Elaboration des nanocristaux de cellulose fonctionnalisés pour la vectorisation d’agents anticancéreux et pour la transfection de gènes

Abstract : Targeting and drug delivery are major areas of research within the LCSN. Indeed, most of the active molecules used in cancer therapy are not very selective against tumors and are toxic to healthy cells. The development of nanobiomaterials able to specifically target tumors by EPR effect but also capable of destroying them by the action of the drug transported turns capital. In this work we achieved the binding of triphenylphosphonium cation (to target the mitochondria), hydrophobic active ingredients and a nucleic acid on cellulose nanocrystals issued from the acid hydrolysis of cotton. The first therapeutic platform synthesized according to the technique.
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Gautier Mark Arthur Ndong Ntoutoume. Elaboration des nanocristaux de cellulose fonctionnalisés pour la vectorisation d’agents anticancéreux et pour la transfection de gènes. Autre. Université de Limoges, 2015. Français. ⟨NNT : 2015LIMO0126⟩. ⟨tel-01309470⟩

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