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Conception d’un dispositif de caractérisation polarimétrique de Mueller à travers une fibre optique endoscopique, destiné à l’imagerie biomédicale avancée

Abstract : Optical polarimetric imaging techniques can be very attractive for early diagnosis of diseases such as fibrosis or some cancers as they can provide valuable information on the structure of biological tissues at the submicronic scale. Among them, Mueller polarimetry is the only one able to determine all the polarimetric characteristics of any sample (retardance, diattenuation, depolarization). This PhD thesis aims to achieve, for the first time, Mueller polarimetry through an optical fiber in order to allow in vivo in situ characterizations of biological tissues. The challenge is to overcome the uncontrollable perturbations induced by the optical fiber on the polarization states of the guided light. The investigated solution consists in deducing the polarimetric characteristics of the sample from the Mueller matrix of the fiber only (2 m long), and from that of the « fiber + sample » assembly, thanks to a specific mathematical processing. A fibered Mueller polarimeter, working in backscattering configuration has been specially designed. Two versions, based on either sequential or simultaneous measurements, were investigated and compared. Measurements of different sets of calibrated polarimetric components are in a very good agreement with the expected ones: discrepancies lower than 1.5°, 1° and 0.02 respectively have been found on retardance, relative orientations of birefringence eingenaxes and on linear and circular diattenuations. Very first Mueller polarimetric images of manufactured and biological samples (type I collagen) realized through an endoscopic optical fiber are also shown and discussed.
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https://tel.archives-ouvertes.fr/tel-01224771
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Submitted on : Friday, January 29, 2016 - 4:21:06 PM
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Jeremy Vizet. Conception d’un dispositif de caractérisation polarimétrique de Mueller à travers une fibre optique endoscopique, destiné à l’imagerie biomédicale avancée. Imagerie. Université de Limoges, 2015. Français. ⟨NNT : 2015LIMO0057⟩. ⟨tel-01224771⟩

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