Skip to Main content Skip to Navigation
Theses

Etude du cortex sensori-moteur en Imagerie par Résonance Magnétique Fonctionnelle : du sujet sain à l'enfant avec paralysie cérébrale

Abstract : Cerebral palsy (CP) is a non-progressive injury to the developing central nervous system resulting in permanent disorders of the development of movement and posture, causing activity limitation. Therefore physical and rehabilitation medicine has a particular interest in the study of organization and reorganization of the sensorimotor cortex following early brain injury in order to propose new methods for motor rehabilitation. We first showed that motor cortex could be analyzed in functional magnetic resonance imaging (fMRI) using action-observation and passive movement tasks. We then demonstrated in patients with unilateral CP that resting state analysis could study functional connectivity in sensorimotor system. Moreover, our work showed that observing hand movement produced, in CP patients, large bilateral activations in temporo-parieto-fronto-occipital network, comprising most of the nodes of the well described action-observation network. For either side, observing hand movements recruits the primary motor cortex, contralateral to the viewed hand, as would be expected in healthy persons. In addition, we showed that the combination of observation of congruent hand movement simultaneously to passive movement of the paretic hand recruits more motor areas, giving neuronal substrate to propose video-guided passive movement of paretic hand in CP rehabilitation. Finally we present the perinatal stroke as a well suited model to analyze the postlesional neural plasticity notably the "mal-adaptive" plasticity.
Document type :
Theses
Complete list of metadata

Cited literature [223 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01021084
Contributor : Anne-Marie Plé Connect in order to contact the contributor
Submitted on : Wednesday, July 9, 2014 - 9:23:55 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:29 AM
Long-term archiving on: : Thursday, October 9, 2014 - 10:59:23 AM

Identifiers

  • HAL Id : tel-01021084, version 1

Citation

Mickael Dinomais. Etude du cortex sensori-moteur en Imagerie par Résonance Magnétique Fonctionnelle : du sujet sain à l'enfant avec paralysie cérébrale. Médecine humaine et pathologie. Université d'Angers, 2013. Français. ⟨tel-01021084⟩

Share

Metrics

Record views

985

Files downloads

2212