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Nucléation non-photochimique induite par laser (NPLIN) : Application à la carbamazépine et résultats préliminaires sur le sulfathiazole

Abstract : Polymorphism study of pharmaceutical compounds is a growing field. This is due, on one hand, to the economic pressure of the pharmaceutical industry and on the other hand, to the more awareness of the polymorphism consequences on the drug properties (chemical and physical stability, solubility, dissolution rate, bioavailibality, mechanical properties,manufacturing process, etc).This thesis studies the crystallisation of organic pharmaceutical molecules by using the Non Photochemical Light Induced technique. Within this context, a new semi-automatic experimental setup suitable to the requirements of NPLIN studies was devised and realised,allowing the control of many parameters and a simultaneous processing of a great number of samples and thus saving a considerable amount of time. A strict working methodology is also established to limit experimental errors. The study of the impact of laser parameters on the crystallisation of carbamazepine and sulfathiazole within different solvents (methanol,ethanol, acetonitrile) was carried-out. The obtained results allowed demonstrating, for the first time in literature, that NPLIN allows to obtain CBZ and sulfathiazole crystals for which the polymorphic forms depend upon the laser polarisation and solvent type. An approach for predicting the polymorphic form of organic molecules in the CSD database, for the case of NPLIN, was proposed and applied for the case of CBZ and sulfathiazole that were studied experimentally. We have also provided hypotheses to explain the mechanisms involved in NPLIN nucleation.
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Submitted on : Tuesday, June 30, 2015 - 11:02:07 AM
Last modification on : Tuesday, December 7, 2021 - 2:58:02 PM
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  • HAL Id : tel-01169762, version 1

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Aziza Ikni. Nucléation non-photochimique induite par laser (NPLIN) : Application à la carbamazépine et résultats préliminaires sur le sulfathiazole. Autre. Ecole Centrale Paris, 2015. Français. ⟨NNT : 2015ECAP0022⟩. ⟨tel-01169762⟩

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