L. Merle, M. Laroche, and T. Dantoine, Predicting and Preventing Adverse Drug Reactions in the Very Old, Drugs & Aging, vol.21, issue.3, pp.375-392, 2006.
DOI : 10.2165/00002512-200522050-00003
URL : https://hal.archives-ouvertes.fr/hal-01335822

L. Fried, C. Tangen, and J. Walston, Frailty in Older Adults: Evidence for a Phenotype, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.56, issue.3, pp.146-56, 2001.
DOI : 10.1093/gerona/56.3.M146

M. Cesari, G. Gambassi, A. Van-kan, and G. , The frailty phenotype and the frailty index: different instruments for different purposes, Age and Ageing, vol.43, issue.1, pp.10-12, 2013.
DOI : 10.1093/ageing/aft160

J. Morley, B. Vellas, and G. Van-kan, Frailty Consensus: A Call to Action, Journal of the American Medical Directors Association, vol.14, issue.6, pp.392-399, 2013.
DOI : 10.1016/j.jamda.2013.03.022

A. Clegg, J. Young, and S. Lliffe, Frailty in elderly people, The Lancet, vol.381, issue.9868, pp.752-62, 2013.
DOI : 10.1016/S0140-6736(12)62167-9

T. Gill, E. Gahbauer, H. Allore, and L. Han, Transitions Between Frailty States Among Community-Living Older Persons, Archives of Internal Medicine, vol.166, issue.4, pp.418-441, 2006.
DOI : 10.1001/archinte.166.4.418

E. Kelaiditi, M. Cesari, and M. Canevelli, Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group, The journal of nutrition, health & aging, vol.6, issue.3, pp.726-760, 2013.
DOI : 10.1007/s12603-013-0367-2

A. Mclachlan, S. Bath, and V. Naganathan, Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment, British Journal of Clinical Pharmacology, vol.10, issue.2, pp.351-64, 2011.
DOI : 10.1111/j.1365-2125.2010.03847.x

R. Hubbard, I. Lang, and D. Llewellyn, Frailty, Body Mass Index, and Abdominal Obesity in Older People, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.65, issue.4, pp.377-81, 2010.
DOI : 10.1093/gerona/glp186

M. Bonnefoy, G. Berrut, and B. Lesourd, Frailty and nutrition: Searching for evidence, The journal of nutrition, health & aging, vol.13, issue.8, pp.250-257, 2015.
DOI : 10.1007/s12603-014-0568-3

M. Shlipak, C. Stehman-breen, and L. Fried, The presence of frailty in elderly persons with chronic renal insufficiency, American Journal of Kidney Diseases, vol.43, issue.5, pp.861-868, 2004.
DOI : 10.1053/j.ajkd.2003.12.049

D. Gnjidic, S. Hilmer, and F. Blyth, Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes, Journal of Clinical Epidemiology, vol.65, issue.9, pp.989-95, 2012.
DOI : 10.1016/j.jclinepi.2012.02.018

M. Herr, J. Robine, and J. Pinot, Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people, Pharmacoepidemiology and Drug Safety, vol.349, issue.10, 2015.
DOI : 10.1002/pds.3772

V. Crentsil, M. Ricks, and Q. Xue, A pharmacoepidemiologic study of community-dwelling, disabled older women: Factors associated with medication use, The American Journal of Geriatric Pharmacotherapy, vol.8, issue.3, pp.215-239, 2010.
DOI : 10.1016/j.amjopharm.2010.06.003

M. Runganga, N. Peel, and R. Hubbard, Multiple medication use in older patients in post-acute transitional care: a prospective cohort study, Clin Interv Aging, vol.9, pp.1453-62, 2014.

A. Bennett, D. Gnjidic, and M. Gillett, Prevalence and Impact of Fall-Risk-Increasing Drugs, Polypharmacy, and Drug???Drug Interactions in Robust Versus Frail Hospitalised Falls Patients: A Prospective Cohort Study, Drugs & Aging, vol.12, issue.6, pp.225-257, 2014.
DOI : 10.1007/s40266-013-0151-3

D. Gnjidic, S. Hilmer, and F. Blyth, High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men, Clinical Pharmacology & Therapeutics, vol.24, issue.3, pp.521-529, 2012.
DOI : 10.1038/clpt.2011.258

J. Peklar, O. Halloran, A. Maidment, and I. , Sedative Load and Frailty Among Community-Dwelling Population Aged ???65 Years, Journal of the American Medical Directors Association, vol.16, issue.4, pp.282-291, 2015.
DOI : 10.1016/j.jamda.2014.10.010

L. Saarelainen, J. Turner, and S. Shakib, Potentially inappropriate medication use in older people with cancer: Prevalence and correlates, Journal of Geriatric Oncology, vol.5, issue.4, pp.439-485, 2014.
DOI : 10.1016/j.jgo.2014.07.001

J. Hanlon, C. Pieper, and E. Hajjar, Incidence and Predictors of All and Preventable Adverse Drug Reactions in Frail Elderly Persons After Hospital Stay, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.61, issue.5, pp.511-516, 2006.
DOI : 10.1093/gerona/61.5.511

R. Hubbard, O. Mahony, M. Woodhouse, and K. , Medication prescribing in frail older people, European Journal of Clinical Pharmacology, vol.17, issue.2, pp.319-345, 2013.
DOI : 10.1007/s00228-012-1387-2

A. Poudel, R. Hubbard, and L. Nissen, Frailty: a key indicator to minimize inappropriate medication in older people, QJM, vol.106, issue.10, pp.969-75
DOI : 10.1093/qjmed/hct146

K. Schmader, J. Hanlon, and C. Pieper, Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly, The American Journal of Medicine, vol.116, issue.6
DOI : 10.1016/j.amjmed.2003.10.031

N. Tavassoli, S. Guyonnet, A. Vankan, and G. , Description of 1,108 older patients referred by their physician to the ???Geriatric Frailty Clinic (G.F.C) for assessment of frailty and prevention of disability??? at the gerontopole, The journal of nutrition, health & aging, vol.190, issue.5, pp.457-64, 2014.
DOI : 10.1007/s12603-014-0462-z

H. Holmes, D. Hayley, and G. Alexander, Reconsidering Medication Appropriateness for Patients Late in Life, Archives of Internal Medicine, vol.166, issue.6, pp.605-614, 2006.
DOI : 10.1001/archinte.166.6.605

M. Schaufelberger, G. Andersson, and B. Eriksson, Skeletal muscle changes in patients with chronic heart failure before and after treatment with enalapril, European Heart Journal, vol.17, issue.11, pp.1678-85, 1996.
DOI : 10.1093/oxfordjournals.eurheartj.a014751

G. Onder, B. Penninx, and R. Balkrishnan, Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study, The Lancet, vol.359, issue.9310, pp.926-956, 2002.
DOI : 10.1016/S0140-6736(02)08024-8

S. Basaria, A. Coviello, and T. Travison, Adverse Events Associated with Testosterone Administration, New England Journal of Medicine, vol.363, issue.2, pp.109-131, 2010.
DOI : 10.1056/NEJMoa1000485

I. Wicherts, N. Van-schoor, and A. Boeke, Vitamin D Status Predicts Physical Performance and Its Decline in Older Persons, The Journal of Clinical Endocrinology & Metabolism, vol.92, issue.6, pp.2058-65, 2007.
DOI : 10.1210/jc.2006-1525

S. Chang, C. Weiss, and Q. Xue, Association between inflammatory-related disease burden and frailty: Results from the Women's Health and Aging Studies (WHAS) I and II, Archives of Gerontology and Geriatrics, vol.54, issue.1, pp.9-15, 2012.
DOI : 10.1016/j.archger.2011.05.020

A. Lacroix, S. Gray, and A. Aragaki, Statin Use and Incident Frailty in Women Aged 65 Years or Older: Prospective Findings From the Women's Health Initiative Observational Study, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.63, issue.4, pp.369-75, 2008.
DOI : 10.1093/gerona/63.4.369

H. Nessighaoui, H. Lillamand, and K. Patel, Frailty and pain: two related conditions, J Frailty Aging, vol.4, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01335015

B. Abdulla, A. Adams, N. Bone, and M. , Guidance on the management of pain in older people

A. Van-kan, G. Rolland, Y. Andrieu, and S. , Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force, The journal of nutrition, health & aging, vol.26, issue.10, pp.881-890, 2009.
DOI : 10.1007/s12603-009-0246-z

J. Artner, B. Cakir, and J. Spiekermann, Prevalence of sleep deprivation in patients with chronic neck and back pain: a retrospective evaluation of 1016 patients, Journal of Pain Research, vol.6, pp.1-6, 2013.
DOI : 10.2147/JPR.S36386

T. Auyeung, J. Lee, and T. Kwok, Physical frailty predicts future cognitive decline ??? A four-year prospective study in 2737 cognitively normal older adults, The journal of nutrition, health & aging, vol.60, issue.9, pp.690-694, 2011.
DOI : 10.1007/s12603-011-0110-9

A. Avenell, W. Gillespie, L. Gillespie, O. Connel, and D. , Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis

J. Barzilay, C. Blaum, and T. Moore, Insulin Resistance and Inflammation as Precursors of Frailty, Archives of Internal Medicine, vol.167, issue.7, pp.635-676, 2007.
DOI : 10.1001/archinte.167.7.635

S. Basaria, A. Coviello, and T. Travison, Adverse Events Associated with Testosterone Administration, New England Journal of Medicine, vol.363, issue.2, pp.109-131, 2010.
DOI : 10.1056/NEJMoa1000485

H. Bergman, F. Beland, and S. Karunananthan, pour l'initiative canadienne sur la fragilité et le vieillissement. Developpement d'un cadre de travail pour comprendre et étudier la fragilité, Gerontologie et societe, vol.109, pp.15-29, 2004.

H. Bergman, L. Ferrucci, and J. Guralnik, Frailty: An Emerging Research and Clinical Paradigm--Issues and Controversies, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.62, issue.7, pp.731-738, 2007.
DOI : 10.1093/gerona/62.7.731

R. Bernasconi, R. Smieskova, and A. Schmidt, Hippocampal volume correlates with attenuated negative psychotic symptoms irrespective of antidepressant medication, NeuroImage: Clinical, vol.8
DOI : 10.1016/j.nicl.2015.04.016

P. Bertin, L. Becquemont, E. Corruble, S. For, . Ages et al., The therapeutic management of chronic pain in ambulatory care patients aged 65 and over in France: the S.AGES cohort. Baseline data, The journal of nutrition, health & aging, vol.11, issue.3, pp.681-687, 2013.
DOI : 10.1007/s12603-013-0338-7

A. Beswick, K. Rees, and P. Dieppe, Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis, The Lancet, vol.371, issue.9614
DOI : 10.1016/S0140-6736(08)60342-6

E. Binder, Effects of Exercise Training on Frailty in Community-Dwelling Older Adults: Results of a Randomized, Controlled Trial, Journal of the American Geriatrics Society, vol.3, issue.12, pp.1921-1929, 2002.
DOI : 10.1053/apmr.2000.4425

D. Boche, Review: Activation patterns of microglia and their identification in the human brain, Neuropathology and Applied Neurobiology, vol.101, issue.1, pp.3-18, 2013.
DOI : 10.1111/nan.12011

D. Bonnet-zamponi, H. Arailh, and C. Konrat, Drug-Related Readmissions to Medical Units of Older Adults Discharged from Acute Geriatric Units: Results of the Optimization of Medication in AGEd Multicenter Randomized Controlled Trial, Journal of the American Geriatrics Society, vol.59, issue.1, pp.113-134, 2013.
DOI : 10.1111/jgs.12037
URL : https://hal.archives-ouvertes.fr/hal-01077312

R. V. Borrat-besson and B. Wernli, First results from SHARE after the economic crisis Transitions between frailty states ? a European comparison, in Active ageing and solidarity between generations in Europe, pp.175-86, 2013.

D. Bouharissa, N. Attal, and H. Alchaar, Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4), Pain, vol.114, pp.29-36, 2005.

K. Bouillon, M. Kivimaki, and M. Hamer, Measures of frailty in population-based studies: an overview, BMC Geriatrics, vol.14, issue.Suppl 1, p.64, 2013.
DOI : 10.1080/13607863.2010.508772
URL : https://hal.archives-ouvertes.fr/inserm-00843913

P. Boyle, A. Buchman, and R. Wilson, Physical Frailty Is Associated with Incident Mild Cognitive Impairment in Community-Based Older Persons, Journal of the American Geriatrics Society, vol.63, issue.230, pp.248-255, 2010.
DOI : 10.1111/j.1532-5415.2009.02671.x

H. Breivik, B. Collett, and V. Ventafridda, Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment, European Journal of Pain, vol.106, issue.4, pp.287-333, 2006.
DOI : 10.1016/j.ejpain.2005.06.009

F. Brennan, D. Carr, and M. Cousins, Pain Management: A Fundamental Human Right, Anesthesia & Analgesia, vol.105, issue.1, pp.205-227, 2007.
DOI : 10.1213/01.ane.0000268145.52345.55

P. Bruckenthal, Implications for opioid analgesia for medically complicated patients, Drugs Aging, vol.27, pp.417-433, 2010.

A. Buchman, L. Yu, and R. Wilson, Association of brain pathology with the progression of frailty in older adults, Neurology, vol.80, issue.22, pp.1-7, 2013.
DOI : 10.1212/WNL.0b013e318294b462

A. Buchman, P. Boyle, and R. Wilson, Frailty is Associated With Incident Alzheimer???s Disease and Cognitive Decline in the Elderly, Psychosomatic Medicine, vol.69, issue.5, pp.483-489, 2007.
DOI : 10.1097/psy.0b013e318068de1d

S. Campbell and C. Szoeke, Pharmacological treatment of frailty in the elderly Journal of pharmacy practice and research, pp.147-51, 2009.

J. Campisi, Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes, Experimental Gerontology, vol.38, issue.1-2, pp.5-11, 2003.
DOI : 10.1016/S0531-5565(02)00152-3

A. Cappola, Q. Xue, and L. Ferrucci, Insulin-Like Growth Factor I and Interleukin-6 Contribute Synergistically to Disability and Mortality in Older Women, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.5, pp.2019-2025, 2003.
DOI : 10.1210/jc.2002-021694

T. Cavalieri, Pain management in the elderly, J Am Osteopath Assoc, vol.102, issue.9, pp.481-485, 2002.

F. Cerreta, H. Eichler, and G. Rasi, Drug Policy for an Aging Population ??? The European Medicines Agency's Geriatric Medicines Strategy, New England Journal of Medicine, vol.367, issue.21, pp.1972-1974, 2012.
DOI : 10.1056/NEJMp1209034

C. Wong, C. Weiss, D. Sourial, and N. , Frailty and its association with disability and comorbidity in a community-dwelling sample of seniors in Montreal: a cross-sectional study, Aging Clinical and Experimental Research, vol.59, issue.1, pp.54-62, 2010.
DOI : 10.1007/BF03324816

Q. Chen, L. Hayman, and R. Shmerling, Characteristics of Chronic Pain Associated with Sleep Difficulty in Older Adults: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) Boston Study, Journal of the American Geriatrics Society, vol.110, issue.8, pp.1385-1392, 2011.
DOI : 10.1111/j.1532-5415.2011.03544.x

J. Chibnall and R. Tait, Pain assessment in cognitively impaired and unimpaired older adults: a comparison of four scales, Pain, vol.92, issue.1, pp.173-186, 2001.
DOI : 10.1016/S0304-3959(00)00485-1

L. Chu, M. Angst, and D. Clark, Opioid-induced Hyperalgesia in Humans, The Clinical Journal of Pain, vol.24, issue.6, pp.479-496, 2008.
DOI : 10.1097/AJP.0b013e31816b2f43

A. Clegg, J. Young, and S. Iliffe, Frailty in elderly people, The Lancet, vol.381, issue.9868, pp.752-62, 2013.
DOI : 10.1016/S0140-6736(12)62167-9

S. Closs, B. Barr, and M. Briggs, A comparison of five pain assessment scales for nursing home residents with varying degrees of cognitive impairment, Journal of Pain and Symptom Management, vol.27, issue.3, pp.196-205, 2004.
DOI : 10.1016/j.jpainsymman.2003.12.010

L. Cole, M. Farrell, and S. Gibson, Age-related differences in pain sensitivity and regional brain activity evoked by noxious pressure, Neurobiology of Aging, vol.31, issue.3, pp.494-503, 2010.
DOI : 10.1016/j.neurobiolaging.2008.04.012

M. Costigan, J. Scholz, and C. Woolf, Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage, Annual Review of Neuroscience, vol.32, issue.1, pp.1-32, 2009.
DOI : 10.1146/annurev.neuro.051508.135531

C. Cunningham, D. Wilcockson, and S. Campion, Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration, Journal of Neuroscience, vol.25, issue.40, pp.9275-84, 2005.
DOI : 10.1523/JNEUROSCI.2614-05.2005

E. Dansie, D. Turk, and K. Martin, Association of Chronic Widespread Pain With Objectively Measured Physical Activity in Adults: Findings From the National Health and Nutrition Examination Survey, The Journal of Pain, vol.15, issue.5, pp.507-522, 2014.
DOI : 10.1016/j.jpain.2014.01.489

M. Delmonico, T. Harris, and J. Lee, Alternative Definitions of Sarcopenia, Lower Extremity Performance, and Functional Impairment with Aging in Older Men and Women, Journal of the American Geriatrics Society, vol.12, issue.5, pp.769-74, 2007.
DOI : 10.1111/j.1532-5415.2007.01140.x

R. Dworkin, D. Turk, and N. Katz, Evidence-based clinical trial design for chronic pain pharmacotherapy: A blueprint for ACTION, Pain, vol.152, issue.Supplement, pp.107-115, 2011.
DOI : 10.1016/j.pain.2010.11.008

R. Edwards, R. Fillingim, and T. Ness, Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults, Pain, vol.101, issue.1, pp.155-165, 2003.
DOI : 10.1016/S0304-3959(02)00324-X

L. Eggermont, S. Leveille, and L. Shi, Pain Characteristics Associated with the Onset of Disability in Older Adults: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly Boston Study, Journal of the American Geriatrics Society, vol.46, issue.Suppl 6, pp.1007-1016, 2014.
DOI : 10.1111/jgs.12848

L. Eidson and A. Murphy, Blockade of Toll-Like Receptor 4 Attenuates Morphine Tolerance and Facilitates the Pain Relieving Properties of Morphine, Journal of Neuroscience, vol.33, issue.40, pp.15952-15963, 2013.
DOI : 10.1523/JNEUROSCI.1609-13.2013

G. Ellis, M. Whitehead, and D. Robinson, Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials, BMJ, vol.343, issue.oct27 1, p.6553, 2011.
DOI : 10.1136/bmj.d6553

K. Ensrud, S. Ewing, and B. Taylor, Comparison of 2 Frailty Indexes for Prediction of Falls, Disability, Fractures, and Death in Older Women, Archives of Internal Medicine, vol.168, issue.4, pp.382-391, 2008.
DOI : 10.1001/archinternmed.2007.113

W. Ershler and E. Keller, Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty, Annual Review of Medicine, vol.51, issue.1, pp.245-270, 2000.
DOI : 10.1146/annurev.med.51.1.245

W. Evans and W. Campbell, Sarcopenia and age-related changes in body composition and functional capacity, J Nutr, vol.123, issue.2, pp.465-468, 1993.

J. Farrar, Advances in clinical research methodology for pain clinical trials, Nature Medicine, vol.16, issue.11, pp.1284-1293, 2010.
DOI : 10.1038/nm.2249

L. Ferrucci, C. Cavazzini, and A. Corsi, Biomarkers of frailty in older persons, J Endocrinol Invest, vol.25, issue.10, pp.10-15, 2002.

H. Flor, T. Fydrich, and D. Turk, Efficacy of Multidisciplinary Pain Treatment Centers, Survey of Anesthesiology, vol.37, issue.1, pp.221-224, 1992.
DOI : 10.1097/00132586-199302000-00029

L. Fried, L. Ferrucci, and J. Darer, Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.59, issue.3, pp.255-63, 2004.
DOI : 10.1093/gerona/59.3.M255

L. Fried, W. J. Frailty, Q. Xue, and A. Cappola, Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.64, issue.10, pp.387-4021049, 1998.
DOI : 10.1093/gerona/glp076

A. Friedlander, G. Butterfield, and S. Moynihan, One Year of Insulin-Like Growth Factor I Treatment Does Not Affect Bone Density, Body Composition, or Psychological Measures in Postmenopausal Women, Journal of Clinical Endocrinology & Metabolism, vol.86, issue.4, pp.1496-503, 2001.
DOI : 10.1210/jc.86.4.1496

G. Gauchard, P. Gangloff, and C. Jeandel, Influence of Regular Proprioceptive and Bioenergetic Physical Activities on Balance Control in Elderly Women, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.58, issue.9, pp.846-850, 2003.
DOI : 10.1093/gerona/58.9.M846

T. Gill, E. Gahbauer, and L. Han, Trajectories of Disability in the Last Year of Life, New England Journal of Medicine, vol.362, issue.13, pp.1173-1180, 2010.
DOI : 10.1056/NEJMoa0909087

T. M. Gill, A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home, New England Journal of Medicine, vol.347, issue.14, pp.1068-74, 2002.
DOI : 10.1056/NEJMoa020423

L. Gillespie, M. Robertson, and W. Gillespie, Interventions for preventing falls in older people living in the community, Cochrane Database Syst Rev, issue.2, p.7146, 2009.

B. Goodpaster, S. Park, and T. Harris, The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.61, issue.10, pp.1059-64, 2006.
DOI : 10.1093/gerona/61.10.1059

S. Gray, M. Anderson, and R. Hubbard, Frailty and Incident Dementia, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.68, issue.9, pp.1083-90, 2013.
DOI : 10.1093/gerona/glt013
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738027

T. Hadjistavropoulos, K. Herr, and D. Turk, An Interdisciplinary Expert Consensus Statement on Assessment of Pain in Older Persons, The Clinical Journal of Pain, vol.23, issue.Supplement 1, pp.1-43, 2007.
DOI : 10.1097/AJP.0b013e31802be869

K. Herr, K. Spratt, and P. Mobily, Pain Intensity Assessment in Older Adults, The Clinical Journal of Pain, vol.20, issue.4, pp.207-219, 2004.
DOI : 10.1097/00002508-200407000-00002

R. A. Heuberger, The Frailty Syndrome: A Comprehensive Review, Journal of Nutrition in Gerontology and Geriatrics, vol.72, issue.4, pp.315-68, 2011.
DOI : 10.1080/21551197.2011.623931

R. Hubbard, O. Mahony, M. Savva, and G. , Inflammation and frailty measures in older people, Journal of Cellular and Molecular Medicine, vol.103, issue.9b, pp.3103-3112, 2009.
DOI : 10.1111/j.1582-4934.2009.00733.x

J. Jacobs, A. Cohen, and E. Ein-mor, Frailty, cognitive impairment and mortality among the oldest old. The journal of nutrition, health & aging, pp.678-682, 2011.

J. F. Karp, J. W. Shega, and N. Morone, Advances in understanding the mechanisms and management of persistant pain in older adults, Br J Anaesth, 2008.

J. Kemp, O. Després, T. Pebayle, and A. Dufour, Differences in age-related effects on myelinated and unmyelinated peripheral fibres: A sensitivity and evoked potentials study, European Journal of Pain, vol.8, issue.Suppl 2, pp.482-488, 2014.
DOI : 10.1002/j.1532-2149.2013.00388.x

F. Ko, The Clinical Care of Frail, Older Adults, Clinics in Geriatric Medicine, vol.27, issue.1, pp.89-100, 2011.
DOI : 10.1016/j.cger.2010.08.007

A. Kuchinad, P. Schweinhardt, and D. Seminowicz, Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?, Journal of Neuroscience, vol.27, issue.15, pp.4004-4007, 2007.
DOI : 10.1523/JNEUROSCI.0098-07.2007

M. Laroche, J. Charmes, and F. Bouthier, Inappropriate Medications in the Elderly, Clinical Pharmacology & Therapeutics, vol.45, issue.1, pp.94-101, 2009.
DOI : 10.1038/clpt.2008.214
URL : https://hal.archives-ouvertes.fr/hal-00738892

M. Laroche, J. Charmes, and M. L. , Potentially inappropriate medications in the elderly: a French consensus panel list, European Journal of Clinical Pharmacology, vol.23, issue.8, pp.725-756, 2007.
DOI : 10.1007/s00228-007-0324-2

S. Lautenbacher and M. Kunz, Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain, Pain, vol.115, issue.3, pp.410-418, 2005.
DOI : 10.1016/j.pain.2005.03.025

S. Lautenbacher, Experimental Approaches in the Study of Pain in the Elderly, Pain Medicine, vol.13, issue.suppl 2, pp.44-50, 2012.
DOI : 10.1111/j.1526-4637.2012.01326.x

R. Leadley, N. Armstrong, and K. Reid, Healthy Aging in Relation to Chronic Pain and Quality of Life in Europe, Pain Practice, vol.13, issue.suppl 21, pp.547-558, 2013.
DOI : 10.1111/papr.12125

S. Leng, P. Chaves, and K. Koenig, Serum Interleukin-6 and Hemoglobin as Physiological Correlates in the Geriatric Syndrome of Frailty: A Pilot Study, Journal of the American Geriatrics Society, vol.2, issue.Suppl 6, pp.1268-1271, 2002.
DOI : 10.1046/j.1532-5415.2002.50315.x

S. Leng, A. Cappola, and R. Andersen, Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty, Aging Clinical and Experimental Research, vol.162, issue.3, pp.153-157, 2004.
DOI : 10.1007/BF03324545

C. Li, X. Mao, and L. Wei, Genes and (Common) Pathways Underlying Drug Addiction, PLoS Computational Biology, vol.33, issue.1, 2008.
DOI : 10.1371/journal.pcbi.0040002.st004

T. Linjakumpu, S. Hatikainen, and T. Klaukka, Use of medications and polypharmacy are increasing among the elderly, Journal of Clinical Epidemiology, vol.55, issue.8, pp.809-826, 2002.
DOI : 10.1016/S0895-4356(02)00411-0

L. Lipsitz, Dynamics of Stability: The Physiologic Basis of Functional Health and Frailty, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.57, issue.3, pp.115-125, 2002.
DOI : 10.1093/gerona/57.3.B115

X. Luo, J. Ding, and S. Chen, Microglia in the aging brain: relevance to neurodegeneration, Molecular Neurodegeneration, vol.5, issue.1
DOI : 10.1186/1750-1326-5-12

R. Mackin, J. Nelson, and K. Delucchi, Association of Age at Depression Onset with Cognitive Functioning in Individuals with Late-Life Depression and Executive Dysfunction, The American Journal of Geriatric Psychiatry, vol.22, issue.12, pp.1633-1641, 2014.
DOI : 10.1016/j.jagp.2014.02.006

C. Maher, T. Martin, and S. Childers, Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration, Life Sciences, vol.77, issue.10, pp.1140-54, 2005.
DOI : 10.1016/j.lfs.2005.03.004

E. Marzetti, R. Calvani, and M. Cesari, Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials, The International Journal of Biochemistry & Cell Biology, vol.45, issue.10, pp.2288-301, 2013.
DOI : 10.1016/j.biocel.2013.06.024

C. Mendes-de-leon and T. Glass, Social networks and disability transitions across eight intervals of yearly data in the New Haven EPESE, J Gerontol B Psychol Sci Soc Sci, vol.54, pp.162-172, 1999.

S. Merighi, S. Gessi, and K. Varani, Morphine mediates a proinflammatory phenotype via ??-opioid receptor???PKC?????Akt???ERK1/2 signaling pathway in activated microglial cells, Biochemical Pharmacology, vol.86, issue.4, pp.487-496, 2013.
DOI : 10.1016/j.bcp.2013.05.027

L. Merle, M. Laroche, and T. Dantoine, Predicting and Preventing Adverse Drug Reactions in the Very Old, Drugs & Aging, vol.21, issue.3, pp.375-3922, 2006.
DOI : 10.2165/00002512-200522050-00003
URL : https://hal.archives-ouvertes.fr/hal-01335822

J. Michel, S. Bonin-guillaume, and G. Gold, Cognition and Frailty: Possible Interrelations, Longevity and Frailty, pp.119-143, 2005.
DOI : 10.1007/3-540-27388-3_11

A. Mitnitski, N. Fallah, and M. Rockwood, Transitions in cognitive status in relation to frailty in older adults: A Comparison of three frailty measures. The journal of nutrition, health & aging, pp.863-867, 2011.

S. Modig, P. Midlo?v, and J. Kristensson, Depressive symptoms among frail elderly in ordinary living: who is affected and who is treated?, Aging & Mental Health, vol.8, issue.6, pp.1022-1028, 2014.
DOI : 10.1016/0022-3956(82)90033-4

J. Morley, R. Baumgartner, and R. Roubenoff, Sarcopenia, Journal of Laboratory and Clinical Medicine, vol.137, issue.4, pp.231-274, 2001.
DOI : 10.1067/mlc.2001.113504

J. Morley, B. Vellas, and G. Van-kan, Frailty Consensus: A Call to Action, Journal of the American Medical Directors Association, vol.14, issue.6, pp.392-399, 2013.
DOI : 10.1016/j.jamda.2013.03.022

K. Naugle, Y. Cruz-almeida, and R. Fillingim, Offset analgesia is reduced in older adults, Pain, vol.154, issue.11, pp.2381-2387, 2013.
DOI : 10.1016/j.pain.2013.07.015

. Nilwik, The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size, Experimental Gerontology, vol.48, issue.5, pp.492-500, 2013.
DOI : 10.1016/j.exger.2013.02.012

A. Noble, S. Tregear, and J. Treadwell, Long-Term Opioid Therapy for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety, Journal of Pain and Symptom Management, vol.35, issue.2, pp.214-228, 2008.
DOI : 10.1016/j.jpainsymman.2007.03.015

D. Norden, Review: Microglia of the aged brain: primed to be activated and resistant to regulation, Neuropathology and Applied Neurobiology, vol.26, issue.1, pp.19-34, 2013.
DOI : 10.1111/j.1365-2990.2012.01306.x

A. Paladini, M. Fusco, and S. Coaccioli, Chronic Pain in the Elderly: The Case for New Therapeutic Strategies, Pain Physician, vol.18, issue.5, pp.863-76, 2015.

F. Panza, V. Frisardi, and C. Capurso, Late-Life Depression, Mild Cognitive Impairment, and Dementia: Possible Continuum?, The American Journal of Geriatric Psychiatry, vol.18, issue.2, pp.98-116, 2010.
DOI : 10.1097/JGP.0b013e3181b0fa13

K. Patel, E. Dansie, and D. Turk, Impact of chronic musculoskeletal pain on objectively measured daily physical activity: a review of current findings, Pain Management, vol.3, issue.6, pp.467-74, 2013.
DOI : 10.2217/pmt.13.46

K. Patel, J. Guralnik, and E. Dansie, Prevalence and impact of pain among older adults in the United States: Findings from the 2011 National Health and Aging Trends Study, Pain, vol.154, issue.12, pp.2649-57, 2013.
DOI : 10.1016/j.pain.2013.07.029

K. Patel, J. Guralnik, and E. Dansie, Prevalence and impact of pain among older adults in the United States : findings from the, National Health and Aging Trends Study. Pain, vol.154, issue.12, pp.2649-2654, 2011.

K. Patel, E. Phelan, and S. Leveille, High Prevalence of Falls, Fear of Falling, and Impaired Balance in Older Adults with Pain in the United States: Findings from the 2011 National Health and Aging Trends Study, Journal of the American Geriatrics Society, vol.21, issue.Suppl 1, pp.1844-1852, 2014.
DOI : 10.1111/jgs.13072

P. Perrin, C. Jeandel, and C. Perrin, Influence of Visual Control, Conduction, and Central Integration on Static and Dynamic Balance in Healthy Older Adults, Gerontology, vol.43, issue.4, pp.223-231, 1997.
DOI : 10.1159/000213854

S. Perrot, Particularités de la prise en charge des douleurs chroniques non cancéreuses du sujet âgé, Psychol NeuroPsychiatr Vieil, vol.4, issue.3, pp.163-70, 2006.

M. Puts, M. Visser, and J. Twisk, Endocrine and inflammatory markers as predictors of frailty, Clinical Endocrinology, vol.56, issue.4, pp.403-414, 2005.
DOI : 10.1111/j.1532-5415.2004.52307.x

N. Resnick and E. Marcantonio, How should clinical care of the aged differ?, The Lancet, vol.350, issue.9085, pp.1157-1158, 1997.
DOI : 10.1016/S0140-6736(05)63817-2

J. Riley, C. King, and F. Wong, Lack of endogenous modulation and reduced decay of prolonged heat pain in older adults, Pain, vol.150, issue.1, pp.153-160, 2010.
DOI : 10.1016/j.pain.2010.04.020

K. Rockwood, X. Song, and C. Macknight, A global clinical measure of fitness and frailty in elderly people, Canadian Medical Association Journal, vol.173, issue.5, pp.489-95, 2005.
DOI : 10.1503/cmaj.050051

L. Rodri?guez-man?as, C. Féart, and G. Mann, Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.68, issue.1, pp.62-67, 2013.
DOI : 10.1093/gerona/gls119

Y. Rolland, A. Benetos, and A. Gentric, Frailty in older population: a brief position paper from the French society of geriatrics and gerontology, Geriatr Psychol Neuropsychiatr Vieil, vol.9, issue.4, pp.387-390, 2011.

I. Rosenberg, Sarcopenia: Origins and Clinical Relevance, Clinics in Geriatric Medicine, vol.27, issue.3, pp.990-91, 1997.
DOI : 10.1016/j.cger.2011.03.003

I. Rosenberg, Summary comments: epidemiological and methodological problems in determining nutritional status of older persons, Am J Clin Nutr, vol.50, pp.1231-1234, 1989.

R. Samper-ternent, A. Snih, S. Raji, and M. , Relationship Between Frailty and Cognitive Decline in Older Mexican Americans, Journal of the American Geriatrics Society, vol.57, issue.10, pp.1845-52, 2008.
DOI : 10.1111/j.1532-5415.2008.01947.x

L. Schaap, S. Pluijm, and D. Deeg, Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength, The American Journal of Medicine, vol.119, issue.6, pp.526-917, 2006.
DOI : 10.1016/j.amjmed.2005.10.049

C. Sheen, R. Schleimer, and M. Kulka, Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation, Allergy, vol.59, issue.5, pp.532-538, 2007.
DOI : 10.1038/sj.bjp.0706671

J. Shega, W. Dale, and M. Andrew, Persistent Pain and Frailty: A Case for Homeostenosis, Journal of the American Geriatrics Society, vol.140, issue.1, pp.113-120, 2012.
DOI : 10.1111/j.1532-5415.2011.03769.x

J. Shega, L. Emanuel, and L. Vargish, Pain in Persons With Dementia: Complex, Common, and Challenging, The Journal of Pain, vol.8, issue.5, pp.373-378, 2007.
DOI : 10.1016/j.jpain.2007.03.003

R. Sinatra, Causes and Consequences of Inadequate Management of Acute Pain, Pain Medicine, vol.11, issue.12, pp.1859-187, 2010.
DOI : 10.1111/j.1526-4637.2010.00983.x

S. Skaper, L. Facci, and M. Fusco, Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain, Inflammopharmacology, vol.105, issue.3 Suppl, pp.79-94, 2014.
DOI : 10.1007/s10787-013-0191-7

N. Sourial, H. Bergman, and S. Karunananthan, Implementing Frailty Into Clinical Practice: A Cautionary Tale, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.68, issue.12, pp.1505-1516, 2013.
DOI : 10.1093/gerona/glt053

N. Sourial, C. Wolfson, and H. Bergman, A correspondence analysis revealed frailty deficits aggregate and are multidimensional, Journal of Clinical Epidemiology, vol.63, issue.6, pp.647-54, 2010.
DOI : 10.1016/j.jclinepi.2009.08.007

N. Sparkman, Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress, Neuroimmunomodulation, vol.15, issue.4-6, pp.323-330, 2008.
DOI : 10.1159/000156474

R. Stowe, Plasma Cytokine Levels in a Population-Based Study: Relation to Age and Ethnicity, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.65, issue.4, pp.429-433, 2010.
DOI : 10.1093/gerona/glp198

W. Streit, Microglial senescence: does the brain's immune system have an expiration date?, Trends in Neurosciences, vol.29, issue.9, pp.506-516, 2006.
DOI : 10.1016/j.tins.2006.07.001

A. Stuck, M. Egger, and A. Hammer, Home Visits to Prevent Nursing Home Admission and Functional Decline in Elderly People, JAMA, vol.287, issue.8, pp.1022-1030, 2002.
DOI : 10.1001/jama.287.8.1022

S. Studensky, R. Hayes, and R. Leibowitz, Clinical Global Impression of Change in Physical Frailty: development of a maesure based on clinical judgement, J Am Geriatr Soc, vol.52, pp.1560-1566, 2004.
DOI : 10.1037/t28713-000

D. Sumukadas, M. Witham, and A. Struthers, Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial, Canadian Medical Association Journal, vol.177, issue.8, pp.867-74, 2007.
DOI : 10.1503/cmaj.061339

L. Taylor, J. Harris, and C. Epps, Psychometric Evaluation of Selected Pain Intensity Scales for Use with Cognitively Impaired and Cognitively Intact Older Adults, Rehabilitation Nursing, vol.30, issue.2, pp.55-61, 2005.
DOI : 10.1002/j.2048-7940.2005.tb00360.x

O. Theou, T. Brothers, and A. Mitnitski, Operationalization of Frailty Using Eight Commonly Used Scales and Comparison of Their Ability to Predict All-Cause Mortality, Journal of the American Geriatrics Society, vol.46, issue.Suppl 1, pp.1537-51, 2013.
DOI : 10.1111/jgs.12420

O. Theou, M. R. Rockwood, and A. Mitnitski, Disability and co-morbidity in relation to frailty: How much do they overlap?, Archives of Gerontology and Geriatrics, vol.55, issue.2, pp.1-8, 2012.
DOI : 10.1016/j.archger.2012.03.001

E. Thomas, S. Mottram, and G. Peat, The effect of age on the onset of pain interference in a general population of older adults: Prospective findings from the North Staffordshire Osteoarthritis Project (NorStOP), Pain, vol.129, issue.1, pp.21-28, 2007.
DOI : 10.1016/j.pain.2006.09.027

R. Tracy, Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging, International Journal of Obesity, vol.27, issue.3, pp.29-34, 2003.
DOI : 10.1038/sj.ijo.0802497

M. Tseng, M. Chiang, and K. Yazhuo, Effect of aging on the cerebral processing of thermal pain in the human brain, Pain, vol.154, issue.10, pp.2120-2129, 2013.
DOI : 10.1016/j.pain.2013.06.041

W. Van-gool, D. Van-de-beek, and P. Eikelenboom, Systemic infection and delirium: when cytokines and acetylcholine collide, The Lancet, vol.375, issue.9716, pp.773-778, 2010.
DOI : 10.1016/S0140-6736(09)61158-2

B. Vellas, P. Cestac, and J. Morley, Implementing frailty into clinical practice: We cannot wait, The journal of nutrition, health & aging, vol.1, issue.1, pp.599-600, 2012.
DOI : 10.1007/s12603-012-0096-y

E. Volpi, R. Nazemi, and S. Fujita, Muscle tissue changes with aging, Current Opinion in Clinical Nutrition and Metabolic Care, vol.7, issue.4, pp.405-410, 2004.
DOI : 10.1097/01.mco.0000134362.76653.b2

K. Wade, D. Lee, and J. Mcbeth, Chronic widespread pain is associated with worsening frailty in European men, Age and Ageing, vol.45, issue.2, pp.1-7, 2015.
DOI : 10.1093/ageing/afv170

J. Walston, E. Hadley, and L. Ferrucci, Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults, Journal of the American Geriatrics Society, vol.347, issue.(S, pp.991-1001, 2006.
DOI : 10.1111/j.1532-5415.2006.00745.x

J. Walston, M. Mcburnie, and A. Newman, Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>, Archives of Internal Medicine, vol.162, issue.20, pp.2333-234, 2002.
DOI : 10.1001/archinte.162.20.2333

D. Weiner, C. Haggerty, and S. Krichevsky, How Does Low Back Pain Impact Physical Function in Independent, Well-Functioning Older Adults? Evidence from the Health ABC Cohort and Implications for the Future, Pain Medicine, vol.4, issue.4, pp.311-320, 2003.
DOI : 10.1111/j.1526-4637.2003.03042.x

H. Whitson, S. Thielke, and P. Diehr, Patterns and Predictors of Recovery from Exhaustion in Older Adults: The Cardiovascular Health Study, Journal of the American Geriatrics Society, vol.16, issue.2, pp.207-213, 2011.
DOI : 10.1111/j.1532-5415.2010.03238.x

J. Wong and K. Collins, Telomere maintenance and disease, The Lancet, vol.362, issue.9388, pp.983-988, 2003.
DOI : 10.1016/S0140-6736(03)14369-3

J. Woo, J. Leung, and J. Morley, Comparison of Frailty Indicators Based on Clinical Phenotype and the Multiple Deficit Approach in Predicting Mortality and Physical Limitation, Journal of the American Geriatrics Society, vol.59, issue.8, pp.1478-86, 2012.
DOI : 10.1111/j.1532-5415.2012.04074.x

Q. Xue, The Frailty Syndrome: Definition and Natural History, Clinics in Geriatric Medicine, vol.27, issue.1, pp.1-15, 2011.
DOI : 10.1016/j.cger.2010.08.009

J. Yesavage, T. Brink, and T. Rose, Development and validation of a geriatric depression screening scale: A preliminary report, Journal of Psychiatric Research, vol.17, issue.1, pp.37-49, 1982.
DOI : 10.1016/0022-3956(82)90033-4

J. Younger, A. A. Parke, and S. , Viewing Pictures of a Romantic Partner Reduces Experimental Pain: Involvement of Neural Reward Systems, PLoS ONE, vol.112, issue.10, p.13309, 2010.
DOI : 10.1371/journal.pone.0013309.s002

J. Younger, L. Chu, D. Arcy, and N. , Prescription opioid analgesics rapidly change the human brain, Pain, vol.152, issue.8, pp.1803-1810, 2011.
DOI : 10.1016/j.pain.2011.03.028

K. Zakoscielna and P. Parmelee, Pain Variability and Its Predictors in Older Adults, Journal of Aging and Health, vol.3, issue.8, pp.1329-1339, 2013.
DOI : 10.1016/0022-3956(82)90033-4

M. Zarrindast, S. Ahmadi, and A. Haeri-rohani, GABAA receptors in the basolateral amygdala are involved in mediating morphine reward, Brain Research, vol.1006, issue.1, pp.49-58, 2004.
DOI : 10.1016/j.brainres.2003.12.048

X. Zhang, Positive Feedback Loop of Autocrine BDNF from Microglia Causes Prolonged Microglia Activation, Cellular Physiology and Biochemistry, vol.34, issue.3, pp.715-723, 2014.
DOI : 10.1159/000363036