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Développement de nouveaux supports basés sur des nanofibres de matériaux hybrides électrofilées pour le développement de biocapteurs électrochimiques

Abstract : The work detailed within this manuscript describes the development of three novel efficient electroactive platforms based on electrospun nanofibrous hybrid materials for further application to electrochemical biosensors elaboration. The performance of biosensors is enhanced by their coupling with nanoscale materials, due to the unique properties that the latter exhibit. Although electroctrospun fibers find applications in various fields, their exploitation for biosensing is still in an early but promising stage. Herein, different polymeric nanofibers incorporating carbon nanotubes, decorated with gold nanoparticles or coated with conducting polypyrrole/poly(pyrrole-3-carboxylic acid) films were used as platforms for the development of biosensors. Glucose oxidase was used as a model enzyme to validate the performance of the developed biosensors. The enzyme was either incorporated into the nanofibers or covalently immobilized onto their surface. These innovative biosensors, characterized by different microscopic and electrochemical techniques, enabled successful detection of glucose by employing cyclic voltammetry and electrochemical impedance spectroscopy, whilst demonstrating enhanced performances over conventional biosensors in terms of sensitivity, reproducibility and stability
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Submitted on : Friday, October 9, 2015 - 4:27:33 PM
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Eleni Sapountzi. Développement de nouveaux supports basés sur des nanofibres de matériaux hybrides électrofilées pour le développement de biocapteurs électrochimiques. Micro et nanotechnologies/Microélectronique. Université Claude Bernard - Lyon I, 2015. Français. ⟨NNT : 2015LYO10122⟩. ⟨tel-01214059⟩

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