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Élaboration de nano-objets magnétiques dendronisés à vocation théranostic

Abstract : This thesis presents the design of dendronized magnetic nano- objects for both diagnostic imaging by MRI and magnetic hyperthermia therapy (HM). In vitro and in vivo validation of these nano-objects properties and the demonstrattion of their effectiveness for specific targeting of tumors are reported. A state of the art on the synthesis of metal oxide NPs, their functionalization and their properties in MRI and HM is presented. The influence of the NPs iron oxide functionalization method and the influence of the molecule architecture on the colloidal stability and relaxivity were studied. NPs of different sizes, morphologies and composition were then synthesized and functionalized with a dendron molecule and the MRI and HM properties were investigated. The specific targeting of melanin in melanoma was demonstrated.
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Submitted on : Friday, March 6, 2015 - 11:26:37 PM
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  • HAL Id : tel-01127005, version 1

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Aurélie Walter. Élaboration de nano-objets magnétiques dendronisés à vocation théranostic. Chimie-Physique [physics.chem-ph]. Université de Strasbourg, 2014. Français. ⟨NNT : 2014STRAE020⟩. ⟨tel-01127005⟩

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