Skip to Main content Skip to Navigation
Theses

Étude de la variabilité des contributions de nutriments à un réseau métabolique : modélisation, optimisation et application en nutrition

Oumarou Abdou Arbi 1
1 Dyliss - Dynamics, Logics and Inference for biological Systems and Sequences
Inria Rennes – Bretagne Atlantique , IRISA-D7 - GESTION DES DONNÉES ET DE LA CONNAISSANCE
Abstract : This thesis proposes a generic approach to understanding how different diets affect the quality and composition of milk. This question is addressed in the framework of Flux Balance Analysis (FBA), which considers metabolic network analysis as an optimization issue on a system of linear constraints. In this work, we extended FBA to take into account nutrients transformation by incorporating general assumptions made by various numerical methods in a generic stoichiometric model of the mammary gland. Our method tries to quantify the precursor composition of each system output and to discuss the biological relevance of a set of flux in a given metabolic network. The composition is called contribution of inputs over outputs [AIO]. Using this method on the mammary metabolism, we could show that nutrients transformation cannot be properly modelled by optimizing a linear combination of reactions fluxes in the mammary gland model. In order to further investigate metabolic network flexibility, we have proposed an efficient local search algorithm computing the extremal values of AIO coefficients. This approach enables to discriminate diets without making any assumption on the internal behaviour of the system.
Document type :
Theses
Complete list of metadatas

Cited literature [131 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01128059
Contributor : Abes Star :  Contact
Submitted on : Monday, March 9, 2015 - 11:05:53 AM
Last modification on : Friday, July 10, 2020 - 4:03:09 PM
Long-term archiving on: : Wednesday, June 10, 2015 - 1:26:04 PM

File

2013REN1S119.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01128059, version 1

Citation

Oumarou Abdou Arbi. Étude de la variabilité des contributions de nutriments à un réseau métabolique : modélisation, optimisation et application en nutrition. Autre [cs.OH]. Université Rennes 1, 2013. Français. ⟨NNT : 2013REN1S119⟩. ⟨tel-01128059⟩

Share

Metrics

Record views

545

Files downloads

596