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Approches synthétiques de la Dasyscyphine D et du Laingolide A

Abstract : This manuscript presents the synthetic approach of two natural products, Dasyscyphin D and Laingolide A. Concerning Dasysphin D, the key step of the synthesis is a Diels-Alder cycloaddition between a diene and a dienophile, which were prepared by palladium-catalyzedcross coupling and/or metathesis reactions. For Laingolide A, several isomers have been synthesized in order to determine the relative configuration of the three stereogenic centers.This synthesis involves a tandem cross dimerization/oxonia-Cope reaction, and a final macrocyclization to install the enamide moiety.
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Submitted on : Thursday, March 15, 2018 - 10:27:07 AM
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  • HAL Id : tel-01127638, version 1


Gaétan Lemaire. Approches synthétiques de la Dasyscyphine D et du Laingolide A. Chimie organique. Université Pierre et Marie Curie - Paris VI, 2014. Français. ⟨NNT : 2014PA066501⟩. ⟨tel-01127638⟩