Biodegradable sponge like microparticles for drug delivery and cosmetotextile

Abstract : The objective of this thesis was to prepare and characterize cyclodextrin based biodegradable,cationic and sponge like multifunctional microparticles that not only can be used for thedelivery of cosmetic and therapeutic agent (anti-inflammatory) but also can be potentiallyapplied onto specifically selected textile for their functionalization. For achieving these goals,polymethylmethacrylate based microparticles were prepared using double emulsion-diffusionsolvent evaporation technique. Systematic studies were performed for optimization of processcontrol parameters. Once desired size of sponge like particles was obtained from thesystematic study, the polyamide textile surface was functionalized with these particles whilededicating special attention to electrokinetic properties of textile as a function of variousparameters such as; particles amount present during adsorption process. Finally, encapsulationof pure vitamin E, Lauryl Isoquinolinium Bromide (LIB), Indomethacin (IMC) as well asencapsulation of complexes of vit E-Hydroxypropyl-beta-cyclodextrin (HPBCD), LIBHPBCDand IMC-HPBCD into microparticles was done separately. These particles werecharacterized for skin penetration and encapsulation efficiency
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Submitted on : Tuesday, November 8, 2016 - 2:51:06 PM
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Nadiah Zafar. Biodegradable sponge like microparticles for drug delivery and cosmetotextile. Chemical engineering. Université de Lyon, 2016. English. ⟨NNT : 2016LYSE1068⟩. ⟨tel-01394020⟩



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