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, La solution légèrement visqueuse obtenue est refroidie puis diluée dans 150 ml d'eau déminéralisée Après deux centrifugations successives (3700 rpm, 10 mn), le surnageant obtenu est purifiée par dialyse (coupure de membrane, 6-8 kDa) Au bout de 5 jours, la suspension est concentrée à 1 mg/ml
, ?OH) ; 2896 (?CH); 1640 (?OH) ; 1430 (?sCH 2 ) ; 1368 (?CH) ; 1335 (?OH) (dans le plan) ; 1317 (CH 2 ou ?C-O-H) ; 1282 (?CH) ; 1280 (SO3 H ) ; 1201 (? s C-O : cycle pyranose) ; 1158 (? as C-O-C : pont) ; 1104 (?OH : cycle symétrique ou ? as : cycle, p.3340
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, ? en nm (?. 10 -3 ) : 423 (118,5), p.1
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, CHCl 3 ) ? en nm (? x 10 -4, pp.408-506
, CHCl 3 ) ? en nm (?. 10 -3, pp.408-578
, CHCl 3 ) ? en nm (?. 10 -3, pp.417-546
, CHCl 3 ) ? en nm (? x 10 -3, pp.415-545
, CHCl 3 ) ? en nm (? x 10 -3 )
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, O) ? en nm (?, p.422
, 0 x 10 -8 mol en curcumine) d'une solution de complexe 14 est ajouté délicatement dans une cuve en quartz contenant 2 mL de chloroforme. Après trois essais répétitifs dans les mêmes conditions, les pourcentages de relargage obtenus en curcumine sont de 20, pp.5-5
, O) ? en nm (?, p.330
, O) ? en nm (?, p.417
, O) ? en nm (?, p.415
, O) ? en nm (?, p.276
, Un excès d'éthylène glycol (1 mL) est ajouté après 100h de réaction. Le brut réactionnel est purifié par dialyse (seuil de coupure 6-8 kDa).Plusieurs dosages iodométriques de la solution de CNCox 19
, ?OH) ; 2900 (?CH); 1634 (?OH) ; 1430 (?sCH 2 ) ; 1368 (?CH) ; 1335 (?OH) (dans le plan, pp.3340-1158
, sont ajoutés goutte à goutte à l'aide d'une ampoule à brome à l'abri de la lumière et sous ultrasons dans un bain de glace. Après 1h d'agitation à température ambiante, quatre équivalents de NaBH 3 CN (2 mg) sont additionnés au mélange. Le milieu réactionnel est maintenu sous agitation ultrasonique dans un bain de glace pendant 3h puis sous agitation magnétique pendant 24h
, O) ? en nm (?, p.502
, Vincent Sol PEI-Cellulose Nanocrystals Hydrids and their use as siRNA Delivery Agents Carbohydrate Polymers b-Publication en préparation Nicolas Drogat, Chlorin-p6/PEI -Cellulose Nanocrystals Hybrids: their in Vivo Evaluation as New Potential Anticancer Agents for Application in Photodynamic Therapy
, Vincent Sol Elaboration de nanocristaux de cellulose pour la vectorisation et le ciblage d'agents anticancéreux : curcumine et protoporphyrine IX de zinc
, Bertrand Liagre Vincent Sol Synthesis and functionalization of cellulose nanocrystal for the vectorization of anticancer drugs SyCOCAL IX, 2014.
, Cellulose Nanocrystals Hybrids: Synthesis, characterization and their in Vivo Evaluation as New Potential Anticancer Agents for Application in Photodynamic Therapy
, Development of cellulose nanocrystals for the vectorization of anticancer Drugs RCOM 8, 8ème rencontre de Chimie Organique de Marseille ? 12, Elaboration de complexes curcumine-cyclodextrine cationique fixés sur les nanocristaux de cellulose pour le ciblage des cellules cancéreuses. 9 ème journées Cancéropôle Grand Sud-Ouest (CGSO), pp.16-18, 2014.
, Vincent Sol Elaboration de nanocristaux de cellulose pour le transport d'agents thérapeutiques et le ciblage des cellules cancéreuses Glucidoc, 2013.
, Vincent Sol Elaboration de nanocristaux de cellulose à motifs porphyriniques pour une application en photothérapie dynamique des cancers