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Theses

Applicateurs destinés aux études d’effets biologiques des ondes électromagnétiques sub-nanosecondes

Abstract : Since the years 1960, scientists have been interested to the study of biologic effects caused by pulsed electrical fields. The first effects were obtained with microseconds pulses and milliseconds pulses. This phenomenon has been called electroporation and it’s used in anticancerous therapies called electrochimiotherapies. Laboratory studies are continuing, but with shorter pulses like high level subnanoseconds pulses (100MV/m). These studies are emerging and must be pursued, but it’s necessary to design reliable electromagnetic systems. The goal of this thesis was to design two electrical field applicators: an in vitro applicator, to illuminate biologic cells contained in test tube and an in vivo applicator to predict future non invasive therapies. For the in vitro applicator, simulations and experimental results are very encouraging and biological experimentations would be possible with this system. For the applicator in vivo, which is the PSIRA antenna designed par C. E. Baum, many problems are highlighted. First, biological tissues like skin and muscle have high permittivity and high dielectric losses with frequencies in the order of GHz and behind. To maximize electric field penetration in these backgrounds it was decided to submerge the antenna in high permittivity background too, like glycerin and water. These liquids have high dielectric losses which have a strong negative impact on the antenna performances. To make this system operational, some modifications must be done, like changing the actual background with a no losses background.
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Mathieu Croizer. Applicateurs destinés aux études d’effets biologiques des ondes électromagnétiques sub-nanosecondes. Electromagnétisme. Université de Limoges, 2015. Français. ⟨NNT : 2015LIMO0127⟩. ⟨tel-01298291⟩

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