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Synthèse de nanoparticules par polymérisation radicalaire en émulsion pour le développement d’une nouvelle phase stationnaire dans des microsystèmes en copolymère d’oléfine cyclique

Abstract : The aim of this thesis is the synthesis of nanoparticles in cyclic olefin copolymer (COC) microchips in order to develop a new stationary phase. The bibliography review reveals the interest of this project in increasing column performance (efficiency and resolution) and reducing the analysis time. A general review on stationary phases and separation mode in microchips is presented. The synthesis of nanoparticles by radical polymerization of micro and miniemulsion is then detailed. The preliminary results helped defining the methodological approach: 1) Synthesis of nanoparticles via miniemulsion radical polymerization and 2) functionalization of COC surfaces. First, miniemulsion composition is optimized by an experimental design. The optimal miniemulsion led, after photopolymerization, to monodisperse nanoparticles with a diameter size inferior to 200 nm. The anchorage on COC surface is then investigated and shows that COC functionalization with a hydrophilic monomer is essential. Photografting of polyethylene glycol methacrylate (PEGDA) optimization is carried out by an experimental design. The UV synthesis of nanoparticles on COC surfaces functionalized by PEGDA is demonstrated. Monodisperse and spherical nanoparticles with a diameter size inferior to 200 nm are obtained. This work is considered as a first step in the development of a new stationary phase for chromatography
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Josiane Saadé. Synthèse de nanoparticules par polymérisation radicalaire en émulsion pour le développement d’une nouvelle phase stationnaire dans des microsystèmes en copolymère d’oléfine cyclique. Chimie analytique. Université Claude Bernard - Lyon I, 2015. Français. ⟨NNT : 2015LYO10260⟩. ⟨tel-01282736⟩

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