Towards a bio-inspired photoherbicide : Synthesis and studies of fluorescent tagged or water-soluble

Abstract : Over the past decade, intensive use of herbicide in agriculture has caused several sanitary and environmental problems. Finding new bio-inspired herbicides preventing pollution has appeared crucial. Naturally present in plants, porphyrins are photosensitive. In the presence of oxygen, their photo-activation leads to production of Reactive Oxygen Species, which induce cell death. Already used in Photodynamic Therapy, this effect can be used to plant. In that purpose, a series of charged porphyrins (commercial and synthesized) were selected, and their physicochemical properties (e.g. UV-Vis absorption, fluorescence emission, photostability, ROS production) as well as their effects on TBY-2 (Tobacco Bright Yellow) cells were evaluated. Second, localizing molecules in plants is mandatory to understand mechanisms of the herbicide action. In this context, porphyrins were covalently grafted to a fluorescent marker, by a series of spacers that were chosen according to a preliminary molecular modeling evaluation of their conformational flexibility. The new dyads obtained were thoroughly studied both theoretically and experimentally for their photophysical properties.
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Olivier Rezazgui. Towards a bio-inspired photoherbicide : Synthesis and studies of fluorescent tagged or water-soluble. Other. Université de Limoges, 2015. English. ⟨NNT : 2015LIMO0132⟩. ⟨tel-01326291⟩

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