Etude de la variabilité hémodynamique chez l’enfant et l’adulte sains en IRMf

Solveig Badillo 1
1 PARIETAL - Modelling brain structure, function and variability based on high-field MRI data
Inria Saclay - Ile de France, NEUROSPIN - Service NEUROSPIN
Abstract : In fMRI, the conclusions of experimental paradigms remain unreliable as far as they supposesome a priori knowledge on the neuro-vascular coupling which is characterized by thehemodynamic response function modeling the link between the stimulus input and the fMRIsignal as output. To improve our understanding of the neuronal and vascular changes inducedby the realization of a cognitive task given in fMRI, it seems thus critical to study thecharacteristics of the hemodynamic response in depth.This thesis gives a new perspective on this topic, supported by an original method for intra-subjectanalysis of fMRI data : the Joint Detection-Estimation (or JDE). The JDE approachmodels the hemodynamic response in a not parametric and multivariate manner, while itjointly detects the cerebral areas which are activated in response to stimulations deliveredalong an experimental paradigm.The first contribution of this thesis is centered on the thorough analysis of the interindividualand inter-regiona hemodynamic variability from a population of young healthyadults. This work has allowed to validate the JDE method at the group level and to highlightthe striking hemodynamic variability in some cerebral regions : parietal, temporal, occipitallobes, motor cortex. This variability is much more important as the region is involved in morecomplex cognitive processes.The second research axis has consisted in focusing on the study of the hemodynamic orga-nizationof a particularly important cerebral area in Humans, the language system. Becausethis function embeds the reading learning ability, groups of healthy children of 6 and 9 yearsold respectively, who were in the process of learning or of strenghting reading, were chosen forthis study. Two important methodological contributions have been proposed. First, a multi-sessionsextension of the JDE approach (until now limited to the processing of mono-sessiondata in fMRI) was worked out in order to improve the robustness and the reproducibility ofthe results. Then, a new framework was developed to overcome the main shortcoming of theJDE approach. The latter indeed relies on a prior parcellation of the data in functionally ho-mogeneousregions, the choice of which is critical for the subsequent inference and impacts thehemodynamic results. In order to avoid this a priori choice, the finalized alternative combinesthe results from various random data fragmentations by using “consensus clustering”.Finally, a second extension of the JDE approach was developed in order to robustly estimatethe shape of the hemodynamic response at the group level. So far, this model was validatedon simulations, and we plan to apply it on children data to improve the study of the BOLDresponse temporal characteristics in the language areas. Thus, this PhD work proposes onone hand new methodological contributions to characterize the hemodynamic response infMRI, and on the other hand a validation and a neuroscientific application of the proposedapproaches.
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Solveig Badillo. Etude de la variabilité hémodynamique chez l’enfant et l’adulte sains en IRMf. Autre [cond-mat.other]. Université Paris Sud - Paris XI, 2013. Français. ⟨NNT : 2013PA112279⟩. ⟨tel-01208140⟩

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