Acousto-optic and photoacoustic imaging of scattering media using wavefront adaptive holography techniques in NdYO4

Baptiste Jayet 1, 2
2 POM - Physique des Ondes pour la Médecine et la Biologie
INSERM - Institut National de la Santé et de la Recherche Médicale : U979, Institut Langevin ondes et images
Abstract : Strong scattering properties of biological media make their optical imaging in depth a challenge. A solution to probe the local optical properties is to couple the optical information with ultrasound. Two imaging techniques were born from this idea, acousto-optic imaging and photoacoustic imaging. The first technique is based on the local modulation of light by ballistic ultrasound. The latter relies on the emission of ultrasound following the absorption of light by an object. Whether it is acousto-optic imaging or photoacoustic imaging, the recording of the the signal requires a detection system sensitive to weak phase modulation. In addition, the detection system must be compatible with a speckle pattern. Dynamic holography is a good solution. Indeed, as it is based on interferometry, it is very sensitive to small phase variations and holography can be used to correct the speckle nature of light. In this manuscript, we show the use of an holographic detection system based on a laser medium (Nd:YVO4). One of the main advantage of this type of material is the very fast response time. It will be highlighted that the recording of a hologram inside our crystal can be done in less than 100 μs, much faster than the speckle decorrelation time (≈ 1ms), which is one of the major obstacle towards in vivo imaging. Three optical setups will be presented in this manuscript. The first one is a phase conjugation setup for acousto-optic detection. The second one is a wavefront adaption setup, also for acousto-optic detection. Finally, the third setup is an adaptive vibrometry setup for photoacoustic detection. In each setups the measured response time is between 15 μs and 50 μs.
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Baptiste Jayet. Acousto-optic and photoacoustic imaging of scattering media using wavefront adaptive holography techniques in NdYO4. Other [cond-mat.other]. Université Pierre et Marie Curie - Paris VI, 2015. English. ⟨NNT : 2015PA066039⟩. ⟨tel-01137779⟩

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