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Etude des phénomènes de reconnaissance moléculaire spécifique aux interfaces biologiques par AFM : investigation de l'influence de la multivalence sur les interactions sucre-lectine

Abstract : This project aims to analyze the influence of multivalency in sugar-lectin interactions. In collaboration with external teams, a study by atomic force microscopy (AFM) of the ineraction between synthetic ligands of different valences and their specific lectins was conducted. In this study, a first fundamental characterization of sugar-lectin interaction was investigated. This characterization concerns more particularly the influence of multivalency on the adhesion forces and the dynamics of interaction between multivalent ligands and synthetic model lectin, peanut lectin PNA. A second characterization, of a more applied aspect, concerns the use of synthetic multivalent ligands in a new therapeutic approach, based on anti-adhesion, for the treatment of chronic urinary infections caused by uropathogenic Escherichia coli (UPEC). The innovative nature of the ligands (obtained by rational chemical synthesis) and the approach used to characterize their interactions with lectins at the molecular level by AFM reflects the originality of the project.
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Amira Mastouri. Etude des phénomènes de reconnaissance moléculaire spécifique aux interfaces biologiques par AFM : investigation de l'influence de la multivalence sur les interactions sucre-lectine. Sciences agricoles. Université de Technologie de Compiègne, 2013. Français. ⟨NNT : 2013COMP2108⟩. ⟨tel-01067126⟩

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