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La maurocalcine : substance naturelle d'intérêt thérapeutique

Abstract : Maurocalcine (MCa) is a 33-mer toxin originally isolated from the venom of the scorpioScorpio maurus palmatus, and has been considered as a cell-penetrating peptide (CPP) for severalyears. MCa presents a therapeutic interest for the intracellular delivery of cargoes, andthis thesis aims to characterise the cell penetration properties of the native molecule as well assome of its variants’.After quantifying several truncated (linear) variants’ internalisation, I have been able tohighlight the fact that all of those analogs possess a higher internalization ability than those ofstandard CPP (especially Tat and penetratin). Among those variants, the analog MCaUF1−9 hasa relatively high rentention time within cells, as well as a slightly increased accumulation whenin an acidic environment (which occurs during solid tumours formation). This new CPP showsa certain therapeutic potential but the study of nativeMCa, remarkably stable in vivo, remainsa priority.
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Céline Tisseyre. La maurocalcine : substance naturelle d'intérêt thérapeutique. Santé publique et épidémiologie. Université de Grenoble, 2014. Français. ⟨NNT : 2014GRENV047⟩. ⟨tel-01141065⟩

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