Skip to Main content Skip to Navigation

Magnesium-based biodegradable materials : from surface functionalization to cellular evaluation

Abstract : Magnesium (Mg) alloys are a new generation of biodegradable materials with good osseointegration and elastic modulus similar to that of human bone. These properties make them attractive materials to produce biodegradable implants for bone repairing applications that require temporary support. However, Mg alloys degrade rapidly in the in vivo environment making necessary to control their corrosion rate to accompany the tissue healing processes. Several approaches have been proposed for reducing corrosion rate and improving biocompatibility of Mg alloys. The most used ones are conversion films and surface coatings. This project proposes a synergistic approach that combines both decreased corrosion rate and improved biocompatibility of Mg alloys: we developed novel bi-layered coatings to functionalize the surface of AZ31 and ZE41 Mg alloys for bone repair applications. First, a bottom silane-TiO2 coating was formulated and deposited on both alloys by the dip-coating technique. The silane-based coating was effective in slowing down the corrosion rate of the substrates in simulated body fluid (SBF) and in Dulbecco’s Modified Eagle’s Medium (DMEM). Secondly, top layers of type I collagen and/or chitosan were developed. Cell in vitro tests, with fibroblasts and osteoblasts, revealed that the biopolymers enhanced the biological response of the silane-TiO2 coating. Furthermore, the findings showed that there is a combined effect of the bi-layered coatings and the nature of the alloys on their final corrosion response and on the fate of the cells. In the same way, this work contributes to elucidating corrosion processes of Mg alloys in organic solutions in the long-term.
Document type :
Complete list of metadata

Cited literature [210 references]  Display  Hide  Download
Contributor : Abes Star :  Contact
Submitted on : Friday, January 13, 2017 - 11:25:13 AM
Last modification on : Monday, December 14, 2020 - 9:44:04 AM
Long-term archiving on: : Friday, April 14, 2017 - 8:22:51 PM


Version validated by the jury (STAR)


  • HAL Id : tel-01434181, version 1


Laura Catalina Córdoba Román. Magnesium-based biodegradable materials : from surface functionalization to cellular evaluation. Material chemistry. Université Pierre et Marie Curie - Paris VI; Instituto superior técnico (Lisbonne), 2016. English. ⟨NNT : 2016PA066237⟩. ⟨tel-01434181⟩



Record views


Files downloads