Skip to Main content Skip to Navigation
Theses

Spectral modulation of melanopsin responses : role of melanopsin bistability in pupillary light reflex

Abstract : In addition to the canonical photoreceptors, rods and cones, a novelmelanopsin-expressing retinal ganglion cell (mRGC) was recently discovered.The novel photopigment melanopsin in the human retinahas been shown to express invertebrate-like bistable properties bothin vitro and in vivo. In bistable photopigment systems, light elicitsphotosensory responses and drives photoregeneration of the chromophoreto restore photic responsiveness. These studies have shownthat prior light exposure can modulate the amplitude of subsequentphotic responses of melanopsin.In this thesis, the putative bistability of melanopin in humans isexamined. The bistability was studied using 1) pupillary light reflex(PLR) as a tool, 2) developing a method for quantifying the effectsof lens density for melanopsin-mediated photoreception, and 3) providinga quantitative mathematical framework for modeling bistablepigment systems and non-image forming (NIF) visual system.Exploiting the bistable properties of melanopsin could allow foroptimization of spectral light distribution in experimental, industrial,domestic and clinical phototherapy applications by appropriate useof the photoregenerative effects of long wavelength light.
Document type :
Theses
Complete list of metadata

https://tel.archives-ouvertes.fr/tel-00999326
Contributor : ABES STAR :  Contact
Submitted on : Tuesday, June 3, 2014 - 2:17:10 PM
Last modification on : Saturday, November 27, 2021 - 3:40:16 AM
Long-term archiving on: : Wednesday, September 3, 2014 - 11:25:59 AM

File

TH2012_Teikari_Petteri_ii.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00999326, version 1

Collections

Citation

Petteri Teikari. Spectral modulation of melanopsin responses : role of melanopsin bistability in pupillary light reflex. Human health and pathology. Université Claude Bernard - Lyon I, 2012. English. ⟨NNT : 2012LYO10037⟩. ⟨tel-00999326⟩

Share

Metrics

Record views

242

Files downloads

1538