Elaboration par voie sol-gel de supports macroporeux à base de verre bioactif pour l'ingénierie tissulaire. Caractérisation par micro-PIXE de leurs réactivités in vitro et in vivo

Abstract : Bioactive glasses are very interesting materials for bone regeneration because of their ability to stimulate cells responsible for bone growth with ionic products released during dissolution and for their bone bonding ability. Beyond their role as bone filling materials, they can be used as support for growth of laboratory-made bone grafts cultivated from just a few cells of a patient. This support, named scaffold, has to be an interconnected macroporous architecture in order to allow cell invasion and vascularization which is essential to cell survival. The aim of this thesis work is the realization of such a scaffold using the sol-gel foaming process. This process has been used for the synthesis of materials with different properties that were compared for determination of the most promising for in vivo implantation and was indeed able to allow cell invasion. Moreover, this process was improved to be safer by replacement of hazardous catalyst. This new process also allowed the structuration of the mesoporosity inside the foams. Incorporation of a biologically active element (strontium) was realized and its influence on the glass properties and reactivity was evaluated. Finally, the synthesis of new composite materials has been proposed: the high bioactivity of bioactive glasses is preserved while better mechanical properties are obtained thank to the use of gelatin as organic phase.
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  • HAL Id : tel-01065128, version 1

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Joséphine Lacroix. Elaboration par voie sol-gel de supports macroporeux à base de verre bioactif pour l'ingénierie tissulaire. Caractérisation par micro-PIXE de leurs réactivités in vitro et in vivo. Sciences agricoles. Université Blaise Pascal - Clermont-Ferrand II, 2013. Français. ⟨NNT : 2013CLF22372⟩. ⟨tel-01065128⟩

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