P. Alexandridis and T. Hatton, Poly(ethylene Oxide) poly(propylene Oxide) poly(ethylene Oxide, 1995.

E. Balo?lu, S. Y. Karavana, I. Y. Hyusein, and T. Köse, Design and Formulation of Mebeverine HCl Semisolid Formulations for Intraorally Administration, AAPS PharmSciTech, vol.11, issue.1, pp.181-188, 2010.
DOI : 10.1208/s12249-009-9374-3

E. Baloglu, S. Y. Karavana, Z. A. Senyigit, S. Hilmioglu-polat, D. Y. Metin et al., In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation, Journal of Pharmacy and Pharmacology, vol.326, issue.10, pp.1274-1282, 2011.
DOI : 10.1111/j.2042-7158.2011.01315.x

G. Bernstein, system, Expert Opinion on Drug Delivery, vol.8, issue.9, pp.1047-1055, 2008.
DOI : 10.2337/diacare.28.6.1353

URL : https://hal.archives-ouvertes.fr/hal-00427795

M. Bhowmik, P. Kumari, G. Sarkar, M. K. Bain, B. Bhowmick et al., Effect of xanthan gum and guar gum on in situ gelling ophthalmic drug delivery system based on poloxamer-407, International Journal of Biological Macromolecules, vol.62, pp.117-123, 2013.
DOI : 10.1016/j.ijbiomac.2013.08.024

G. Bonacucina, M. Spina, M. Misici-falzi, M. Cespi, S. Pucciarelli et al., Effect of hydroxypropyl ??-cyclodextrin on the self-assembling and thermogelation properties of Poloxamer 407, European Journal of Pharmaceutical Sciences, vol.32, issue.2, pp.115-122, 2007.
DOI : 10.1016/j.ejps.2007.06.004

D. W. Boulton and J. P. Fawcett, The Pharmacokinetics of Levosalbutamol, Clinical Pharmacokinetics, vol.20, issue.1, pp.23-40, 2001.
DOI : 10.2165/00003088-200140010-00003

J. Ceulemans, I. Vinckier, and A. Ludwig, The Use of Xanthan Gum in An Ophthalmic Liquid Dosage Form: Rheological Characterization of the Interaction With Mucin, Journal of Pharmaceutical Sciences, vol.91, issue.4, pp.1117-1127, 2002.
DOI : 10.1002/jps.10106

J. Y. Chang, Y. K. Oh, H. Choi, Y. B. Kim, and C. Kim, Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions, International Journal of Pharmaceutics, vol.241, issue.1, pp.155-163, 2002.
DOI : 10.1016/S0378-5173(02)00232-6

C. Chen, C. Fang, S. A. Al-suwayeh, Y. Leu, and J. Fang, Transdermal delivery of selegiline from alginate???Pluronic composite thermogels, International Journal of Pharmaceutics, vol.415, issue.1-2, pp.119-128, 2011.
DOI : 10.1016/j.ijpharm.2011.05.060

J. Chen, R. Zhou, L. Li, B. Li, X. Zhang et al., Mechanical, rheological and release behaviors of a poloxamer 407, pp.12415-12425, 2013.

C. Reddy, P. Chaitanya, K. S. Madhusudan-rao, and Y. , A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods, J. Pharm. Sci, vol.19, pp.385-403, 2011.

H. Choi, M. Lee, M. Kim, and C. Kim, Effect of additives on the physicochemical properties of liquid suppository bases, International Journal of Pharmaceutics, vol.190, issue.1, pp.13-19, 1999.
DOI : 10.1016/S0378-5173(99)00225-2

P. Costa and J. M. Sousa-lobo, Modeling and comparison of dissolution profiles, European Journal of Pharmaceutical Sciences, vol.13, issue.2, pp.123-133, 2001.
DOI : 10.1016/S0928-0987(01)00095-1

G. Dumortier, N. Kateb, M. Sahli, S. Kedjar, A. Boulliat et al., Development of a Thermogelling Ophthalmic Formulation of Cysteine, Drug Development and Industrial Pharmacy, vol.89, issue.1, pp.63-72, 2006.
DOI : 10.1016/S0378-5173(01)00809-2

G. Dumortier, J. L. Grossiord, F. Agnely, and J. C. Chaumeil, A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics, Pharmaceutical Research, vol.43, issue.6, pp.2709-2728, 2006.
DOI : 10.1007/s11095-006-9104-4

D. A. Goldstein, Y. K. Tan, and S. J. Soldin, Pharmacokinetics and absolute bioavailability of salbutamol in healthy adult volunteers, European Journal of Clinical Pharmacology, vol.59, issue.Suppl 135, pp.631-634, 1987.
DOI : 10.1007/BF02456001

J. Hao and P. W. Heng, Buccal Delivery Systems, Drug Development and Industrial Pharmacy, vol.20, issue.8, pp.821-832, 2003.
DOI : 10.1016/S0378-5173(00)00396-3

S. Hsu, Y. Leu, J. Hu, and J. Fang, Physicochemical Characterization and Drug Release of Thermosensitive Hydrogels Composed of a Hyaluronic Acid/Pluronic F127 Graft, CHEMICAL & PHARMACEUTICAL BULLETIN, vol.57, issue.5, pp.453-458, 2009.
DOI : 10.1248/cpb.57.453

R. Imboden and G. Imanidis, Effect of the amphoteric properties of salbutamol on its release rate through a polypropylene control membrane, European Journal of Pharmaceutics and Biopharmaceutics, vol.47, issue.2, pp.161-167, 1999.
DOI : 10.1016/S0939-6411(98)00053-8

A. A. Koffi, F. Agnely, G. Ponchel, and J. L. Grossiord, Modulation of the rheological and mucoadhesive properties of thermosensitive poloxamer-based hydrogels intended for the rectal administration of quinine, European Journal of Pharmaceutical Sciences, vol.27, issue.4, pp.328-335, 2006.
DOI : 10.1016/j.ejps.2005.11.001

L. Mälkki-laine, K. Purra, K. Kähkönen, and S. Tammilehto, Decomposition of salbutamol in aqueous solutions. II. The effect of buffer species, pH, buffer concentration and antioxidants, International Journal of Pharmaceutics, vol.117, issue.2, pp.189-195, 1995.
DOI : 10.1016/0378-5173(94)00329-4

T. Moore, S. Croy, S. Mallapragada, and N. Pandit, Experimental investigation and mathematical modeling of Pluronic?? F127 gel dissolution: drug release in stirred systems, Journal of Controlled Release, vol.67, issue.2-3, pp.191-202, 2000.
DOI : 10.1016/S0168-3659(00)00215-7

D. J. Morgan, J. D. Paull, B. H. Richmond, E. Wilson-evered, and S. P. Ziccone, Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate., British Journal of Clinical Pharmacology, vol.305, issue.5, pp.587-593, 1986.
DOI : 10.1111/j.1365-2125.1986.tb02939.x

G. Murtaza, M. Ahmad, and N. Akhtar, Biowaiver study of oral tabletted ethylcellulose microcapsules of a BCS class I drug, Bulletin of the Chemical Society of Ethiopia, vol.23, issue.2, 2009.
DOI : 10.4314/bcse.v23i2.44959

S. Nie, W. W. Hsiao, W. Pan, and Z. Yang, Thermoreversible Pluronic® F127-based Hydrogel Containing Liposomes for the Controlled Delivery of Paclitaxel: In Vitro Drug Release, Cell Cytotoxicity, and Uptake Studies, Int. J. Nanomedicine, vol.6, pp.151-166, 2011.

N. K. Pandit and J. Kisaka, Loss of gelation ability of Pluronic?? F127 in the presence of some salts, International Journal of Pharmaceutics, vol.145, issue.1-2, pp.129-136, 1996.
DOI : 10.1016/S0378-5173(96)04748-5

N. K. Pandit and D. Wang, Salt effects on the diffusion and release rate of propranolol from poloxamer 407 gels, International Journal of Pharmaceutics, vol.167, issue.1-2, pp.183-189, 1998.
DOI : 10.1016/S0378-5173(98)00074-X

R. S. Patel and S. S. Poddar, Development and Characterization of Mucoadhesive Buccal Patches of Salbutamol Sulphate, Current Drug Delivery, vol.6, issue.1, pp.140-144, 2009.
DOI : 10.2174/156720109787048177

N. A. Peppas and J. J. Sahlin, A simple equation for the description of solute release. III. Coupling of diffusion and relaxation, International Journal of Pharmaceutics, vol.57, issue.2, pp.169-172, 1989.
DOI : 10.1016/0378-5173(89)90306-2

E. J. Ricci, L. O. Lunardi, D. M. Nanclares, and J. M. Marchetti, Sustained release of lidocaine from Poloxamer 407 gels, International Journal of Pharmaceutics, vol.288, issue.2, pp.235-244, 2005.
DOI : 10.1016/j.ijpharm.2004.09.028

R. Rowe, P. Sheskey, and S. Owen, Handbook of Pharmaceutical Excipients, 2005.

I. R. Schmolka, Artificial skin I. Preparation and properties of pluronic F-127 gels for treatment of burns, Journal of Biomedical Materials Research, vol.39, issue.6, pp.571-582, 1972.
DOI : 10.1002/jbm.820060609

I. R. Schmolka, Physical Basis for Poloxamer Interactions, Annals of the New York Academy of Sciences, vol.106, issue.suppl. I, pp.92-97, 1994.
DOI : 10.1111/j.1749-6632.1994.tb30437.x

D. H. Shastri, S. T. Prajapati, and L. D. Patel, Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers, Acta Pharmaceutica, vol.60, issue.3, pp.349-360, 2010.
DOI : 10.2478/v10007-010-0029-4

D. H. Shastri, S. T. Prajapati, and L. D. Patel, Design and Development of Thermoreversible Ophthalmic In Situ Hydrogel of Moxifloxacin HCl, Current Drug Delivery, vol.7, issue.3, 2010.
DOI : 10.2174/156720110791560928

V. Singh, P. Khullar, P. N. Dave, and N. Kaur, Micelles, mixed micelles, and applications of polyoxypropylene (PPO)-polyoxyethylene (PEO)-polyoxypropylene (PPO) triblock polymers, International Journal of Industrial Chemistry, vol.4, issue.1, 2013.
DOI : 10.1007/s10800-007-9471-5

Y. Su, X. Wei, and H. Liu, Effect of sodium chloride on association behavior of poly(ethylene oxide)???poly(propylene oxide)???poly(ethylene oxide) block copolymer in aqueous solutions, Journal of Colloid and Interface Science, vol.264, issue.2, 2003.
DOI : 10.1016/S0021-9797(03)00472-7

T. Ur-rehman, S. Tavelin, and G. Gröbner, Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407, International Journal of Pharmaceutics, vol.394, issue.1-2, pp.92-98, 2010.
DOI : 10.1016/j.ijpharm.2010.05.012

T. Ur-rehman, S. Tavelin, and G. Gröbner, Chitosan in situ gelation for improved drug loading and retention in poloxamer 407 gels, International Journal of Pharmaceutics, vol.409, issue.1-2, pp.19-29, 2011.
DOI : 10.1016/j.ijpharm.2011.02.017

M. Vadnere, G. Amidon, S. Lindenbaum, and J. L. Haslam, Thermodynamic studies on the gel-sol transition of some pluronic polyols, International Journal of Pharmaceutics, vol.22, issue.2-3, pp.207-218, 1984.
DOI : 10.1016/0378-5173(84)90022-X

P. V. Vasantha, A. Puratchikody, S. T. Mathew, and A. K. Balaraman, Development and characterization of Eudragit based mucoadhesive buccal patches of salbutamol sulfate, Saudi Pharmaceutical Journal, vol.19, issue.4, pp.207-214, 2011.
DOI : 10.1016/j.jsps.2011.07.003

K. Vermani, S. Garg, and L. J. Zaneveld, Assemblies for In Vitro Measurement of Bioadhesive Strength and Retention Characteristics in Simulated Vaginal Environment, Drug Development and Industrial Pharmacy, vol.50, issue.3, pp.1133-1146, 2002.
DOI : 10.1093/HUMREP/11.2.357

J. Xuan, Y. Yan, D. H. Oh, Y. K. Choi, C. S. Yong et al., Development of thermo-sensitive injectable hydrogel with sustained release of doxorubicin: Rheological characterization and in vivo evaluation in rats, Drug Delivery, vol.374, issue.5, pp.305-311, 2011.
DOI : 10.1016/S0731-7085(99)00070-9

L. Zhang, D. L. Parsons, C. Navarre, and U. B. Kompella, Development and in-vitro evaluation of sustained release Poloxamer 407 (P407) gel formulations of ceftiofur, Journal of Controlled Release, vol.85, issue.1-3, pp.73-81, 2002.
DOI : 10.1016/S0168-3659(02)00273-0

Y. Zhang, M. Huo, J. Zhou, A. Zou, W. Li et al., DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles, The AAPS Journal, vol.12, issue.3, pp.263-271, 2010.
DOI : 10.1208/s12248-010-9185-1

. Fig, 6. Percentage of diffusion and erosion contributions as a function of time, p.407

. Fig, In vitro SS (salbutamol) release profiles from various hydrogels using the semisolid adaptor (SSA) (a) Effect of P407 concentration. (b) Effect of NaCl

G. Campisi, C. Paderni, R. Saccone, D. Fede, O. Wolff et al., Human Buccal Mucosa as an Innovative Site of Drug Delivery, Current Pharmaceutical Design, vol.16, issue.6, pp.641-52, 2010.
DOI : 10.2174/138161210790883778

H. Zhang, J. Zhang, and J. Streisand, Oral Mucosal Drug Delivery, Clinical Pharmacokinetics, vol.38, issue.12, pp.661-80, 2002.
DOI : 10.2165/00003088-200241090-00003

N. Zeng, G. Dumortier, M. Maury, N. Mignet, and V. Boudy, Influence of additives on a thermosensitive hydrogel for buccal delivery of salbutamol: Relation between micellization, gelation, mechanic and release properties, International Journal of Pharmaceutics, vol.467, issue.1-2, pp.70-83, 2014.
DOI : 10.1016/j.ijpharm.2014.03.055

L. Trong, M. Djabourov, and A. Ponton, Mechanisms of micellization and rheology of PEO???PPO???PEO triblock copolymers with various architectures, Journal of Colloid and Interface Science, vol.328, issue.2, pp.278-87, 2008.
DOI : 10.1016/j.jcis.2008.09.029

G. Dumortier, J. Grossiord, F. Agnely, and J. Chaumeil, A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics, Pharmaceutical Research, vol.43, issue.6, pp.2709-2737, 2006.
DOI : 10.1007/s11095-006-9104-4

L. Mälkki-laine, K. Purra, K. Kähkönen, and S. Tammilehto, Decomposition of salbutamol in aqueous solutions. II. The effect of buffer species, pH, buffer concentration and antioxidants, International Journal of Pharmaceutics, vol.117, issue.2, pp.189-95, 1995.
DOI : 10.1016/0378-5173(94)00329-4

J. Jacobsen, B. Van-deurs, M. Pedersen, and M. Rassing, TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability, International Journal of Pharmaceutics, vol.125, issue.2, pp.165-84, 1995.
DOI : 10.1016/0378-5173(95)00109-V

J. Kühn, E. Shaffer, J. Mena, B. Breton, J. Parent et al., Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy, ASSAY and Drug Development Technologies, vol.11, issue.2, pp.101-108, 2013.
DOI : 10.1089/adt.2012.476

J. Jacobsen, E. Nielsen, K. Brøndum-nielsen, M. Christensen, H. Olin et al., Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability, European Journal of Oral Sciences, vol.107, issue.2, pp.138-184, 1999.
DOI : 10.1046/j.0909-8836.1999.eos107210.x

M. Nielsen, H. , R. Rassing, and M. , TR146 cells grown on filters as a model of human buccal epithelium: V. Enzyme activity of the TR146 cell culture model, human buccal epithelium and porcine buccal epithelium, and permeability of leu-enkephalin, International Journal of Pharmaceutics, vol.200, issue.2, pp.261-70, 2000.
DOI : 10.1016/S0378-5173(00)00394-X

H. Eirheim, C. Bundgaard, and H. Nielsen, Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate, Toxicology in Vitro, vol.18, issue.5, pp.649-57, 2004.
DOI : 10.1016/j.tiv.2004.02.003

R. Hamid, Y. Rotshteyn, L. Rabadi, R. Parikh, and P. Bullock, Comparison of alamar blue and MTT assays for high through-put screening, Toxicology in Vitro, vol.18, issue.5, pp.703-713, 2004.
DOI : 10.1016/j.tiv.2004.03.012

G. Fotakis and J. Timbrell, In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride, Toxicology Letters, vol.160, issue.2, pp.171-178, 2006.
DOI : 10.1016/j.toxlet.2005.07.001

S. 1. Rampersad, J. O-'brien, I. Wilson, T. Orton, and F. Pognan, Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity, Sensors Eur J Biochem FEBS, vol.12267, pp.5421-5427, 2000.

M. Dutot, J. Warnet, C. Baudouin, and P. Rat, Cytotoxicity of contact lens multipurpose solutions: Role of oxidative stress, mitochondrial activity and P2X7 cell death receptor activation, European Journal of Pharmaceutical Sciences, vol.33, issue.2, pp.138-183, 2008.
DOI : 10.1016/j.ejps.2007.10.006

J. Weyermann, D. Lochmann, and A. Zimmer, A practical note on the use of cytotoxicity assays, International Journal of Pharmaceutics, vol.288, issue.2, pp.369-76, 2005.
DOI : 10.1016/j.ijpharm.2004.09.018

M. Dutot, E. Reveneau, T. Pauloin, R. Fagon, C. Tanter et al., Multipurpose Solutions and Contact Lens: Modulation of Cytotoxicity and Apoptosis on the Ocular Surface, Cornea, vol.29, issue.5, pp.541-550, 2010.
DOI : 10.1097/ICO.0b013e3181bd4bc1

F. Belloc, P. Dumain, M. Boisseau, C. Jalloustre, J. Reiffers et al., A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells, Cytometry, vol.7, issue.1, pp.59-65, 1994.
DOI : 10.1002/cyto.990170108

M. Dutot, F. Pouzaud, I. Larosche, F. Brignole-baudouin, J. Warnet et al., Fluoroquinolone eye dropinduced cytotoxicity: role of preservative in P2X7 cell death receptor activation and apoptosis New in vitro fluorimetric microtitration assays for toxicological screening of drugs, Invest Ophthalmol Vis Sci Cell Biol Toxicol, vol.4710, pp.329-366, 1994.

H. Nielsen and M. Rassing, TR146 cells grown on filters as a model of human buccal epithelium: III. Permeability enhancement by different pH values, different osmolality values, and bile salts, International Journal of Pharmaceutics, vol.185, issue.2, pp.215-240, 1999.
DOI : 10.1016/S0378-5173(99)00165-9

D. Caro, V. Giandalia, G. Siragusa, M. Paderni, C. Campisi et al., Evaluation of galantamine transbuccal absorption by reconstituted human oral epithelium and porcine tissue as buccal mucosa models: Part I Broad Institute. CellProfiler cell image analysis software [Internet]. [last accessed 28Available from: http://www.cellprofiler.org/ 25 CellProfiler: image analysis software for identifying and quantifying cell phenotypes, Eur J Pharm Biopharm Genome Biol, vol.707, issue.24, p.100, 2006.

A. Exner, T. Krupka, K. Scherrer, and J. Teets, Enhancement of carboplatin toxicity by Pluronic block copolymers, Journal of Controlled Release, vol.106, issue.1-2, pp.188-97, 2005.
DOI : 10.1016/j.jconrel.2005.04.015

N. Pavillon, J. Kühn, C. Moratal, P. Jourdain, C. Depeursinge et al., Early Cell Death Detection with Digital Holographic Microscopy, General Cell Collection TR146 [Internet]. [last accessed 22, pp.30912-30940, 2012.
DOI : 10.1371/journal.pone.0030912.s001

G. Bernstein, system, Expert Opinion on Drug Delivery, vol.8, issue.9, pp.1047-55, 2008.
DOI : 10.2337/diacare.28.6.1353

URL : https://hal.archives-ouvertes.fr/hal-00427795

J. Hao and P. Heng, Buccal Delivery Systems, Drug Development and Industrial Pharmacy, vol.20, issue.8, pp.821-853, 2003.
DOI : 10.1016/S0378-5173(00)00396-3

N. Madhav, A. Shakya, P. Shakya, and K. Singh, Orotransmucosal drug delivery systems: A review, Journal of Controlled Release, vol.140, issue.1, pp.2-11, 2009.
DOI : 10.1016/j.jconrel.2009.07.016

L. Giannola, D. Caro, V. Giandalia, G. Siragusa, M. Tripodo et al., Release of naltrexone on buccal mucosa: Permeation studies, histological aspects and matrix system design, European Journal of Pharmaceutics and Biopharmaceutics, vol.67, issue.2, pp.425-458, 2007.
DOI : 10.1016/j.ejpb.2007.02.020

U. Kulkarni, R. Mahalingam, I. Pather, X. Li, and B. Jasti, Porcine buccal mucosa as in vitro model: Effect of biological and experimental variables, Journal of Pharmaceutical Sciences, vol.99, issue.3, pp.1265-77, 2010.
DOI : 10.1002/jps.21907

R. Mashru, V. Sutariya, M. Sankalia, and J. Sankalia, Transbuccal delivery of lamotrigine across porcine buccal mucosa: in vitro determination of routes of buccal transport, J Pharm Pharm Sci, vol.8, pp.54-62, 2005.

Y. Oyama, H. Yamano, A. Ohkuma, K. Ogawara, K. Higaki et al., Carrier???mediated transport systems for glucose in mucosal cells of the human oral cavity, Journal of Pharmaceutical Sciences, vol.88, issue.8, pp.830-834, 1999.
DOI : 10.1021/js980298f

B. Teubl, M. Absenger, E. Fröhlich, G. Leitinger, A. Zimmer et al., The oral cavity as a biological barrier system: Design of an advanced buccal in vitro permeability model, European Journal of Pharmaceutics and Biopharmaceutics, vol.84, issue.2, pp.386-93, 2013.
DOI : 10.1016/j.ejpb.2012.10.021

E. Batrakova, S. Lee, S. Li, A. Venne, V. Alakhov et al., Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells

C. Luo, X. Chen, L. Li, Q. Li, B. Li et al., Traumatic Brain Injury-Induced Mitochondrial and Lysosomal Membrane Permeabilization Damage in Cultured Primary Neurons, Journal of Neurotrauma, vol.30, issue.7, pp.597-607, 2013.
DOI : 10.1089/neu.2012.2425

G. Serbest, J. Horwitz, M. Jost, and K. Barbee, Mechanisms of cell death and neuroprotection by poloxamer 188 after mechanical trauma, The FASEB Journal, vol.20, pp.308-318, 2006.
DOI : 10.1096/fj.05-4024fje

E. Batrakova and A. Kabanov, Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers, Journal of Controlled Release, vol.130, issue.2, pp.98-106, 2008.
DOI : 10.1016/j.jconrel.2008.04.013

D. Guo, H. Moon, R. Arote, J. Seo, J. Quan et al., Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells, Cancer Letters, vol.254, issue.2, pp.244-54, 2007.
DOI : 10.1016/j.canlet.2007.03.007

F. Yan, C. Zhang, Y. Zheng, L. Mei, L. Tang et al., The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity, Nanomedicine: Nanotechnology, Biology and Medicine, vol.6, issue.1, pp.170-178, 2010.
DOI : 10.1016/j.nano.2009.05.004

P. Marquet, B. Rappaz, P. Magistretti, E. Cuche, Y. Emery et al., Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy, Optics Letters, vol.30, issue.5, pp.468-70, 2005.
DOI : 10.1364/OL.30.000468

B. Rappaz, P. Marquet, E. Cuche, Y. Emery, C. Depeursinge et al., Measurement of the integral refractive index and dynamic cell morphometry of living cells with digital holographic microscopy, Optics Express, vol.13, issue.23, pp.9361-73, 2005.
DOI : 10.1364/OPEX.13.009361.m003

A. Tóth, F. Walter, A. Bocsik, P. Sántha, S. Veszelka et al., Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells, Available from, p.2014, 2014.
DOI : 10.1371/journal.pone.0100152.s006

P. Palumbo, U. Picchini, B. Beck, J. Van-gelder, N. Delbar et al., A general approach to the apparent permeability index, Journal of Pharmacokinetics and Pharmacodynamics, vol.54, issue.1???2, pp.235-283, 2008.
DOI : 10.1007/s10928-008-9086-4

K. Albrecht, M. Greindl, C. Kremser, C. Wolf, P. Debbage et al., Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection, Journal of Controlled Release, vol.115, issue.1, pp.78-84, 2006.
DOI : 10.1016/j.jconrel.2006.06.023

K. Alm, Z. El-schich, M. Falck, A. Gjrloff-wingren, B. Janicke et al., Cells and Holograms ??? Holograms and Digital Holographic Microscopy as a Tool to Study the Morphology of Living Cells, Holography -Basic Principles and Contemporary Applications. InTech. Available from, 2013.
DOI : 10.5772/54505

D. Ameye, D. Mus, P. Foreman, and J. P. Remon, Spray-dried Amioca?? starch/Carbopol?? 974P mixtures as buccal bioadhesive carriers, International Journal of Pharmaceutics, vol.301, issue.1-2, pp.170-180, 2005.
DOI : 10.1016/j.ijpharm.2005.05.016

G. P. Andrews, T. P. Laverty, and D. S. Jones, Mucoadhesive polymeric platforms for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, vol.71, issue.3, pp.505-518, 2009.
DOI : 10.1016/j.ejpb.2008.09.028

G. S. Asane, S. A. Nirmal, K. B. Rasal, A. A. Naik, M. S. Mahadik et al., Polymers for Mucoadhesive Drug Delivery System: A Current Status, Drug Development and Industrial Pharmacy, vol.4, issue.1, pp.1246-1266, 2008.
DOI : 10.1081/DDC-100104320

M. A. Attia, I. El-gibaly, S. E. Shaltout, and G. N. Fetih, Transbuccal permeation, anti-inflammatory activity and clinical efficacy of piroxicam formulated in different gels, International Journal of Pharmaceutics, vol.276, issue.1-2, pp.11-28, 2004.
DOI : 10.1016/j.ijpharm.2004.01.041

E. Balo?lu, S. Y. Karavana, I. Y. Hyusein, and T. Köse, Design and Formulation of Mebeverine HCl Semisolid Formulations for Intraorally Administration, AAPS PharmSciTech, vol.11, issue.1, pp.181-188, 2010.
DOI : 10.1208/s12249-009-9374-3

E. Balo?lu, M. Ozyazici, S. Y. Hizarcio?lu, and H. A. Karavana, An in vitro investigation for vaginal bioadhesive formulations: bioadhesive properties and swelling states of polymer mixtures, Il Farmaco, vol.58, issue.5, pp.391-396, 2003.
DOI : 10.1016/S0014-827X(03)00044-2

M. Bard, R. Yazji, and S. Salmeron, Place respective des beta2-agonistes de courte et de longue durée d'action dans la maladie asthmatique. Médecine Thérapeutique, pp.654-662, 1999.

B. W. Barry, Mode of action of penetration enhancers in human skin, Journal of Controlled Release, vol.6, issue.1, pp.85-97, 1987.
DOI : 10.1016/0168-3659(87)90066-6

J. P. Basly and J. L. Duroux, The effect of gamma radiation on the degradation of Salbutamol, Journal of Pharmaceutical and Biomedical Analysis, vol.15, issue.8, pp.1137-1178, 1997.
DOI : 10.1016/S0731-7085(96)01947-4

H. K. Batchelor, D. Banning, P. W. Dettmar, F. C. Hampson, I. G. Jolliffe et al., An in vitro mucosal model for prediction of the bioadhesion of alginate solutions to the oesophagus, International Journal of Pharmaceutics, vol.238, issue.1-2, pp.123-132, 2002.
DOI : 10.1016/S0378-5173(02)00062-5

E. Batrakova, S. Lee, S. Li, A. Venne, V. Alakhov et al., Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells, Pharmaceutical Research, vol.16, issue.9, pp.1373-1379, 1999.
DOI : 10.1023/A:1018942823676

E. V. Batrakova and A. V. Kabanov, Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers, Journal of Controlled Release, vol.130, issue.2, pp.98-106, 2008.
DOI : 10.1016/j.jconrel.2008.04.013

A. H. Beckett and A. C. Moffat, The influence of alkyl substitution in acids on their performance in the buccal absorption test, Journal of Pharmacy and Pharmacology, vol.125, issue.S1, p.239, 1968.
DOI : 10.1111/j.2042-7158.1968.tb09889.x

A. H. Beckett and A. C. Moffat, Correlation of partition coefficients in n-heptane-aqueous systems with buccal absorption data for a series of amines and acids, Journal of Pharmacy and Pharmacology, vol.36, issue.Suppl., p.144, 1969.
DOI : 10.1111/j.2042-7158.1969.tb08365.x

A. H. Beckett and A. C. Moffat, The buccal absorption of some barbiturates, Journal of Pharmacy and Pharmacology, vol.120, issue.Suppl. 21, pp.15-18, 1971.
DOI : 10.1111/j.2042-7158.1971.tb12774.x

V. Belgamwar, V. Shah, and S. J. Surana, Formulation and Evaluation of Oral Mucoadhesive Multiparticulate System Containing Metoprolol Tartarate: An In Vitro ??? Ex Vivo Characterization, Current Drug Delivery, vol.6, issue.1, pp.113-121, 2009.
DOI : 10.2174/156720109787048285

T. R. Bhardwaj, M. Kanwar, R. Lal, and A. Gupta, Natural Gums and Modified Natural Gums as Sustained-Release Carriers, Drug Development and Industrial Pharmacy, vol.4, issue.10, pp.1025-1038, 2000.
DOI : 10.1016/0142-9612(91)90068-L

L. Boulmedarat, A. Bochot, S. Lesieur, and E. Fattal, Evaluation of Buccal Methyl-??-Cyclodextrin Toxicity on Human Oral Epithelial Cell Culture Model, Journal of Pharmaceutical Sciences, vol.94, issue.6, pp.1300-1309, 2005.
DOI : 10.1002/jps.20350

J. Ceulemans, I. Vinckier, and A. Ludwig, The Use of Xanthan Gum in An Ophthalmic Liquid Dosage Form: Rheological Characterization of the Interaction With Mucin, Journal of Pharmaceutical Sciences, vol.91, issue.4, pp.1117-1127, 2002.
DOI : 10.1002/jps.10106

J. Y. Chang, Y. K. Oh, H. Choi, Y. B. Kim, and C. Kim, Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions, International Journal of Pharmaceutics, vol.241, issue.1, pp.155-163, 2002.
DOI : 10.1016/S0378-5173(02)00232-6

C. C. Chen, C. L. Fang, S. A. Al-suwayeh, Y. L. Leu, and J. Y. Fang, Transdermal delivery of selegiline from alginate???Pluronic composite thermogels, International Journal of Pharmaceutics, vol.415, issue.1-2, pp.119-128, 2011.
DOI : 10.1016/j.ijpharm.2011.05.060

J. Chen, R. Zhou, L. Li, B. Li, X. Zhang et al., Mechanical, rheological and release behaviors of a poloxamer 407, pp.12415-12425, 2013.

D. E. Chickering, W. P. Harris, and E. Mathiowitz, A microtensiometer for the analysis of bioadhesive microspheres, Biomed. Instrum. Technol, vol.29, pp.501-512, 1995.

H. Choi, M. Lee, M. Kim, and C. Kim, Effect of additives on the physicochemical properties of liquid suppository bases, International Journal of Pharmaceutics, vol.190, issue.1, pp.13-19, 1999.
DOI : 10.1016/S0378-5173(99)00225-2

F. N. Christensen, S. S. Davis, J. G. Hardy, M. J. Taylor, D. R. Whalley et al., The use of gamma scintigraphy to follow the gastrointestinal transit of pharmaceutical formulations, Journal of Pharmacy and Pharmacology, vol.18, issue.Suppl, pp.91-95, 1985.
DOI : 10.1111/j.2042-7158.1985.tb05013.x

M. A. Clark, B. H. Hirst, and M. A. Jepson, Lectin-mediated mucosal delivery of drugs and microparticles, Advanced Drug Delivery Reviews, vol.43, issue.2-3, pp.207-223, 2000.
DOI : 10.1016/S0169-409X(00)00070-3

P. Costa and J. M. Sousa-lobo, Modeling and comparison of dissolution profiles, European Journal of Pharmaceutical Sciences, vol.13, issue.2, pp.123-133, 2001.
DOI : 10.1016/S0928-0987(01)00095-1

C. Médecine and . Ostéopathie-, Physiologie --Partie 2 : La sécrétion salivaire

S. Dash, P. N. Murthy, L. Nath, and P. Chowdhury, Kinetic modeling on drug release from controlled drug delivery systems, Acta Pol. Pharm, vol.67, pp.217-223, 2010.

N. Das, P. Madan, and S. Lin, Development and in vitro evaluation of insulin-loaded buccal Pluronic F-127 gels, Pharmaceutical Development and Technology, vol.53, issue.5, pp.192-208, 2010.
DOI : 10.1016/S0378-5173(99)00339-7

M. Davidovich-pinhas and H. Bianco-peled, Mucoadhesion: a review of characterization techniques, Expert Opinion on Drug Delivery, vol.5118, issue.12, pp.259-271, 2010.
DOI : 10.1016/j.addr.2005.07.008

D. Caro, V. Giandalia, G. Siragusa, M. G. Paderni, C. Campisi et al., Evaluation of galantamine transbuccal absorption by reconstituted human oral epithelium and porcine tissue as buccal mucosa models: Part I, European Journal of Pharmaceutics and Biopharmaceutics, vol.70, issue.3, pp.869-873, 2008.
DOI : 10.1016/j.ejpb.2008.06.025

P. R. Delvadia, W. H. Barr, and H. T. Karnes, A biorelevant in vitro release/permeation system for oral transmucosal dosage forms, International Journal of Pharmaceutics, vol.430, issue.1-2, pp.104-113, 2012.
DOI : 10.1016/j.ijpharm.2012.03.050

D. Dodou, P. Breedveld, and P. A. Wieringa, Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications, European Journal of Pharmaceutics and Biopharmaceutics, vol.60, issue.1, pp.1-16, 2005.
DOI : 10.1016/j.ejpb.2005.01.007

L. G. Dodson, R. A. Vogt, J. Marks, C. Reichardt, and C. E. Crespo-hernández, Photophysical and photochemical properties of the pharmaceutical compound salbutamol in aqueous solutions, Chemosphere, vol.83, issue.11, pp.1513-1523, 2011.
DOI : 10.1016/j.chemosphere.2011.01.048

G. Dumortier, J. L. Grossiord, F. Agnely, and J. C. Chaumeil, A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics, Pharmaceutical Research, vol.43, issue.6, pp.2709-2728, 2006.
DOI : 10.1007/s11095-006-9104-4

K. Edsman, J. Carlfors, and R. Petersson, Rheological evaluation of poloxamer as an in situ gel for ophthalmic use, European Journal of Pharmaceutical Sciences, vol.6, issue.2, pp.105-112, 1998.
DOI : 10.1016/S0928-0987(97)00075-4

K. Edsman and H. Hägerström, Pharmaceutical applications of mucoadhesion for the non-oral routes, Journal of Pharmacy and Pharmacology, vol.135, issue.1, pp.3-22, 2005.
DOI : 10.1211/0022357055227

H. U. Eirheim, C. Bundgaard, and H. M. Nielsen, Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate, Toxicology in Vitro, vol.18, issue.5, pp.649-657, 2004.
DOI : 10.1016/j.tiv.2004.02.003

J. Engblom, S. Engström, and K. Fontell, The effect of the skin penetration enhancer Azone?? on fatty acid-sodium soap-water mixtures, Journal of Controlled Release, vol.33, issue.2, pp.299-305, 1995.
DOI : 10.1016/0168-3659(94)00105-4

A. A. Exner, T. M. Krupka, K. Scherrer, and J. M. Teets, Enhancement of carboplatin toxicity by Pluronic block copolymers, Journal of Controlled Release, vol.106, issue.1-2, pp.188-197, 2005.
DOI : 10.1016/j.jconrel.2005.04.015

J. G. Forte and S. G. Schultz, Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion. in: Handbook of Physiology: Section 6: The Gastrointestinal System, 1989.

W. R. Galey, H. K. Lonsdale, and S. Nacht, The In Vitro Permeability Of Skin And Buccal Mucosa To Selected Drugs And Tritiated Water, Journal of Investigative Dermatology, vol.67, issue.6, pp.713-717, 1976.
DOI : 10.1111/1523-1747.ep12598596

R. B. Gandhi and J. R. Robinson, Oral cavity as a site for bioadhesive drug delivery, Advanced Drug Delivery Reviews, vol.13, issue.1-2, pp.43-74, 1994.
DOI : 10.1016/0169-409X(94)90026-4

J. Glantzmann and J. Raton, A Review of Dissolution tests with the Flow Through MethodA-Review-of-Dissolution-tests-with-the- Flow-Through-Method, 2007.

G. Inc, GSK-Monographie de produit : Solution Ventolin pour respirateur, 2007.

G. Inc, Product monograph : Ventolin I.V. infusion solution, 2011.

T. Goswami, B. Jasti, and X. Li, Sublingual Drug Delivery, Critical Reviews?? in Therapeutic Drug Carrier Systems, vol.25, issue.5, pp.449-484, 2008.
DOI : 10.1615/CritRevTherDrugCarrierSyst.v25.i5.20

V. Grabovac, D. Guggi, and A. Bernkop-schnürch, Comparison of the mucoadhesive properties of various polymers, Advanced Drug Delivery Reviews, vol.57, issue.11, pp.1713-1723, 2005.
DOI : 10.1016/j.addr.2005.07.006

V. Gray, G. Kelly, M. Xia, C. Butler, S. Thomas et al., The Science of USP 1 and 2 Dissolution: Present Challenges and Future Relevance, Pharmaceutical Research, vol.23, issue.2, pp.1289-1302, 2009.
DOI : 10.1007/s11095-008-9822-x

D. D. Guo, H. S. Moon, R. Arote, J. H. Seo, J. S. Quan et al., Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells, Cancer Letters, vol.254, issue.2, pp.244-254, 2007.
DOI : 10.1016/j.canlet.2007.03.007

H. Hägerström and K. Edsman, Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method, Journal of Pharmacy and Pharmacology, vol.84, issue.12, pp.1589-1599, 2001.
DOI : 10.1211/0022357011778197

H. Hägerström, M. Strømme, and K. Edsman, Drug Molecules as Probes for Studying the Compatibility Between Gels and Mucous Tissue with Dielectric Spectroscopy, Journal of Pharmaceutical Sciences, vol.94, issue.5, pp.1090-1100, 2005.
DOI : 10.1002/jps.20329

L. B. Hakes, T. C. Corby, and B. J. Meakin, THE STABILITY OF SALBUTAMOL SOLUTION, Journal of Pharmacy and Pharmacology, vol.6, issue.S1, pp.25-25, 1979.
DOI : 10.1111/j.2042-7158.1979.tb11573.x

D. Harris and J. R. Robinson, Drug Delivery via the Mucous Membranes of the Oral Cavity, Journal of Pharmaceutical Sciences, vol.81, issue.1, pp.1-10, 1992.
DOI : 10.1002/jps.2600810102

E. E. Hassan and J. M. Gallo, A simple rheological method for the in vitro assessment of mucinpolymer bioadhesive bond strength, Pharmaceutical Research, vol.07, issue.5, pp.491-495, 1990.
DOI : 10.1023/A:1015812615635

N. Hassan, A. Ahad, M. Ali, and J. Ali, Chemical permeation enhancers for transbuccal drug delivery, Expert Opinion on Drug Delivery, vol.1, issue.7, pp.97-112, 2010.
DOI : 10.1016/j.ijpharm.2005.11.013

V. Hearnden, V. Sankar, K. Hull, D. V. Juras, M. Greenberg et al., New developments and opportunities in oral mucosal drug delivery for local and systemic disease, Advanced Drug Delivery Reviews, vol.64, issue.1, pp.16-28, 2012.
DOI : 10.1016/j.addr.2011.02.008

P. He, S. S. Davis, and L. Illum, In vitro evaluation of the mucoadhesive properties of chitosan microspheres, International Journal of Pharmaceutics, vol.166, issue.1, pp.75-88, 1998.
DOI : 10.1016/S0378-5173(98)00027-1

T. R. Hoare and D. S. Kohane, Hydrogels in drug delivery: Progress and challenges, Polymer, vol.49, issue.8, 1993.
DOI : 10.1016/j.polymer.2008.01.027

R. Holm, E. Meng-lund, M. B. Andersen, M. L. Jespersen, J. Karlsson et al., In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and G??ttingen minipigs, European Journal of Pharmaceutical Sciences, vol.49, issue.2, pp.117-124, 2013.
DOI : 10.1016/j.ejps.2013.02.024

S. H. Hsu, Y. L. Leu, J. W. Hu, and J. Y. Fang, Physicochemical Characterization and Drug Release of Thermosensitive Hydrogels Composed of a Hyaluronic Acid/Pluronic F127 Graft, CHEMICAL & PHARMACEUTICAL BULLETIN, vol.57, issue.5, pp.453-458, 2009.
DOI : 10.1248/cpb.57.453

S. P. Humphrey and R. T. Williamson, A review of saliva: Normal composition, flow, and function, The Journal of Prosthetic Dentistry, vol.85, issue.2, pp.162-169, 2001.
DOI : 10.1067/mpr.2001.113778

A. P. Ijzerman, T. Bultsma, H. Timmerman, and J. Zaagsma, The ionization of ??-adrenoceptor agonists: a method for unravelling ionization schemes, Journal of Pharmacy and Pharmacology, vol.218, issue.1, pp.11-15, 1984.
DOI : 10.1111/j.2042-7158.1984.tb02978.x

Y. Ikeuchi-takahashi, N. Watanabe, M. Sasatsu, and H. Onishi, Formulation and evaluation of matrix type mucoadhesive tablets aimed at treating oral aphtha, Drug Development and Industrial Pharmacy, vol.72, issue.8, pp.1254-1261, 2013.
DOI : 10.3109/03639045.2011.633263

R. Imboden and G. Imanidis, Effect of the amphoteric properties of salbutamol on its release rate through a polypropylene control membrane, European Journal of Pharmaceutics and Biopharmaceutics, vol.47, issue.2, pp.161-167, 1999.
DOI : 10.1016/S0939-6411(98)00053-8

H. Inoue, K. Ono, W. Masuda, T. Inagaki, M. Yokota et al., Rheological Properties of Human Saliva and Salivary Mucins, Journal of Oral Biosciences, vol.50, issue.2, pp.134-141, 2008.
DOI : 10.1016/S1349-0079(08)80027-8

J. Jacobsen, S. Bjerregaard, and M. Pedersen, Cyclodextrin inclusion complexes of antimycotics intended to act in the oral cavity ??? drug supersaturation, toxicity on TR146 cells and release from a delivery system, European Journal of Pharmaceutics and Biopharmaceutics, vol.48, issue.3, pp.217-224, 1999.
DOI : 10.1016/S0939-6411(99)00043-0

J. Jacobsen, E. B. Nielsen, K. Brøndum-nielsen, M. E. Christensen, H. B. Olin et al., Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability, European Journal of Oral Sciences, vol.107, issue.2, pp.138-146, 1999.
DOI : 10.1046/j.0909-8836.1999.eos107210.x

J. Jacobsen, B. Van-deurs, M. Pedersen, and M. R. Rassing, TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability, International Journal of Pharmaceutics, vol.125, issue.2, pp.165-184, 1995.
DOI : 10.1016/0378-5173(95)00109-V

Y. Jacques and P. Buri, An investigation of the physical behaviour of moisture-activated mucoadhesive hydrogels upon contact with biological and non-biological substrates, Pharmaceutica Acta Helvetiae, vol.72, issue.4, 1997.
DOI : 10.1016/S0031-6865(97)00017-4

A. C. Jain, B. J. Aungst, and M. C. Adeyeye, Development and in vivo evaluation of buccal tablets prepared using danazol???sulfobutylether 7 ?????cyclodextrin (SBE 7) complexes, Journal of Pharmaceutical Sciences, vol.91, issue.7, pp.1659-1668, 2002.
DOI : 10.1002/jps.10163

C. Janson, Plasma levels and effects of salbutamol after inhaled or i.v. administration in stable asthma, Eur. Respir. J, vol.4, pp.544-550, 1991.

E. Jantratid, V. De-maio, E. Ronda, V. Mattavelli, M. Vertzoni et al., Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form, European Journal of Pharmaceutical Sciences, vol.37, issue.3-4, pp.434-441, 2009.
DOI : 10.1016/j.ejps.2009.03.015

D. S. Jones, M. L. Bruschi, O. De-freitas, M. P. Gremião, E. H. Lara et al., Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity, International Journal of Pharmaceutics, vol.372, issue.1-2, pp.49-58, 2009.
DOI : 10.1016/j.ijpharm.2009.01.006

K. Kafedjiiski, R. K. Jetti, F. Föger, H. Hoyer, M. Werle et al., Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery, International Journal of Pharmaceutics, vol.343, issue.1-2, pp.48-58, 2007.
DOI : 10.1016/j.ijpharm.2007.04.019

S. Kanjanabat and T. Pongjanyakul, Preparation and Characterization of Nicotine???Magnesium Aluminum Silicate Complex-Loaded Sodium Alginate Matrix Tablets for Buccal Delivery, AAPS PharmSciTech, vol.12, issue.2, pp.683-692, 2011.
DOI : 10.1208/s12249-011-9633-y

S. Y. Karavana, P. Güneri, and G. Ertan, Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: Preparation, rheological, textural, mucoadhesive and release properties, Pharmaceutical Development and Technology, vol.63, issue.6, pp.623-631, 2009.
DOI : 10.1080/00986449608936658

V. V. Khutoryanskiy, Advances in Mucoadhesion and Mucoadhesive Polymers, Macromolecular Bioscience, vol.334, issue.6, pp.748-764, 2011.
DOI : 10.1002/mabi.201000388

A. A. Koffi, F. Agnely, G. Ponchel, and J. L. Grossiord, Modulation of the rheological and mucoadhesive properties of thermosensitive poloxamer-based hydrogels intended for the rectal administration of quinine, European Journal of Pharmaceutical Sciences, vol.27, issue.4, pp.328-335, 2006.
DOI : 10.1016/j.ejps.2005.11.001

C. Kremser, K. Albrecht, M. Greindl, C. Wolf, P. Debbage et al., In vivo determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract, Magnetic Resonance Imaging, vol.26, issue.5, pp.638-643, 2008.
DOI : 10.1016/j.mri.2008.01.004

U. Kulkarni, R. Mahalingam, I. Pather, X. Li, and B. Jasti, Porcine buccal mucosa as in vitro model: Effect of biological and experimental variables, Journal of Pharmaceutical Sciences, vol.99, issue.3, pp.1265-1277, 2010.
DOI : 10.1002/jps.21907

U. Kulkarni, R. Mahalingam, S. I. Pather, X. Li, and B. Jasti, Porcine Buccal Mucosa as an In Vitro Model: Relative Contribution of Epithelium and Connective Tissue as Permeability Barriers, Journal of Pharmaceutical Sciences, vol.98, issue.2, pp.471-483, 2009.
DOI : 10.1002/jps.21436

J. W. Lee, J. H. Park, and J. R. Robinson, Bioadhesive???Based Dosage Forms: The Next Generation, Journal of Pharmaceutical Sciences, vol.89, issue.7, pp.850-866, 2000.
DOI : 10.1002/1520-6017(200007)89:7<850::AID-JPS2>3.0.CO;2-G

V. H. Lee, Protease inhibitors and penetration enhancers as approaches to modify peptide absorption, Journal of Controlled Release, vol.13, issue.2-3, pp.213-223, 1990.
DOI : 10.1016/0168-3659(90)90011-H

V. M. Leitner, G. F. Walker, and A. Bernkop-schnürch, Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins, European Journal of Pharmaceutics and Biopharmaceutics, vol.56, issue.2, pp.207-214, 2003.
DOI : 10.1016/S0939-6411(03)00061-4

L. Ray, A. M. Iooss, P. Gouyette, A. Vonarx, V. Patrice et al., Development of a ???Continuous-Flow Adhesion Cell??? for the Assessment of Hydrogel Adhesion, Drug Development and Industrial Pharmacy, vol.6, issue.4, pp.897-904, 1999.
DOI : 10.3109/03639049209043695

C. C. Lin and A. T. Metters, Hydrogels in controlled release formulations: Network design and mathematical modeling, Advanced Drug Delivery Reviews, vol.58, issue.12-13, pp.1379-1408, 2006.
DOI : 10.1016/j.addr.2006.09.004

A. Ludwig, The use of mucoadhesive polymers in ocular drug delivery, Advanced Drug Delivery Reviews, vol.57, issue.11, pp.1595-1639, 2005.
DOI : 10.1016/j.addr.2005.07.005

H. L. Luessen, J. C. Verhoef, A. De-boer, ). G. Bert, H. E. Junginger et al., Multifunctional Polymers for the Peroral Delivery of Peptide Drugs, Bioadhesive Drug Delivery Systems, Drugs and the Pharmaceutical Sciences, pp.299-339, 1999.
DOI : 10.1201/b14099-13

C. Luo, X. Chen, L. Li, Q. Li, B. Li et al., Traumatic Brain Injury-Induced Mitochondrial and Lysosomal Membrane Permeabilization Damage in Cultured Primary Neurons, Journal of Neurotrauma, vol.30, issue.7, pp.597-607, 2013.
DOI : 10.1089/neu.2012.2425

F. Madsen, K. Eberth, and J. D. Smart, A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration, Journal of Controlled Release, vol.50, issue.1-3, pp.167-178, 1998.
DOI : 10.1016/S0168-3659(97)00138-7

F. Madsen, K. Eberth, and J. D. Smart, A rheological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel, Biomaterials, vol.19, issue.11-12, pp.1083-1092, 1998.
DOI : 10.1016/S0142-9612(98)00037-4

L. Mälkki-laine and E. Hartikainen, Electrokinetic behaviour of salbutamol and its decomposition products and determination of salbutamol by micellar electrokinetic capillary chromatography, Journal of Chromatography A, vol.724, issue.1-2, pp.297-306, 1996.
DOI : 10.1016/0021-9673(95)00918-3

L. Mälkki-laine, K. Purra, K. Kähkönen, and S. Tammilehto, Decomposition of salbutamol in aqueous solutions. II. The effect of buffer species, pH, buffer concentration and antioxidants, International Journal of Pharmaceutics, vol.117, issue.2, pp.189-195, 1995.
DOI : 10.1016/0378-5173(94)00329-4

L. Mälkki-laine and S. Tammilehto, Decomposition of salbutamol in aqueous solutions. I. The effect of pH, temperature and drug concentration, International Journal of Pharmaceutics, vol.63, issue.1, pp.17-22, 1990.
DOI : 10.1016/0378-5173(90)90095-L

L. Mälkki-laine and S. Tammilehto, Optimization of the separation of salbutamol and its decomposition products by liquid chromatography with diode-array detection, Journal of Pharmaceutical and Biomedical Analysis, vol.11, issue.1, pp.79-84, 1993.
DOI : 10.1016/0731-7085(93)80151-P

E. Marttin, J. C. Verhoef, C. Cullander, S. G. Romeijn, J. F. Nagelkerke et al., Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats: effects of absorption enhancers, Pharmaceutical Research, vol.14, issue.5, pp.631-637, 1997.
DOI : 10.1023/A:1012109329631

E. Marttin, J. C. Verhoef, F. Spies, J. Van-der-meulen, J. F. Nagelkerke et al., The effect of methylated ??-cyclodextrins on the tight junctions of the rat nasal respiratory epithelium: Electron microscopic and confocal laser scanning microscopic visualization studies, Journal of Controlled Release, vol.57, issue.2, pp.205-213, 1999.
DOI : 10.1016/S0168-3659(98)00115-1

R. Mashru, V. Sutariya, M. Sankalia, and J. Sankalia, Transbuccal delivery of lamotrigine across porcine buccal mucosa: in vitro determination of routes of buccal transport, J. Pharm. Pharm. Sci, vol.8, pp.54-62, 2005.

J. Moore, Mathematical comparison of dissolution profiles, 1996.

M. Nielsen, H. , R. Rassing, and M. , TR146 cells grown on filters as a model of human buccal epithelium: V. Enzyme activity of the TR146 cell culture model, human buccal epithelium and porcine buccal epithelium, and permeability of leu-enkephalin, International Journal of Pharmaceutics, vol.200, issue.2, pp.261-270, 2000.
DOI : 10.1016/S0378-5173(00)00394-X

D. J. Morgan, J. D. Paull, B. H. Richmond, E. Wilson-evered, and S. P. Ziccone, Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate., British Journal of Clinical Pharmacology, vol.305, issue.5, pp.587-593, 1986.
DOI : 10.1111/j.1365-2125.1986.tb02939.x

M. Morishita, J. M. Barichello, K. Takayama, Y. Chiba, S. Tokiwa et al., Pluronic?? F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin, International Journal of Pharmaceutics, vol.212, issue.2, pp.289-293, 2001.
DOI : 10.1016/S0378-5173(00)00615-3

M. A. Mughal, Z. Iqbal, and S. H. Neau, Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride, AAPS PharmSciTech, vol.12, issue.1, pp.77-87, 2011.
DOI : 10.1208/s12249-010-9570-1

D. L. Munday and P. J. Cox, Compressed xanthan and karaya gum matrices: hydration, erosion and drug release mechanisms, International Journal of Pharmaceutics, vol.203, issue.1-2, pp.179-192, 2000.
DOI : 10.1016/S0378-5173(00)00444-0

N. A. Nafee, F. A. Ismail, N. A. Boraie, and L. M. Mortada, Mucoadhesive Delivery Systems. II. Formulation and In???Vitro/In???Vivo Evaluation of Buccal Mucoadhesive Tablets Containing Water???Soluble Drugs, Drug Development and Industrial Pharmacy, vol.12, issue.4, pp.995-1004, 2004.
DOI : 10.1016/0378-5173(95)00058-Q

N. A. Nafee, F. A. Ismail, N. A. Boraie, and L. M. Mortada, Mucoadhesive Delivery Systems. I. Evaluation of Mucoadhesive Polymers for Buccal Tablet Formulation, Drug Development and Industrial Pharmacy, vol.2, issue.6, pp.985-993, 2004.
DOI : 10.1016/S0939-6411(96)00009-4

J. A. Nicolazzo and B. C. Finnin, In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa Drug Absorption Studies, Biotechnology: Pharmaceutical Aspects, pp.89-111, 2008.

J. A. Nicolazzo, B. L. Reed, and B. C. Finnin, The Effect of Various In Vitro Conditions on the Permeability Characteristics of the Buccal Mucosa, Journal of Pharmaceutical Sciences, vol.92, issue.12, pp.2399-2410, 2003.
DOI : 10.1002/jps.10505

J. A. Nicolazzo, B. L. Reed, and B. C. Finnin, Buccal penetration enhancers???How do they really work?, Journal of Controlled Release, vol.105, issue.1-2, pp.1-15, 2005.
DOI : 10.1016/j.jconrel.2005.01.024

H. M. Nielsen and M. R. Rassing, TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and ??-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa, International Journal of Pharmaceutics, vol.194, issue.2, pp.155-167, 2000.
DOI : 10.1016/S0378-5173(99)00368-3

L. S. Nielsen, L. Schubert, and J. Hansen, Bioadhesive drug delivery systems, European Journal of Pharmaceutical Sciences, vol.6, issue.3, pp.231-239, 1998.
DOI : 10.1016/S0928-0987(97)10004-5

D. A. Norris, N. Puri, and P. J. Sinko, The effect of physical barriers and properties on the oral absorption of particulates, Advanced Drug Delivery Reviews, vol.34, issue.2-3, pp.135-154, 1998.
DOI : 10.1016/S0169-409X(98)00037-4

O. 'hara, T. Dunne, A. Butler, J. Devane, and J. , A review of methods used to compare dissolution profile data, Pharmaceutical Science & Technology Today, vol.1, issue.5, pp.214-223, 1998.
DOI : 10.1016/S1461-5347(98)00053-4

C. Paderni, D. Compilato, L. I. Giannola, and G. Campisi, Oral local drug delivery and new perspectives in oral drug formulation, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol.114, issue.3, pp.25-34, 2012.
DOI : 10.1016/j.oooo.2012.02.016

M. M. Patel, J. D. Smart, T. G. Nevell, R. J. Ewen, P. J. Eaton et al., Mucin/Poly(acrylic acid) Interactions:?? A Spectroscopic Investigation of Mucoadhesion, Biomacromolecules, vol.4, issue.5, pp.1184-1190, 2003.
DOI : 10.1021/bm034028p

R. S. Patel and S. S. Poddar, Development and Characterization of Mucoadhesive Buccal Patches of Salbutamol Sulphate, Current Drug Delivery, vol.6, issue.1, pp.140-144, 2009.
DOI : 10.2174/156720109787048177

V. F. Patel, F. Liu, and M. B. Brown, Advances in oral transmucosal drug delivery, Journal of Controlled Release, vol.153, issue.2, pp.106-116, 2011.
DOI : 10.1016/j.jconrel.2011.01.027

V. F. Patel, F. Liu, and M. B. Brown, Modeling the oral cavity: In vitro and in vivo evaluations of buccal drug delivery systems, Journal of Controlled Release, vol.161, issue.3, pp.746-756, 2012.
DOI : 10.1016/j.jconrel.2012.05.026

N. A. Peppas, P. Bures, W. Leobandung, and H. Ichikawa, Hydrogels in pharmaceutical formulations, European Journal of Pharmaceutics and Biopharmaceutics, vol.50, issue.1, pp.27-46, 2000.
DOI : 10.1016/S0939-6411(00)00090-4

N. A. Peppas and Y. Huang, Nanoscale technology of mucoadhesive interactions, Advanced Drug Delivery Reviews, vol.56, issue.11, pp.1675-1687, 2004.
DOI : 10.1016/j.addr.2004.03.001

N. A. Peppas and J. J. Sahlin, Hydrogels as mucoadhesive and bioadhesive materials: a review, Biomaterials, vol.17, issue.16, pp.1553-1561, 1996.
DOI : 10.1016/0142-9612(95)00307-X

2. Pharmatutor, . Formulation, . Evaluation, . Amoxicillin, . Modified et al., URL http://www.pharmatutor.org/articles/formulation-evaluation-amoxicillin-trihydrate-modified- release-dosage-forms?page=0, p.13

G. Pickering, N. Macian, F. Libert, J. M. Cardot, S. Coissard et al., Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers, Drug Design, Development and Therapy, vol.8, pp.1621-1627, 2014.
DOI : 10.2147/DDDT.S63476

A. Portero, D. Teijeiro-osorio, M. J. Alonso, and C. Remuñán-lópez, Development of chitosan sponges for buccal administration of insulin, Carbohydrate Polymers, vol.68, issue.4, pp.617-625, 2007.
DOI : 10.1016/j.carbpol.2006.07.028

A. Puratchikody, V. V. Prasanth, S. T. Mathew, and B. A. Kumar, Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery, Acta Pharmaceutica, vol.61, issue.2, pp.157-170, 2011.
DOI : 10.2478/v10007-011-0011-9

A. Puratchikody, V. V. Prasanth, S. T. Mathew, and B. A. Kumar, Mucoadhesive Patches of Salbutamol Sulphate for Unidirectional Buccal Drug Delivery: Development and Evaluation, Current Drug Delivery, vol.8, issue.4, pp.416-425, 2011.
DOI : 10.2174/156720111795768004

H. Qi, W. Chen, C. Huang, L. Li, C. Chen et al., Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin, International Journal of Pharmaceutics, vol.337, issue.1-2, pp.178-187, 2007.
DOI : 10.1016/j.ijpharm.2006.12.038

Y. Qiu and K. Park, Environment-sensitive hydrogels for drug delivery, Advanced Drug Delivery Reviews, vol.53, issue.3, pp.321-339, 2001.
DOI : 10.1016/S0169-409X(01)00203-4

K. V. Rao and P. Buri, A novel in situ method to test polymers and coated microparticles for bioadhesion, International Journal of Pharmaceutics, vol.52, issue.3, pp.265-270, 1989.
DOI : 10.1016/0378-5173(89)90229-9

M. J. Rathbone and I. G. Tucker, Mechanisms, barriers and pathways of oral mucosal drug permeation, Advanced Drug Delivery Reviews, vol.12, issue.1-2, pp.41-60, 1993.
DOI : 10.1016/0169-409X(93)90040-B

E. J. Ricci, L. O. Lunardi, D. M. Nanclares, and J. M. Marchetti, Sustained release of lidocaine from Poloxamer 407 gels, International Journal of Pharmaceutics, vol.288, issue.2, pp.235-244, 2005.
DOI : 10.1016/j.ijpharm.2004.09.028

S. Rossi, F. Ferrari, M. C. Bonferoni, and C. Caramella, Characterization of chitosan hydrochloride???mucin interaction by means of viscosimetric and turbidimetric measurements, European Journal of Pharmaceutical Sciences, vol.10, issue.4, pp.251-257, 2000.
DOI : 10.1016/S0928-0987(00)00065-8

R. Rowe, P. Sheskey, and S. Owen, Handbook of Pharmaceutical Excipients, 2005.

E. Ruel-gariépy and J. C. Leroux, In situ-forming hydrogels???review of temperature-sensitive systems, European Journal of Pharmaceutics and Biopharmaceutics, vol.58, issue.2, pp.409-426, 2004.
DOI : 10.1016/j.ejpb.2004.03.019

N. Salamat-miller, M. Chittchang, and T. P. Johnston, The use of mucoadhesive polymers in buccal drug delivery, Advanced Drug Delivery Reviews, vol.57, issue.11, pp.1666-1691, 2005.
DOI : 10.1016/j.addr.2005.07.003

C. Sander, H. M. Nielsen, and J. Jacobsen, Buccal delivery of metformin: TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement, International Journal of Pharmaceutics, vol.458, issue.2, pp.254-261, 2013.
DOI : 10.1016/j.ijpharm.2013.10.026

G. Sandri, M. C. Bonferoni, F. Ferrari, S. Rossi, C. Del-fante et al., An In Situ Gelling Buccal Spray Containing Platelet Lysate for the Treatment of Oral Mucositis, Current Drug Discovery Technologies, vol.8, issue.3, pp.277-285, 2011.
DOI : 10.2174/157016311796799017

V. Senthil, S. Kumar, C. V. Nagaraju, N. Jawahar, G. Ganesh et al., Design and development of hydrogel nanoparticles for mercaptopurine, Journal of Advanced Pharmaceutical Technology & Research, vol.1, issue.3, p.334, 2010.
DOI : 10.4103/0110-5558.72431

G. Serbest, J. Horwitz, M. Jost, and K. Barbee, Mechanisms of cell death and neuroprotection by poloxamer 188 after mechanical trauma, The FASEB Journal, vol.20, pp.308-310, 2006.
DOI : 10.1096/fj.05-4024fje

D. H. Shastri, S. T. Prajapati, and L. D. Patel, Design and Development of Thermoreversible Ophthalmic In Situ Hydrogel of Moxifloxacin HCl, Current Drug Delivery, vol.7, issue.3, 2010.
DOI : 10.2174/156720110791560928

S. C. Shin, J. Y. Kim, and I. J. Oh, Mucoadhesive and Physicochemical Characterization of Carbopol-Poloxamer Gels Containing Triamcinolone Acetonide, Drug Development and Industrial Pharmacy, vol.19, issue.3, pp.307-312, 2000.
DOI : 10.1016/0168-3659(95)00064-F

A. H. Shojaei, Buccal mucosa as a route for systemic drug delivery: a review, J. Pharm. Pharm. Sci, vol.1, pp.15-30, 1998.

S. Singh, R. Soni, M. K. Rawat, A. Jain, S. B. Deshpande et al., In Vitro and in Vivo Evaluation of Buccal Bioadhesive Films Containing Salbutamol Sulphate, CHEMICAL & PHARMACEUTICAL BULLETIN, vol.58, issue.3, pp.307-311, 2010.
DOI : 10.1248/cpb.58.307

B. L. Slomiany, V. L. Murty, J. Piotrowski, and A. Slomiany, Salivary mucins in oral mucosal defense, General Pharmacology: The Vascular System, vol.27, issue.5, pp.761-771, 1996.
DOI : 10.1016/0306-3623(95)02050-0

J. D. Smart, Buccal drug delivery, Expert Opinion on Drug Delivery, vol.13, issue.2, pp.507-517, 2005.
DOI : 10.1016/S1461-5347(98)00076-5

G. Smistad, J. Jacobsen, and S. A. Sande, Multivariate toxicity screening of liposomal formulations on a human buccal cell line, International Journal of Pharmaceutics, vol.330, issue.1-2, pp.14-22, 2007.
DOI : 10.1016/j.ijpharm.2006.08.044

I. A. Sogias, A. C. Williams, and V. V. Khutoryanskiy, Why is chitosan mucoadhesive? Biomacromolecules, pp.1837-1842, 2008.

R. R. Stoughton and W. O. Mcclure, Azone??: A New Non-Toxic Enhancer of Cu'Taneous Penetration, Drug Development and Industrial Pharmacy, vol.51, issue.4, pp.725-744, 1983.
DOI : 10.1001/archderm.1978.01640220012003

Y. Su, X. Wei, and H. Liu, Effect of sodium chloride on association behavior of poly(ethylene oxide)???poly(propylene oxide)???poly(ethylene oxide) block copolymer in aqueous solutions, Journal of Colloid and Interface Science, vol.264, issue.2, pp.526-531, 2003.
DOI : 10.1016/S0021-9797(03)00472-7

J. Swarbrick and J. C. Boylan, Encyclopedia of Pharmaceutical Technology, 2000.

H. Takeuchi, J. Thongborisute, Y. Matsui, H. Sugihara, H. Yamamoto et al., Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems, Advanced Drug Delivery Reviews, vol.57, issue.11, pp.1583-1594, 2005.
DOI : 10.1016/j.addr.2005.07.008

S. Tamburic and D. Q. Craig, A comparison of different in vitro methods for measuring mucoadhesive performance, European Journal of Pharmaceutics and Biopharmaceutics, vol.44, issue.2, pp.159-167, 1997.
DOI : 10.1016/S0939-6411(97)00073-8

T. Ur-rehman, S. Tavelin, and G. Gröbner, Chitosan in situ gelation for improved drug loading and retention in poloxamer 407 gels, International Journal of Pharmaceutics, vol.409, issue.1-2, pp.19-29, 2011.
DOI : 10.1016/j.ijpharm.2011.02.017

M. Vadnere and G. Amidon, Thermodynamic studies on the gel-sol transition of some pluronic polyols, International Journal of Pharmaceutics, vol.22, issue.2-3, pp.207-218, 1984.
DOI : 10.1016/0378-5173(84)90022-X

S. Van-vlierberghe, P. Dubruel, and E. Schacht, Biopolymer-Based Hydrogels As Scaffolds for Tissue Engineering Applications: A Review, Biomacromolecules, vol.12, issue.5, pp.1387-1408, 2011.
DOI : 10.1021/bm200083n

J. Varshosaz, N. Tavakoli, and F. Kheirolahi, Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride, AAPS PharmSciTech, vol.7, issue.1, pp.168-174, 2006.
DOI : 10.1208/pt070124

P. V. Vasantha, A. Puratchikody, S. T. Mathew, and A. K. Balaraman, Development and characterization of Eudragit based mucoadhesive buccal patches of salbutamol sulfate, Saudi Pharmaceutical Journal, vol.19, issue.4, pp.207-214, 2011.
DOI : 10.1016/j.jsps.2011.07.003

E. Verhoeven, C. Vervaet, and J. P. Remon, Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation, European Journal of Pharmaceutics and Biopharmaceutics, vol.63, issue.3, pp.320-330, 2006.
DOI : 10.1016/j.ejpb.2005.12.004

K. Vermani, S. Garg, and L. J. Zaneveld, Assemblies for In Vitro Measurement of Bioadhesive Strength and Retention Characteristics in Simulated Vaginal Environment, Drug Development and Industrial Pharmacy, vol.50, issue.3, pp.1133-1146, 2002.
DOI : 10.1093/HUMREP/11.2.357

F. Veuillez, Y. N. Kalia, Y. Jacques, J. Deshusses, and P. Buri, Factors and strategies for improving buccal absorption of peptides, European Journal of Pharmaceutics and Biopharmaceutics, vol.51, issue.2, pp.93-109, 2001.
DOI : 10.1016/S0939-6411(00)00144-2

G. F. Walker, N. Langoth, and A. Bernkop-schnürch, Peptidase activity on the surface of the porcine buccal mucosa, International Journal of Pharmaceutics, vol.233, issue.1-2, pp.141-147, 2002.
DOI : 10.1016/S0378-5173(01)00934-6

J. Weyermann, D. Lochmann, and A. Zimmer, A practical note on the use of cytotoxicity assays, International Journal of Pharmaceutics, vol.288, issue.2, pp.369-376, 2005.
DOI : 10.1016/j.ijpharm.2004.09.018

O. Wichterle and D. Lím, Hydrophilic Gels for Biological Use, Nature, vol.185, issue.4706, pp.117-118, 1960.
DOI : 10.1038/185117a0

J. J. Xuan, Y. D. Yan, D. H. Oh, Y. K. Choi, C. S. Yong et al., Development of thermo-sensitive injectable hydrogel with sustained release of doxorubicin: Rheological characterization and in vivo evaluation in rats, Drug Delivery, vol.374, issue.5, pp.305-311, 2011.
DOI : 10.1016/S0731-7085(99)00070-9

F. Yan, C. Zhang, Y. Zheng, L. Mei, L. Tang et al., The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity, Nanomedicine: Nanotechnology, Biology and Medicine, vol.6, issue.1, pp.170-178, 2010.
DOI : 10.1016/j.nano.2009.05.004

N. Yuksel, A. E. Kanik, and T. Baykara, Comparison of in vitro dissolution profiles by ANOVA-based, model-dependent and -independent methods, International Journal of Pharmaceutics, vol.209, issue.1-2, pp.57-67, 2000.
DOI : 10.1016/S0378-5173(00)00554-8

Y. Zhang, M. Huo, J. Zhou, A. Zou, W. Li et al., DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles, The AAPS Journal, vol.12, issue.3, pp.263-271, 2010.
DOI : 10.1208/s12248-010-9185-1