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Développement de systèmes de microscopie par cohérence optique plein champ étendus spatialement et spectralement

Antoine Federici 1 
1 Laboratoire Charles Fabry / Biophotonique
LCF - Laboratoire Charles Fabry
Abstract : Full-field optical coherence tomography (FF-OCT) is an optical technology based on low-coherence interference microscopy for tomographic imaging of semitransparent samples. Non-invasive three-dimensional imaging can be performed with an isotropic spatial resolution of the order of 1 µm. During the PhD thesis, several FF-OCT systems have been reported achieving extended performances or contrast enhanced images relevant for biological tissues imaging. Firstly, a three-band, 1.9-μm axial resolution FF-OCT system has been implemented to perform spectroscopic contrast enhanced imaging of biological tissues over a 530-1700 nm wavelength range. Then, a study of the FF-OCT axial response has been carried out for maximizing the axial resolution of the system. An isotropic spatial resolution of 0.5 µm (in water) has been obtained by combining 1.2-NA microscope objectives with an optimized broad spectral band adapted to biological tissues imaging, such as skin samples. A set-up with an extended field of view of 18 mm x 18 mm has been also designed and applied to amplitude signal detection as well as depth-resolved quantitative phase signal measurement. At last, we developed a technique based on the combination of full-field swept-source optical coherence tomography (FF-SSOCT) with low spatial coherence illumination and a special numerical processing that allows for numerically focused mechanical motion-free three-dimensional imaging.
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  • HAL Id : tel-01301378, version 1

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Antoine Federici. Développement de systèmes de microscopie par cohérence optique plein champ étendus spatialement et spectralement. Optique [physics.optics]. Université Paris Saclay (COmUE), 2015. Français. ⟨NNT : 2015SACLS024⟩. ⟨tel-01301378⟩

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