Modèles d’évolution de protéines en environnement variable

Abstract : This thesis studies the influence of an evolutionary fluctuating environment on the functional architecture of proteins. The appearance of restricted groups of amino acids – sectors, with particular functional, evolutional and structural properties has no simple explanation in the classical paradigm of proteins physics. So we choose to study the role of evolutionary history on the construction of this particular architecture and the resulting properties. We have thus constructed a model of functional protein inspired by the elastic network models, that we have evolved in silico while temporarily varying the targeted function with various frequencies. We have shown that these fluctuations induce a form of sparsity close to that observed in proteins and has identified the key parameters of this phenomenon. We finally investigate the link between the temporal statistics of the environment and the appearance of different independent sectors.
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Mathieu Hemery. Modèles d’évolution de protéines en environnement variable. Biophysique [physics.bio-ph]. Université Pierre et Marie Curie, 2015. Français. ⟨tel-01273695⟩

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