D. Unreliable and . Warfarin-coagulopathy, A Prospective Cohort Study, Thrombosis Journal, vol.12, issue.1

G. M. Liumbruno, for the Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Working Party Thromboelastography and Thromboelastometry and the Management of Intra-Operative Transfusion Therapy in Massively Bleeding Patients, Blood Transfusion, vol.10, issue.3, pp.130-141, 2012.

J. Gill, G. M. Erica, S. D. Kerins, A. D. Langton, and . Macnicoll, The development of a blood clotting response test for discriminating between difenacoum-resistant and susceptible Norway rats (Rattus norvegicus, berk.), Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, vol.104, issue.1, pp.29-36, 1993.
DOI : 10.1016/0742-8413(93)90106-U

J. Gill, G. M. Erica, S. D. Kerins, A. D. Langton, and . Macnicoll, Blood-Clotting Response Test for Bromadiolone Resistance in Norway Rats, The Journal of Wildlife Management, vol.58, issue.3, pp.454-61, 1994.
DOI : 10.2307/3809316

K. Gorlinger, A. Dirkmann, . Hanke, . Kamler, . Kottenberg et al., First-Line Therapy with Coagulation Factor Concentrates Combined with Point-of-Care Coagulation Testing Is Associated with Decreased Allogeneic Blood Transfusion in Cardiovascular Surgery: A Retrospective, Single-Center Cohort Study, Anesthesiology, vol.115, issue.6, 2011.

J. Greaves, Warfarin-Resistant Rats, Royal Society of Health Journal, vol.90, issue.6, p.289, 1970.

J. H. Greaves, Resistance to anticoagulants in rodents, Pesticide Science, vol.67, issue.6, pp.276-79, 1971.
DOI : 10.1002/ps.2780020609

M. Kuruvilla and C. Gurk-turner, A Review of Warfarin Dosing and Monitoring Proceedings (Baylor University, Medical Center), vol.14, issue.3, pp.305-311, 2001.

P. Berny and E. Benoit, Warfarin Resistance in a French Strain of Rats, Journal of Biochemical and Molecular Toxicology, vol.19, issue.6, pp.379-85, 2006.

A. D. Macnicoll and J. E. Gill, Revised methodology for a blood-clotting response test for identification of warfarin-resistant Norway rats (Rattus norvegicus), EPPO Bulletin, vol.840, issue.4, 1993.
DOI : 10.1016/0006-2952(90)90238-G

. Markussen, D. Mette, A. Heiberg, M. Fredholm, and M. Kristensen, Differential expression of cytochrome P450 genes between bromadiolone-resistant and anticoagulant-susceptible Norway rats: a possible role for pharmacokinetics in bromadiolone resistance, Pest Management Science, vol.104, issue.3, pp.239-287, 2008.
DOI : 10.1002/ps.1506

. Tranholm, A Novel F8 Rat as a Translational Model of Human Hemophilia A, Journal of Thrombosis and Haemostasis, vol.12, issue.8, pp.1274-82, 2014.

P. Plum, Relation between Prothrombin Concentration and Clotting Time1, Acta Medica Scandinavica, vol.237, issue.1-2, pp.41-56, 1943.
DOI : 10.1111/j.0954-6820.1943.tb15042.x

S. Rost, H. Pelz, S. Menzel, A. D. Macnicoll, V. León et al., Vitamin K-Dependent g-Glutamylcarboxylation: An Ancient Posttranslational Modification, Novel Mutations References Bandyopadhyay, P.K. Vitamins & Hormones, Vitamin K, pp.157-184, 2008.

M. M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976.
DOI : 10.1016/0003-2697(76)90527-3

D. Cain, S. M. Hutson, and R. Wallin, Warfarin resistance is associated with a protein component of the vitamin K 2,3-epoxide reductase enzyme complex in rat liver, Thromb. Haemost, vol.80, pp.128-133, 1998.

K. Chu, S. M. Wu, T. Stanley, D. W. Stafford, and K. A. High, A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism., Journal of Clinical Investigation, vol.98, issue.7, pp.1619-1625, 1996.
DOI : 10.1172/JCI118956

E. J. Favaloro, S. Soltani, J. Mcdonald, E. Grezchnik, and L. Easton, Cross-laboratory audit of normal reference ranges and assessment of ABO blood group, gender and age on detected levels of plasma coagulation factors, Blood Coagulation & Fibrinolysis, vol.16, issue.8, pp.597-605, 2005.
DOI : 10.1097/01.mbc.0000187250.32630.56

G. Ferland, The Discovery of Vitamin K and Its Clinical Applications, Annals of Nutrition and Metabolism, vol.61, issue.3, pp.213-218, 2012.
DOI : 10.1159/000343108

B. Furie, B. A. Bouchard, and B. C. Furie, Vitamin K-dependent biosynthesis of g-carboxyglutamic acid, Blood, vol.93, pp.1798-1808, 1999.

J. E. Gill, G. M. Kerins, S. D. Langton, and A. D. Macnicoll, Blood-Clotting Response Test for Bromadiolone Resistance in Norway Rats, The Journal of Wildlife Management, vol.58, issue.3, pp.454-461, 1994.
DOI : 10.2307/3809316

T. M. Guenthner, D. Cai, and R. Wallin, Co-purification of Microsomal Epoxide Hydrolase with the Warfarin-Sensitive Vitamin K1 Oxide Reductase of the Vitamin K Cycle, Biochemical Pharmacology, vol.55, issue.2, pp.169-175, 1998.
DOI : 10.1016/S0006-2952(97)00431-0

T. Harauchi, K. Takano, M. Matsuura, and T. Yoshizaki, Liver and plasma levels of descarboxyprothrombin (PIVKA II) in vitamin K deficiency in rats., The Japanese Journal of Pharmacology, vol.40, issue.4, pp.491-499, 1986.
DOI : 10.1254/jjp.40.491

A. Hodroge, C. Longin-sauvageon, I. Fourel, E. Benoit, and V. Lattard, Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants, Archives of Biochemistry and Biophysics, vol.515, issue.1-2, 2011.
DOI : 10.1016/j.abb.2011.08.010

A. Hodroge, B. Matagrin, C. Moreau, I. Fourel, A. Hammed et al., mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity, Journal of Thrombosis and Haemostasis, vol.6, issue.12, pp.2535-2543, 2012.
DOI : 10.1111/jth.12019

A. M. Huber, K. W. Davidson, M. E. O-'brien-morse, and J. A. Sadowski, Tissue phylloquinone and menaquinones in rats are affected by age and gender, J. Nutr, vol.129, pp.1039-1044, 1999.

G. M. Kerins and A. D. Macnicoll, Comparison of the half-lives and regeneration rates of blood clotting factors II, VII, and X in anticoagulant-resistant and susceptible Norway rats (Rattus norvegicus Berk.), Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, vol.122, issue.3, pp.307-316, 1999.
DOI : 10.1016/S0742-8413(98)10128-7

M. H. Kohn and H. J. Pelz, Genomic assignment of the warfarin resistance locus, Rw, in the rat, Mammalian Genome, vol.10, issue.7, pp.696-698, 1999.
DOI : 10.1007/s003359901073

C. Lemini, R. Jaimez, and Y. Franco, Gender and inter-species influence on coagulation tests of rats and mice, Thrombosis Research, vol.120, issue.3, pp.415-419, 2007.
DOI : 10.1016/j.thromres.2006.10.012

T. Li, C. Chang, D. Jin, P. Lin, A. Khvorova et al., Identification of the gene for vitamin K epoxide reductase, Nature, vol.427, issue.6974, pp.541-544, 2004.
DOI : 10.1038/nature02254

M. D. Markussen, A. Heiberg, M. Fredholm, and M. Kristensen, Differential expression of cytochrome P450 genes between bromadiolone-resistant and anticoagulant-susceptible Norway rats: a possible role for pharmacokinetics in bromadiolone resistance, Pest Management Science, vol.104, issue.3, pp.239-248, 2008.
DOI : 10.1002/ps.1506

M. D. Markussen, A. Heiberg, M. Fredholm, and M. Kristensen, Characterization of bromadiolone resistance in a danish strain of Norway rats,rattus norvegicus, by hepatic gene expression profiling of genes involved in vitamin k-dependent ??-carboxylation, Journal of Biochemical and Molecular Toxicology, vol.25, issue.6, pp.373-381, 2007.
DOI : 10.1002/jbt.20201

T. M. Misenheimer and J. W. Suttie, Warfarin resistance in a chicago strain of rats, Biochemical Pharmacology, vol.40, issue.9, pp.2079-2084, 1990.
DOI : 10.1016/0006-2952(90)90238-G

P. Moroni, C. Longinsauvageon, and E. Benoit, The Flavin-Containing Monooxygenase in Rat Liver: Evidence for the Expression of a Second Form Different from FMO1, Biochemical and Biophysical Research Communications, vol.212, issue.3, pp.820-826, 1995.
DOI : 10.1006/bbrc.1995.2042

C. A. Mugford and G. L. Kedderis, Sex-Dependent Metabolism of Xenobiotics, Drug Metabolism Reviews, vol.24, issue.3, pp.441-498, 1998.
DOI : 10.1089/dna.1993.12.1

J. Oldenburg, C. G. Bevans, C. R. Müller, and M. Watzka, Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1): The Key Protein of the Vitamin K Cycle, Antioxidants & Redox Signaling, vol.8, issue.3-4, pp.347-353, 2006.
DOI : 10.1089/ars.2006.8.347

H. Pelz, S. Rost, M. Hünerberg, A. Fregin, A. Heiberg et al., The Genetic Basis of Resistance to Anticoagulants in Rodents, Genetics, vol.170, issue.4, pp.1839-1847, 2005.
DOI : 10.1534/genetics.104.040360

H. Pelz, S. Rost, E. Müller, A. Esther, R. G. Ulrich et al., Distribution and frequency of VKORC1 sequence variants conferring resistance to anticoagulants in Mus musculus, Pest Management Science, vol.2, issue.2, pp.254-259, 2012.
DOI : 10.1002/ps.2254

C. Petterino and B. Paolo, Toxicology of various anticoagulant rodenticides in animals, Vet. Hum. Toxicol, vol.43, pp.353-360, 2001.

S. Rost, A. Fregin, V. Ivaskevicius, E. Conzelmann, K. Hörtnagel et al., Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2, Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2, pp.537-541, 2004.
DOI : 10.1038/nature02214

H. H. Thijssen, Warfarin resistance, Biochemical Pharmacology, vol.36, issue.17, pp.2753-2757, 1987.
DOI : 10.1016/0006-2952(87)90260-7

H. H. Thijssen and L. G. Baars, Microsomal warfarin binding and vitamin K 2,3-epoxide reductase, Biochemical Pharmacology, vol.38, issue.7, pp.1115-1120, 1989.
DOI : 10.1016/0006-2952(89)90257-8

D. J. Waxman, Interactions of hepatic cytochromes P-450 with steroid hormones, Biochemical Pharmacology, vol.37, issue.1, pp.71-84, 1988.
DOI : 10.1016/0006-2952(88)90756-3

R. Wallin, S. M. Hutson, D. Cain, A. Sweatt, and D. C. Sane, A molecular mechanism for genetic warfarin resistance in the rat, The FASEB Journal, vol.doi, 2001.
DOI : 10.1096/fj.01-0337fje

M. Watzka, C. Geisen, C. G. Bevans, K. Sittinger, G. Spohn et al., Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment, Journal of Thrombosis and Haemostasis, vol.16, issue.Suppl. 1, 2011.
DOI : 10.1111/j.1538-7836.2010.04095.x

X. Zhu and W. G. Shin, Gender differences in pharmacokinetics of oral warfarin in rats, Biopharmaceutics & Drug Disposition, vol.5, issue.4, pp.147-150, 2005.
DOI : 10.1002/bdd.442

R. Appendino, G. Tagliapietra, S. Gariboldi, P. Nano, G. M. Picci et al., ??-Oxygenated prenylated coumarins from Ferula communis, Phytochemistry, vol.27, issue.11, pp.3619-3624, 1987.
DOI : 10.1016/0031-9422(88)80778-7

G. Appendino, S. Tagliapietra, G. M. Nano, and V. Picci, Ferprenin, a prenylated coumarin from Ferula communis, Phytochemistry, vol.27, issue.3, pp.944-946, 1988.
DOI : 10.1016/0031-9422(88)84130-X

G. Appendino, S. Tagliapietra, G. M. Nano, and V. Picci, An antiplatelet acetylene from the leaves of Ferula communis, Fitoterapia, vol.64, p.179, 1993.

G. Appendino, G. C. Cravotto, O. Sterner, and M. Ballero, ), Journal of Natural Products, vol.64, issue.3, pp.393-395, 2001.
DOI : 10.1021/np000468f

M. Aragno, S. Tagliapietra, G. M. Nano, and G. Ugazio, Experimental studies on the toxicity of Ferula communis in the rat, Res. Commun. Chem. Pathol. Pharmacol, vol.59, pp.399-402, 1988.

F. Benkhalti and D. Lamnaouer, Activité anticoagulante de quelques principes isolés de Ferula communis L, Actes du 1er colloque international «La pharmacopée Arabo-islamique, Hier et Aujourd'hui, pp.215-220, 1994.

S. Carboni, V. Malaguzi, and A. Marsili, Ferulenol a new coumarin derivative from ferula communis, Tetrahedron Letters, vol.5, issue.38, pp.2783-2786, 1964.
DOI : 10.1016/S0040-4039(00)71730-8

A. M. Cauwet-marc, Le complexe Ferula communis L. dans ses populations du sud de la France et de la Corse, Biol. Ecol. Méditerranéenne, vol.8, pp.101-118, 1981.

A. M. Cauwet-marc, Le genre Ferula communis L. sur le pourtour du bassin méditerranéen. 106 ème congrès des Sociétés savantes, pp.77-87, 1981.

C. Cornevin, Des plantes vénéneuses et des empoisonnements qu'elles déterminent. Librairie de Firmin-Didot et Cie, pp.380-396, 1887.
DOI : 10.5962/bhl.title.10844
URL : https://babel.hathitrust.org/cgi/imgsrv/download/pdf?id=coo.31924002888802;orient=0;size=100;seq=9;attachment=0

A. Egber, A. Perevolotsky, R. Yonatan, A. Shlosberg, M. Belaich et al., Creating aversion to giant fennel (Ferula communis, 1998.
DOI : 10.1016/s0168-1591(98)00168-3

O. Fraigui, D. Lamnaouer, and M. Y. Faouzi, Acute toxicity of ferulenol, a 4- hydroxycoumarin isolated from Ferula communis L, Vet. Hum. Toxicol, vol.44, pp.5-7, 2001.

O. Fraigui, D. Lamnaouer, and M. Y. Faouzi, Acute toxicity of ferulenol, a 4- hydroxycoumarin isolated from Ferula communis L, Vet. Hum. Tox, vol.44, pp.5-7, 2002.

G. Gault, M. Riera, P. Berny, E. Benoit, and D. Grancher, Giant fennel (Ferula communis L.) intoxications in livestock in France, Proceedings of the 9th Congress of the International Society of Poisonous plants (ISOPP). Hohhot (PR China), pp.95-99, 2015.

M. Gebauer, Synthesis and structure???activity relationships of novel warfarin derivatives, Bioorganic & Medicinal Chemistry, vol.15, issue.6, pp.2414-2420, 2007.
DOI : 10.1016/j.bmc.2007.01.014

A. Grandemange, R. Lasseur, C. Longin-sauvageon, E. Benoit, and P. Berny, in France, Pest Management Science, vol.14, issue.3, pp.270-276, 2010.
DOI : 10.1002/ps.1869

A. Hammed, B. Matagrin, G. Spohn, C. Prouillac, E. Benoit et al., VKORC1L1, an Enzyme Rescuing the Vitamin K 2,3-Epoxide Reductase Activity in Some Extrahepatic Tissues during Anticoagulation Therapy, Journal of Biological Chemistry, vol.288, issue.40, pp.28733-28742, 2013.
DOI : 10.1074/jbc.M113.457119

H. Hu, T. J. Harrison, and P. D. Wilson, A Modular and Concise Total Synthesis of (??)-Daurichromenic Acid and Analogues, The Journal of Organic Chemistry, vol.69, issue.11, pp.3782-3786, 2004.
DOI : 10.1021/jo049703f

M. Infante, Intoxicacion por Ferula communis L. (intoxication by Ferula communis L.) Archivos de zootecnia 14, pp.25-54, 1965.

E. J. Jung, B. H. Park, and Y. R. Lee, Environmentally benign, one-pot synthesis of pyrans by domino Knoevenagel/6p-electrocyclization in water and application to natural products, Green Chem, vol.12, 2003.

D. Lamnaouer, O. Fraigui, and F. Abadome, Toxicité et activité anticoagulante de quelques constituants de Ferula communis L. chez le rat, Al Biruniya. Rev. Marocaine Pharm. Rabat, vol.7, pp.135-142, 1991.

D. Lamnaouer, M. Omari, A. Mounir, and M. El-alouani, Activité anticoagulante de Ferula communis L. chez le mouton, Maghreb Vétérinaire, vol.5, pp.5-10, 1990.

Y. Lannehoa, P. Harry, C. Michau, A. Fareta, and R. Merad, Anal bleeding due to hypovitamin K caused by ingesting «fassoukh», Presse médicale 31, p.1579, 1998.

T. Li, C. Y. Chang, D. Y. Jin, P. J. Lin, A. Khvorova et al., Identification of the gene for vitamin K epoxide reductase, Nature, vol.427, issue.6974, pp.541-544, 2004.
DOI : 10.1038/nature02254

T. M. Misenheimer and J. W. Suttie, Warfarin resistance in a chicago strain of rats, Biochemical Pharmacology, vol.40, issue.9, pp.2079-2084, 1990.
DOI : 10.1016/0006-2952(90)90238-G

M. Miski and T. Mabry, Daucane esters from Ferula communis subsp. communis, Phytochemistry, vol.24, issue.8, pp.1735-1741, 1985.
DOI : 10.1016/S0031-9422(00)82543-1

M. Monti, M. Pinotti, G. Appendino, F. Dallocchio, T. Bellini et al., Characterization of anti-coagulant properties of prenylated coumarin ferulenol, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1770, issue.10, pp.1437-1440, 2007.
DOI : 10.1016/j.bbagen.2007.06.013

C. Moroni, C. Longin-sauvageon, and E. Benoit, The Flavin-Containing Monooxygenase in Rat Liver: Evidence for the Expression of a Second Form Different from FMO1, Biochemical and Biophysical Research Communications, vol.212, issue.3, pp.820-826, 1995.
DOI : 10.1006/bbrc.1995.2042

J. Oldenburg, M. Marinova, C. Müller-reible, and M. Watzka, The Vitamin K Cycle, Vitamins Hormones, vol.78, pp.35-62, 2008.
DOI : 10.1016/S0083-6729(07)00003-9

P. Otieno, Toxicity of Ferula communis in sheep and goats. Annual report of the scientific research division of the Kenya Ministry of Agriculture, pp.23-24, 1975.

P. Rubiolo, M. Matteodo, G. Riccio, M. Ballero, P. Christen et al., L.) through Their Biologically Active and Volatile Fractions, Journal of Agricultural and Food Chemistry, vol.54, issue.20, pp.7556-7563, 2006.
DOI : 10.1021/jf061592t
URL : https://hal.archives-ouvertes.fr/hal-00895742

G. Sacchetti, G. Appendino, M. Ballero, C. Loy, and F. Poli, Vittae fluorescence as a tool to differentiate between poisonous and non-poisonous populations of giant fennel (Ferula communis) of the island Sardinia (Italy), Biochemical Systematics and Ecology, vol.31, issue.5, pp.527-534, 2003.
DOI : 10.1016/S0305-1978(02)00199-0

A. Shlosberg and M. N. Egyed, Experimental Ferula communis (giant fennel) Toxicosis in Sheep, Zentralblatt f??r Veterin??rmedizin Reihe A, vol.113, issue.1-10, pp.778-784, 1985.
DOI : 10.1111/j.1439-0442.1985.tb02000.x

R. B. Silverman, A model for a molecular mechanism of anticoagulant activity of 3-substituted 4-hydroxycoumarins, Journal of the American Chemical Society, vol.102, issue.16, pp.5421-5423, 1980.
DOI : 10.1021/ja00536a064

S. Tagliapietra, M. Aragno, G. Ugazio, and G. M. Nano, Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat, Res. Commun. Chem. Pathol. Pharmacol, vol.66, pp.333-336, 1989.

H. Thijssen, Warfarin resistance, Biochemical Pharmacology, vol.36, issue.17, pp.2753-2757, 1987.
DOI : 10.1016/0006-2952(87)90260-7

H. Thijssen and L. Baars, Microsomal warfarin binding and vitamin K 2,3-epoxide reductase, Biochemical Pharmacology, vol.38, issue.7, pp.1115-1120, 1989.
DOI : 10.1016/0006-2952(89)90257-8

M. Tishler, L. Fieser, and N. Wendler, and Related Compounds, Journal of the American Chemical Society, vol.62, issue.10, pp.2866-2871, 1940.
DOI : 10.1021/ja01867a066

N. Tligui, G. R. Ruth, and L. J. Felice, Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication, Am. J. Vet. Res, vol.55, pp.1564-1569, 1994.

M. G. Valle, G. Appendino, G. M. Nano, and V. Picci, Prenylated coumarins and sesquiterpenoids from Ferula communis, Phytochemistry, vol.26, issue.1, pp.253-256, 1987.
DOI : 10.1016/S0031-9422(00)81522-8

G. Appendino, S. Tagliapietra, P. Gariboldi, G. M. Nano, and V. Picci, ??-Oxygenated prenylated coumarins from Ferula communis, Phytochemistry, vol.27, issue.11, pp.3619-3624, 1987.
DOI : 10.1016/0031-9422(88)80778-7

G. Appendino, S. Tagliapietra, G. M. Nano, and V. Picci, Ferprenin, a prenylated coumarin from Ferula communis, Phytochemistry, vol.27, issue.3, pp.944-946, 1988.
DOI : 10.1016/0031-9422(88)84130-X

G. Appendino, G. C. Cravotto, O. Sterner, and M. Ballero, ), Journal of Natural Products, vol.64, issue.3, pp.393-395, 2001.
DOI : 10.1021/np000468f

L. Arnoldi, M. Ballero, N. Fuzzati, A. Maxia, E. Mercalli et al., HPLC-DAD-MS identification of bioactive secondary metabolites from Ferula communis roots, Fitoterapia, vol.75, issue.3-4, 2004.
DOI : 10.1016/j.fitote.2004.03.001

F. Benkhalti and D. Lamnaouer, Activité anticoagulante de quelques principes isolés de Ferula communis L. Actes du 1 er colloque international « La pharmacopée Arabo-islamique, Hier et Aujourd'hui, pp.215-220, 1994.

S. Carboni, V. Malaguzi, and A. Marsili, Ferulenol a new coumarin derivative from ferula communis, Tetrahedron Letters, vol.5, issue.38, pp.2783-2786, 1964.
DOI : 10.1016/S0040-4039(00)71730-8

A. M. Cauwet-marc, Le complexe Ferula communis L. dans ses populations du sud de la France et de la Corse, Biologie Ecologie Méditerranéenne, vol.8, pp.101-118, 1981.

A. M. Cauwet-marc, Les populations audoises et roussillonnaises de Ferula communis L. (Apiacées) Actes del Simposi Internacional de, Botanica Pius Font i Quer, vol.2, pp.129-135, 1988.

M. Damin-pernik, B. Espana, S. Besse, I. Fourel, F. Popowycz et al., Development of an Ecofriendly Anticoagulant Rodenticide Based on the Stereochemistry of Difenacoum, Drug Metabolism and Disposition, vol.44, issue.12, 2016.
DOI : 10.1124/dmd.116.071688
URL : https://hal.archives-ouvertes.fr/hal-01478383

J. De-pascual-teresa, M. A. Villaseco, J. M. Hernandez, J. R. Moran, J. G. Urones et al., Complex acetylenes from the roots of Ferula communis, Planta Medica, pp.458-462, 1986.

O. Fraigui, D. Lamnaouer, M. Y. Faouzi, Y. Cherrah, and M. Tijjane, Acute and chronic toxicity of Fessoukh, the resinous gum of Ferula communis L, 2001.

G. Gault, M. Riera, P. Berny, E. Benoit, and D. Grancher, Giant fennel (Ferula communis L.) intoxications in livestock in France, Proceedings of the 9 th Congress of the International Society of Poisonous plants (ISOPP). Hohhot (PR China, pp.95-99, 2015.

M. Gebauer, Synthesis and structure???activity relationships of novel warfarin derivatives, Bioorganic & Medicinal Chemistry, vol.15, issue.6, pp.2414-2420, 2007.
DOI : 10.1016/j.bmc.2007.01.014

M. Infante, Intoxicacion por Ferula communis L. (intoxication by Ferula communis L.). Archivos de zootecnia, pp.25-54, 1965.

E. J. Jung, B. H. Park, and Y. R. Lee, ChemInform Abstract: Environmentally Benign, One-Pot Synthesis of Pyrans by Domino Knoevenagel/6??-Electrocyclization in Water and Application to Natural Products., ChemInform, vol.12, issue.12, 2010.
DOI : 10.1002/chin.201112132

D. Lamnaouer, Ferula communis L. : recherches sur la toxicologie et la composition chimique des taxons marocains, 1987.

Y. Lannehoa, P. Harry, C. Michau, A. Fareta, and R. Merad, Anal bleeding due to hypovitamin K caused by ingesting « fassoukh, Presse médicale, pp.31-1579, 1998.

M. S. Louvet, G. Gault, S. Lefebvre, F. Popowycz, M. Boulven et al., Comparative inhibitory effect of prenylated coumarins, ferulenol and ferprenin, contained in the ???poisonous chemotype??? of Ferula communis on mammal liver microsomal VKORC1 activity, Phytochemistry, vol.118, pp.124-130, 2015.
DOI : 10.1016/j.phytochem.2015.08.012

F. Maggi, D. Lucarini, B. Tirillini, G. Sagratini, E. Papa et al., Chemical analysis of the essential oil of Ferula glauca L, Apiaceae) growing in Marche (central Italy), 2009.

M. Miski and T. Mabry, Daucane esters from Ferula communis subsp. communis, Phytochemistry, vol.24, issue.8, 1985.
DOI : 10.1016/S0031-9422(00)82543-1

M. G. Pimenov and M. V. Leonov, The Asian Umbelliferae biodiversity database (ASIUM) with particular reference to South-West Asian Taxa, Turkish Journal of Botany, vol.28, pp.139-145, 2004.

J. P. Reduron, Ombellifères de France, pp.1260-1300, 2007.

A. Shlosberg and M. N. Egyed, Experimental Ferula communis (giant fennel) Toxicosis in Sheep, Zentralblatt f??r Veterin??rmedizin Reihe A, vol.113, issue.1-10, 1985.
DOI : 10.1111/j.1439-0442.1985.tb02000.x

A. Shlosberg, Plant Toxicoses in Israel, Israel Journal of Veterinary Medicine, vol.66, pp.171-174, 2011.

M. G. Valle, G. Appendino, G. M. Nano, V. Picci, W. S. Abohelaika et al., Prenylated coumarins and sesquiterpenoids from Ferula communis, Phytochemistry, vol.26, issue.1, pp.253-256, 1987.
DOI : 10.1016/S0031-9422(00)81522-8

A. W. , G. A. , W. A. , and C. M. Hylek-e, ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion [Internet], Thrombelastography (TEG) or thromboelastometry, 2011.

O. Anticoagulant-therapyahmad, E. Hussain-i, B. J. Aithal-g, . P. Day-c, . J. Kesteven-p et al., Losses of stored foods due to rats at grain markets in Pakistan Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis). [Internet] Vitamin K treatment of sweet clover poisoning in calves [Internet], Internet]. Int. Biodeterior. BiodegradationInternet]. Lancet Iran. J. Basic Med. Sci. J. Am. Vet. Med. Assoc, vol.141, issue.8, pp.44-88, 1985.

D. J. Laveau-p, A. D. , M. H. Balas-d, . T. Kumfer-k, . Sandbo-n et al., Complications of warfarin therapy monitored by the international normalized ratio versus the prothrombin time ratio [Internet], Clin. Cardiol, vol.18, issue.10, pp.80-82, 1995.

M. Absence-of-vitamin-k-dependentaragno, T. S. Nano-g, U. G. Aral, C. A. Usta-m, . B. Inal-b et al., Experimental studies on the toxicity of Ferula communis in the rat Verifying reference intervals for coagulation tests by using stored data [Internet]. Scand, Res. Commun. Chem. Pathol. Pharmacol. J. Clin. Lab. Invest, vol.10, issue.71, pp.399-402, 1988.

B. S. Kumar-r, 3 epoxide reductase system from rat liver [Internet] Thrombin, fibrin and platelets: a resonance loop in which von Willebrand factor is a necessary link [Internet], Biosynthesis of vitamin K (menaquinone) in bacteria, pp.481-486, 1997.

-. , G. A. , L. R. , C. J. Kunze-k, . C. Wienkers-l et al., Fonctions nouvelles de Gas-6 et de la protéine S [Internet]. médecine/sciences, pp.241-280, 1982.

E. J. , B. J. , T. W. Born-g, G. J. Cross-m, D. S. Gundberg-c et al., Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies The aggregation of blood platelets [Internet] Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin, Drug Metab. Dispos. J. Physiol. Bone, vol.24, issue.23, pp.422-428, 1963.

2. E. , F. L. Bryckaert, R. , D. C. Lenting-p, and W. A. , Vertebrate Pests: Damage on stored foods [Internet]. 23 Of von Willebrand factor and platelets [Internet], Biochimie Cell. Mol. Life Sci, vol.82, issue.24, pp.851-859, 2000.

L. K. , H. M. Calder-p, . C. Provensal-m, and . Pini-n, Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats, 25. -CARLSON B.: Declaring War on Warfarin Misdosing, pp.73-79, 2008.

M. A. Steinmann-a, P. J. Castoldi, B. J. , N. G. , and G. D. Tans-g, Commensal and wild rodents in an urban area of Argentina [Internet], Int. Biodeterior. Biodegradation, vol.52, issue.27, pp.135-141, 2003.

A. Impaired, E. , and R. J. , Thrombin generation tests, the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations [Internet]. Blood, pp.4173-4179, 2004.

3. Huang-t.-y, W. J. , S. D. Loscalzo, . A. Zimmerman-g, and . P. Mcever-r, Gender bias in clinical research, pharmaceutical marketing, and the prescription of drugs [Internet]. Glob. Health Action Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2 [Internet], Fatty Acid Composition of Hepatic and Plasma Lipids Differ by Both Sex and Dietary Fat Intake in Rats, pp.245-250, 2006.

P. J. Wick-t, K. B. Schwartz-b, . S. Barnathan-e, . R. Mccrae-k, . A. Hug-b et al., Endothelial Cells in Physiology and in the Pathophysiology of 34. -CLINICAL AND LABORATORY STANDARD INSTITUTE: Platelet function testing by aggregometry. Approved guideline, The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis [Internet]. Prog. Food Nutr, pp.3527-3561, 1998.

B. Scicorticelli, D. S. Palmas-g, . D. Blostein-m, and . Galipeau, [Protective antihemorrhagic effects of vitamin K-1 in poisoning by Ferula communis], Boll. della Soc. Ital. di Biol. Sper, vol.16, issue.33, pp.307-343, 1957.

G. H. Periostin-dam, . H. Knapen-m, and . Van-der, Vitamin K in the plant [Internet], Proteins Mesenchymal Stromal Cells [Internet]. J. Biol. Chem. Biochem. J, vol.283, issue.39, pp.17991-18001, 1938.

S. Y. , B. J. Drake, . H. Morrissey-j, and . S. Edgington-t, Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults [Internet] Selective cellular expression of tissue factor in human tissues Implications for disorders of hemostasis and thrombosis, J. Clin. Endocrinol. Metab, vol.100, issue.40, pp.2472-2479, 2015.

B. J. Goldstein-s, B. A. Gundberg-c, K. G. Dunham-c, R. C. Hileman-b, S. J. et al., Increased bone formation in osteocalcin-deficient mice [Internet], Nature, vol.382, issue.42, pp.448-452, 1996.

M. A. Hoffman-d, P. Z. Edson-k, U. J. Suhara-y, and G. F. Okano-t, TEG® and RapidTEG® are unreliable for detecting warfarincoagulopathy: a prospective cohort study [Internet], Thromb. J, vol.12, 2014.

P. Pept and U. A. Sci-erickson-w, Potential risks of nine rodenticides to birds and nontarget mammals: a comparative approach, pp.287-299, 2002.

O. Agencyespitia, Office of Prevention, Pesticides and Toxic Substances Washington, DC, 2004.

R. A. Pereira-m, . I. Ko-a, . G. Reis-m, P. J. Fasco-m, and S. J. Hildebrandt-e, Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil Formation of hydroxyvitamin K by vitamin K epoxide reductase of warfarin-resistant rats. [Internet], Acta Trop. J. Biol, vol.108, 2008.

. J. Chem-favaloro-e, . Soltani-s, . Mcdonald-j, and E. B. Grezchnik-e, Crosslaboratory audit of normal reference ranges and assessment of ABO blood group, gender and age on detected levels of plasma coagulation factors [Internet] Blood Coagul. Fibrinolysis An Int The factor VIII/von Willebrand factor complex: basic and clinical issues: The secret life of the city rat: a review of the ecology of urban Norway and black rats (Rattus norvegicus and Rattus rattus), The Discovery of Vitamin K and Its Clinical Applications [Internet]. Ann, pp.4372-4380, 1983.

M. Hinoi-e, D. P. Karsenty-g, . A. Fleck-r, R. V. Rao-l, L. X. Varki-n et al., Osteocalcin differentially regulates cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody [Internet], Proc. Natl. Acad. Sci, pp.213-218, 1990.

P. Pept, . D. Lett-56.-fraser-j, . Otawara-y, T. K. Price, and D. E. , A.: 1,25-dihydroxyvitamin D3 stimulates the synthesis of matrix y-carboxyglutamic acid protein by osteosarcoma cells Activation of bovine factor X, J. Biol. Chem, vol.15, issue.57, pp.43-46, 1988.

G. L. Harry-p-59.-garcia-d, R. S. , C. M. Hughes-r, -. M. Hylek-e, . Coppola-r et al., Warfarin Maintenance Dosing Patterns in Clinical Practice [Internet] The role of the spleen in regulating the plasma levels of factor VIII--von Willebrand's factor after DDAVP [Internet] Tissue Factor Pathway Inhibitor and the Revised Theory of Coagulation [Internet]: Effect of food composition on vitamin K absorption in human volunteers [Internet], Proc. Natl. Acad. Sci, pp.3359-3363, 1975.

H. D. Benoit-e, Functional role of periostin in development and wound repair: implications for connective tissue disease. [Internet], J. Clin. Pharmacol. Can. Vet. J. J. Cell Commun. Signal, vol.12, issue.67, pp.621-629, 1980.

H. V. Merad-r, . T. Azzouz, M. M. Takano-k, . Yoshizaki-t-barger-k, . S. Lamon-fava et al., Férule commune [Internet], VKORC1L1, an Enzyme Rescuing the Vitamin K Liver and Plasma Levels of Descarboxyprothrombin (PIVKA II) in Vitamin K Deficiency in Rats [Internet], pp.28733-28742, 1986.

G. A. , S. D. Shen-x, -. L. Booth-s, H. S. Levine-m, -. V. et al., Tissue Concentrations of Vitamin K and Expression of Key Enzymes of Vitamin K Metabolism Are Influenced by Sex and Diet but Not Housing in C57Bl6 Mice [Internet] Anticoagulation Drug Therapy: A Review [Internet] Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone, Platelet activation and blood coagulation [Internet] 75. -HERTZBERG M.: Biochemistry of factor X [Internet], pp.11-17, 1948.

H. A. Longin-sauvageon, . Fourel-i, L. V. Benoit-e, Ø. H. Holmsen, D. H. James et al., Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants Vitamin K1 absorption by everted intestinal sacs of the rat [Internet] Behaviour of endogenous and newly absorbed serotonin in the platelet release reaction [Internet] Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1 Gender differences in hepatic phylloquinone and menaquinones in the vitamin K-deficient and supplemented rat [Internet] Tissue phylloquinone and menaquinones in rats are affected by age and gender, IQBAL J., HUSSAIN M.M.: Intestinal lipid absorption [Internet], pp.1692-1711, 1941.

. Thromb, R. W. Haemost-88.-kalat-j, . E. Wolfe-b, and . Saltzman-e, « Learned safety » as a mechanism in long-delay tasteaversion learning in rats, J. Comp. Physiol. Psychol, vol.1, issue.83, pp.390-392, 1973.

Z. L. Booth-s, Fecal menaquinone profiles of overweight adults are associated with gut microbiota composition during a gut microbiota-targeted dietary intervention

9. M. Macnicoll-a, Comparison of the half-lives and regeneration rates of blood clotting factors II, VII, and X in anticoagulant-resistant and susceptible Norway rats (Rattus norvegicus Berk.) [Internet] Mathematical Model for the Blood, J. Clin. Nutr. Comp. Biochem. Physiol. Part C Pharmacol. Toxicol. Endocrinol, vol.102, issue.122, pp.84-93, 1999.

9. , Q. D. Kornfield-r, S. R. , and A. G. , National Trends in Oral Anticoagulant Use in the United States, Thromb. Res, vol.89, pp.227-232, 1998.

. Cardiovasc, B. Qualkohn, . Weingart-c, P. H. Giger-u.-94.-kohn-m, R. C. Kriz-n et al., Haemorrhage in seven cats with suspected anticoagulant rodenticide intoxication Genomic assignment of the warfarin resistance locus, Rw, in the rat [Internet] Physiology of Hemostasis: With Relevance to Current and Future Laboratory Testing A general review of major global coagulation assays: thrombelastography, thrombin generation test and clot waveform analysis, J. Feline Med. Surg. Mamm. Genome Off. J. Int. Mamm. Genome Soc. Clin. Lab. Med. Thromb. J, vol.5, issue.96, pp.615-621, 1999.

L. R. Longin-sauvageon, . Videmann-b, and B. P. Billeret-m, The population pharmacokinetics of R-and S-warfarin: effect of genetic and clinical factors. [Internet]. Br, J. Clin. Pharmacol, vol.73, issue.98, pp.66-76, 2012.

B. G. Milani-c, . S. De-giori-g, . Sesma-f, . Van-sinderen-d, and . Ventura-m, Warfarin resistance in a French strain of rats [Internet], J. Biochem. Mol. Toxicol, vol.19, pp.379-385, 2006.

-. , W. A. Lechner, C. J. Weltermann-a, and . Dacquin-r, Papers of the 4th Symposium on Hemostasis with Special Focus on Factor VIIa and Tissue Factor-Understanding the Molecular MechanismCirculating tissue factor-exposing microparticles Circulating tissue factor-exposing microparticles [Internet], Curr. Opin. Biotechnol. Thromb. Res. Thromb. Res, vol.24, issue.102, pp.160-168, 2008.

M. P. Mckee-m, J. D. Zhang-z, K. J. Mauvais-jarvis, K. G. Ducy-p, J. C. Lemini et al., Endocrine Regulation of Energy Metabolism by the Skeleton Gender and inter-species influence on coagulation tests of rats and mice [Internet] Influence of CYP2C9 genotype on warfarin dose requirements?a systematic review and meta-analysis. Eur, Cell Thromb. Res. J. Clin. Pharmacol, vol.130, issue.65, pp.456-469, 2007.

. Lab, . Haematol-106.-luo-g, . Ducy-p, . D. Mckee-m, . J. Pinero-g et al., Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein [Internet] A Thrombin Generation Test, MACKMAN N.: Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development [Internet] The Role of Tissue Factor and Factor VIIa in Hemostasis [Internet], pp.81-90, 1953.

. Anesth, H. D. Analg-110.-markussen-m, . Fredholm-m, M. M. Kristensen, H. Fredholm-m et al., Characterization of bromadiolone resistance in a danish strain of Norway rats, rattus norvegicus, by hepatic gene expression profiling of genes involved in vitamin k-dependent carboxylation [Internet] Differential expression of cytochrome P450 genes between bromadiolone-resistant and anticoagulantsusceptible Norway rats: a possible role for pharmacokinetics in bromadiolone resistance [Internet] Tissue factor is rapidly induced in arterial smooth muscle after balloon injury, J. Biochem. Mol. Toxicol. Pest Manag. Sci. J. Clin. Invest, vol.108, issue.113, pp.1447-1452, 1993.

T. J. , G. H. Binh-t, . Epidemic, . Haemorrhagic, . In et al., Activation of human factor VII by activated factors IX and X [Internet] New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) ? The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations [Internet] Recommendations for nomenclature on fibrinogen and fibrin [Internet], Blood FEBS Open Bio J. Thromb. Haemost, vol.321, issue.117, pp.230-232, 1982.

S. Cts, D. Pc, M. I. Pm-miyoshi, P. L. Stahmann-m, and C. T. Midtvedt, 3-substituted 4-hydroxycoumarin and process of making it, MOGIL J.S.: Perspective: Equality need not be painful [Internet]. Nature, pp.29-37, 1947.

B. A. Kedderis-g and H. P. Noris-p, Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study [Internet] Sex-Dependent Metabolism of Xenobiotics [Internet], Appl. Environ. Microbiol. Drug Metab. Rev, vol.72, issue.123, pp.1027-1033, 1998.

M. H. , S. D. , K. A. , C. J. Watanabe-m, and . Uchino-y, A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders Eradication revisited: dealing with exotic species [Internet], Thromb. Haemost. Trends Ecol. Evol, vol.114, issue.125, pp.14-25, 2000.

O. N. Shimomura-y, . Suhara-y, and . E. Okano-t-nazari-z, Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme [Internet] Biologically active sesquiterpene coumarins from Ferula species [Internet], Nature Phyther. Res, vol.468, issue.126, pp.117-121, 2010.

S. S. , R. B. Ducy-p, and K. P. Mackman-n, Endocrine Regulation of Male Fertility by the Skeleton Tissue factor and thrombosis: The clot starts here [Internet] 131. itor in patients with various thyroid disorders, Overview of the coagulation system [Internet], pp.796-809, 2003.

J. Indian, A. Anaesthparkinson, M. D. , J. C. Dwyer-a, and C. K. , The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes, -esters of 3, pp.515-523, 2004.

.. J. Finlayson-j and P. M. , [Cross-link in fibrin polymerized by factor 13: epsilon-(gamma-glutamyl)lysine], A Simple Method of Studying the Generation, pp.892-895, 1941.

. Clin, P. P. Pathol-, and U. M. Otawara-y, 137. -PLUM P.: Relation between Prothrombin Concentration and Clotting Time1 [Internet] 138. -PRESCOTT C. V.: A Reappraisal of Blood Clotting Response Tests for Anticoagulant Resistance and a proposal for a standardised BCR Test Methodology. 21 pages, CropLife international Matrix Gla protein, a new -carboxyglutamic acid-containing protein which is associated with the organic matrix of bone, Acta Med. Scand, vol.6, issue.139, pp.9-14, 1943.

P. P. Williamson-m, D. R. Haba-t, and . S. Jee-w, Excessive mineralization with growth plate closure in rats on chronic warfarin treatment, Biochem. Biophys. Res. Commun, vol.117, issue.140, pp.765-771, 1983.

A. , R. E. Borel-p.-reverter-j, K. H. Béguin-s, H. H. Kumar-r, C. B. Brynda et al., Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes [Internet] 143. -REUMANN S.: Biosynthesis of vitamin K1 (phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and « clinical restenosis ». [Internet], Prog. Lipid Res. Subcell. Biochem. J. Clin. Invest, vol.85, issue.145, pp.6687-6691, 1988.

A. Fibrinopeptides, release in the process of surface fibrin formation [Internet], Blood, vol.117, pp.1700-1706, 2011.

J. , R. K. Berkner-k, R. L. Dummer-s, A. A. Booth-n, B. H. Factor-o et al., A new model for vitamin K-dependent carboxylation: The catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine [Internet] Plasminogen activator inhibitor 2 and urokinase-type plasminogen activator in plasma and leucocytes in patients with severe sepsis [Internet] Specific hungers and poison avoidance as adaptive specializations of learning, Proc. Natl. Acad. Sci. U. S. A. Br. J. Haematol. Psychol. Rev, vol.101, issue.150, pp.13732-13737, 1971.

S. S. Veuthey-j.-l, C. L. Bicchi, . Delecroix-e, . Scherrer-f, L. A. Gros-a et al., Analytical Discrimination of Poisonous and Nonpoisonous Chemotypes of Giant Fennel ( Ferula communis L.) through Their Biologically Active and Volatile Fractions [Internet], J. Agric. Food Chem, vol.54, issue.151, pp.7556-7563, 2006.

-. E. Hundal-o, . Holme-i, . B. Herland-o, . Husby-g, and . E. Giercksky-k, Thromboélastométrie rotative : réhabilitation de l'ancienne thromboélastographie, Immunoanalyse Biol. Spécialisée, vol.21, issue.152, pp.380-387, 2006.

N. C. Piroxicam, . D. Holmes-n, . J. Sabol-b, . R. Basa-r, . E. Wilkins-c et al., Tropical island conservation: Rat eradication for species recovery [Internet] Malabsorption-associated warfarin resistance [Internet] Determination of bromadiolone residues in fox faeces by LC/ESI-MS in relationship with toxicological data and clinical signs after repeated exposure, Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners [Internet]. Proc. Natl. Acad, pp.389-98, 1986.

. U. Sci, D. K. Segers, and N. G. , Coagulation factor V and thrombophilia: Background and mechanisms [Internet], SERVICE ÉVALUATION DES ACTES PROFESSIONNELS: BIOLOGIE DES ANOMALIES NEMENT (ÉPREUVE DE DUKE ET TESTS D'IVY), pp.15027-15032, 2007.

1. A. Hanin-l, . A. Khanin-m, . J. Shearer-m, . Fu-x, E. L. Booth-s et al., Vitamin K Nutrition, Metabolism, and Requirements: Current Concepts and Future Research Experimental Ferula communis (giant fennel) toxicosis in sheep A model for a molecular mechanism of anticoagulant activity of 3-substituted 4-hydroxycoumarins Chemical model studies for the mechanism of vitamin K epoxide reductase [Internet] Amino Acids Responsible for Reduced Affinities of Vitamin K-Dependent Propeptides for the Carboxylase 166. -STENFLO J.: Dicumarol-induced prothrombin in bovine plasma: Vitamin K and the Biosynthesis of Prothrombin II. Structural comparison of normal and dicoumarol-induced bovine prothrombin Structural comparison of an NH2-terminal fragment from normal and from abnormal dicoumarolinduced bovine prothrombin Isolation of peptides containing prosthetic groups from normal prothrombin and the corresponding peptides from dicoumarol-induced prothrombin, STENFLO J.: Vitamin K and the Biosynthesis of Prothrombin IIISTENFLO J.: Vitamin K and the Biosynthesis of Prothrombin IV Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin [Internet]. Proc. Natl. Acad. Sci. U. S, pp.96-104, 1970.

J. O. Ganrot-p, . A. Stepanian, . C. Biron-andreani, . N. Fuller, M. J. Motomura-y et al., Binding of Ca2+ to normal and dicoumarol-induced prothrombin [Internet] Exploration de l'hémostase primaire [Internet] Urban rats as chronic carriers of leptospirosis: an ultrastructural investigation, J. Biol. Chem. Biochem. Biophys. Res. Commun. Ann. Biol. Clin. (Paris). Vet. Pathol, vol.50, issue.176, pp.247-173, 1972.

E. M. , H. C. Tagliapietra, . Aragno-m, . Ugazio-g, and . M. Nano-g, Endocytosis and storage of plasma factor V by human megakaryocytes [Internet], Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat. [Internet]. Res, pp.585-592, 2005.

Y. H. Suzuki-h-thijssen-h, . M. Vervoort-l, . J. Schurgers-l, and . J. Shearer-m, 275ra23. 179. -TALSTAD I.: Which coagulation factors interfere with the one-stage prothrombin time? [Internet] Menadione is a metabolite of oral vitamin K [Internet], 181. -TLIGUI N., RUTH G.R.: Ferula communis variety brevifolia intoxication of sheep, pp.19-25, 1993.

V. K. , R. J. Tans-g, . P. Schwarz-h, J. C. Vermeer, . H. Knapen-m et al., Influence of factor V and factor Va on APC-induced cleavage of human factor VIII [Internet] Role of Vitamin K in Bone Metabolism, Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration, pp.437-445, 1995.

P. P. Cancela-m, S. D. Glass-g, . E. Flexner-c, K. D. Mueller-p, and S. J. , Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. [Internet] Sporadic Urban Leptospirosis [Internet], Am. J. Pathol. Ann. Intern. Med, vol.175, issue.187, pp.2288-98, 1996.

W. Factor, . Thromb, R. Haemostwallin, C. M. Hutson-s, and S. D. Sweatt-a, A molecular mechanism for genetic warfarin resistance in the rat [Internet], FASEB J, vol.79, issue.188, pp.456-465, 1998.

W. D. , J. A. Papp-a, and K. D. Sadee-w, Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement, pp.1013-1034, 0190.

B. C. Müller-c, W. H. Oldenburg-j-, F. J. , C. E. Brzezinski-w, -. R. et al., 3-Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Mediates Vitamin K-dependent Intracellular Antioxidant Function [Internet] Effect of patientspecific factors on weekly warfarin dose, Phylloquinone (vitamin K1) biosynthesis in plants: two peroxisomal thioesterases of lactobacillales origin hydrolyze 1, pp.15085-15094, 0193.

L. S. Gault-g, L. V. Louvet-m-s, and G. D. Et, Ferulenol levels in french continental Giant fennel (Ferula sp.) In : XIXth Congress European society of Veterinary & Comparative Nutrition (ESVCN), 2015.