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Exposition professionnelle maternelle aux solvants organiques et malformations congenitales

Abstract : The aim of this project was to study the relation between maternal occupational exposure to solvents and congenital malformations.This project used data from the PELAGIE study. This is a mother child cohort which had included 3 421 women from the general population at the beginning of their pregnancy in Britany. Occupational exposure to solvents was assessed by different methods (self-report, job exposure matrix, and urinary determination of glycol ethers and chlorinated solvents metabolites).We have shown an association between solvent exposure using indirect method of assessment and congenital malformations. Using a randomized sample of 451 women, we have studied the occupational and non occupational determinants of urinary detection of glycol ethers and chlorinated solvents metabolites. Finally, we have studied in a nested case-control study, the relation between urinary solvent metabolites and congenital malformations.
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https://tel.archives-ouvertes.fr/tel-01020810
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Submitted on : Tuesday, July 8, 2014 - 3:28:19 PM
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  • HAL Id : tel-01020810, version 1

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Ronan Garlantézec. Exposition professionnelle maternelle aux solvants organiques et malformations congenitales. Santé publique et épidémiologie. Université Paris Sud - Paris XI, 2011. Français. ⟨NNT : 2011PA11T003⟩. ⟨tel-01020810⟩

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