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L'hélicase RECG1, un facteur-clé dans le maintien et la ségrégation de l'ADN mitochondrial d'Arabidopsis thaliana

Abstract : The mitochondrial DNA (mtDNA) of flowering plants is characterized by the recombination activities that modulate its structure. These activities are required for the mtDNA maintenance, and drive its rapid structural evolution. The factors that control recombination are therefore essential for plant mtDNA stability. During my PhD, I identified and characterized two DNA helicases that are present in the organelles of Arabidopsisthaliana. One is the homologue of a bacterial helicase involved in transcription-coupled repair. Its role in the plant organelles is still not determined. The other one, the RECG1 helicase, has roles in recombination dependent repair, the surveillance of ectopic recombination involving short repeated sequences, and also the segregation of the mtDNA. We have found that in the absence of RECG1 there is loss of recombination control resulting in the occurrence of alternative versions of the mtDNA generated by recombination. The analysis oftheir segregation, induced by RECG1, allowed us to build a model to how new stable mtDNA configurations are generated by the stoichiometric shift of mtDNA sub-genomes. This work allowed us to better understand the recombination and segregation mechanisms that modulate the Arabidopsis mtDNA.
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Submitted on : Thursday, November 24, 2016 - 3:12:09 PM
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Clementine Wallet. L'hélicase RECG1, un facteur-clé dans le maintien et la ségrégation de l'ADN mitochondrial d'Arabidopsis thaliana. Biologie végétale. Université de Strasbourg, 2016. Français. ⟨NNT : 2016STRAJ016⟩. ⟨tel-01402317⟩

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