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Élaboration d'assemblages colloïdaux à partir de nanoparticules de poly(acide lactique) et de chitosane

Abstract : Colloidal assemblies may be a promising pathway to obtain injectable scaffolds favoring the development of neo-tissue in regenerative medicine. This work investigates the formation of such assemblies composed of chitosan, soluble or in suspension (nano-hydrogel), and poly(lactic acid) (PLA) nanoparticles. Two types of assemblies are studied. As a first approach, mixing negatively charged PLA particles and chitosan solution leads to the formation of “composite gels”, based on colloidpolymer interactions. Rheological and Small Angle X-Ray Scattering measurements highlighted the formation process and the influence of various parameters on final properties of these gels, which features shear-thinning and reversibility behavior, that is, the capacity to gel again after yielding. PLA nanoparticles could also be mixed with cationic chitosan nanoparticles, which are crosslinker free nano-hydrogels, leading to the formation of “colloidal gels”, based on colloid-colloid interactions. Influence of various parameters on gel synthesis and properties are investigated through rheological measurements. The study also focuses on the characterization and control of the morphological and cohesion properties of chitosan nanogel
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  • HAL Id : tel-01174097, version 1

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Rémi Roux. Élaboration d'assemblages colloïdaux à partir de nanoparticules de poly(acide lactique) et de chitosane. Matériaux. Université Claude Bernard - Lyon I, 2013. Français. ⟨NNT : 2013LYO10088⟩. ⟨tel-01174097⟩

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