Targeting Multiple Kinase Pathways: A Change In Paradigm, Clinical Cancer Research, vol.16, issue.7, pp.1973-1981, 2010. ,
DOI : 10.1158/1078-0432.CCR-09-3182
Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis, Pharmacology & Therapeutics, vol.131, issue.1, pp.80-90, 2011. ,
DOI : 10.1016/j.pharmthera.2011.03.012
Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity, Molecular Cancer Therapeutics, vol.5, issue.8, pp.2051-2060, 2006. ,
DOI : 10.1158/1535-7163.MCT-06-0007
Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to ,
DOI : 10.1158/0008-5472.can-05-3387
Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors, Cancer Science, vol.20, issue.11, pp.1946-54, 2012. ,
DOI : 10.1111/j.1349-7006.2012.02408.x
Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner, AJP: Cell Physiology, vol.290, issue.2, pp.592-600, 2006. ,
DOI : 10.1152/ajpcell.00278.2005
Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis, Oncogene, vol.59, issue.5, pp.548-60, 2011. ,
DOI : 10.1016/j.ccr.2009.09.029
Selfreinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer, Oncogene, 2013. ,
Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti???Epidermal Growth Factor Receptor Monoclonal Antibody Therapy, Journal of Clinical Oncology, vol.27, issue.12 ,
DOI : 10.1200/JCO.2009.21.9170
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients, International Journal of Cancer, vol.75, issue.3, pp.241-246, 1996. ,
DOI : 10.1002/(SICI)1097-0215(19960621)69:3<241::AID-IJC15>3.0.CO;2-A
Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer, Oncology Reports, vol.21, issue.5 ,
DOI : 10.3892/or_00000352
Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction BIBLIOGRAPHIE 1 Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value, PLoS Med, issue.5, pp.10-1001453, 2013. ,
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER, Annual Review of Cell and Developmental Biology, vol.20, issue.1, pp.695-723, 2004. ,
DOI : 10.1146/annurev.cellbio.20.010403.092805
The search for the causes of breast and colon cancer, Nature, vol.338, issue.6214, pp.338-389, 1989. ,
DOI : 10.1038/338389a0
Colorectal cancer screening: 20 years of development and recent progress, World Journal of Gastroenterology, vol.20, issue.14, pp.3825-3834, 2014. ,
DOI : 10.3748/wjg.v20.i14.3825
Screening for colorectal cancer using the faecal occult blood test, Hemoccult, Hemoccult. Cochrane Database Syst Rev, vol.329, issue.6, p.1216, 2007. ,
DOI : 10.1002/14651858.CD001216.pub2
Improving colorectal cancer screening outcomes: Proceedings of the second meeting of the International Colorectal Cancer Screening Network, a global quality initiative, Journal of Medical Screening, vol.319, issue.3, pp.152-159, 2010. ,
DOI : 10.1258/jms.2010.010002
Immunochemical Detection of Human Blood in Feces, American Journal of Clinical Pathology, vol.69, issue.3, pp.342-348, 1978. ,
DOI : 10.1093/ajcp/69.1.342
FIT Testing: An Overview, Current Gastroenterology Reports, vol.366, issue.Suppl, pp.15-357, 2013. ,
DOI : 10.1007/s11894-013-0357-x
Colorectal cancer, The Lancet, vol.365, issue.9454, pp.365-153, 1991. ,
DOI : 10.1016/S0140-6736(05)17706-X
Clues to the pathogenesis of familial colorectal cancer, Science, vol.260, issue.5109, pp.812-818, 1993. ,
DOI : 10.1126/science.8484121
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair, Nature, vol.365, issue.6443, pp.365-274, 1993. ,
DOI : 10.1038/365274a0
Identification and characterization of the familial adenomatous polyposis coli gene, Cell, vol.66, issue.3, pp.589-600, 1991. ,
DOI : 10.1016/0092-8674(81)90021-0
Comprehensive molecular characterization of human colon and rectal cancer, Nature, issue.7407, pp.487-330, 2012. ,
Prognostic Impact of Microsatellite Instability and DNA Ploidy in Human Colon Carcinoma Patients, Gastroenterology, vol.131, issue.3, pp.729-766, 2006. ,
DOI : 10.1053/j.gastro.2006.06.005
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines, Cancer Res, vol.57, issue.5, pp.808-819, 1997. ,
A genetic model for colorectal tumorigenesis, Cell, vol.61, issue.5, pp.61-759, 1990. ,
DOI : 10.1016/0092-8674(90)90186-I
Constitutive Transcriptional Activation by a beta -Catenin-Tcf Complex in APC-/- Colon Carcinoma, Science, vol.275, issue.5307, pp.275-5307, 1997. ,
DOI : 10.1126/science.275.5307.1784
Genetic Alterations during Colorectal-Tumor Development, New England Journal of Medicine, vol.319, issue.9, pp.525-557, 1988. ,
DOI : 10.1056/NEJM198809013190901
RAS oncogenes: The first 30 years, Nature Reviews Cancer, vol.245, issue.9, pp.459-65, 2003. ,
DOI : 10.1038/nrc1193
Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?, Trends in Cell Biology, vol.14, issue.11, pp.14-639, 2004. ,
DOI : 10.1016/j.tcb.2004.09.014
Mutations in BRAF and KRAS converge on activation of the mitogenactivated protein kinase pathway in lung cancer mouse models, Cancer Res, issue.10, pp.67-4933, 2007. ,
Dependence receptors: when apoptosis controls tumor progression, Bull Cancer, vol.94, issue.4, pp.12-19, 2007. ,
Cancer. p53, guardian of the genome, Nature, issue.6381, pp.358-373, 1992. ,
URL : https://hal.archives-ouvertes.fr/hal-00868358
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage, Proceedings of the National Academy of Sciences, vol.96, issue.24, pp.96-13777, 1999. ,
DOI : 10.1073/pnas.96.24.13777
Mutational landscape and significance across 12 major cancer types, Nature, vol.339, issue.7471, pp.333-342, 2013. ,
DOI : 10.1038/nature12634
TGF-beta signalling from cell membrane to nucleus through SMAD proteins, Nature, issue.6659, pp.390-465, 1997. ,
Epithelial-mesenchymal transition and its implications for fibrosis, Journal of Clinical Investigation, vol.112, issue.12, pp.1776-84, 2003. ,
DOI : 10.1172/JCI200320530
Oncogenic roles of EMT-inducing transcription factors, Nature Cell Biology, vol.11, issue.6, pp.488-94, 2014. ,
DOI : 10.1126/science.1164853
Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling, Journal of Mammary Gland Biology and Neoplasia, vol.7, issue.4, pp.415-447, 2002. ,
DOI : 10.1023/A:1024090116451
Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells, J Cell Sci, issue.121, pp.3317-3341, 2008. ,
Snail and Slug promote epithelialmesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3, Mol Biol Cell, issue.11, pp.19-4875, 2008. ,
Slug is a direct Notch target required for initiation of cardiac cushion cellularization, The Journal of Cell Biology, vol.122, issue.2, pp.315-340, 2008. ,
DOI : 10.1038/sj.emboj.7600069
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer, pp.415-443, 2007. ,
Epithelial???mesenchymal transitions in tumour progression, Nature Reviews Cancer, vol.59, issue.6, pp.442-54, 2002. ,
DOI : 10.1038/nrc822
Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer, Journal of Clinical Pathology, vol.138, issue.(Suppl 3), 2014. ,
DOI : 10.1136/jclinpath-2014-202499
Epithelial mesenchymal transition in colorectal cancer: Seminal role in promoting disease progression and resistance to neoadjuvant therapy, Surgical Oncology, vol.21, issue.4, pp.316-339, 2012. ,
DOI : 10.1016/j.suronc.2012.08.003
EMT is the dominant program in human colon cancer, BMC Medical Genomics, vol.116, issue.3, p.9, 2011. ,
DOI : 10.1002/cncr.24760
Epithelial???mesenchymal and mesenchymal???epithelial transitions in carcinoma progression, Journal of Cellular Physiology, vol.61, issue.2, pp.374-83, 2007. ,
DOI : 10.1002/jcp.21223
Inflammation and cancer, Nature, vol.2, issue.6917, pp.420-860, 2002. ,
DOI : 10.1006/cyto.1996.0074
Cancer and Inflammation: Promise for Biologic Therapy, Journal of Immunotherapy, vol.33, issue.4, pp.335-51, 2010. ,
DOI : 10.1097/CJI.0b013e3181d32e74
The Dukes classification of colorectal cancer): p. 1447. 43. Sobin, L.H. and I.D. Fleming, TNM Classification of Malignant Tumors, Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer, pp.256-80, 1986. ,
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor, Journal of Leukocyte Biology, vol.87, issue.4, pp.713-738, 2010. ,
DOI : 10.1189/jlb.0909607
Regulation of tumor cell growth at organ-specific metastases, In Vivo, vol.6, issue.4, pp.325-356, 1992. ,
Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma, Cancer Res, vol.14, issue.2, pp.119-142, 1954. ,
The comparative utilization of uracil-2-C14 by liver, intestinal mucosa, and Flexner-Jobling carcinoma in the rat, Cancer Res, vol.17, issue.5, pp.399-404, 1957. ,
XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients With Metastatic Colorectal Cancer, Journal of Clinical Oncology, vol.22, issue.11, pp.22-2084, 2004. ,
DOI : 10.1200/JCO.2004.11.069
5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line, Journal of Applied Toxicology, vol.2, issue.4, pp.308-324, 2009. ,
DOI : 10.1002/jat.1411
5-Fluorouracil: mechanisms of action and clinical strategies, Nature Reviews Cancer, vol.3, issue.5, pp.330-338, 2003. ,
DOI : 10.1038/nrc1074
High-dose continuous infusion folinic acid and bolus 5-fluorouracil in patients with advanced colorectal cancer: a phase II study., Journal of Clinical Oncology, vol.4, issue.7, pp.1058-61, 1986. ,
DOI : 10.1200/JCO.1986.4.7.1058
The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer Leucovorin and fluorouracil with or without oxaliplatin as firstline treatment in advanced colorectal cancer, Pharmacogenomics J J Clin Oncol, vol.8, issue.416, pp.256-67, 2000. ,
Oxaliplatin: a review of preclinical and clinical studies, Ann Oncol, issue.910, pp.1053-71, 1998. ,
Clinical pharmacokinetics of oxaliplatin: a critical review, Clin Cancer Res, vol.6, issue.4, pp.1205-1223, 2000. ,
Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy, Cancer Treatment Reviews, vol.31, issue.2, pp.31-90, 2005. ,
DOI : 10.1016/j.ctrv.2004.12.006
Cytotoxicity, cellular accumulation and DNA binding of oxaliplatin isomers, Cancer Letters, vol.97, issue.2, pp.177-84, 1995. ,
DOI : 10.1016/0304-3835(95)03974-2
Ongoing and unsaid on oxaliplatin: the hope, British Journal of Cancer, vol.77, issue.4, pp.8-11, 1998. ,
DOI : 10.1038/bjc.1998.429
Adjuvant Therapy With Fluorouracil and Oxaliplatin in Stage II and Elderly Patients (between ages 70 and 75 years) With Colon Cancer: Subgroup Analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer Trial, Journal of Clinical Oncology, vol.30, issue.27, pp.30-3353, 2012. ,
DOI : 10.1200/JCO.2012.42.5645
Isolation and chemical characterization of antitumor agents from plants, Cancer Treat Rep, issue.8, pp.60-1011, 1976. ,
Irinotecan-based combinations for the adjuvant treatment of stage III colon cancer, Oncology, vol.12, issue.14, pp.47-50, 2000. ,
In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1alpha target genes and decreases tumor angiogenesis, Mol Med, vol.18, pp.83-94, 2012. ,
Irinotecan and high-dose fluorouracil/leucovorin for metastatic colorectal cancer, Oncology, vol.12, issue.14, pp.51-56, 2000. ,
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial Adjuvant therapy for stage II and III colorectal cancer, Lancet Semin Oncol, vol.355, issue.92092, pp.34-37, 2000. ,
Tumor angiogenesis: therapeutic implications, N Engl J Med, vol.285, issue.21, pp.1182-1188, 1971. ,
Role of angiogenesis in tumor growth and metastasis, Semin Oncol, vol.296, pp.15-23, 2002. ,
Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells, Lab Invest, issue.6, pp.51-624, 1984. ,
Peptide Hormone Regulation of Angiogenesis, Physiological Reviews, vol.89, issue.4, pp.1177-215, 2009. ,
DOI : 10.1152/physrev.00024.2009
What Is the Evidence That Tumors Are Angiogenesis Dependent?, JNCI Journal of the National Cancer Institute, vol.82, issue.1, pp.4-6, 1990. ,
DOI : 10.1093/jnci/82.1.4
Significance of blood vessel leakiness in cancer, Cancer Res, vol.62, issue.18, pp.5381-5386, 2002. ,
Imaging of angiogenesis: from microscope to clinic, Nature Medicine, vol.9, issue.6, pp.713-738, 2003. ,
DOI : 10.1038/nm0603-713
Endothelial cells of tumor vessels: abnormal but not absent, Cancer and Metastasis Reviews, vol.19, issue.1/2, pp.109-129, 2000. ,
DOI : 10.1023/A:1026529222845
Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors, The American Journal of Pathology, vol.160, issue.3, pp.985-1000, 2002. ,
DOI : 10.1016/S0002-9440(10)64920-6
Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness, The American Journal of Pathology, vol.156, issue.4, pp.1363-80, 2000. ,
DOI : 10.1016/S0002-9440(10)65006-7
Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy, Cancer Research, vol.73, issue.10, pp.73-2943, 2013. ,
DOI : 10.1158/0008-5472.CAN-12-4354
New perspectives in clinical oncology from angiogenesis research, European Journal of Cancer, vol.32, issue.14, pp.32-2534, 1996. ,
DOI : 10.1016/S0959-8049(96)00423-6
Induction of angiogenesis during the transition from hyperplasia to
neoplasia, Nature, vol.339, issue.6219, pp.58-61, 1989. ,
DOI : 10.1038/339058a0
Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice., Proceedings of the National Academy of Sciences, vol.91, issue.6, pp.2081-2086, 1994. ,
DOI : 10.1073/pnas.91.6.2081
Local Recurrences Following Mastectomy: Support for the Concept of Tumor Dormancy, JNCI Journal of the National Cancer Institute, vol.86, issue.1, pp.45-53, 1994. ,
DOI : 10.1093/jnci/86.1.45
Cancer dormancy: Opportunities for new therapeutic approaches, Nature Medicine, vol.343, issue.5, pp.505-514, 1997. ,
DOI : 10.1038/nm0196-52
Advances in Diagnostic Imaging and Overestimations of Disease Prevalence and the Benefits of Therapy, New England Journal of Medicine, vol.328, issue.17, pp.328-1237, 1993. ,
DOI : 10.1056/NEJM199304293281706
Cancer without disease The biology of VEGF and its receptors, Nature Nat Med, vol.85, issue.6977 96, pp.427-787, 2003. ,
The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA, Molecular Endocrinology, vol.5, issue.12, pp.1806-1820, 1991. ,
DOI : 10.1210/mend-5-12-1806
Crystal Structures of Novel Vascular Endothelial Growth Factors (VEGF) from Snake Venoms: INSIGHT INTO SELECTIVE VEGF BINDING TO KINASE INSERT DOMAIN-CONTAINING RECEPTOR BUT NOT TO fms-LIKE TYROSINE KINASE-1, Journal of Biological Chemistry, vol.280, issue.3, pp.280-2126, 2005. ,
DOI : 10.1074/jbc.M411395200
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid, Science, vol.219, issue.4587, pp.219-983, 1983. ,
DOI : 10.1126/science.6823562
Biology and Clinical Development of Vascular Endothelial Growth Factor???Targeted Therapy in Renal Cell Carcinoma, Journal of Clinical Oncology, vol.23, issue.5, pp.1028-1071, 2005. ,
DOI : 10.1200/JCO.2005.01.186
VEGF isoforms and mutations in human colorectal cancer, International Journal of Cancer, vol.100, issue.1, pp.32-38, 2002. ,
DOI : 10.1002/ijc.10552
VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix, Journal of Biological Chemistry, vol.272, issue.11, pp.272-7151, 1997. ,
DOI : 10.1074/jbc.272.11.7151
VEGF165b, an Inhibitory Vascular Endothelial Growth Factor Splice Variant: Mechanism of Action, In vivo Effect On Angiogenesis and Endogenous Protein Expression, Cancer Research, vol.64, issue.21, pp.64-7822, 2004. ,
DOI : 10.1158/0008-5472.CAN-04-0934
Vascular endothelial growth factor B, a novel growth factor for endothelial cells., Proceedings of the National Academy of Sciences, vol.93, issue.6, pp.93-2576, 1996. ,
DOI : 10.1073/pnas.93.6.2576
Genomic Organization of the Mouse and Human Genes for Vascular Endothelial Growth Factor B (VEGF-B) and Characterization of a Second Splice Isoform, Journal of Biological Chemistry, vol.271, issue.32, pp.271-19310, 1996. ,
DOI : 10.1074/jbc.271.32.19310
Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C, Journal of Biological Chemistry, vol.273, issue.14, pp.273-8413, 1998. ,
DOI : 10.1074/jbc.273.14.8413
Vascular Endothelial Growth Factor-B in Physiology and Disease, Physiological Reviews, vol.94, issue.3, pp.779-794, 2014. ,
DOI : 10.1152/physrev.00028.2013
Proteolytic processing regulates receptor specificity and activity of VEGF-C, The EMBO Journal, vol.16, issue.13, pp.3898-911, 1997. ,
DOI : 10.1093/emboj/16.13.3898
Lymphangiogenesis: Molecular Mechanisms and Future Promise, Cell, vol.140, issue.4, pp.460-76, 2010. ,
DOI : 10.1016/j.cell.2010.01.045
URL : http://doi.org/10.1016/j.cell.2010.01.045
Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers, British Journal of Cancer, vol.5, issue.3, pp.91-466, 2004. ,
DOI : 10.1038/sj.bjc.6690356
Restricted Expression Pattern ofvegf-din the Adult and Fetal Mouse: High Expression in the Embryonic Lung, Biochemical and Biophysical Research Communications, vol.257, issue.3, pp.891-895, 1999. ,
DOI : 10.1006/bbrc.1999.0562
Vascular Endothelial Growth Factor (VEGF), VEGF Receptors and Their Inhibitors for Antiangiogenic Tumor Therapy, Biological & Pharmaceutical Bulletin, vol.34, issue.12, pp.34-1785, 2011. ,
DOI : 10.1248/bpb.34.1785
Placenta growth factor Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk- 1/KDR, J Biol Chem, issue.41, pp.269-25646, 1994. ,
Down-Regulation of Placenta Growth Factor by Promoter Hypermethylation in Human Lung and Colon Carcinoma, Molecular Cancer Research, vol.5, issue.9, pp.873-80, 2007. ,
DOI : 10.1158/1541-7786.MCR-06-0141
PGF isoforms, PLGF-1 and PGF-2, in colorectal cancer and the prognostic significance, Cancer Genomics Proteomics, vol.6, issue.4, pp.239-285, 2009. ,
Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus, J Virol, vol.68, issue.1, pp.84-92, 1994. ,
Vegf, vegf-B, vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa, International Journal of Cancer, vol.86, issue.2, pp.174-81, 2000. ,
DOI : 10.1002/(SICI)1097-0215(20000415)86:2<174::AID-IJC5>3.3.CO;2-5
Characterization of Vascular Endothelial Cell Growth Factor Interactions with the Kinase Insert Domain-containing Receptor Tyrosine Kinase: A REAL TIME KINETIC STUDY, Journal of Biological Chemistry, vol.274, issue.26, pp.274-18421, 1999. ,
DOI : 10.1074/jbc.274.26.18421
Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells, Oncogene, vol.135, issue.16, pp.24-2647, 2005. ,
DOI : 10.1038/sj.onc.1208246
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family, Cardiovascular Research, vol.49, issue.3, pp.568-81, 2001. ,
DOI : 10.1016/S0008-6363(00)00268-6
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1, Blood, vol.87, issue.8, pp.3336-3379, 1996. ,
The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities: IMPLICATIONS FOR A FUNCTIONAL ROLE OF PLACENTA GROWTH FACTOR IN MONOCYTE ACTIVATION AND CHEMOTAXIS, Journal of Biological Chemistry, vol.271, issue.30, pp.271-17629, 1996. ,
DOI : 10.1074/jbc.271.30.17629
Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1, Science, vol.299, issue.5608, pp.890-893, 2003. ,
DOI : 10.1126/science.1079562
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor., Proceedings of the National Academy of Sciences, vol.90, issue.22, pp.90-10705, 1993. ,
DOI : 10.1073/pnas.90.22.10705
Identification of a new endothelial cell growth factor receptor tyrosine kinase, Oncogene, vol.6, issue.9, pp.1677-83, 1991. ,
Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer, Cancer Genomics Proteomics, vol.10, issue.2, pp.55-67, 2013. ,
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells, The EMBO Journal, vol.20, issue.11, pp.20-2768, 2001. ,
DOI : 10.1093/emboj/20.11.2768
Immunological functions of the neuropilins and plexins as receptors for semaphorins, Nature Reviews Immunology, vol.174, issue.11, pp.802-816, 2013. ,
DOI : 10.1038/nri3545
Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis, Development, vol.141, issue.3, pp.141-556, 2014. ,
DOI : 10.1242/dev.103028
Neuropilin-1 Identifies Endothelial Precursors in Human and Murine Embryonic Stem Cells Before CD34 Expression, Circulation, vol.119, issue.16, pp.2170-2178, 2009. ,
DOI : 10.1161/CIRCULATIONAHA.109.849596
Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway, EMBO reports, vol.53, issue.10, pp.983-992, 2008. ,
DOI : 10.1158/1535-7163.MCT-06-0082
Structural and Functional Relation of Neuropilins, Adv Exp Med Biol, vol.515, pp.55-69, 2002. ,
DOI : 10.1007/978-1-4615-0119-0_5
Targeting VEGF signalling via the neuropilin coreceptor, Drug Discov Today, vol.18, pp.9-10, 2013. ,
Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins, Mechanisms of Development, vol.109, issue.1, pp.115-124, 2001. ,
DOI : 10.1016/S0925-4773(01)00518-4
Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer, Immunology, vol.163, issue.1, pp.129-167, 2008. ,
DOI : 10.1038/nri1919
VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding, Journal of Cellular Biochemistry, vol.97, issue.2, pp.357-68, 2002. ,
DOI : 10.1002/jcb.10140
The interaction of Neuropilin-1 with Vascular Endothelial Growth Factor and its receptor Flt-1, Journal of Biological Chemistry, issue.35, pp.275-26690, 2000. ,
DOI : 10.1074/jbc.M003955200
Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth, Cancer Cell, vol.11, issue.1, pp.53-67, 2007. ,
DOI : 10.1016/j.ccr.2006.10.018
Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction, Journal of Medicinal Chemistry, vol.53, issue.5, pp.2215-2241, 2010. ,
DOI : 10.1021/jm901755g
Pharmacokinetic and Pharmacodynamic Analysis of Circulating Biomarkers of Anti-NRP1, a Novel Antiangiogenesis Agent, in Two Phase I Trials in Patients with Advanced Solid Tumors, Clinical Cancer Research, vol.18, issue.21, pp.18-6040, 2012. ,
DOI : 10.1158/1078-0432.CCR-12-1652
A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors, Investigational New Drugs, vol.411, issue.10, 2014. ,
DOI : 10.1007/s10637-014-0071-z
A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro, Proceedings of the National Academy of Sciences, vol.71, issue.4, pp.1207-1217, 1974. ,
DOI : 10.1073/pnas.71.4.1207
A platelet factor stimulating human normal glial cells, Experimental Cell Research, vol.98, issue.1, pp.170-174, 1976. ,
DOI : 10.1016/0014-4827(76)90476-6
Platelets as a source of fibroblast growth-promoting activity, Experimental Cell Research, vol.87, issue.2, pp.297-301, 1974. ,
DOI : 10.1016/0014-4827(74)90484-4
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors, The Journal of Cell Biology, vol.13, issue.3, pp.489-500, 2007. ,
DOI : 10.1016/S0008-6363(00)00268-6
Vascular Endothelial Growth Factor A Competitively Inhibits Platelet-Derived Growth Factor (PDGF)-Dependent Activation of PDGF Receptor and Subsequent Signaling Events and Cellular Responses, Molecular and Cellular Biology, vol.32, issue.10, pp.32-1955, 2012. ,
DOI : 10.1128/MCB.06668-11
Role of platelet-derived growth factors in physiology and medicine, Genes & Development, vol.22, issue.10, pp.22-1276, 2008. ,
DOI : 10.1101/gad.1653708
PDGF receptor signaling networks in normal and cancer cells, Cytokine & Growth Factor Reviews, vol.25, issue.3, 2014. ,
DOI : 10.1016/j.cytogfr.2014.03.003
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab, Angiogenesis, vol.28, issue.281, pp.171-85, 2012. ,
DOI : 10.1007/s10456-011-9249-6
Flt-1-Dependent Survival Characterizes the Epithelial-Mesenchymal Transition of Colonic Organoids, Current Biology, vol.13, issue.19, pp.13-1721, 2003. ,
DOI : 10.1016/j.cub.2003.09.002
Activated Vegfr2/kdr Pathway In Tumour Cells And Tumour Associated Vessels Of Colorectal Cancer, European Journal of Clinical Investigation, vol.25, issue.11, pp.37-878, 2007. ,
DOI : 10.1016/j.yexcr.2005.05.022
Differential Involvement of Vascular Endothelial Growth Factor in the Survival of Hypoxic Colon Cancer Cells, Cancer Research, vol.68, issue.1, pp.285-91, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-5564
Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines, Molecular Cancer Therapeutics, vol.8, issue.9, pp.2546-58, 2009. ,
DOI : 10.1158/1535-7163.MCT-09-0380
EGFR- and VEGF(R)-Targeted Small Molecules Show Synergistic Activity in Colorectal Cancer Models Refractory to Combinations of Monoclonal Antibodies, Clinical Cancer Research, vol.17, issue.20, pp.17-6522, 2011. ,
DOI : 10.1158/1078-0432.CCR-11-1607
Blocking effects of siRNA on VEGF expression in human colorectal cancer cells, World Journal of Gastroenterology, vol.16, issue.9, pp.1086-92, 2010. ,
DOI : 10.3748/wjg.v16.i9.1086
Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer, BMC Cancer, vol.14, issue.26, p.93, 2010. ,
DOI : 10.3748/wjg.14.4156
Vascular Endothelial Growth Factor Receptor Expression as a Prognostic Marker for Survival in Colorectal Cancer, Japanese Journal of Clinical Oncology, vol.39, issue.9, pp.595-600, 2009. ,
DOI : 10.1093/jjco/hyp066
Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast, Human Reproduction, vol.23, issue.6, pp.1407-1422, 2008. ,
DOI : 10.1093/humrep/den114
PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth, Cell, vol.141, issue.1, pp.166-77, 2010. ,
DOI : 10.1016/j.cell.2010.01.033
A Novel Tumor-Promoting Function Residing in the 5??? Non-coding Region of vascular endothelial growth factor mRNA, PLoS Medicine, vol.12, issue.5, p.94, 2008. ,
DOI : 10.1371/journal.pmed.0050094.st002
Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases, British Journal of Cancer, vol.269, issue.11, pp.94-1710, 2006. ,
DOI : 10.1038/sj.onc.1205989
Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells, Oncogene, vol.65, issue.10, pp.30-1205, 2011. ,
DOI : 10.1126/science.6823562
Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis., Proceedings of the National Academy of Sciences, vol.92, issue.3, pp.92-768, 1995. ,
DOI : 10.1073/pnas.92.3.768
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth, Proceedings of the National Academy of Sciences, vol.94, issue.15, pp.94-8104, 1997. ,
DOI : 10.1073/pnas.94.15.8104
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis, Nature, issue.6692, pp.394-485, 1998. ,
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha, Mol Biol Cell, issue.11, pp.18-4528, 2007. ,
Hypoxia-Inducible Factors in Physiology and Medicine, Cell, vol.148, issue.3, pp.399-408, 2012. ,
DOI : 10.1016/j.cell.2012.01.021
Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes., Molecular and Cellular Biology, vol.15, issue.10, pp.15-5363, 1995. ,
DOI : 10.1128/MCB.15.10.5363
c-Jun N-Terminal Kinase Mediated VEGFR2 Sustained Phosphorylation is Critical for VEGFA-Induced Angiogenesis In Vitro and In Vivo, Cell Biochemistry and Biophysics, vol.20, issue.1, pp.17-27, 2012. ,
DOI : 10.1007/s12013-012-9363-0
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes: Flt-1, BUT NOT Flk-1/KDR, IS UP-REGULATED BY HYPOXIA, Journal of Biological Chemistry, vol.272, issue.38, pp.272-23659, 1997. ,
DOI : 10.1074/jbc.272.38.23659
Hypoxia Influences the Vascular Expansion and Differentiation of Embryonic Stem Cell Cultures Through the Temporal Expression of Vascular Endothelial Growth Factor Receptors in an ARNT-Dependent Manner, STEM CELLS, vol.218, issue.Suppl 1, pp.799-809, 2010. ,
DOI : 10.1002/stem.316
Increased Expression of KDR/Flk-1 (VEGFR-2) in Murine Model of Ischemia-Induced Retinal Neovascularization, Microvascular Research, vol.56, issue.3, pp.183-91, 1998. ,
DOI : 10.1006/mvre.1998.2111
Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression, Kidney International, vol.61, issue.5, pp.61-1696, 2002. ,
DOI : 10.1046/j.1523-1755.2002.00329.x
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status., Molecular and Cellular Biology, vol.14, issue.9, pp.6264-77, 1994. ,
DOI : 10.1128/MCB.14.9.6264
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network, Proceedings of the National Academy of Sciences, vol.103, issue.5, pp.1406-1417, 2006. ,
DOI : 10.1073/pnas.0508103103
beta-Catenin and peroxisome proliferator-activated receptor-delta coordinate dynamic chromatin loops for the transcription of vascular endothelial growth factor A gene in colon cancer cells, J Biol Chem, issue.49, pp.287-41364, 2012. ,
Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer, Clin Cancer Res, issue.24, pp.15-7529, 2009. ,
Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis, Biochemical Pharmacology, vol.75, issue.3, pp.75-627, 2008. ,
DOI : 10.1016/j.bcp.2007.09.029
Vascular endothelial growth factor is an autocrine survival factor for breast tumour cells under hypoxia, International Journal of Oncology, vol.32, issue.1, pp.41-49, 2008. ,
DOI : 10.3892/ijo.32.1.41
Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization, Cancer Research, vol.71, issue.12, pp.71-4214, 2011. ,
DOI : 10.1158/0008-5472.CAN-11-0242
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders, Cancer Res, issue.20, pp.57-4593, 1997. ,
Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11, British Journal of Cancer, vol.88, issue.12, pp.1979-86, 2003. ,
DOI : 10.1038/sj.bjc.6601005
Vascular Endothelial Growth Factor Modulates the Transendothelial Migration of MDA-MB-231 Breast Cancer Cells through Regulation of Brain Microvascular Endothelial Cell Permeability, Journal of Biological Chemistry, vol.278, issue.7, pp.278-5277, 2003. ,
DOI : 10.1074/jbc.M210063200
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer, Nature Medicine, vol.10, issue.2, pp.145-152, 2004. ,
DOI : 10.1038/nm988
Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial, The Lancet Oncology, vol.13, issue.12, pp.13-1225, 2012. ,
DOI : 10.1016/S1470-2045(12)70509-0
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinumsensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer, J Clin Oncol, issue.17, pp.30-2039, 2012. ,
Standard chemotherapy with or without bevacizumab in advanced ovarian cancer: quality-of-life outcomes from the International Collaboration on Ovarian Neoplasms (ICON7) phase 3 randomised trial, The Lancet Oncology, vol.14, issue.3, pp.236-279, 2013. ,
DOI : 10.1016/S1470-2045(12)70567-3
BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy, Cancer Research, vol.68, issue.12, pp.68-4774, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-6307
A preclinical and clinical review of aflibercept for the management of cancer, Cancer Treatment Reviews, vol.38, issue.5, pp.484-93, 2012. ,
DOI : 10.1016/j.ctrv.2011.12.008
VEGF-Trap: A VEGF blocker with potent antitumor effects, Proceedings of the National Academy of Sciences, vol.99, issue.17, pp.99-11393, 2002. ,
DOI : 10.1073/pnas.172398299
Vascular Endothelial Growth Factor-Trap Suppresses Tumorigenicity of Multiple Pancreatic Cancer Cell Lines, Clinical Cancer Research, vol.10, issue.10, pp.3327-3359, 2004. ,
DOI : 10.1158/1078-0432.CCR-03-0820
Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen, Journal of Clinical Oncology, vol.30, issue.28, pp.30-3499, 2012. ,
DOI : 10.1200/JCO.2012.42.8201
Epidermal Growth Factor, Annual Review of Biochemistry, vol.48, issue.1, pp.193-216, 1979. ,
DOI : 10.1146/annurev.bi.48.070179.001205
Role of HER receptors family in development and differentiation, Journal of Cellular Physiology, vol.94, issue.3, pp.343-50, 2004. ,
DOI : 10.1002/jcp.20007
ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms, J Biol Chem, issue.40, pp.269-25226, 1994. ,
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling, The EMBO Journal, vol.16, issue.7, pp.16-1647, 1997. ,
DOI : 10.1093/emboj/16.7.1647
EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway, J Cell Sci, issue.111, pp.615-639, 1998. ,
Epithelioid and fibroblastic rat kidney cell clones: Epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation, Journal of Cellular Physiology, vol.69, issue.3, pp.94-335, 1978. ,
DOI : 10.1002/jcp.1040940311
An Essential Role for Ectodomain Shedding in Mammalian Development, Science, vol.282, issue.5392, pp.1281-1285, 1998. ,
DOI : 10.1126/science.282.5392.1281
ADAM-mediated amphiregulin shedding and EGFR transactivation, Cell Proliferation, vol.13, issue.6, pp.799-812, 2009. ,
DOI : 10.1111/j.1365-2184.2009.00645.x
ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion, Blood, vol.116, issue.17, pp.3219-3245, 2010. ,
DOI : 10.1182/blood-2010-01-265611
Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells ,
Lung Tumor-Associated Dendritic Cell-Derived Amphiregulin Increased Cancer Progression, The Journal of Immunology, vol.187, issue.4, pp.1733-1777, 2011. ,
DOI : 10.4049/jimmunol.1100996
Epidermal Growth Factor Receptor Pathway Analysis Identifies Amphiregulin as a Key Factor for Cisplatin Resistance of Human Breast Cancer Cells, Journal of Biological Chemistry, vol.283, issue.2, pp.739-50, 2008. ,
DOI : 10.1074/jbc.M706287200
ERBBs in the gastrointestinal tract: Recent progress and new perspectives, Experimental Cell Research, vol.315, issue.4, pp.315-583, 2009. ,
DOI : 10.1016/j.yexcr.2008.10.043
Epithelial immaturity and multiorgan failure in mice lacking epidermal
growth factor receptor, Nature, vol.376, issue.6538, pp.337-378, 1995. ,
DOI : 10.1038/376337a0
Role of Epidermal Growth Factor and Other Growth Factors in the Prevention of Necrotizing Enterocolitis, Seminars in Perinatology, vol.32, issue.2, pp.107-120, 2008. ,
DOI : 10.1053/j.semperi.2008.01.007
Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis, Pharmacology & Therapeutics, vol.131, issue.1, pp.80-90, 2011. ,
DOI : 10.1016/j.pharmthera.2011.03.012
Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology., Molecular Biology of the Cell, vol.4, issue.1, pp.121-154, 1993. ,
DOI : 10.1091/mbc.4.1.121
Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis, Journal of Experimental Medicine, vol.180, issue.3, pp.1141-1147, 1994. ,
DOI : 10.1084/jem.180.3.1141
Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells, Clin Cancer Res, vol.6, issue.9, pp.3739-3786, 2000. ,
EGFR Tyrosine Kinase Inhibitors Decrease VEGF Expression by Both Hypoxia-Inducible Factor (HIF)-1-Independent and HIF-1-Dependent Mechanisms, Cancer Research, vol.66, issue.6, pp.66-3197, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-3090
Neutralizing antibodies against epidermal growth factor and ErbB- 2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors, Am J Pathol, issue.6, pp.151-1523, 1997. ,
Requirement of hypoxia-inducible factor-1?? down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab, Molecular Cancer Therapeutics, vol.7, issue.5, pp.1207-1224, 2008. ,
DOI : 10.1158/1535-7163.MCT-07-2187
Combined Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor (EGFR) Blockade Inhibits Tumor Growth in Xenograft Models of EGFR Inhibitor Resistance, Clinical Cancer Research, vol.15, issue.10, pp.15-3484, 2009. ,
DOI : 10.1158/1078-0432.CCR-08-2904
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms, Cancer Res, issue.4, pp.61-1464, 2001. ,
The Antitumor and Antiangiogenic Activity of Vascular Endothelial Growth Factor Receptor Inhibition Is Potentiated by ErbB1 Blockade, Clinical Cancer Research, vol.11, issue.12, pp.4521-4553, 2005. ,
DOI : 10.1158/1078-0432.CCR-04-1954
Synergistic Antitumor Effects of Combined Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor-2 Targeted Therapy, Clinical Cancer Research, vol.12, issue.7, pp.2197-207, 2006. ,
DOI : 10.1158/1078-0432.CCR-05-1682
Dual Inhibition of Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor Phosphorylation by AEE788 Reduces Growth and Metastasis of Human Colon Carcinoma in an Orthotopic Nude Mouse Model, Cancer Research, vol.65, issue.9, pp.65-3716, 2005. ,
DOI : 10.1158/0008-5472.CAN-04-3700
More is less???combining targeted therapies in metastatic colorectal cancer, Nature Reviews Clinical Oncology, vol.97, issue.12, pp.731-734, 2009. ,
DOI : 10.1038/nrclinonc.2009.168
Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer, New England Journal of Medicine, vol.360, issue.6, pp.563-72, 2009. ,
DOI : 10.1056/NEJMoa0808268
A Randomized Phase IIIB Trial of Chemotherapy, Bevacizumab, and Panitumumab Compared With Chemotherapy and Bevacizumab Alone for Metastatic Colorectal Cancer, Journal of Clinical Oncology, vol.27, issue.5, pp.672-80, 2009. ,
DOI : 10.1200/JCO.2008.19.8135
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer, Proceedings of the National Academy of Sciences, vol.104, issue.32, pp.13092-13099, 2007. ,
DOI : 10.1073/pnas.0702387104
Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry, Journal of Clinical Oncology, vol.23, issue.9, pp.1803-1813, 2005. ,
DOI : 10.1200/JCO.2005.08.037
Multicenter Phase II and Translational Study of Cetuximab in Metastatic Colorectal Carcinoma Refractory to Irinotecan, Oxaliplatin, and Fluoropyrimidines, Journal of Clinical Oncology, vol.24, issue.30, pp.24-4914, 2006. ,
DOI : 10.1200/JCO.2006.06.7595
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study, The Lancet Oncology, vol.6, issue.5, pp.279-86, 2005. ,
DOI : 10.1016/S1470-2045(05)70102-9
in Stage II and III Resected Colon Cancer: Results of the Translational Study on the PETACC-3, EORTC 40993, SAKK 60-00 Trial, Journal of Clinical Oncology, vol.28, issue.3, pp.28-466, 2010. ,
DOI : 10.1200/JCO.2009.23.3452
Activating K-Ras mutations outwith ???hotspot??? codons in sporadic colorectal tumours ??? implications for personalised cancer medicine, British Journal of Cancer, vol.59, issue.4, pp.693-703, 2010. ,
DOI : 10.1126/science.1174229
Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti???Epidermal Growth Factor Receptor Monoclonal Antibody Therapy, Journal of Clinical Oncology, vol.27, issue.12, pp.27-2091, 2009. ,
DOI : 10.1200/JCO.2009.21.9170
The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis, PLoS One, issue.710, p.47054, 2012. ,
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis, The Lancet Oncology, vol.11, issue.8, pp.11-753, 2010. ,
DOI : 10.1016/S1470-2045(10)70130-3
Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer, Journal of Clinical Oncology, vol.26, issue.35, pp.26-5705, 2008. ,
DOI : 10.1200/JCO.2008.18.0786
Metastatic Colon Cancer, Journal of Clinical Oncology, vol.27, issue.35, pp.27-5924, 2009. ,
DOI : 10.1200/JCO.2008.21.6796
URL : https://hal.archives-ouvertes.fr/hal-00618089
New Strategies in Colorectal Cancer: Biomarkers of Response to Epidermal Growth Factor Receptor Monoclonal Antibodies and Potential Therapeutic Targets in Phosphoinositide 3-Kinase and Mitogen-Activated Protein Kinase Pathways, Clinical Cancer Research, vol.16, issue.15, pp.16-3811, 2010. ,
DOI : 10.1158/1078-0432.CCR-09-2283
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model, Clin Cancer Res, issue.111, pp.1311-1319, 1995. ,
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation., Proceedings of the National Academy of Sciences, vol.83, issue.11, pp.83-3825, 1986. ,
DOI : 10.1073/pnas.83.11.3825
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC323616
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models, Oncogene, vol.6, issue.34, pp.27-4702, 2008. ,
DOI : 10.1016/j.ccr.2006.05.023
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy, Proceedings of the National Academy of Sciences, vol.106, issue.2 ,
DOI : 10.1073/pnas.0808930106
Mutations, Journal of Clinical Oncology, vol.31, issue.27, pp.31-3327, 2013. ,
DOI : 10.1200/JCO.2012.44.2806
The bases for cancer chemotherapy, Stanford Med Bull, vol.6, issue.1, pp.257-69, 1948. ,
[Oxaliplatin, folinic acid and 5-fluorouracil (folfox) in pretreated patients with metastatic advanced cancer. The GERCOD], Rev Med Interne, issue.10, pp.18-769, 1997. ,
CPT-11 (Irinotecan) addition to bimonthly, high-dose leucovorin and bolus and continuous-infusion 5-fluorouracil (FOLFIRI) for pretreated metastatic colorectal cancer, European Journal of Cancer, vol.35, issue.9, pp.1343-1350, 1999. ,
DOI : 10.1016/S0959-8049(99)00150-1
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma, Science Translational Medicine, vol.5, issue.196, pp.196-98, 0196. ,
DOI : 10.1126/scitranslmed.3005753
mTORC1 inhibition is required for sensitivity to PI3K p110alpha inhibitors in PIK3CA-mutant breast cancer, Sci Transl Med, issue.5, pp.196-99, 0196. ,
Passing the baton: the HIF switch, Trends in Biochemical Sciences, vol.37, issue.9, pp.364-72, 2012. ,
DOI : 10.1016/j.tibs.2012.06.004
Chronic exposure of colorectal cancer cells to bevacizumab promotes compensatory pathways that mediate tumour cell migration, British Journal of Cancer, vol.59, issue.8, pp.1270-1277, 2011. ,
DOI : 10.1002/cncr.21145
Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells, BMC Cancer, vol.8, issue.10, p.229, 2013. ,
DOI : 10.1586/14737140.8.10.1545
A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma, Cancer Res, issue.16, pp.65-7267, 2005. ,
The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose-and reoxygenation-dependent manner in irradiated tumors, J Biol Chem, issue.8, pp.284-5332, 2009. ,
Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors, Cancer Science, vol.20, issue.11, pp.1946-54, 2012. ,
DOI : 10.1111/j.1349-7006.2012.02408.x
Challenges for patient selection with VEGF inhibitors, Cancer Chemotherapy and Pharmacology, vol.6, issue.11, pp.151-70, 2007. ,
DOI : 10.1007/s00280-006-0403-6
Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy, British Journal of Cancer, vol.2, issue.6, pp.1316-1339, 2013. ,
DOI : 10.1016/S0022-5347(05)00736-6
Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy, Clinical Cancer Research, vol.17, issue.14, pp.17-4892, 2011. ,
DOI : 10.1158/1078-0432.CCR-10-2918
Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients, British Journal of Cancer, vol.22, issue.5, pp.799-804, 2012. ,
DOI : 10.1038/bjc.2012.17
Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy, Clinical Cancer Research, vol.18, issue.11, pp.18-3100, 2012. ,
DOI : 10.1158/1078-0432.CCR-11-1877
Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis, New England Journal of Medicine, vol.370, issue.22, pp.2071-82, 2014. ,
DOI : 10.1056/NEJMoa1402584
Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial, The Lancet Oncology, vol.15, issue.2, pp.143-55, 2014. ,
DOI : 10.1016/S1470-2045(13)70586-2
Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner, AJP: Cell Physiology, vol.290, issue.2, pp.592-600, 2006. ,
DOI : 10.1152/ajpcell.00278.2005
Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis, Oncogene, vol.59, issue.5, pp.548-60, 2011. ,
DOI : 10.1016/j.ccr.2009.09.029
Irinotecan resistance is accompanied by upregulation of EGFR and Src signaling in human cancer models, Curr Pharm Des, vol.19, issue.5, pp.958-64, 2013. ,
HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress, Carcinogenesis, vol.30, issue.12, pp.30-1997, 2009. ,
DOI : 10.1093/carcin/bgp233
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1, Proceedings of the National Academy of Sciences, vol.109, issue.13, pp.4892-4899 ,
DOI : 10.1073/pnas.1112129109
Regulation of endocytosis via the oxygen-sensing pathway, Nature Medicine, vol.11, issue.3, pp.319-343, 2009. ,
DOI : 10.1126/science.1134389
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice, Clin Cancer Res, vol.5, issue.2, pp.257-65, 1999. ,
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms, Clin Cancer Res, vol.6, issue.5, pp.1936-1984, 2000. ,
Tumor Endothelial Cells Express Epidermal Growth Factor Receptor (EGFR) but not ErbB3 and Are Responsive to EGF and to EGFR Kinase Inhibitors, Cancer Research, vol.66, issue.4, pp.2173-80, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-3387
Modification of the Primary Tumor Microenvironment by Transforming Growth Factor ??-Epidermal Growth Factor Receptor Signaling Promotes Metastasis in an Orthotopic Colon Cancer Model, The American Journal of Pathology, vol.173, issue.1, pp.205-221, 2008. ,
DOI : 10.2353/ajpath.2008.071147
Phosphorylated Epidermal Growth Factor Receptor on Tumor-Associated Endothelial Cells Is a Primary Target for Therapy with Tyrosine Kinase Inhibitors, Neoplasia, vol.10, issue.5, pp.489-500, 2008. ,
DOI : 10.1593/neo.08200
Production and auto-induction of transforming growth factoralpha in human keratinocytes, Nature, issue.6133, pp.328-817, 1987. ,
Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer, Oncogene, vol.320, issue.22, pp.33-2846, 2014. ,
DOI : 10.1073/pnas.95.25.14863
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC, Nature Reviews Clinical Oncology, vol.276, issue.9, pp.519-546, 2009. ,
DOI : 10.1038/nrclinonc.2009.111
Mutation: Should We Test for It, and Does It Matter?, Journal of Clinical Oncology, vol.31, issue.8, pp.31-1112, 2013. ,
DOI : 10.1200/JCO.2012.43.0454
Intermittent versus continuous erlotinib with concomitant modified ???XELOX??? (q3W) in first-line treatment of metastatic colorectal cancer, Cancer, vol.23, issue.suppl 4, pp.119-4145, 2013. ,
DOI : 10.1002/cncr.28327
Escargueil and Paul Mésange Angiogenesis inhibitors: accomplishments and challenges ,
Angiogenesis inhibition triggers a survival response in colorectal tumor models ,
AK Larsen Exposure to nintedanib, a triple angiokinase inhibitor, is accompanied by activation of EGFR and other ErbB/HER-family members in colorectal cancer (CRC) models, providing a rational for combinations of nintedanib with the ErbB family blocker afatinib ,
Larsen Bevacizumab exposure is accompanied by EGFR activation in colorectal cancer (CRC) models providing a rational for combinations of bevacizumab and erlotinib in the GERCOR DREAM phase III trial ,