Skip to Main content Skip to Navigation
Theses

The effects of central sympathetic nervous system modulation on metabolic and microcirculatory parameters in obese rats with metabolic syndrome

Abstract : Cardiovascular and metabolic risk factors that characterize the metabolic syndrome (MS), including high blood pressure, obesity and glucose intolerance, are accompanied by sympathetic hyperactivity. In this study, we investigated the effects of a chronic oral antihypertensive treatment using centrally-acting sympatho-inhibitory drugs on the metabolic and microvascular parameters in rats under long-term high-fat diet with salt supplementation. For that, fifty male adult Wistar rats were maintained under normal or high-fat diet during 20 weeks. The HFD group received oral clonidine, rilmenidine, LNP 599 or vehicle. Functional microcirculation was evaluated by intravital videomicroscopy and the structural was studied using histochemical analysis. We concluded that the modulation of sympathetic activity reverses the capillary rarefaction in the skeletal muscle and left ventricle in an experimental model of MS in rats.
Complete list of metadata

Cited literature [189 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01150661
Contributor : Abes Star :  Contact
Submitted on : Monday, May 11, 2015 - 4:22:06 PM
Last modification on : Saturday, September 22, 2018 - 3:08:01 AM
Long-term archiving on: : Monday, September 14, 2015 - 10:26:20 PM

File

Nascimento_Alessandro_2013_ED4...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01150661, version 1

Collections

Citation

Alessandro Nascimento. The effects of central sympathetic nervous system modulation on metabolic and microcirculatory parameters in obese rats with metabolic syndrome. Endocrinology and metabolism. Université de Strasbourg, 2013. Portuguese. ⟨NNT : 2013STRAJ120⟩. ⟨tel-01150661⟩

Share

Metrics

Record views

433

Files downloads

381