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Theses

Caractérisation de la réponse immune dans la neuromyelite optique

Abstract : Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system in which a specific antibody targeting aquaporin 4 (anti-AQP4) was recently found. The aim of this thesis is to develop a translational research in order to improve our knowledge of the immune response in NMO. We have therefore studied a animal model mimicking NMO and allowing a better comprehension of optico-spinal inflammation. In the human subjects suffering from NMO, we have also found that anti-AQP4 reactivity was not correlated to the disease activity and that reactivities against other proteins may exist. We have discovered changes in the serum concentrations of some metabolites (scyllo-inositol and acetate) and a decrease in the volume of brain white matter. These findings have to be confirmed by other studies and may improve our comprehension of NMO.
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https://tel.archives-ouvertes.fr/tel-01037926
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Submitted on : Wednesday, July 23, 2014 - 9:39:08 AM
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  • HAL Id : tel-01037926, version 1

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Jean-Baptiste Chanson. Caractérisation de la réponse immune dans la neuromyelite optique. Neurosciences [q-bio.NC]. Université de Strasbourg, 2013. Français. ⟨NNT : 2013STRAJ036⟩. ⟨tel-01037926⟩

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