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Joint use of dual-frequency electrowetting and interferometry in a digital microsystem : application to evaporation and surface ageing at drop scale

Abstract : This PhD research is thought of as a first step towards label freedigital biosensing. A novel transduction mechanism is developed, based on thegeneration of capillary waves along a drop surface induced by dual-frequencyelectrowetting. Acapillary resonance is measured by interferometry at the movingdrop apex. Aproof of concept of this electro-optical methodology for furtherintegration in a digital microsystem is given with characterization of drop evaporationkinetics. A second part focuses on modeling and numerical calculationsof the transport of surface active biomolecules in the drop. The model includesdiffusion, ad-/desorption phenomena together with a kinematic condition of avariable drop radius (evaporation) as well as a finite molecular amount of surfaceactive biomolecules. A dimensionless number is suggested to take into accountfinite size effects. Drop steady streaming due to oscillating electrowetting isfinally taken into account. Low- and high-frequency electrowetting is appliedto a drop laden with bovine serum albumin. By jointly using interferometry andimaging, enhancement of surface ageing is made evident under electrowetting.
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Johannes Theisen. Joint use of dual-frequency electrowetting and interferometry in a digital microsystem : application to evaporation and surface ageing at drop scale. Fluids mechanics [physics.class-ph]. Université de Grenoble, 2013. English. ⟨NNT : 2013GRENI084⟩. ⟨tel-01204769⟩

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