Elaboration de matériaux bioactifs à partir de fibres lignocellulosiques

Abstract : Surface contamination by pathogens constitutes a major public health problem encountered in many areas such as hospitals, environment and food industry. This contamination consists in the adhesion of pathogenic or opportunistic bacteria that can attach to a biotic or abiotic surface and lead to the formation of biofilm. An effective way to fight against microbial contamination is the development of antibacterial surfaces, in order to prevent or reduce bacterial adhesion. Based on the expertise of the Laboratoire de Chimie des Substances Naturelles in the field of polysaccharides, we have undertaken the development of antibacterial materials by grafting through covalent bonds molecules presenting antibacterial properties onto lignocellulosic fibers (in this case Kraft pulp fibers). Triazoles are resistant to acid and basic hydrolysis, reductive and oxidative conditions. This moiety is also relatively resistant to metabolic degradation and is not posing particular toxicity problems. The study of the antibacterial effect has shown a bactericidal activity of the triclosan-Kraft pulp sheet against three strains frequently found in hospitals: Pseudomonas aeruginosa, Bacillus cereus and Escherichia coli. In the case of grafting photosensitizers, only the neutral porphyrin-Kraft pulp sheet material displayed a strong photobactericidal activity after irradiation.
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Jean Kerim Nzambe Ta Keki. Elaboration de matériaux bioactifs à partir de fibres lignocellulosiques. Chimie organique. Université de Limoges, 2015. Français. ⟨NNT : 2015LIMO0133⟩. ⟨tel-01421485⟩

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