Imagerie multimodale optique, élastique et photo-thermique des tissus biologiques par OCT plein champ

Amir Nahas 1, 2
2 POM - Physique des Ondes pour la Médecine et la Biologie
Institut Langevin ondes et images, INSERM - Institut National de la Santé et de la Recherche Médicale : U979
Abstract : Full Field OCT (FF-OCT) is an imaging technic use to do microscopy inside scattering media at a given depth using an interferometric setup. One of the main objectives that motivated the development of FF-OCT was to provide during surgery to the surgeon images similar to histological slices but in real time. Currently, diagnostic made from FF-OCT images gives good results, especially in the case of some breast disease. However, the major difference between the histological and FF-OCT is that FF-OCT has only a morphological contrast and in some cases, this contrast is not enough to make the diagnosis. In the research described in this thesis we are committed to developing new tomographic approaches, leading to new forms of contrast may enhance images of FF- OCT for a better quality of diagnosis. Specifically, we worked on the optical and photothermal detection of gold nanoparticles by FF-OCT and the mechanical properties mapping by three methods in order to develop new types of contrasts that will help improve the diagnosis.
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Amir Nahas. Imagerie multimodale optique, élastique et photo-thermique des tissus biologiques par OCT plein champ. Autre [cond-mat.other]. Université Pierre et Marie Curie - Paris VI, 2014. Français. ⟨NNT : 2014PA066680⟩. ⟨tel-01232302⟩

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