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Evaluation de traitement de la sclérose en plaques par analyses morphométriques de données d'imagerie par résonance magnétique

Abstract : Multiple sclerosis is a chronic inflammatory and demyelinating disease of the central nervous system having a highly variable clinical expression from patient to another. Given this heterogeneity, the identification of neuroimaging biomarkers able to reflect damages responsible for cognitive and motor deficits found in these patients is crucial for evaluating the efficacy of new therapies. In this thesis, we studied and highlighted the morphological damages (changes in volume and shape) of the thalamus , a central brain structure, through populations representing all clinical forms of the disease. We then evaluated the effect of treatment in a longitudinal volumetric analysis conducted over 12 months. Repeatability of thalamic volume results attests the quality of the method used.
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https://tel.archives-ouvertes.fr/tel-01296997
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Charlotte Dutilleul. Evaluation de traitement de la sclérose en plaques par analyses morphométriques de données d'imagerie par résonance magnétique. Ingénierie biomédicale. Université Paul Sabatier - Toulouse III, 2015. Français. ⟨NNT : 2015TOU30138⟩. ⟨tel-01296997⟩

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