Imagerie photoacoustique: application au contrôle de la thérapie ultrasonore et étude de la génération par des nanoparticules d'or

Abstract : This work falls within the field of photoacoustic imaging as a promising modality for biomedical applications. It consists in experimenting photoacoustic guidance of high intensity focused ultrasound (HIFU) for therapy, and in studying photoacoustic generation by gold nanoparticles as contrast agents. First of all, a probe designed for both photoacoustic imaging and ultrasound therapy was employed for \textit{in vitro} experiments. We demonstrate the feasability of photoacoustic guidance to treat a target embedded in biological tissue, as a promising tool for HIFU control. In a second part we model the physical mechanisms of photoacoustic generation by gold nanoparticles. This allows to quantify thermoelastic nonlinearities impacting the emitted signal, which origins derive from the temperature dependence of the thermal expansion coefficient of water. In the case of a single gold nanosphere, we describe the nonlinear contribution to the signal according to the different parameters of the problem. We infer a set of quantitative predictions concerning the weight of nonlinearities on photoacoustic signals. Then we generalize these theoretical results to a collection of gold nanospheres, and confront them to our experimental results. Thermoelastic nonlinearity thereby offers a promising new type of contrast for photoacoustic imaging.
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  • HAL Id : tel-01068272, version 1

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Amaury Prost. Imagerie photoacoustique: application au contrôle de la thérapie ultrasonore et étude de la génération par des nanoparticules d'or. Physique Médicale [physics.med-ph]. Université Pierre et Marie Curie - Paris VI, 2014. Français. ⟨tel-01068272⟩

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