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Stabilité de systèmes complexes d'intérêt biologique sous rayonnements ionisants.

Abstract : This PhD work presents the study of stability of molecular systems of biological interest in the gas phase after interaction with ionising radiations. The use of ionising radiation can probe the physical chemistry of complex systems at the molecular scale and thus consider their intrinsic properties. Beyond the fundamental aspect, this work is part of the overall understanding of radiation effects on living organisms and in particular the use of ionizing radiation in radiotherapy. Specifically, this study focused on the use of low-energy multiply charged ions (tens of keV) provided by the GANIL (Caen), which includes most of the experiments presented. In addition, experiments using VUV photons were also conducted at synchrotron ELETTRA (Trieste, Italy). The biomolecular systems studied are amino acids and nucleic acid constituents. Using an experimental crossed beams device allows interaction between biomolecules and ionising radiation leads mainly to the ionization and fragmentation of the system. The study of its relaxation dynamics is by time-of-flight mass spectrometry coupled to a coincidences measurements method. It is shown that an approach combining experiment and theory allows a detailed study of the fragmentation dynamics of complex systems. The results indicate that fragmentation is generally governed by the Coulomb repulsion but the intramolecular rearrangements involve specific relaxation mechanisms.
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Contributor : Sylvain Maclot <>
Submitted on : Thursday, October 16, 2014 - 5:59:15 PM
Last modification on : Thursday, January 14, 2021 - 9:45:14 AM
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  • HAL Id : tel-01074592, version 1


S. Maclot. Stabilité de systèmes complexes d'intérêt biologique sous rayonnements ionisants.. Physique [physics]. Université de Caen Basse-Normandie, 2014. Français. ⟨tel-01074592⟩



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