Skip to Main content Skip to Navigation
New interface
Theses

Deciphering regulatory mecharnsms of the lMD pathway activation during the innate immune response in Drosophila

Abstract : The innate immune responseis required by all metazoan to defend themselves against microorganisms. When abnormally activated however, innate immune responses cause deleterious chronic inflammation. The study of the fragile equilibrium between immune responses and tolerance has fundamentally shaped the projects of my PhD work.First, using Drosophila melangoaster as a model, I characterized Big-Bang as a major player of the immune balance in the gut. I could show that Big-Bang is a bona fide component of midgut epithelium septate junctions. Consequently, big-Bang deficient flies have an impaired tolerance against commensal microorganisms and are susceptible to invasive gut pathogens, ultimately leading to a premature death of flies.I focused the second part of my PhD work on the characterization of Akirin, a nuclear protein required for the activation of NF-ΚB response from Drosophila to humans. My results showed that Akirin is a selector molecule, acting together with NF-ΚB and the SWI/SNF chromatin-Remodeling complex to sustain the transcription of a subset of pro-Inflammatory genes.
Document type :
Theses
Complete list of metadata

https://tel.archives-ouvertes.fr/tel-01381998
Contributor : ABES STAR :  Contact
Submitted on : Saturday, October 15, 2016 - 1:01:15 AM
Last modification on : Friday, June 7, 2019 - 3:09:16 AM

File

Bonnay_francois_2014_ED414.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01381998, version 1

Collections

Citation

François Bonnay. Deciphering regulatory mecharnsms of the lMD pathway activation during the innate immune response in Drosophila. Innate immunity. Université de Strasbourg, 2014. English. ⟨NNT : 2014STRAJ019⟩. ⟨tel-01381998⟩

Share

Metrics

Record views

149

Files downloads

212