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Effets électrophysiologiques de la stimulation du cortex moteur sur les noyaux somatosensorielslatéraux du thalamus : étude expérimentale sur un modèle de stimulation du cortex moteur chez le chat

Abstract : Motor cortex stimulation (MCS) is a neurosurgical technique developed on empirical basis and currently used as last solution for patients suffering from refractory neuropathic pain. The present work is a new attempt among other contemporary studies aiming to understand the mechanisms of action of MCS, which remain incompletely elucidated at that time. The main objective of this thesis is to study the electrophysiological effect of MCS at the thalamic level, in a cat model. The first part of this work aims to establish the stereotactic somatotopic map of the cat motor cortex (MC), not available so far in the literature. Based on this mapping, we created and validated a cat model of MCS, using a mini-invasive electrode implantation. The second part of this study included a recording and analysis of the potential changes of the unitary extracellular activity of cells located in the thalamic ventro-postero-lateral (VPL) nucleus, induced by different MCS protocols. Our results indicate a modulation of the VPL cells activity after MCS, depending on the nociceptive or non-nociceptive nature of the recorded thalamic cell. MCS increases the activity of non-nociceptive cells and decreases that of nociceptive cells. For a given cell the matching between the somatotopy of the MC stimulated region and the receptive field localization of the recorded thalamic cell is not a prerequisite for obtaining such a modulation. In conclusion, the present work has proven a neuro-modulatory differential effect of MCS on nociceptive and non-nociceptive cells in the thalamic VPL nucleus
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https://tel.archives-ouvertes.fr/tel-01176200
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Submitted on : Wednesday, July 15, 2015 - 9:52:06 AM
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  • HAL Id : tel-01176200, version 1

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Sandra Kobaïter Maarawi. Effets électrophysiologiques de la stimulation du cortex moteur sur les noyaux somatosensorielslatéraux du thalamus : étude expérimentale sur un modèle de stimulation du cortex moteur chez le chat. Neurosciences [q-bio.NC]. Université Claude Bernard - Lyon I, 2013. Français. ⟨NNT : 2013LYO10100⟩. ⟨tel-01176200⟩

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