study, The Lancet, vol.354, issue.9175, pp.281-286, 1999.
DOI : 10.1016/S0140-6736(98)10166-6

D. Caparros-lefèbvre, N. Sergeant, A. Lees, A. Camuzat, S. Daniel et al., Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy, Brain, vol.125, issue.4, pp.801-811, 2002.
DOI : 10.1093/brain/awf086

A. Cavé, D. Cortes, B. Figadère, A. Laurens, and G. R. Pettit, Acetogenins from Annonaceae in " Progress in the Chemistry of Organic Natural Products, Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, 1997.

N. Chahboune, I. Barrachina, I. Royo, V. Romero, J. Sáez et al., Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors, Bioorganic & Medicinal Chemistry, vol.14, issue.4, pp.1089-94, 2006.
DOI : 10.1016/j.bmc.2005.09.036

P. Champy, Etude chimique et biologiquedes neurotoxines d'Annona muricata L. (Annonaceae) pouvant être impliquées dans la survenue de parkinsonismes atypiques en Guadeloupe, 2004.

P. Champy, F. Jean, C. Gleye, A. Laurens, V. Guérineau et al., Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe, Journal of Neurochemistry, vol.99, issue.1, pp.63-69, 2004.
DOI : 10.1046/j.1471-4159.2003.02138.x

P. Champy, A. Melot, V. Guérineau, C. Gleye, D. Fall et al., Quantification of acetogenins inAnnona muricata linked to atypical parkinsonism in guadeloupe, Movement Disorders, vol.19, issue.12, pp.1629-1633, 2005.
DOI : 10.1002/mds.20632

M. P. Chander, C. Kartick, J. Gangadhar, and P. Vijayachari, Ethno medicine and healthcare practices among Nicobarese of Car Nicobar ??? An indigenous tribe of Andaman and Nicobar Islands, Journal of Ethnopharmacology, vol.158, pp.18-24, 2014.
DOI : 10.1016/j.jep.2014.09.046

L. W. Chatrou, R. H. Erkens, J. E. Richardson, R. M. Saunders, and M. F. Fay, The natural history of Annonaceae, Botanical Journal of the Linnean Society, vol.169, issue.1, pp.1-4, 2012.
DOI : 10.1111/j.1095-8339.2012.01242.x

L. W. Chatrou, M. D. Pirie, R. H. Erkens, T. L. Couvreur, K. M. Neubig et al., A new subfamilial and tribal classification of the pantropical flowering plant family Annonaceae informed by molecular phylogenetics, Botanical Journal of the Linnean Society, vol.169, issue.1, pp.5-40, 2012.
DOI : 10.1111/j.1095-8339.2012.01235.x

K. R. Chaudhuri, F. Edin, F. Lond, M. T. Hu, M. Uk et al., Atypical parkinsonism in Afro-Caribbean and Indian origin immigrants to the UK, Movement Disorders, vol.228, issue.1, pp.18-23, 2000.
DOI : 10.1002/1531-8257(200001)15:1<18::AID-MDS1005>3.0.CO;2-Z

Y. Chen, J. Chen, and X. Li, Monotetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa, Phytochemistry Letters, vol.5, issue.1, pp.33-36, 2012.
DOI : 10.1016/j.phytol.2011.08.015

Y. Chen, J. Chen, S. Xu, Y. Wang, X. Li et al., Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing mice, Bioorganic & Medicinal Chemistry Letters, vol.22, issue.8, pp.2717-2719, 2012.
DOI : 10.1016/j.bmcl.2012.02.109

Y. Chen, S. Xu, J. Chen, Y. Wang, H. Xu et al., Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds, Journal of Ethnopharmacology, vol.142, issue.2, pp.462-466, 2012.
DOI : 10.1016/j.jep.2012.05.019

Y. Chen, J. Chen, J. Zhai, Y. Wang, S. Wang et al., Antitumor activity and toxicity relationship of annonaceous acetogenins, Food and Chemical Toxicology, vol.58, pp.394-400, 2013.
DOI : 10.1016/j.fct.2013.05.028

K. W. Cheong, C. P. Tan, H. Mirhosseini, S. T. Chin, C. Man et al., Optimization of equilibrium headspace analysis of volatile flavor compounds of malaysian soursop (Annona muricata): Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC??GC-TOFMS), Food Chemistry, vol.125, issue.4, pp.1481-1489, 2011.
DOI : 10.1016/j.foodchem.2010.10.067

I. Chinou, Monographs, list entries, public statements, Journal of Ethnopharmacology, vol.158, pp.458-462, 2014.
DOI : 10.1016/j.jep.2014.08.033

M. Coelho-ferreira, Medicinal knowledge and plant utilization in an Amazonian coastal community of Marud??, Par?? State (Brazil), Journal of Ethnopharmacology, vol.126, issue.1, pp.159-75, 2009.
DOI : 10.1016/j.jep.2009.07.016

V. Cohen-de-cock, A. Lannuzel, S. Verhaeghe, E. Roze, M. Ruberg et al., REM sleep behavior disorder in patients with Guadeloupean Parkinsonism, a Tauopathy, Sleep, vol.30, pp.1026-1032, 2007.

M. A. Collins, Atypical parkinsonism in the French West Indies, The Lancet, vol.354, issue.9188, pp.1473-1474, 1999.
DOI : 10.1016/S0140-6736(05)77613-3

D. Cortes, B. Figadère, and A. Cavé, Bis-tetrahydrofuran acetogenins from annonaceae, Phytochemistry, vol.32, issue.6, pp.1467-1473, 1993.
DOI : 10.1016/0031-9422(93)85161-J

L. V. Costa-lotufo, G. M. Cunha, P. A. Farias, G. S. Viana, K. M. Cunha et al., The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin, Toxicon, vol.40, issue.8, pp.1231-1234, 2002.
DOI : 10.1016/S0041-0101(02)00128-9

T. L. Couvreur, P. J. Maas, S. Meinke, D. M. Johnson, and P. J. Keßler, Keys to the genera of Annonaceae, Botanical Journal of the Linnean Society, vol.169, issue.1, pp.74-83, 2012.
DOI : 10.1111/j.1095-8339.2012.01230.x

T. L. Couvreur, R. Niangadouma, B. Sonké, and H. Sauquet, Sirdavidia, an extraordinary new genus of Annonaceae from Gabon, PhytoKeys, vol.77, issue.3, pp.1-19, 2015.
DOI : 10.5091/plecevo.2011.588

P. A. Cox, S. A. Banack, and S. J. Murch, Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam, Proceedings of the National Academy of Sciences, vol.100, issue.23, pp.13380-13383, 2003.
DOI : 10.1073/pnas.2235808100

M. Cuendet, C. P. Oteham, R. C. Moon, W. J. Keller, P. Peaden et al., .-nitrosourea???Treated Rats, Pharmaceutical Biology, vol.37, issue.1-2, pp.3-7, 2008.
DOI : 10.1021/np50068a001
URL : https://hal.archives-ouvertes.fr/hal-00627001

C. Da, T. Alves, M. R. Gonçalves, F. C. Correia, V. C. Da-silva et al., New acetogenins from the seeds of Annona coriacea, Helv. Chim. Acta, vol.97, pp.1469-1474, 2014.

Y. J. Dang, H. Z. Feng, L. Zhang, C. H. Hu, and C. Y. Zhu, In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins, Gastroenterology Research and Practice, vol.9, issue.3, 2012.
DOI : 10.1016/j.drudis.2007.09.005

D. Esposti, M. Ghelli, A. Ratta, M. Cortes, D. Estornell et al., are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I), Biochemical Journal, vol.301, issue.1, pp.161-167, 1994.
DOI : 10.1042/bj3010161

D. Esposti and M. , Inhibitors of NADH???ubiquinone reductase: an overview, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1364, issue.2, pp.222-235, 1998.
DOI : 10.1016/S0005-2728(98)00029-2

S. Derbré, S. Gil, M. Taverna, C. Boursier, V. Nicolas et al., Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: New putative biological targets of squamocin detected by activity-based protein profiling, Bioorganic & Medicinal Chemistry Letters, vol.18, issue.21, pp.5741-5744, 2008.
DOI : 10.1016/j.bmcl.2008.09.091

S. Derbré, G. Roué, E. Poupon, S. A. Susin, and R. Hocquemiller, Annonaceous Acetogenins: The Hydroxyl Groups and THF Rings Are Crucial Structural Elements for Targeting the Mitochondria, Demonstration with the Synthesis of Fluorescent Squamocin Analogues, ChemBioChem, vol.1585, issue.6, pp.1-4, 2005.
DOI : 10.1002/cbic.200400396

P. Duret, Etudes chimiques et biologiques des acetogenines des racines d'Annona cherimolia et des graines d'Annona atemoya (Annonnaceae) Doctorat de l, 1997.

P. Duret, B. Figadère, R. Hocquemiller, and A. Cavé, Epimerization of annonaceous acetogenins under basic conditions, Tetrahedron Letters, vol.38, issue.51, pp.8849-8852, 1997.
DOI : 10.1016/S0040-4039(97)10390-2

P. Duret, R. Hocquemiller, J. Gantier, and B. Figadère, Semisynthesis and cytotoxicity of amino acetogenins and derivatives, Bioorganic & Medicinal Chemistry, vol.7, issue.9, pp.1821-1826, 1999.
DOI : 10.1016/S0968-0896(99)00135-2

R. Duval, Hémisynthèse et évaluation biologique d'analogues de la squamocine, une acétogénine d'Annonaceae : contribution à l'étude du mécanisme d'action, 2003.

R. A. Duval, G. Lewin, E. Peris, N. Chahboune, A. Garofano et al., Heterocyclic Analogues of Squamocin as Inhibitors of Mitochondrial Complex I. On the Role of the Terminal Lactone of Annonaceous Acetogenins, Biochemistry, vol.45, issue.8, pp.2721-2728, 2006.
DOI : 10.1021/bi051261u

D. Enneking, The nutritive value of grasspea (Lathyrus sativus) and allied species, their toxicity to animals and the role of malnutrition in neurolathyrism, Food and Chemical Toxicology, vol.49, issue.3, pp.694-709, 2011.
DOI : 10.1016/j.fct.2010.11.029

M. Escobar-khondiker, M. Höllerhage, M. Muriel, P. Champy, A. Bach et al., Annonacin, a Natural Mitochondrial Complex I Inhibitor, Causes Tau Pathology in Cultured Neurons, Journal of Neuroscience, vol.27, issue.29, pp.7827-7837, 2007.
DOI : 10.1523/JNEUROSCI.1644-07.2007

Y. Fujimoto, T. Eguchi, K. Kakinuma, N. Ikekawa, M. Sahai et al., Squamocin, a new cytotoxic bis-tetrahydrofuran containing acetogenin from Annona squamosa., CHEMICAL & PHARMACEUTICAL BULLETIN, vol.36, issue.12, pp.4802-4806, 1988.
DOI : 10.1248/cpb.36.4802

V. C. George, D. R. Kumar, V. Rajkumar, P. K. Suresh, and R. A. Kumar, Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines. Asian Pac, J. Cancer Prev, vol.13, pp.699-704, 2012.

P. Grover, S. P. Singh, P. V. Prabhakar, U. A. Reddy, A. Balasubramanyam et al., In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats, Food and Chemical Toxicology, vol.47, issue.8, 1964.
DOI : 10.1016/j.fct.2009.05.013

Z. Gu, D. Zhou, N. J. Lewis, J. Wu, H. A. Johnson et al., Quantitative evaluation of Annonaceous acetogenins in monthly samples of paw paw (Asimina triloba) twigs by liquid chromatography/electrospray ionization/tandem mass spectrometry, Phytochemical Analysis, vol.53, issue.1, pp.32-38, 1999.
DOI : 10.1002/(SICI)1099-1565(199901/02)10:1<32::AID-PCA433>3.0.CO;2-D

Z. Gu, D. Zhou, N. J. Lewis, J. Wu, G. Shi et al., Isolation of new bioactive annonaceous acetogenins from Rollinia mucosa guided by liquid chromatography/mass spectrometry, Bioorganic & Medicinal Chemistry, vol.5, issue.10, pp.1911-1916, 1997.
DOI : 10.1016/S0968-0896(97)00129-6

Z. Gu, D. Zhou, and J. Wu, Screening for Annonaceous Acetogenins in Bioactive Plant Extracts by Liquid Chromatography/Mass Spectrometry, Journal of Natural Products, vol.60, issue.3, pp.242-248, 1997.
DOI : 10.1021/np960487i

F. P. Guengerich, Cytochrome P450s and other enzymes in drug metabolism and toxicity, The AAPS Journal, vol.8, issue.1, pp.101-111, 2006.
DOI : 10.1208/aapsj080112

R. Guillopé, M. Escobar-khondiker, V. Guérineau, O. Laprévote, G. U. Höglinger et al., Kaurenoic Acid from Pulp of Annona cherimolia in regard to Annonaceae-induced Parkinsonism, Phytotherapy Research, vol.6, issue.S1, pp.1861-1865, 2011.
DOI : 10.1002/ptr.3508

D. M. Hansra, O. Silva, A. Mehta, and E. Ahn, Patient with Metastatic Breast Cancer Achieves Stable Disease for 5 Years on Graviola and Xeloda after Progressing on Multiple Lines of Therapy, Advances in Breast Cancer Research, vol.03, issue.03, pp.84-87, 2014.
DOI : 10.4236/abcr.2014.33012

J. A. Hasrat, L. Pieters, J. P. De-backer, G. Vauquelin, and A. J. Vlietinck, Screening of medicinal plants from Suriname for 5-HT1A ligands: Bioactive isoquinoline alkaloids from the fruit of Annona muricata, Phytomedicine, vol.4, issue.2, pp.133-140, 1997.
DOI : 10.1016/S0944-7113(97)80059-1

M. Heinrich, H. Rimpler, and N. A. Barrera, Indigenous phytotherapy of gastrointestinal disorders in a lowland Mixe community (Oaxaca, Mexico): Ethnopharmacologic evaluation, Journal of Ethnopharmacology, vol.36, issue.1, pp.63-80, 1992.
DOI : 10.1016/0378-8741(92)90062-V

G. U. Höglinger, W. H. Oertel, and E. C. Hirsch, The Rotenone model of Parkinsonism ??? the five years inspection, J. Neural Transm, vol.70, pp.269-272, 2006.
DOI : 10.1007/978-3-211-45295-0_41

M. Höllerhage, T. W. Rosler, M. Berjas, R. Luo, K. Tran et al., Neurotoxicity of dietary supplements from Annonaceae species, Int. J. Toxicol. in press, 2015.

N. Hué-faucheur, Dissociation en phase gazeuse d'ions organiques complexes par collision de haute énergie et spectrométrie de masse tandem, 2002.

Y. Hui, J. K. Rupprecht, E. Anderson, J. Liu, Y. Smith et al., Bullatalicin, a novel bioactive acetogenin from Annona bullata (Annonaceae), Tetrahedron, vol.45, issue.22, pp.6941-6948
DOI : 10.1016/S0040-4020(01)89160-2

M. Jecmenica-lukic, I. N. Petrovic, T. Pekmezovic, and V. S. Kostic, Clinical outcomes of two main variants of progressive supranuclear palsy and multiple system atrophy: a prospective natural history study, Journal of Neurology, vol.125, issue.Pt 2, pp.1575-1583, 2014.
DOI : 10.1007/s00415-014-7384-x

V. M. Jiménez, M. Gruschwitz, R. M. Schweiggert, R. Carle, and P. Esquivel, Identification of phenolic compounds in soursop (Annona muricata) pulp by high-performance liquid chromatography with diode array and electrospray ionization mass spectrometric detection, Food Research International, vol.65, pp.42-46, 2014.
DOI : 10.1016/j.foodres.2014.05.051

M. E. Johnson and L. Bobrovskaya, An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene???environment interactions, NeuroToxicology, vol.46, pp.101-116, 2015.
DOI : 10.1016/j.neuro.2014.12.002

S. D. Jolad, J. J. Hoffmann, K. H. Schram, J. R. Cole, M. S. Tempesta et al., Uvaricin, a new antitumor agent from Uvaria accuminata (Annonaceae), J. Org. Chem, vol.47, pp.3151-3153, 1982.

H. Joseph, Ethnopharmacognosie des Annonaceae de la Guadeloupe. Doctorat d'Etat en pharmacie, 1983.

V. T. Karamyan and R. C. Speth, Animal models of BMAA neurotoxicity: A critical review, Life Sciences, vol.82, issue.5-6, pp.233-246, 2008.
DOI : 10.1016/j.lfs.2007.11.020

N. Kojima and T. Tanaka, Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues, Molecules, vol.14, issue.9, pp.3621-3661, 2009.
DOI : 10.3390/molecules14093621

Y. Kotake, M. Yoshida, M. Ogawa, Y. Tasaki, M. Hirobe et al., Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate, Neuroscience Letters, vol.217, issue.1, pp.69-71, 1996.
DOI : 10.1016/0304-3940(96)13065-2

K. Kuwabara, M. Takada, J. Iwata, K. Tatsumoto, K. Sakamoto et al., Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics, European Journal of Biochemistry, vol.1276, issue.9, pp.2538-2584, 2000.
DOI : 10.1046/j.1432-1327.2000.01263.x

J. L. Landolt, K. I. Ahammadsahib, R. M. Hollingworth, R. Barr, F. L. Crane et al., Determination of structure-activity relationships of Annonaceous acetogenins by inhibition of oxygen uptake in rat liver mitochondria, Chemico-Biological Interactions, vol.98, issue.1, pp.1-13, 1995.
DOI : 10.1016/0009-2797(95)03628-Y

A. Lannuzel, P. P. Michel, D. Caparros-lefèbvre, J. Abaul, R. Hocquemiller et al., Toxicity of Annonaceae for dopaminergic neurons: Potential role in atypical parkinsonism in Guadeloupe, Movement Disorders, vol.354, issue.1, pp.84-90, 2002.
DOI : 10.1002/mds.1246

A. Lannuzel, P. Michel, G. Höglinger, P. Champy, A. Jousset et al., The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism, Neuroscience, vol.121, issue.2, pp.287-296, 2003.
DOI : 10.1016/S0306-4522(03)00441-X

A. Lannuzel, G. U. Höglinger, S. Verhaeghe, L. Gire, S. Belson et al., Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes?, Brain, vol.130, issue.3, pp.816-827, 2007.
DOI : 10.1093/brain/awl347

A. Lannuzel, M. Ruberg, and P. P. Michel, Atypical parkinsonism in the Caribbean island of Guadeloupe: Etiological role of the mitochondrial complex I inhibitor annonacin, Movement Disorders, vol.48, issue.15, pp.2122-2128, 2008.
DOI : 10.1002/mds.22300

A. Lannuzel, S. Mecharles, B. Tressières, A. Demoly, R. Alhendi et al., Clinical varieties and epidemiological aspects of amyotrophic lateral sclerosis in the Caribbean island of Guadeloupe: A new focus of ALS associated with Parkinsonism, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol.62, issue.1, pp.216-223, 2015.
DOI : 10.1001/archneurol.2012.1219

C. A. Lans, Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus, Journal of Ethnobiology and Ethnomedicine, vol.2, issue.1, p.45, 2006.
DOI : 10.1186/1746-4269-2-45

O. Laprévote, F. Roblot, R. Hocquemiller, A. Cavé, B. Charles et al., Structural elucidation of five stereoisomeric acetogenins, uleicins A???E, by tandem mass spectrometry, Phytochemistry, vol.30, issue.8, pp.2721-2727, 1991.
DOI : 10.1016/0031-9422(91)85131-I

O. Laprévote, C. Girard, B. C. Das, D. Cortes, and A. Cave, Formation of gas-phase lithium complexes from acetogenins and their analysis by fast atom bombardment mass spectrometry, Tetrahedron Letters, vol.33, issue.36, pp.5237-5240, 1992.
DOI : 10.1016/S0040-4039(00)79142-8

O. Laprévote, C. Girard, B. C. Das, T. Laugel, F. Roblot et al., Location of epoxy rings in a long chain acetogenin by fast-atom bombardment and linked scan (B/E) mass spectrometry of lithium-cationized molecules, Rapid Communications in Mass Spectrometry, vol.47, issue.5, pp.352-355, 1992.
DOI : 10.1002/rcm.1290060509

O. Laprévote and B. C. Das, Structural Elucidation of Acetogenins from Annonaceae by Fast Atom Bombardment Mass Spectrometry, Tetrahedron, vol.50, issue.28, pp.8479-8490, 1994.
DOI : 10.1016/S0040-4020(01)85568-X

N. Larranaga and J. I. Hormaza, DNA barcoding of perennial fruit tree species of agronomic interest in the genus Annona (Annonaceae), Frontiers in Plant Science, vol.111, p.589, 2015.
DOI : 10.1111/j.1755-0998.2011.03076.x

S. Lehéricy, A. Hartmann, A. Lannuzel, D. Galanaud, C. Delmaire et al., Magnetic resonance imaging lesion pattern in Guadeloupean parkinsonism is distinct from progressive supranuclear palsy, Brain, vol.133, issue.8, pp.2410-2425, 2010.
DOI : 10.1093/brain/awq162

L. Thomas and J. A. Doyle, Implications d'une analyse cladistique dans l'histoire géographique des Annonaceae : famille d'Angiospermes primitives, Actes du Colloque International. de Phytogéographie Tropicale, pp.173-180, 1993.

L. Ven, J. Schmitz-afonso, I. Touboul, D. Buisson, D. Akagah et al., Annonaceae fruits and parkinsonism risk: Metabolisation study of annonacin, a model neurotoxin; evaluation of human exposure, Toxicology Letters, vol.205, pp.50-51, 2011.
DOI : 10.1016/j.toxlet.2011.05.197

L. Ven and J. , Contribution à l'étude du lien entre Annonaceae et parkinsonismes : identification et quantification d'acétogénines par déreplication ; métabolisation de phase I et approche de distribution de l'annonacine, 2012.

L. Ven, J. Schmitz-afonso, I. Lewin, G. Laprévote, O. Brunelle et al., Comprehensive characterization of Annonaceous acetogenins within a complex extract by HPLC-ESI-LTQ-Orbitrap?? using post-column lithium infusion, Journal of Mass Spectrometry, vol.200, issue.33, pp.1500-1509, 2012.
DOI : 10.1002/jms.3092
URL : https://hal.archives-ouvertes.fr/hal-00758261

M. Leboeuf, A. Cavé, P. K. Bhaumik, B. Mukherjee, and R. Mukherjee, The phytochemistry of the annonaceae, Phytochemistry, vol.21, issue.12, pp.2783-2813, 1980.
DOI : 10.1016/0031-9422(80)85046-1

R. A. Levine, K. M. Richards, K. Tran, R. Luo, A. L. Thomas et al., ) Fruit by LC-HRMS, Journal of Agricultural and Food Chemistry, vol.63, issue.4, pp.1053-1056, 2015.
DOI : 10.1021/jf504500g

C. Li, N. Tan, Q. Mu, H. Zheng, X. Hao et al., Cyclopeptide from the seeds of Annona squamosa, Phytochemistry, vol.45, pp.521-523, 1997.

C. Li, N. Tan, H. Zheng, Q. Mu, X. Hao et al., Cyclopeptides from the seeds of Annona glabra, Phytochemistry, vol.50, issue.6, pp.1047-1052, 1999.
DOI : 10.1016/S0031-9422(98)00631-1

X. Li, Oral bioavailability: Basic principles, advanced concepts, and applications, 2011.

C. Liaw, F. Chang, S. Chen, C. Wu, K. Lee et al., Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana, Bioorganic & Medicinal Chemistry, vol.13, issue.15, pp.4767-4776, 2005.
DOI : 10.1016/j.bmc.2005.05.008

C. Liaw, Y. Yang, M. Chen, F. Chang, S. Chen et al., as Cytotoxic Agents and Calcium Ion Chelators, Journal of Natural Products, vol.71, issue.5, pp.764-71, 2008.
DOI : 10.1021/np0704957
URL : http://ntur.lib.ntu.edu.tw/news/agent_contract.pdf

C. Liaw, W. Liao, C. Chen, S. Jao, and Y. Wu, The Calcium-Chelating Capability of Tetrahydrofuranic Moieties Modulates the Cytotoxicity of Annonaceous Acetogenins, Angewandte Chemie International Edition, vol.312, issue.34, pp.7885-7891, 2011.
DOI : 10.1002/anie.201100717

C. A. Lipinski, Lead- and drug-like compounds: the rule-of-five revolution, Drug Discovery Today: Technologies, vol.1, issue.4, pp.337-341, 2004.
DOI : 10.1016/j.ddtec.2004.11.007

M. Londershausen, W. Leicht, F. Lieb, H. Moeschler, and H. Weiss, Molecular mode of action of annonins, Pesticide Science, vol.4, issue.4, pp.427-438, 1991.
DOI : 10.1002/ps.2780330405

J. L. Longuefosse and E. Nossin, Medical ethnobotany survey in Martinique, Journal of Ethnopharmacology, vol.53, issue.3, pp.117-159, 1996.
DOI : 10.1016/0378-8741(96)01425-0

L. S. Mader, Update: FDA Approves Crofelemer as First Oral Botanical Drug, HerbalGram, vol.97, pp.68-69, 2013.

T. E. Mafimisebi, A. E. Oguntade, A. N. Fajemisin, and O. P. Aiyelari, Local knowledge and socioeconomic determinants of traditional medicines' utilization in livestock health management in Southwest Nigeria, J. Ethnobiol. Ethnomed, vol.8, issue.2, 2012.

M. Martínez-vázquez, R. Estrada-reyes, A. G. Araujo-escalona, I. Ledesma-velázquez, L. Martínez-mota et al., Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice, Journal of Ethnopharmacology, vol.139, issue.1, pp.164-70
DOI : 10.1016/j.jep.2011.10.033

M. Cloud, T. G. Smith, D. L. Chang, C. Cassady, and J. M. , Annonacin, a novel, biologically active polyketide from Annona densicoma, Experientia, vol.43, pp.947-949, 1987.

A. Melot, D. Fall, C. Gleye, and P. Champy, Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata, Molecules, vol.14, issue.11, pp.4387-4395, 2009.
DOI : 10.3390/molecules14114387

A. Mootoosamy, F. Mahomoodally, and M. , Ethnomedicinal application of native remedies used against diabetes and related complications in Mauritius, Journal of Ethnopharmacology, vol.151, issue.1, pp.413-457, 2014.
DOI : 10.1016/j.jep.2013.10.069

L. C. Morais, J. M. Barbosa-filho, and R. N. Almeida, Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice, Journal of Ethnopharmacology, vol.62, issue.1, pp.57-61, 1998.
DOI : 10.1016/S0378-8741(98)00044-0

T. Nagatsu, Amine-related neurotoxins in Parkinson's disease, Neurotoxicology and Teratology, vol.24, issue.5, pp.565-569, 2002.
DOI : 10.1016/S0892-0362(02)00209-X

S. S. Ningthoujam, A. Talukdar, . Das, K. S. Potsangbam, and M. D. Choudhury, Challenges in developing medicinal plant databases for sharing ethnopharmacological knowledge, Journal of Ethnopharmacology, vol.141, issue.1, pp.9-32, 2012.
DOI : 10.1016/j.jep.2012.02.042

H. G. Ong and Y. Kim, Quantitative ethnobotanical study of the medicinal plants used by the Ati Negrito indigenous group in Guimaras island, Philippines, Journal of Ethnopharmacology, vol.157, pp.228-242, 2014.
DOI : 10.1016/j.jep.2014.09.015

J. Oravcová, B. Böhs, and W. Lindner, Drug-protein binding studies new trends in analytical and experimental methodology, Journal of Chromatography B: Biomedical Sciences and Applications, vol.677, issue.1, pp.1-28, 1996.
DOI : 10.1016/0378-4347(95)00425-4

V. Padmaja, V. Thankamany, N. Hara, Y. Fujimoto, and A. Hisham, Biological activities of Annona glabra, Journal of Ethnopharmacology, vol.48, issue.1, pp.21-24, 1995.
DOI : 10.1016/0378-8741(95)01277-K

S. Papapetropoulos, Is there a role for naturally occurring cyanobacterial toxins in neurodegeneration?The beta-N-methylamino-l-alanine (BMAA) paradigm, Neurochemistry International, vol.50, issue.7-8, pp.998-1003, 2007.
DOI : 10.1016/j.neuint.2006.12.011

G. F. Pauli, T. Gödecke, B. U. Jaki, and D. C. Lankin, H NMR. Development and Potential of an Analytical Method: An Update, Journal of Natural Products, vol.75, issue.4, pp.834-851, 2012.
DOI : 10.1021/np200993k

D. Picking, R. Delgoda, N. Younger, and L. Germosén-robineau, TRAMIL ethnomedicinal survey in Jamaica, Journal of Ethnopharmacology, vol.169, pp.314-341
DOI : 10.1016/j.jep.2015.04.027

L. P. Pimenta, F. C. Nascimento, and M. A. Boaventura, Acetogenins from the Leaves ofRollinia laurifolia, Helvetica Chimica Acta, vol.4, issue.12, pp.3225-3231, 2005.
DOI : 10.1002/hlca.200590259

M. D. Pirie and J. A. Doyle, Dating clades with fossils and molecules: the case of Annonaceae, Botanical Journal of the Linnean Society, vol.169, issue.1, pp.84-116, 2012.
DOI : 10.1111/j.1095-8339.2012.01234.x

K. W. Pomper, J. D. Lowe, S. B. Crabtree, and W. Keller, Identification of Annonaceous Acetogenins in the Ripe Fruit of the North American Pawpaw (Asimina triloba), Journal of Agricultural and Food Chemistry, vol.57, issue.18, pp.8339-8343, 2009.
DOI : 10.1021/jf9018239

L. F. Potts, F. A. Luzzio, S. C. Smith, M. Hetman, P. Champy et al., Annonacin in Asimina triloba fruit: Implication for neurotoxicity, NeuroToxicology, vol.33, issue.1, pp.53-61, 2012.
DOI : 10.1016/j.neuro.2011.10.009

S. Prabhu, S. Vijayakumar, J. E. Yabesh, K. Ravichandran, and B. Sakthivel, Documentation and quantitative analysis of the local knowledge on medicinal plants in Kalrayan hills of Villupuram district, Tamil Nadu, India, Journal of Ethnopharmacology, vol.157, pp.7-20, 2014.
DOI : 10.1016/j.jep.2014.09.014

F. Qiu, A. Imai, J. B. Mcalpine, D. C. Lankin, I. Burton et al., Triterpenes, Journal of Natural Products, vol.75, issue.3, pp.432-475, 2012.
DOI : 10.1021/np200878s

J. Rageau, Les plantes médicinales de la Nouvelle-Calédonie, O.R.S.T.O.M, 1973.

H. Rainer, Monographic studies in the genus Annona L . ( Annonaceae ): Inclusion of the genus Rollinia A . St -Hil Ann, Nat. Hist. Mus. Wien. Ser. B. Bot. Zool, pp.191-205, 2007.

M. Razafindraibe, A. R. Kuhlman, H. Rabarison, V. Rakotoarimanana, C. Rajeriarison et al., Medicinal plants used by women from Agnalazaha littoral forest (Southeastern Madagascar), Journal of Ethnobiology and Ethnomedicine, vol.9, issue.1, p.73, 2013.
DOI : 10.1186/1746-4269-6-30
URL : http://doi.org/10.1186/1746-4269-9-73

S. Rodrigues, L. A. Lima, S. Pimenta, L. P. , D. Boaventura et al., Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia, Planta Med, vol.75, pp.80-83, 2009.

L. A. Santos, . Dos, M. A. Boaventura, and L. P. Pimenta, Cornifolin, a new bis-tetrahydrofuran Annonaceous acetogenin from Annona cornifolia, Biochemical Systematics and Ecology, vol.34, issue.1, pp.78-82, 2006.
DOI : 10.1016/j.bse.2005.05.004

A. H. Schapira, Complex I: Inhibitors, inhibition and neurodegeneration, Experimental Neurology, vol.224, issue.2, pp.331-335, 2010.
DOI : 10.1016/j.expneurol.2010.03.028

A. H. Schapira and A. Schrag, Parkinson disease: Parkinson disease clinical subtypes and their implications, Nature Reviews Neurology, vol.25, issue.5, pp.247-248, 2011.
DOI : 10.1038/nrneurol.2011.40

S. C. Sinha, Z. Chen, Z. Huang, E. Nakamaru-ogiso, H. Pietraszkiewicz et al., Alteration of the Bis-tetrahydrofuran Core Stereochemistries in Asimicin Can Affect the Cytotoxicity, Journal of Medicinal Chemistry, vol.51, issue.22, pp.7045-7048, 2008.
DOI : 10.1021/jm801028c

M. Spatola and C. Wider, Genetics of Parkinson's disease: the yield, Parkinsonism & Related Disorders, vol.20, pp.35-38, 2014.
DOI : 10.1016/S1353-8020(13)70011-7

P. S. Spencer, D. N. Roy, A. Ludolph, J. Hugon, M. P. Dwivedi et al., LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA, The Lancet, vol.328, issue.8515, pp.1066-1067, 1986.
DOI : 10.1016/S0140-6736(86)90468-X

D. P. Sreekeesoon and M. F. Mahomoodally, Ethnopharmacological analysis of medicinal plants and animals used in the treatment and management of pain in Mauritius, Journal of Ethnopharmacology, vol.157, pp.181-200, 2014.
DOI : 10.1016/j.jep.2014.09.030

J. C. Steele, Atypical parkinsonism in the French West Indies, The Lancet, vol.354, issue.9188, pp.1469-1478, 1999.
DOI : 10.1016/S0140-6736(05)77614-5

S. Sun, J. Liu, H. Kadouh, X. Sun, and K. Zhou, Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata), Bioorganic & Medicinal Chemistry Letters, vol.24, issue.12, pp.2773-2776, 2014.
DOI : 10.1016/j.bmcl.2014.03.099

H. Tag, P. Kalita, P. Dwivedi, A. K. Das, and N. D. Namsa, Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, northeast, India, Journal of Ethnopharmacology, vol.141, issue.3, pp.786-795, 2012.
DOI : 10.1016/j.jep.2012.03.007

M. Takada, K. Kuwabara, H. Nakato, A. Tanaka, H. Iwamura et al., Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1460, issue.2-3, pp.302-310, 2000.
DOI : 10.1016/S0005-2728(00)00156-0

T. Machado, A. R. Lage, G. A. Da-silva-medeiros, F. De-souza-filho, J. D. Pimenta et al., Total ??,??-Unsaturated-??-Lactone Acetogenins in Annona muricata by Proton NMR Spectroscopy, Applied Magnetic Resonance, vol.52, issue.2, pp.153-160, 2014.
DOI : 10.1007/s00723-014-0620-9

V. Tene, O. Malagón, P. V. Finzi, G. Vidari, C. Armijos et al., An ethnobotanical survey of medicinal plants used in Loja and Zamora-Chinchipe, Ecuador, Journal of Ethnopharmacology, vol.111, issue.1, pp.63-81, 2007.
DOI : 10.1016/j.jep.2006.10.032

E. Tolosa, G. Wenning, and W. Poewe, The diagnosis of Parkinson's disease, The Lancet Neurology, vol.5, issue.1, pp.75-86, 2006.
DOI : 10.1016/S1474-4422(05)70285-4

K. B. Tomer, N. J. Jensen, and M. L. Gross, Fast atom bombardment and tandem mass spectrometry for determining structural modification of fatty acids, Analytical Chemistry, vol.58, issue.12, pp.2429-2433, 1986.
DOI : 10.1021/ac00125a017

J. Wagner, S. Krauss, S. Shi, S. Ryazanov, J. Steffen et al., Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies, Acta Neuropathologica, vol.32, issue.Suppl 1, pp.619-631, 2015.
DOI : 10.1007/s00401-015-1483-3

H. Watanabe, M. Ikeda, K. Watanabe, and T. Kikuchi, Effects on Central Dopaminergic Systems of d-Coclaurine and d-Reticuline, extracted from Magnolia salicifolia, Planta Medica, vol.42, issue.07, pp.213-222, 1981.
DOI : 10.1055/s-2007-971630

A. Wélé, C. Mayer, D. Quentin, Y. Zhang, A. Blond et al., 3D-structure of cycloreticulin C and glabrin A, cyclopeptides from the seeds of??Annona reticulata, Tetrahedron, vol.65, issue.1, pp.275-281, 2009.
DOI : 10.1016/j.tet.2008.10.055

N. Wongsa, S. Kanokmedhakul, and K. Kanokmedhakul, Cananginones A???I, linear acetogenins from the stem bark of Cananga latifolia, Phytochemistry, vol.72, issue.14-15, pp.1859-1864, 2011.
DOI : 10.1016/j.phytochem.2011.05.013

P. Wu, M. Wu, L. Xu, H. Xie, and X. Wei, Anti-inflammatory cyclopeptides from exocarps of sugar-apples, Food Chemistry, vol.152, pp.23-28, 2014.
DOI : 10.1016/j.foodchem.2013.11.100

J. E. Yabesh, S. Prabhu, and S. Vijayakumar, An ethnobotanical study of medicinal plants used by traditional healers in silent valley of Kerala, India, Journal of Ethnopharmacology, vol.154, issue.3, pp.774-89, 2014.
DOI : 10.1016/j.jep.2014.05.004

H. Yang, X. Li, Y. Tang, N. Zhang, J. Chen et al., Supercritical fluid CO2 extraction and simultaneous determination of eight annonaceous acetogenins in Annona genus plant seeds by HPLC???DAD method, Journal of Pharmaceutical and Biomedical Analysis, vol.49, issue.1, pp.140-144, 2009.
DOI : 10.1016/j.jpba.2008.09.055

H. Yang, N. Zhang, X. Li, J. Chen, and B. Cai, Structure???activity relationships of diverse annonaceous acetogenins against human tumor cells, Bioorganic & Medicinal Chemistry Letters, vol.19, issue.8, pp.2199-202, 2009.
DOI : 10.1016/j.bmcl.2009.02.105

H. Yang, N. Zhang, X. Li, L. He, and J. Chen, New nonadjacent bis-THF ring acetogenins from the seeds of Annona squamosa, Fitoterapia, vol.80, issue.3, pp.177-181, 2009.
DOI : 10.1016/j.fitote.2009.01.005

M. C. Zafra-polo, M. C. González, E. Estornell, S. Sahpaz, and D. Cortes, Acetogenins from annonaceae, inhibitors of mitochondrial complex I, Phytochemistry, vol.42, issue.2, pp.253-271, 1996.
DOI : 10.1016/0031-9422(95)00836-5

N. Bonneau, I. Schmitz-afonso, A. Brunelle, D. Touboul, and P. Champy, Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC???MS/MS and application to a pharmacokinetic study, Journal of Chromatography B, vol.1004, issue.2, pp.46-52487, 2015.
DOI : 10.1016/j.jchromb.2015.09.039

N. Bonneau, I. Schmitz-afonso, D. Touboul, A. Brunelle, and P. Champy, Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS, Toxicon, vol.118, 2015.
DOI : 10.1016/j.toxicon.2016.03.015

N. Bonneau, F. Sénéjoux, O. Bajin-ba-ndob, L. Baloul, and P. Champy, The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC???MS/MS analysis, Food Chemistry, vol.226
DOI : 10.1016/j.foodchem.2017.01.042

N. Bonneau, T. Cynober, J. Jullian, and P. Champy, * Global quantification of Annonaceous acetogenins in fruits: 1 H qNMR routine technique and its application to soursop (Annona muricata L.). En préparation pour Phytochemical Analysis

N. Bonneau, L. Ven, J. Champy, P. *. Illustrations-de-gueguen, and J. , Toxines alimentaires et maladies neurodégénératives : le cas des Annonaceae, La Phytothérapie Européenne, vol.67, pp.24-28, 2012.

N. Bonneau, I. Schmitz-afonso, D. Touboul, A. Brunelle, and P. Champy, Quantification of annonacin in Rat plasma: Application to pharmacokinetic study, Proceedings of 62 nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, pp.1518-1519, 2014.
DOI : 10.1055/s-0034-1394993

O. Laprévote, A. Brunelle, D. Touboul, and P. Champy, * Annonaceous acetogenins as environmental neurotoxins: Human exposure from edible Annona fruits, Proceedings of ICNPR 2012 ? 8 th joint meeting of AFERP, p.78, 2012.

P. *. Champy, In vitro phase I metabolism and approach to the distribution of annonacin, a neurotoxic annonaceous acetogenin, Planta Medica, p.78, 2012.

N. Bonneau, I. Schmitz-afonso, D. Touboul, A. Brunelle, and P. Champy, Quantitation of annonacin in Rat plasma: Application to a pharmacokinetic study, PSE) Meeting " Phytochemicals in medicine and pharmacognosy, 2014.

N. Bonneau, I. Schmitz-afonso, D. Touboul, A. Brunelle, and P. Champy, Quantitation of annonacin in Rat plasma: Application to a pharmacokinetic study, Phytochemical Society of Europe (PSE) X th Young scientists Meeting (Autriche, 2013.

N. Bonneau, I. Schmitz-afonso, D. Touboul, A. Brunelle, and P. Champy, Mise au point d'une méthode de dosage de l'annonacine dans le plasma de Rat, Journées de l'École Doctorale « Innovation Thérapeutique, du Fondamental à l'Appliqué », 2013.