Formulation et caractérisation d'une forme buccale mucoadhésive thermogélifiante pour administration de sulfate de salbutamol

Abstract : The treatment of asthma concerns a large population and generally necessitates an administration by the pulmonary route. This route has some drawbacks which could be overcome by the buccal route, like considered in this study expecting an improvement of the compliance and the bioavailability. The aim of this work was to develop and characterize a thermogelling mucoadhesive formulation containing salbutamol sulfate. The main properties of the formulation were: (i) thermogelation around 30°C to facilitate the administration by spray; (ii) strong mechanical properties and high mucoadhesive strength to maintain the formulation in situ; (iii) drug release kinetics adapted to the treatment. The excipients were selected with regard to the final formulation safety. The experimental work emphasized the great interest of certain techniques in the characterization of this kind of formulation, for example the drug release study using flow through apparatus, the cytotoxicity study using digital holographic microscopy and also the mucoadhesion study by in vivo imaging. The use of mathematical models provided a relevant understanding of drug release mechanisms. The conclusion of this study is favorable to a further development of the project for a future marketing.
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Ni Zeng. Formulation et caractérisation d'une forme buccale mucoadhésive thermogélifiante pour administration de sulfate de salbutamol. Pharmacologie. Université Sorbonne Paris Cité, 2015. Français. ⟨NNT : 2015USPCB075⟩. ⟨tel-01186766⟩

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