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Nanoparticules dopées terres rares pour l'imagerie médicale et la thérapie

Abstract : This work has been dedicated to the development of a multistep system composed by rare earths doped nanoparticles (core), enclosed by a first undoped crystalline layer (core-shell), serving as protection of the optical properties of the core. Within a shell of mesoporous silica allowing the loading of the photosensitizer (ZnPc) via the pores of the shell of silica for a therapeutic application: the photodynamic therapy. Various lattices were studied namely Y2O3, KY3F10 and NaYF4. These lattices were codoped with Yb3+ and Er3+ ions to obtain emissions in the visible under an infrared excitation (up conversion), the ultimate purpose being to excite in situ ZnPc. Each of these lattices was characterized from a structural and morphological point of view in the first part and, in the second part, spectroscopic studies are developed. The core-shell enhances the red emission stemming from the level 4F9/2 of Er, effect deduced from the analysis of spectra and the dynamics of luminescence. The detection of the singlet oxygen was realized in vitro by the study of the bleaching of ABDA fluorescence. The comparison of the results for nanoparticles loaded with ZnPc and unloaded ones allows demonstrating the generation of singlet oxygen by exciting in the infrared region of the spectra thanks to the efficient upconversion processes occurring in the rare earth doped materials.
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https://tel.archives-ouvertes.fr/tel-01037907
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Submitted on : Wednesday, July 23, 2014 - 9:29:32 AM
Last modification on : Monday, December 14, 2020 - 9:44:02 AM
Long-term archiving on: : Tuesday, November 25, 2014 - 12:25:25 PM

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  • HAL Id : tel-01037907, version 1

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Maroua Dhaouadi. Nanoparticules dopées terres rares pour l'imagerie médicale et la thérapie. Autre [cond-mat.other]. Université Pierre et Marie Curie - Paris VI, 2014. Français. ⟨NNT : 2014PA066064⟩. ⟨tel-01037907⟩

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