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Interactions des protéines du complexe de transduction du signal transmembranaire CnrYXH chez Cupriavidus metallidurans CH34

Abstract : The CnrYXH complex contributes to regulate the expression of the regulatory genes and resistance genes involved in cobalt and nickel resistance in Cupriavidus metallidurans CH34. The binding of nickel or cobalt to CnrX in the periplasm induces conformational modifications that could trigger transmembrane signal transduction. As a result, CnrH is made available in cytoplasm for binding to RNA polymerase. The CnrH:RNA polymerase complex binds specifically the cnr promoters and initiates transcription of both the regulatory genes (cnrYXH) and resistance genes (cnrCBAT). In order to delineate the mechanism of signal transduction through the membrane, I studied the interactions between the three partners in the different cellular compartments: periplasm, plasmic membrane and cytoplasm. The identification of the interaction determinants between CnrX, CnrY and CnrH allowed us to propose a structural and functional model for the CnrYXH complex and its homologues. This model brings up new hypothesis on the function of Cnr system.
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Widade Ziani. Interactions des protéines du complexe de transduction du signal transmembranaire CnrYXH chez Cupriavidus metallidurans CH34. Biologie structurale [q-bio.BM]. Université de Grenoble, 2014. Français. ⟨NNT : 2014GRENV059⟩. ⟨tel-01344080⟩

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