N. Noradrenalina, N. Transportador-de-noradrenalina, N. Núcleo-do-trato-solitário, O. Mundial-de-saúde, and P. , Óxido Nítrico; Nitric Oxide NOS Óxido Nítrico Sintase, Pressão Arterial Sistólica PAI -1 .......... Inibidor do Ativador de Plasminogênio 1

R. Mssenger-ribonucleic-acid, R. Reativa-de-nitrogênio, R. Ventrolateral-rostral-do-bulbo, S. Sistema-nervoso-central, and S. , Ácido Ribonucleico mensageiro Rato Espontaneamente Hipertenso; Spontaneously Hypertensive Rats SNCSistema Nervoso Parassimpático FIGURA 4, p.72

E. Ford, C. Li, and G. Zhao, Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US*, Journal of Diabetes, vol.32, issue.13, pp.180-93, 2010.
DOI : 10.1111/j.1753-0407.2010.00078.x

S. Daniels, D. Arnett, R. Eckel, S. Gidding, L. Hayman et al., Overweight in Children and Adolescents: Pathophysiology, Consequences, Prevention, and Treatment, Circulation, vol.111, issue.15, pp.1999-2012, 2005.
DOI : 10.1161/01.CIR.0000161369.71722.10

S. Lottenberg, A. Glezer, and L. Turatti, Metabolic syndrome: identifying the risk factors, Jornal de Pediatria, vol.83, issue.8, pp.204-212, 2007.
DOI : 10.2223/JPED.1715

G. Reaven and . Banting-lecture, Role of insulin resistance in human disease, 1988.

J. Batsis, R. Nieto-martinez, and F. Lopez-jimenez, Metabolic Syndrome: From Global Epidemiology to Individualized Medicine, Clinical Pharmacology & Therapeutics, vol.120, issue.5, 2007.
DOI : 10.1038/sj.clpt.6100355

R. Eckel, S. Grundy, and P. Zimmet, The metabolic syndrome. Lancet, pp.1415-1443, 2005.

G. Fodor, Le syndrome métobolique. Bulletin -Association canadiense de réadaptation cardiaque, pp.1-4, 2006.

N. Kaplan, The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension, Archives of Internal Medicine, vol.149, issue.7, pp.1514-1534, 1989.
DOI : 10.1001/archinte.149.7.1514

R. Kahn, J. Buse, E. Ferrannini, and M. Stern, The metabolic syndrome: time for a critical appraisal, Diabetologia, vol.28, issue.9, pp.1684-99, 2005.
DOI : 10.1007/s00125-005-1876-2

C. Aguilar-salinas, R. Rojas, F. Gomez-perez, R. Mehta, A. Franco et al., The Metabolic Syndrome: A Concept Hard to Define, Archives of Medical Research, vol.36, issue.3, 2005.
DOI : 10.1016/j.arcmed.2004.12.003

K. Alberti, P. Zimmet, and J. Shaw, The metabolic syndrome???a new worldwide definition, The Lancet, vol.366, issue.9491, pp.1059-62, 2005.
DOI : 10.1016/S0140-6736(05)67402-8

A. Saltiel, Series Introduction: The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases, Journal of Clinical Investigation, vol.106, issue.2, pp.163-167, 2000.
DOI : 10.1172/JCI10533

P. Arner, Not all fat is alike. Lancet, pp.1301-1303, 1998.
DOI : 10.1016/s0140-6736(05)79052-8

G. Boden, X. Chen, J. Ruiz, J. White, and L. Rossetti, Mechanisms of fatty acid-induced inhibition of glucose uptake., Journal of Clinical Investigation, vol.93, issue.6, pp.2438-2484, 1994.
DOI : 10.1172/JCI117252

T. Lam, G. Van-de-werve, and A. Giacca, Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites, American Journal of Physiology - Endocrinology And Metabolism, vol.284, issue.2, pp.281-90, 2003.
DOI : 10.1152/ajpendo.00332.2002

M. Krebs, M. Krssak, P. Nowotny, D. Weghuber, S. Gruber et al., Free Fatty Acids Inhibit the Glucose-Stimulated Increase of Intramuscular Glucose-6-Phosphate Concentration in Humans, Journal of Clinical Endocrinology & Metabolism, vol.86, issue.5, pp.2153-60, 2001.
DOI : 10.1210/jc.86.5.2153

M. Griffin, M. Marcucci, G. Cline, K. Bell, N. Barucci et al., Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade, Diabetes, vol.48, issue.6, pp.1270-1274, 1999.
DOI : 10.2337/diabetes.48.6.1270

M. Ellmerer, M. Hamilton-wessler, S. Kim, K. Huecking, E. Kirkman et al., Reduced access to insulin-sensitive tissues in dogs with obesity secondary to increased fat intake. Diabetes, pp.1769-75, 2006.

J. Pickup and M. Crook, Is type II diabetes mellitus a disease of the innate immune system? Diabetologia, pp.1241-1249, 1998.

J. Yudkin, Adipose tissue, insulin action and vascular disease: inflammatory signals, International Journal of Obesity, vol.27, pp.25-33, 2003.
DOI : 10.1038/sj.ijo.0802496

V. Mohamed-ali, J. Pinkney, and S. Coppack, Adipose tissue as an endocrine and paracrine organ, International Journal of Obesity, vol.22, issue.12, pp.1145-58, 1998.
DOI : 10.1038/sj.ijo.0800770

F. Giorgino, L. Laviola, and J. Eriksson, Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies, Acta Physiologica Scandinavica, vol.19, issue.1, 2005.
DOI : 10.1007/s001250051075

P. Kern, M. Saghizadeh, J. Ong, R. Bosch, R. Deem et al., The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase., Journal of Clinical Investigation, vol.95, issue.5, pp.2111-2120, 1995.
DOI : 10.1172/JCI117899

S. Barroso, V. Abreu, and E. Francischetti, The adipose tissue in the genesis of hypertension and atherosclerotic cardiovascular disease. An emerging concept], Arq Bras Cardiol, vol.78, issue.6, pp.618-648, 2002.

C. Desouza, L. Gilling, and V. Fonseca, Management of the insulin resistance syndrome, Current Diabetes Reports, vol.85, issue.suppl 2, pp.140-147, 2001.
DOI : 10.1007/s11892-001-0026-6

D. Mozaffarian, T. Pischon, S. Hankinson, N. Rifai, K. Joshipura et al., Dietary intake of trans fatty acids and systemic inflammation in women, Am J Clin Nutr, vol.79, issue.4, pp.606-618, 2004.

H. Hermsdorff and J. Monteiro, Gordura visceral, subcut??nea ou intramuscular: onde est?? o problema?, Arquivos Brasileiros de Endocrinologia & Metabologia, vol.48, issue.6, pp.803-814, 2004.
DOI : 10.1590/S0004-27302004000600005

URL : http://www.scielo.br/pdf/abem/v48n6/a05v48n6.pdf

G. Poli, R. Schaur, W. Siems, and G. Leonarduzzi, 4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest, Medicinal Research Reviews, vol.12, issue.132, pp.569-631, 2008.
DOI : 10.1002/med.20117

C. Santos, L. Tanaka, J. Wosniak, and F. Laurindo, Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase, Antioxidants & Redox Signaling, vol.11, issue.10, pp.2409-2436, 2009.
DOI : 10.1089/ars.2009.2625

G. Aldini, I. Dalle-donne, R. Facino, A. Milzani, and M. Carini, Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls, Medicinal Research Reviews, vol.278, issue.132
DOI : 10.1002/med.20073

R. Touyz and E. Schiffrin, Reactive oxygen species in vascular biology: implications in hypertension, Histochemistry and Cell Biology, vol.108, issue.4, pp.339-52, 2004.
DOI : 10.1007/s00418-004-0696-7

P. Pacher, J. Beckman, and L. Liaudet, Nitric Oxide and Peroxynitrite in Health and Disease, Physiological Reviews, vol.87, issue.1, pp.315-424, 2007.
DOI : 10.1152/physrev.00029.2006

E. Ferrannini, Insulin resistance, iron, and the liver, The Lancet, vol.355, issue.9222, pp.2181-2183, 2000.
DOI : 10.1016/S0140-6736(00)02397-7

M. Jehn, J. Clark, and E. Guallar, Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care, pp.2422-2430, 2004.

Q. Chi, T. Wang, and K. Huang, Effect of insulin nitration by peroxynitrite on its biological activity, Biochemical and Biophysical Research Communications, vol.330, issue.3, pp.791-797, 2005.
DOI : 10.1016/j.bbrc.2005.03.034

L. Sobrevia and G. Mann, Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycaemia, Experimental Physiology, vol.82, issue.3, pp.423-52, 1997.
DOI : 10.1113/expphysiol.1997.sp004038

T. Fagan and P. Deedwania, The cardiovascular dysmetabolic syndrome, The American Journal of Medicine, vol.105, issue.1
DOI : 10.1016/S0002-9343(98)00216-2

K. Griendling, D. Sorescu, and M. Ushio-fukai, NAD(P)H Oxidase : Role in Cardiovascular Biology and Disease, Circulation Research, vol.86, issue.5, pp.494-501, 2000.
DOI : 10.1161/01.RES.86.5.494

L. Bahia, L. De-aguiar, N. Villela, D. Bottino, and E. Bouskela, O endot??lio na s??ndrome metab??lica, Arquivos Brasileiros de Endocrinologia & Metabologia, vol.50, issue.2, pp.291-303, 2006.
DOI : 10.1590/S0004-27302006000200015

H. Hong, G. Hsiao, T. Cheng, and M. Yen, Supplemention With Tetrahydrobiopterin Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats, Hypertension, vol.38, issue.5, pp.1044-1052, 2001.
DOI : 10.1161/hy1101.095331

J. Pessin and A. Saltiel, Signaling pathways in insulin action: molecular targets of insulin resistance, Journal of Clinical Investigation, vol.106, issue.2, pp.165-174, 2000.
DOI : 10.1172/JCI10582

J. Pirart, Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (3rd and last part) (author's transl)]. Diabete Metab Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) UK Prospective Diabetes Study (UKPDS) Group. Lancet, pp.245-56837, 1977.

D. Nathan, Long-Term Complications of Diabetes Mellitus, New England Journal of Medicine, vol.328, issue.23, 1993.
DOI : 10.1056/NEJM199306103282306

A. Guyton, J. Hall, T. Lohmeier, T. Jackson, and P. Kastner, Blood pressure regulation: basic concepts. Fed Proc, pp.2252-2258, 1981.

E. Schiffrin, Reactivity of small blood vessels in hypertension: relation with structural changes. State of the art lecture., Hypertension, vol.19, issue.2_Suppl, pp.1-9, 1992.
DOI : 10.1161/01.HYP.19.2_Suppl.II1-a

M. Mulvany, Resistance vessel structure and the pathogenesis of hypertension, Journal of Hypertension, vol.11, issue.5
DOI : 10.1097/00004872-199312050-00003

H. Bohlen, Localization of vascular resistance changes during hypertension, Hypertension, vol.8, issue.3
DOI : 10.1161/01.HYP.8.3.181

J. Iriuchijima, S. Mizogami, and H. Sokabe, Sympathetic Nervous Activity in Renal and DOC Hypertensive Rats, Japanese Heart Journal, vol.16, issue.1, pp.36-43, 1975.
DOI : 10.1536/ihj.16.36

C. Feldstein and J. S. , The complex interaction between overweight, hypertension, and sympathetic overactivity, Journal of the American Society of Hypertension, vol.3, issue.6, 2009.
DOI : 10.1016/j.jash.2009.10.001

B. Folkow, Physiological aspects of primary hypertension, Physiol Rev, 1982.

A. Nascimento, M. Lessa, B. Sabino, P. Bousquet, and E. Tibirica, Microvascular Effects of Centrally Acting Antihypertensive Drugs in Spontaneously Hypertensive Rats, Journal of Cardiovascular Pharmacology, vol.55, issue.3, pp.240-247, 2010.
DOI : 10.1097/FJC.0b013e3181ce9810

J. Frisbee, Hypertension-independent microvascular rarefaction in the obese

R. De-jongh, E. Serne, R. Ij, G. De-vries, and C. Stehouwer, Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle, Jun Diabetes, vol.12109, issue.121, pp.383-92, 2004.

M. Bitar, S. Wahid, S. Mustafa, E. Saleh, G. Dhaunsi et al., Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes, European Journal of Pharmacology, vol.511, issue.1, pp.53-64, 2005.
DOI : 10.1016/j.ejphar.2005.01.014

S. Gudbjornsdottir, M. Sjostrand, L. Strindberg, and P. Lonnroth, Decreased Muscle Capillary Permeability Surface Area in Type 2 Diabetic Subjects, The Journal of Clinical Endocrinology & Metabolism, vol.90, issue.2
DOI : 10.1210/jc.2004-0947

P. Marin, B. Andersson, M. Krotkiewski, and P. Bjorntorp, Muscle fiber composition and capillary density in women and men with NIDDM. Diabetes Care, 1994.

T. Chung, A. Liu, and J. Yu, Increased red cell rigidity might affect retinal capillary blood flow velocity and oxygen transport efficiency in type II diabetes

A. Goldin, J. Beckman, A. Schmidt, and M. Creager, Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury, Circulation, vol.114, issue.6, pp.597-605, 2006.
DOI : 10.1161/CIRCULATIONAHA.106.621854

N. Wiernsperger, P. Nivoit, D. Aguiar, L. Bouskela, and E. , Microcirculation and the metabolic syndrome. Microcirculation, pp.4-5403, 2007.

E. Dusserre, P. Moulin, and H. Vidal, Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1500, issue.1, pp.88-96, 2000.
DOI : 10.1016/S0925-4439(99)00091-5

F. Massiera, M. Bloch-faure, D. Ceiler, K. Murakami, A. Fukamizu et al., Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation, The FASEB Journal, vol.15, issue.14, pp.2727-2736, 2001.
DOI : 10.1096/fj.01-0457fje

M. Katovich and A. Pachori, Effects of inhibition of the renin-angiotensin system on the cardiovascular actions of insulin, Diabetes, Obesity and Metabolism, vol.5, issue.1, pp.3-14, 2000.
DOI : 10.1097/00004872-199816110-00012

J. Hall, Pathophysiology of obesity hypertension, Current Hypertension Reports, vol.44, issue.2, 2000.
DOI : 10.1007/s11906-000-0073-4

S. Verma, S. Bhanot, and J. Mcneill, Effect of chronic endothelin blockade in hyperinsulinemic hypertensive rats, Am J Physiol, vol.269, issue.6 2, pp.2017-2038, 1995.

A. Rocchini, H. Mao, K. Babu, P. Marker, and A. Rocchini, Clonidine Prevents Insulin Resistance and Hypertension in Obese Dogs, Hypertension, vol.33, issue.1, pp.548-53, 1999.
DOI : 10.1161/01.HYP.33.1.548

L. Landsberg, Role of the Sympathetic Adrenal System in the Pathogenesis of the Insulin Resistance Syndrome, Annals of the New York Academy of Sciences, vol.18, issue.1 THE METABOLIC, pp.84-90, 1999.
DOI : 10.1056/NEJM199602083340607

J. Hall, D. Hildebrandt, and J. Kuo, Obesity hypertension: role of leptin and sympathetic nervous system, American Journal of Hypertension, vol.14, issue.11, pp.103-118, 2001.
DOI : 10.1016/S0895-7061(01)02077-5

G. Riccardi and A. Rivellese, Dietary treatment of the metabolic syndrome ??? the optimal diet, British Journal of Nutrition, vol.319, issue.S1, pp.143-151, 2000.
DOI : 10.1016/S0026-0495(96)90129-8

G. Reaven, Do high carbohydrate diets prevent the development or attenuate the manifestations (or both) of syndrome X? A viewpoint strongly against, Current Opinion in Lipidology, vol.8, issue.1, pp.23-30, 1997.
DOI : 10.1097/00041433-199702000-00006

A. Sartorio, F. Agosti, M. Resnik, and C. Lafortuna, Effects of a 3-week integrated body weight reduction program on leptin levels and body composition in severe obese subjects, Journal of Endocrinological Investigation, vol.24, issue.3, pp.250-256, 2003.
DOI : 10.1007/BF03345165

C. Slentz, J. Houmard, and W. Kraus, Exercise, Abdominal Obesity, Skeletal Muscle, and Metabolic Risk: Evidence for a Dose Response, Obesity, vol.286, issue.1, 2009.
DOI : 10.1249/01.jes.0000240019.07502.01

J. Frisbee, J. Samora, J. Peterson, and R. Bryner, Exercise training blunts microvascular rarefaction in the metabolic syndrome, AJP: Heart and Circulatory Physiology, vol.291, issue.5
DOI : 10.1152/ajpheart.00566.2006

H. Kang, B. Gutin, P. Barbeau, S. Owens, C. Lemmon et al., Physical training improves insulin resistance syndrome markers in obese adolescents, Medicine & Science in Sports & Exercise, vol.34, issue.12, pp.1920-1927, 2002.
DOI : 10.1097/00005768-200212000-00010

J. Redon, R. Cifkova, S. Laurent, P. Nilsson, K. Narkiewicz et al., The metabolic syndrome in hypertension: European society of hypertension position statement, Journal of Hypertension, vol.26, issue.10, pp.1891-900, 2008.
DOI : 10.1097/HJH.0b013e328302ca38

M. Granberry and V. Fonseca, Insulin Resistance Syndrome, Southern Medical Journal, vol.92, issue.1
DOI : 10.1097/00007611-199901000-00002

S. Sbdc, III Diretrizes Brasileiras sobre Dislipidemias e Diretriz de Prevenção da Aterosclerose do Departamento de Aterosclerose da SBC, Arquivos Brasileiros de Cardiologia, vol.77, issue.III, pp.1-48, 2001.

S. Aicher, T. Milner, V. Pickel, and D. Reis, Anatomical substrates for baroreflex sympathoinhibition in the rat, Brain Research Bulletin, vol.51, issue.2, pp.107-117, 2000.
DOI : 10.1016/S0361-9230(99)00233-6

M. Kumada, N. Terui, and T. Kuwaki, Arterial baroreceptor reflex: Its central and peripheral neural mechanisms, Progress in Neurobiology, vol.35, issue.5, pp.331-61, 1990.
DOI : 10.1016/0301-0082(90)90036-G

M. Sun, Central neural organization and control of sympathetic nervous system in mammals, Progress in Neurobiology, vol.47, issue.3, pp.157-233, 1995.
DOI : 10.1016/0301-0082(95)00026-8

Y. Landry and J. Gies, Pharmacologie: des cibles vers l'indication thérapeutique Paris: Dunod, 2009.

M. Sun, Pharmacology of reticulospinal vasomotor neurons in cardiovascular regulation, Pharmacol Rev, vol.48, issue.4, pp.465-94, 1996.

E. Tibirica, J. Feldman, C. Mermet, F. Gonon, and P. Bousquet, An imidazolinespecific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan, J Pharmacol Exp Ther. Feb, vol.256, issue.2, pp.606-619, 1991.

B. Szabo, Imidazoline antihypertensive drugs: a critical review on their mechanism of action, Pharmacology & Therapeutics, vol.93, issue.1, pp.1-35, 2002.
DOI : 10.1016/S0163-7258(01)00170-X

L. Isaac, Clonidine in the Central Nervous System, Journal of Cardiovascular Pharmacology, vol.2, issue.1, pp.5-19, 1980.
DOI : 10.1097/00005344-198000021-00002

P. Bousquet, J. Feldman, and J. Schwartz, Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines, J Pharmacol

P. Bousquet, Imidazoline receptors, Neurochemistry International, vol.30, issue.1, pp.3-7, 1997.
DOI : 10.1016/S0197-0186(96)00039-3

D. Reis, G. Li, and S. Regunathan, Endogenous Ligands of Imidazoline Receptors: Classic and Immunoreactive Clonidine-Displacing Substance and Agmatine, Annals of the New York Academy of Sciences, vol.17, issue.1
DOI : 10.1016/0006-2952(89)90044-0

N. Morgan and S. Chan, Imidazoline Binding Sites in the Endocrine Pancreas: Can They Fulfil Their Potential as Targets for the Development of New Insulin Secretagogues?, Current Pharmaceutical Design, vol.7, issue.14
DOI : 10.2174/1381612013397366

G. Mory, F. Tesson, M. Combes-george, M. Nechad, and A. Parini, Binding Site in Rat Brown Adipocytes, Annals of the New York Academy of Sciences, vol.222, issue.1 The Imidazoli, pp.398-400, 1995.
DOI : 10.1016/0006-2952(83)90259-9

D. Separovic, M. Kester, and P. Ernsberger, Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells, Mol Pharmacol

P. Ernsberger, T. Damon, L. Graff, S. Schafer, and C. Mo, Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites, J Pharmacol Exp Ther, vol.264, issue.1, pp.172-82, 1993.

H. Rupp and R. Jacob, Excess catecholamines and the metabolic syndrome: Should central imidazoline receptors be a therapeutic target?, Medical Hypotheses, vol.44, issue.3, 1995.
DOI : 10.1016/0306-9877(95)90139-6

P. Ernsberger, M. Graves, L. Graff, N. Zakieh, P. Nguyen et al., -Imidazoline Receptors., Annals of the New York Academy of Sciences, vol.18, issue.1 The Imidazoli, pp.22-42, 1995.
DOI : 10.1016/S0090-6980(80)80047-5

D. Urosevic, S. Schann, J. Ehrhardt, P. Bousquet, and H. Greney, LNP 906, the first high-affinity photoaffinity ligand selective for I1 imidazoline receptors, Br J Pharmacol

J. Carroll, M. Huang, R. Hester, K. Cockrell, and H. Mizelle, Hemodynamic Alterations in Hypertensive Obese Rabbits, Hypertension, vol.26, issue.3, pp.465-70, 1995.
DOI : 10.1161/01.HYP.26.3.465

J. Young and L. Landsberg, Suppression of sympathetic nervous system during fasting. Science, Jun, vol.24196, issue.4297, pp.1473-1478, 1977.

J. Young and L. Landsberg, Stimulation of the sympathetic nervous system during sucrose feeding, Nature, vol.239, issue.5629, pp.615-622, 1977.
DOI : 10.1038/269615a0

J. Schwartz, J. Young, and L. Landsberg, Effect of dietary fat on sympathetic nervous system activity in the rat., Journal of Clinical Investigation, vol.72, issue.1, pp.361-70, 1983.
DOI : 10.1172/JCI110976

L. Kaufman, J. Young, and L. Landsberg, Effect of protein on sympathetic nervous system activity in the rat. Evidence for nutrient-specific responses., Journal of Clinical Investigation, vol.77, issue.2, 1986.
DOI : 10.1172/JCI112336

A. Mark, M. Correia, D. Morgan, R. Shaffer, and W. Haynes, Obesity-Induced Hypertension : New Concepts From the Emerging Biology of Obesity, Hypertension, vol.33, issue.1, pp.537-578, 1999.
DOI : 10.1161/01.HYP.33.1.537

G. Mancia, P. Bousquet, J. Elghozi, M. Esler, G. Grassi et al., The sympathetic nervous system and the metabolic syndrome, Journal of Hypertension, vol.25, issue.5, 2007.
DOI : 10.1097/HJH.0b013e328048d004

L. Landsberg, Hyperinsulinemia: possible role in obesity-induced hypertension., Hypertension, vol.19, issue.1_Suppl
DOI : 10.1161/01.HYP.19.1_Suppl.I61

M. Tuck, Obesity, the sympathetic nervous system, and essential hypertension., Hypertension, vol.19, issue.1_Suppl
DOI : 10.1161/01.HYP.19.1_Suppl.I67

G. Grassi and M. Esler, How to assess sympathetic activity in humans, Journal of Hypertension, vol.17, issue.6
DOI : 10.1097/00004872-199917060-00001

G. Grassi, R. Dell-'oro, F. Quarti-trevano, F. Scopelliti, G. Seravalle et al., Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome, Diabetologia, vol.23, issue.7
DOI : 10.1007/s00125-005-1798-z

H. S. Van-de-borne, M. W. , S. E. , F. V. , and S. A. , Symathetic overactivity as an early manifestation of metabolic syndrome

G. Grassi, R. Dell-'oro, A. Facchini, Q. Trevano, F. Bolla et al., Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives, Journal of Hypertension, vol.22, issue.12, pp.2363-2372, 2004.
DOI : 10.1097/00004872-200412000-00019

G. Grassi, G. Seravalle, R. Dell-'oro, C. Turri, G. Bolla et al., Adrenergic and Reflex Abnormalities in Obesity-Related Hypertension, Hypertension, vol.36, issue.4, 2000.
DOI : 10.1161/01.HYP.36.4.538

K. Mather, A. Lteif, H. Steinberg, and A. Baron, Interactions Between Endothelin and Nitric Oxide in the Regulation of Vascular Tone in Obesity and Diabetes, Diabetes, vol.53, issue.8
DOI : 10.2337/diabetes.53.8.2060

A. Nascimento, M. Machado, N. De-jesus, F. Gomes, M. Lessa et al., Structural and functional microvascular alterations in a rat model of metabolic syndrome induced by a high-fat diet, Obesity, vol.26, issue.10, 2013.
DOI : 10.1002/oby.20358

B. Sabino, M. Lessa, A. Nascimento, C. Rodrigues, M. Henriques et al., Effects of Antihypertensive Drugs on Capillary Rarefaction in Spontaneously Hypertensive Rats: Intravital Microscopy and Histologic Analysis, Journal of Cardiovascular Pharmacology, vol.51, issue.4, pp.402-411, 2008.
DOI : 10.1097/FJC.0b013e3181673bc5

H. Henrich, W. Romen, W. Heimgartner, E. Hartung, and F. Baumer, Capillary rarefaction characteristic of the skeletal muscle of hypertensive patients, Klinische Wochenschrift, vol.20, issue.Suppl 1, pp.54-60, 1988.
DOI : 10.1007/BF01713011

W. Friedewald, R. Levy, and D. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, vol.18, issue.6, pp.499-502, 1972.

L. Junqueira, G. Bignolas, and R. Brentani, Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections, The Histochemical Journal, vol.9, issue.4
DOI : 10.1007/BF01002772

M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, 1976.
DOI : 10.1016/0003-2697(76)90527-3

Y. Kou, P. Ernsberger, P. Cragg, N. Cherniack, and N. Prabhakar, Role of ??2-adrenergic receptors in the carotid body response to isocapnic hypoxia, Respiration Physiology, vol.83, issue.3, pp.353-64, 1991.
DOI : 10.1016/0034-5687(91)90054-M

G. Young and J. Kirkland, Rat models of caloric intake and activity: relationships to animal physiology and human health, Applied Physiology, Nutrition, and Metabolism, vol.32, issue.2, pp.161-76, 2007.
DOI : 10.1139/h06-082

J. Masek and P. Fabry, High-fat diet and the development of obesity in albino rats

J. Scholmerich, Defining high-fat-diet rat models: metabolic and molecular effects of different fat types, J Mol Endocrinol, vol.36, issue.3, pp.485-501, 2006.

D. Carr, K. Utzschneider, R. Hull, K. Kodama, B. Retzlaff et al., Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome, Diabetes, vol.53, issue.8, 2004.
DOI : 10.2337/diabetes.53.8.2087

C. Fox, J. Massaro, U. Hoffmann, K. Pou, P. Maurovich-horvat et al., Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study, Circulation, vol.116, issue.1, pp.39-48, 2007.
DOI : 10.1161/CIRCULATIONAHA.106.675355

I. Bonomo, P. Lisboa, A. Pereira, M. Passos, and E. De-moura, Prolactin inhibition in dams during lactation programs for overweight and leptin resistance in adult offspring, Journal of Endocrinology, vol.192, issue.2, pp.339-383, 2007.
DOI : 10.1677/joe.1.06952

P. Yaqoob, E. Sherrington, N. Jeffery, P. Sanderson, D. Harvey et al., Comparison of the effects of a range of dietary lipids upon serum and tissue lipid composition in the rat, The International Journal of Biochemistry & Cell Biology, vol.27, issue.3, pp.297-310, 1995.
DOI : 10.1016/1357-2725(94)00065-J

T. Ogihara, T. Asano, K. Ando, H. Sakoda, M. Anai et al., High-Salt Diet Enhances Insulin Signaling and Induces Insulin Resistance in Dahl Salt-Sensitive Rats, Hypertension, vol.40, issue.1
DOI : 10.1161/01.HYP.0000022880.45113.C9

S. Grundy, H. Brewer, J. Cleeman, J. Smith, S. et al., Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition, Circulation, 2004.

D. Quilliot, L. Fluckiger, F. Zannad, P. Drouin, and O. Ziegler, Impaired autonomic control of heart rate and blood pressure in obesity: role of age and of insulin-resistance, Clinical Autonomic Research, vol.311, issue.2
DOI : 10.1007/BF02322050

J. Sowers, M. Nyby, N. Stern, F. Beck, S. Baron et al., Blood pressure and hormone changes associated with weight reduction in the obese, Hypertension, vol.4, issue.5
DOI : 10.1161/01.HYP.4.5.686

A. Dobrian, S. Schriver, T. Lynch, and R. Prewitt, Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity, American Journal of Physiology - Renal Physiology, vol.285, issue.4
DOI : 10.1152/ajprenal.00388.2002

V. Gaal, L. Mertens, I. , D. Block, and C. , Mechanisms linking obesity with cardiovascular disease, Nature, vol.105, issue.7121, pp.875-80, 2006.
DOI : 10.1038/nature05487

H. Hayakawa, K. Coffee, and L. Raij, Endothelial Dysfunction and Cardiorenal Injury in Experimental Salt-Sensitive Hypertension : Effects of Antihypertensive Therapy, Circulation, vol.96, issue.7
DOI : 10.1161/01.CIR.96.7.2407

T. Luscher, L. Raij, and P. Vanhoutte, Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats, Hypertension, vol.9, issue.2, pp.157-63, 1987.
DOI : 10.1161/01.HYP.9.2.157

R. Ostlund, . Jr, J. Yang, S. Klein, and R. Gingerich, Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates, J Clin Endocrinol Metab, vol.81, issue.11, pp.3909-3922, 1996.
DOI : 10.1210/jc.81.11.3909

W. Haynes, D. Morgan, A. Djalali, W. Sivitz, and A. Mark, Interactions Between the Melanocortin System and Leptin in Control of Sympathetic Nerve Traffic, Hypertension, vol.33, issue.1
DOI : 10.1161/01.HYP.33.1.542

C. Alvarez-aguilar, L. Mondragon-jimenez, J. Ramirez-enriquez, A. Gomez-garcia, R. Paniagua-sierra et al., Hiperleptinemia como factor de riesgo en hipertensi??n arterial asociada a obesidad, Medicina Cl??nica, vol.123, issue.20, pp.766-775, 2004.
DOI : 10.1157/13069809

D. Corry and M. Tuck, Obesity, hypertension, and sympathetic nervous system activity, Current Hypertension Reports, vol.30, issue.Suppl I, pp.119-145, 1999.
DOI : 10.1007/s11906-999-0005-x

G. Arcaro, A. Cretti, S. Balzano, A. Lechi, M. Muggeo et al., Insulin Causes Endothelial Dysfunction in Humans: Sites and Mechanisms, Circulation, vol.105, issue.5, pp.576-82, 2002.
DOI : 10.1161/hc0502.103333

H. Debbabi, L. Uzan, J. Mourad, M. Safar, B. Levy et al., Increased Skin Capillary Density in Treated Essential Hypertensive Patients, American Journal of Hypertension, vol.19, issue.5, 2006.
DOI : 10.1016/j.amjhyper.2005.10.021

M. Meyer, M. Pfohl, and H. Schatz, Assessment of diabetic alterations of microcirculation by means of capillaroscopy and laser-Doppler anemometry, Med Klin Feb, vol.1596, issue.2, pp.71-78, 2001.

N. Pangratis, Diagnostic investigation using vital capillary microscopy and dynamic capillaroscopy, Clin Hemorheol Microcirc, vol.17, issue.5, pp.371-83, 1997.

R. Ij, R. De-jongh, M. Beijk, M. Van-weissenbruch, H. Delemarre-van-de-waal et al., Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin, Eur J Clin Invest, 2003.

R. Prewitt, I. Chen, and R. Dowell, Development of microvascular rarefaction in the spontaneously hypertensive rat, Am J Physiol, vol.243, issue.2, pp.243-51, 1982.

R. Melo, E. Martinho, J. Michelini, and L. , Training-Induced, Pressure-Lowering Effect in SHR: Wide Effects on Circulatory Profile of Exercised and Nonexercised Muscles, Hypertension, vol.42, issue.4, pp.851-858, 2003.
DOI : 10.1161/01.HYP.0000086201.27420.33

S. Amaral, T. Zorn, and L. Michelini, Exercise training normalizes wall-to-lumen ratio of the gracilis muscle arterioles and reduces pressure in spontaneously hypertensive rats, Journal of Hypertension, vol.18, issue.11, pp.1563-72, 2000.
DOI : 10.1097/00004872-200018110-00006

T. Mattfeldt, G. Mall, H. Gharehbaghi, and P. Moller, Estimation of surface area and length with the orientator, Journal of Microscopy, vol.3, issue.Suppl II, pp.301-318, 1990.
DOI : 10.1111/j.1365-2818.1990.tb03036.x

G. Gobe, J. Browning, T. Howard, N. Hogg, C. Winterford et al., Apoptosis Occurs in Endothelial Cells during Hypertension-Induced Microvascular Rarefaction, Journal of Structural Biology, vol.118, issue.1
DOI : 10.1006/jsbi.1996.3835

F. Vega, A. Panizo, J. Pardo-mindan, and J. Diez, Susceptibility to apoptosis measured by MYC, BCL-2, and BAX expression in arterioles and capillaries of adult spontaneously hypertensive rats, American Journal of Hypertension, vol.12, issue.8, pp.815-835, 1999.
DOI : 10.1016/S0895-7061(99)00045-X

L. Bongartz, M. Cramer, P. Doevendans, J. Joles, and B. Braam, The severe cardiorenal syndrome: 'Guyton revisited', European Heart Journal, vol.26, issue.1, pp.11-18, 2005.
DOI : 10.1093/eurheartj/ehi020

P. Van-zwieten, M. Thoolen, and P. Timmermans, The hypotensive activity and side effects of methyldopa, clonidine, and guanfacine. Hypertension, 1984.

J. Meana, M. Herrera-marschitz, M. Goiny, and R. Silveira, Modulation of catecholamine release by ??2-adrenoceptors and I1-imidazoline receptors in rat brain, Brain Research, vol.744, issue.2, pp.216-242, 1997.
DOI : 10.1016/S0006-8993(96)01080-3

E. Henriksen, S. Jacob, D. Fogt, E. Youngblood, and J. Godicke, Antihypertensive Agent Moxonidine Enhances Muscle Glucose Transport in Insulin-Resistant Rats, Hypertension, vol.30, issue.6
DOI : 10.1161/01.HYP.30.6.1560

R. Velliquette and P. Ernsberger, Contrasting Metabolic Effects of Antihypertensive Agents, Journal of Pharmacology and Experimental Therapeutics, vol.307, issue.3, pp.1104-1115, 2003.
DOI : 10.1124/jpet.103.054221

M. Berthault, J. Morin, M. Dubar, A. Ktorza, P. Ferre et al., Effects of rilmenidine in rats made resistant to insulin and hypertensive by a high-fructose diet, Journal of Hypertension, vol.15, issue.6
DOI : 10.1097/00004872-199715060-00023

L. Penicaud, M. Berthault, J. Morin, M. Dubar, A. Ktorza et al., Rilmenidine normalizes fructose-induced insulin resistance and hypertension in rats, J Hypertens, vol.16, issue.3, pp.45-54, 1998.
URL : https://hal.archives-ouvertes.fr/hal-00408627

R. Velliquette, R. Kossover, S. Previs, and P. Ernsberger, Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.190, issue.Suppl 4, pp.300-312, 2006.
DOI : 10.1007/s00210-005-0024-3

R. Velliquette and P. Ernsberger, The role of I(1)-imidazoline and alpha(2)- adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X, J Pharmacol Exp Ther, 2003.

C. May, M. Dashwood, C. Whitehead, and C. Mathias, Functional and autoradiographic studies to locate the sites at which clonidine acts to cause hyperglycaemia and inhibition of opiate-induced sympathetic outflow, Neuropharmacology, vol.29, issue.6
DOI : 10.1016/0028-3908(90)90066-Z

I. Angel, S. Bidet, and S. Langer, Pharmacological characterization of the hyperglycemia induced by alpha-2 adrenoceptor agonists, J Pharmacol Exp Ther, 1988.

L. Fellmann, Rôle du système nerveux sympathique dans la physiopathologie du syndrome métabolique : approche expérimentale, 2009.

T. Yamauchi, J. Kamon, Y. Ito, A. Tsuchida, T. Yokomizo et al., Cloning of adiponectin receptors that mediate antidiabetic metabolic effects, Nature, vol.423, issue.6941, pp.762-771, 2003.
DOI : 10.1038/nature01705

URL : https://hal.archives-ouvertes.fr/hal-00094061

S. Deepa and L. Dong, APPL1: role in adiponectin signaling and beyond, AJP: Endocrinology and Metabolism, vol.296, issue.1
DOI : 10.1152/ajpendo.90731.2008

P. Lumb, Z. Mcmahon, G. Chik, and A. Wierzbicki, Effect of moxonidine on lipid subfractions in patients with hypertension, International Journal of Clinical Practice, vol.38, issue.Suppl. 3, pp.465-473, 2004.
DOI : 10.1111/j.1368-5031.2004.00158.x

M. Elisaf, C. Petris, E. Bairaktari, S. Karabina, C. Tzallas et al., The effect of moxonidine on plasma lipid profile and on LDL subclass distribution, Journal of Human Hypertension, vol.13, issue.11, pp.781-786, 1999.
DOI : 10.1038/sj.jhh.1000835

V. Estato, C. Araujo, P. Bousquet, and E. Tibirica, Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats, Brazilian Journal of Medical and Biological Research, vol.37, issue.10
DOI : 10.1590/S0100-879X2004001000014

A. Zhou, S. Egginton, O. Hudlicka, and M. Brown, Internal division of capillaries in rat skeletal muscle in response to chronic vasodilator treatment with ?? 1 -antagonist prazosin, Cell and Tissue Research, vol.293, issue.2, pp.293-303, 1998.
DOI : 10.1007/s004410051121

F. Callens-el-amrani, F. Paolaggi, and B. Swynghedauw, The heart in patients with hypertension: effects of rilmenidine on experimental cardiac hypertrophy of hypertensive origin in rats]. Arch Mal Coeur Vaiss, pp.53-60, 1989.

A. Stabile, H. Aceros, K. Stockmeyer, A. Rahman, A. Noiseux et al., Mukaddam-Daher S. Functional and molecular effects of imidazoline receptor activation in heart failure, Life Sci, vol.88, pp.11-12493, 2011.

T. Michel, B. Hoffman, and R. Lefkowitz, Differential regulation of the ??2-adrenergic receptor by Na+ and guanine nucleotides, Nature, vol.193, issue.5792, pp.709-720, 1980.
DOI : 10.1038/288709a0

H. Kather and B. Simon, -subtype mediating inhibition of the human fat cell adenylate cyclase, European Journal of Clinical Investigation, vol.3, issue.2, pp.111-115, 1981.
DOI : 10.1172/JCI107556

URL : https://hal.archives-ouvertes.fr/hal-00941251

L. Gigou, Identification de protéines de liaison des imidazolines dans des modèles cellulaires de phéochromocytome de rat et d'adipocytes murins, 2011.

Y. Adachi, G. Pavlakis, and T. Copeland, Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia, J Biol Chem, vol.269, issue.3, pp.2258-62, 1994.

M. Chandran, S. Phillips, T. Ciaraldi, and R. Henry, Adiponectin: more than just another fat cell hormone? Diabetes Care, pp.2442-50, 2003.

M. Lafontan and N. Viguerie, Role of adipokines in the control of energy metabolism: focus on adiponectin, Current Opinion in Pharmacology, vol.6, issue.6, pp.580-585, 2006.
DOI : 10.1016/j.coph.2006.08.002

L. Spieker, T. Luscher, and G. Noll, Current Strategies and Perspectives for Correcting Endothelial Dysfunction in Atherosclerosis, Journal of Cardiovascular Pharmacology, vol.38, 2001.
DOI : 10.1097/00005344-200111002-00010

R. Ross, The pathogenesis of atherosclerosis: a perspective for the 1990s, Nature, vol.362, issue.6423
DOI : 10.1038/362801a0

C. Perrins and Y. Bobryshev, Current advances in understanding of immunopathology of atherosclerosis. Virchows Arch, Feb, vol.458, issue.2, pp.117-140, 2011.

W. Franz, O. Mueller, R. Hartong, N. Frey, and H. Katus, Transgenic animal models: new avenues in cardiovascular physiology, Journal of Molecular Medicine, vol.75, issue.2, 1997.
DOI : 10.1007/s001090050096

J. Davignon and M. Roy, Familial hypercholesterolemia in French-Canadians: Taking advantage of the presence of a ???founder effect???, The American Journal of Cardiology, vol.72, issue.10, pp.6-10, 1993.
DOI : 10.1016/0002-9149(93)90003-U

K. Meir and E. Leitersdorf, Atherosclerosis in the Apolipoprotein E-Deficient Mouse: A Decade of Progress, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.24, issue.6, pp.1006-1020, 2004.
DOI : 10.1161/01.ATV.0000128849.12617.f4

R. Tangirala, D. Pratico, G. Fitzgerald, S. Chun, K. Tsukamoto et al., Reduction of Isoprostanes and Regression of Advanced Atherosclerosis by Apolipoprotein E, Journal of Biological Chemistry, vol.276, issue.1, pp.261-267, 2001.
DOI : 10.1074/jbc.M003324200

S. Zhang, R. Reddick, J. Piedrahita, and N. Maeda, Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E, Science, vol.258, issue.5081
DOI : 10.1126/science.1411543

T. Hayek, J. Oiknine, J. Brook, and M. Aviram, Increased Plasma and Lipoprotein Lipid Peroxidation in apo E-Deficient Mice, Biochemical and Biophysical Research Communications, vol.201, issue.3, pp.1567-74, 1994.
DOI : 10.1006/bbrc.1994.1883

A. Daugherty, Mouse Models of Atherosclerosis, The American Journal of the Medical Sciences, vol.323, issue.1, 2002.
DOI : 10.1097/00000441-200201000-00002

K. Makaritsis, H. Gavras, Y. Du, A. Chobanian, and P. Brecher, ??1-Adrenergic Plus Angiotensin Receptor Blockade Reduces Atherosclerosis in Apolipoprotein E??Deficient Mice, Hypertension, vol.32, issue.6, pp.1044-1052, 1998.
DOI : 10.1161/01.HYP.32.6.1044

J. Chen, P. Kuhlencordt, J. Astern, R. Gyurko, and P. Huang, Hypertension Does Not Account for the Accelerated Atherosclerosis and Development of Aneurysms in Male Apolipoprotein E/Endothelial Nitric Oxide Synthase Double Knockout Mice, Circulation, vol.104, issue.20
DOI : 10.1161/hc4501.099729

S. Chrysant and G. Chrysant, Effectiveness of Lowering Blood Pressure to Prevent Stroke Versus to Prevent Coronary Events, The American Journal of Cardiology, vol.106, issue.6, pp.825-834, 2010.
DOI : 10.1016/j.amjcard.2010.05.006

F. Messerli and G. Panjrath, The J-Curve Between Blood Pressure and Coronary Artery Disease or Essential Hypertension, Journal of the American College of Cardiology, vol.54, issue.20, 2009.
DOI : 10.1016/j.jacc.2009.05.073

U. Mccann and W. Agras, Successful treatment of nonpurging bulimia nervosa with desipramine: a double-blind, placebo-controlled study, Am J Psychiatry, 1990.