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Couplage d’approches expérimentales et modélisatrices pour l'étude des mécanismes d'effet de perturbateurs endocriniens chez la limnée des étangs, Lymnaea stagnalis.

Abstract : Plant protection products and biocides may contain chemicals that interfere with the endocrine system and consequently induce adverse effects on wildlife. Such chemicals are known as endocrine disruptors (EDs). To ensure a satisfactory protection level for aquatic molluscs a comprehensive understanding of endocrine disruption is needed. The Organisation for Economic Co-operation and Development supports the standardisation of toxicity tests guideline on mollusc reproductive toxicity, which is intended for environmental risk assessments purposes. This PhD thesis aimed at improving toxicity test protocols and data analysis tools to evaluate effects of chemicals on the great pond snail Lymnaea stagnalis. A suite of toxicity tests was conducted in which snails were exposed to putative androgens (tributyltin, triphenyltin, methyltestosterone), putative oestrogens (alkylphenols and ethynyloestradiol), and solvents. Resulting effects were evaluated using standard statistical approachesand/or a toxicokinetic-toxicodynamic (TKTD) model. Snails were sensitive to tributyltin and triphenyltin, while none of the oestrogenic chemicals and methyltestosterone significantly impacted animals at environmentally relevant concentrations. Triethylene glycol and acetone were the least harmful solvents. Further, the analysis of data from the tributyltin test with the TKTD model suggested a generic mechanism of action of the compound (i.e., not specific for EDs). The demonstration of endocrine disruption in L. stagnalis remained elusive and deserves further research. Finally, the thesis highlight
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https://tel.archives-ouvertes.fr/tel-01251961
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Alpar Barsi. Couplage d’approches expérimentales et modélisatrices pour l'étude des mécanismes d'effet de perturbateurs endocriniens chez la limnée des étangs, Lymnaea stagnalis.. Ecologie, Environnement. Agrocampus Ouest, 2015. Français. ⟨NNT : 2015NSARD077⟩. ⟨tel-01251961⟩

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