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Rationalisation des procédures de séparation des composés chiraux à visée pharmaceutique et cosmétique

Abstract : The subject of enantiomer separation is a major issue in various fields, particularly pharmaceuticals (metabolites and active principle). To prepare pharmaceutical formulations, the racemic form has long been favored at the expense of possible side effects. Since the 90s, the development of the number of enantiomerically pure entities is rising, particularly through the development of separation techniques. Chiral chromatography using enantioselective stationary phases is an excellent technique for fast and direct resolution of stereoisomers. However, limited understanding of the mechanism leads to tedious and expensive trial-and-error systematic chiral method development. No clear guideline for choosing a chromatographic system is available for a new chiral drug. In this project, we wish to achieve a better knowledge of enantioselective separation techniques in order to help in the choice of separation method that will be the most appropriate for any given chiral separation. This project is based on the rationalization of large amounts of experimental data with the help of modelling and chemometric techniques to unravel the enantioselective recognition mechanism.
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Syame Khater. Rationalisation des procédures de séparation des composés chiraux à visée pharmaceutique et cosmétique. Chimie analytique. Université d'Orléans, 2014. Français. ⟨NNT : 2014ORLE2060⟩. ⟨tel-01207211⟩

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