D. Hanahan and R. Weinberg, The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000.
DOI : 10.1016/S0092-8674(00)81683-9

D. Hanahan and R. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-74, 2011.
DOI : 10.1016/j.cell.2011.02.013

. Inca, La situation du cancer en France en 2012, 2012.

H. Herr, V. Laudone, R. Badalament, H. Oettgen, P. Sogani et al., Bacillus Calmette-Gu??rin therapy alters the progression of superficial bladder cancer., Journal of Clinical Oncology, vol.6, issue.9, pp.1450-1455, 1988.
DOI : 10.1200/JCO.1988.6.9.1450

P. Van-der-bruggen, C. Traversari, P. Chomez, C. Lurquin, P. De et al., A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma, Science, vol.254, issue.5038, pp.2617-2638, 2007.
DOI : 10.1126/science.1840703

M. Dougan and G. Dranoff, Immune Therapy for Cancer, Annual Review of Immunology, vol.27, issue.1, pp.83-117, 2009.
DOI : 10.1146/annurev.immunol.021908.132544

R. Marcus and A. Hagenbeek, The therapeutic use of rituximab in non-Hodgkin's lymphoma, Eur J Haematol, pp.5-14, 2007.

A. Rossi, F. Pericle, S. Rashleigh, J. Janiec, and J. Djeu, Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12, Blood, vol.83, issue.5, pp.1323-1331, 1994.

P. Coulie, V. Karanikas, C. Lurquin, D. Colau, T. Connerotte et al., Cytolytic T-cell responses of cancer patients vaccinated with a MAGE antigen, Immunol Rev, 2002.

A. Khammari, N. Labarriere, V. Vignard, J. Nguyen, M. Pandolfino et al., Treatment of Metastatic Melanoma with Autologous Melan-A/Mart-1-Specific Cytotoxic T Lymphocyte Clones, Journal of Investigative Dermatology, vol.129, issue.12, pp.2835-2877, 2009.
DOI : 10.1038/jid.2009.144

S. Negrier, J. Michon, D. Floret, E. Bouffet, J. Gentet et al., Interleukin-2 and lymphokine-activated killer cells in 15 children with advanced metastatic neuroblastoma., Journal of Clinical Oncology, vol.9, issue.8, pp.1363-70, 1991.
DOI : 10.1200/JCO.1991.9.8.1363

S. Rosenberg, M. Lotze, J. Yang, P. Aebersold, W. Linehan et al., Experience with the Use of High-Dose Interleukin-2 in the Treatment of 652 Cancer Patients, Annals of Surgery, vol.210, issue.4, pp.474-84, 1989.
DOI : 10.1097/00000658-198910000-00008

J. Kirkwood, M. Strawderman, M. Ernstoff, T. Smith, E. Borden et al., Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684., Journal of Clinical Oncology, vol.14, issue.1, pp.7-17, 1996.
DOI : 10.1200/JCO.1996.14.1.7

F. Ghiringhelli, C. Menard, P. Puig, S. Ladoire, S. Roux et al., Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients, Cancer Immunology, Immunotherapy, vol.95, issue.5, pp.641-649, 2007.
DOI : 10.1007/s00262-006-0225-8

C. Lopez-larrea, B. Suarez-alvarez, A. Lopez-soto, A. Lopez-vazquez, and S. Gonzalez, The NKG2D receptor: sensing stressed cells, Trends in Molecular Medicine, vol.14, issue.4, pp.179-89, 2008.
DOI : 10.1016/j.molmed.2008.02.004

A. Steinle, P. Li, D. Morris, V. Groh, L. Lanier et al., Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family, Immunogenetics, vol.53, issue.4, pp.279-87, 2001.
DOI : 10.1007/s002510100325

S. Akira, S. Uematsu, and O. Takeuchi, Pathogen Recognition and Innate Immunity, Cell, vol.124, issue.4, pp.783-801, 2006.
DOI : 10.1016/j.cell.2006.02.015

S. Rakoff-nahoum and R. Medzhitov, Toll-like receptors and cancer, Nature Reviews Cancer, vol.5, issue.1, 2009.
DOI : 10.1182/blood-2007-05-088682

M. Sahoo, I. Ceballos-olvera, B. Del, and F. Re, , and IL-18 in Bacterial Infections, The Scientific World JOURNAL, vol.168, issue.1, pp.2037-50, 2011.
DOI : 10.1016/j.chom.2010.04.009

J. Lillard, J. Boyaka, P. Chertov, O. Oppenheim, J. Mcghee et al., Mechanisms for induction of acquired host immunity by neutrophil peptide defensins, Proceedings of the National Academy of Sciences, vol.96, issue.2, pp.651-657, 1999.
DOI : 10.1073/pnas.96.2.651

N. Borregaard, Neutrophils, from Marrow to Microbes, Immunity, vol.33, issue.5, pp.657-70, 2010.
DOI : 10.1016/j.immuni.2010.11.011

V. Witko-sarsat, P. Rieu, B. Scamps-latscha, P. Lesavre, and L. Halbwachs-mecarelli, Neutrophils: Molecules, Functions and Pathophysiological Aspects, Laboratory Investigation, vol.89, issue.5, pp.617-53, 2000.
DOI : 10.1038/42506

N. Gungor, J. Pennings, A. Knaapen, R. Chiu, M. Peluso et al., Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils, Respiratory Research, vol.160, issue.1, p.24, 2010.
DOI : 10.1164/ajrccm.160.1.9808144

A. Mantovani, M. Cassatella, C. Costantini, and S. Jaillon, Neutrophils in the activation and regulation of innate and adaptive immunity, Nature Reviews Immunology, vol.16, issue.8, pp.519-550, 2011.
DOI : 10.1038/nri3024

J. Schymeinsky, A. Mocsai, and B. Walzog, Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications, Thromb Haemost, 2007.
DOI : 10.1160/th07-02-0156

C. Wagner, C. Iking-konert, B. Denefleh, S. Stegmaier, F. Hug et al., Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils, Blood, vol.103, issue.3, pp.1099-104, 2004.
DOI : 10.1182/blood-2003-04-1069

D. Yang, Q. Chen, O. Chertov, and J. Oppenheim, Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells, J Leukoc Biol, vol.68, issue.1, pp.9-14, 2000.

M. Cassatella, The production of cytokines by polymorphonuclear neutrophils, Immunology Today, vol.16, issue.1, pp.21-27, 1995.
DOI : 10.1016/0167-5699(95)80066-2

P. Tessier, P. Naccache, I. Clark-lewis, R. Gladue, K. Neote et al., Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha, J Immunol, vol.159, issue.7, pp.3595-602, 1997.

M. Baggiolini and I. Clark-lewis, Interleukin-8, a chemotactic and inflammatory cytokine, FEBS Letters, vol.2, issue.1, pp.97-101, 1992.
DOI : 10.1016/0014-5793(92)80909-Z

R. Zurier, Release of prostaglandins from human polymorphonuclear leukocytes, Inflammation, vol.157, issue.1, pp.815-823, 1976.
DOI : 10.1007/BF00918062

K. Parks and J. Davis, Epinephrine, Cortisol, Endotoxin, Nutrition, and the Neutrophil, Surgical Infections, vol.13, issue.5, pp.300-306, 2012.
DOI : 10.1089/sur.2012.161

T. Springer, Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration, Annual Review of Physiology, vol.57, issue.1, pp.827-72, 1995.
DOI : 10.1146/annurev.ph.57.030195.004143

M. Bevilacqua, S. Stengelin, M. Gimbrone, J. Seed, and B. , Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins, Science, vol.243, issue.4895, pp.1160-1165, 1989.
DOI : 10.1126/science.2466335

T. Carlos and J. Harlan, Leukocyte-endothelial adhesion molecules, Blood Oct, vol.184, issue.7, pp.2068-101, 1994.

M. Dustin, R. Rothlein, A. Bhan, C. Dinarello, and T. Springer, Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1), J Immunol, vol.137, issue.1, pp.245-54, 1986.

J. Pober, M. Bevilacqua, D. Mendrick, L. Lapierre, W. Fiers et al., Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells, J Immunol, vol.136, issue.5, pp.1680-1687, 1986.

A. Sparmann and D. Bar-sagi, Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis, Cancer Cell, vol.6, issue.5, pp.447-58, 2004.
DOI : 10.1016/j.ccr.2004.09.028

. Dupre-'sa, K. Hunter, and J. , Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: Association with tumor-derived growth factors, Experimental and Molecular Pathology, vol.82, issue.1, pp.12-24, 2007.
DOI : 10.1016/j.yexmp.2006.06.007

C. Di, A. Coletti, A. Modesti, M. Giovarelli, G. Forni et al., Local release of interleukin-10 by transfected mouse adenocarcinoma cells exhibits pro-and antiinflammatory activity and results in a delayed tumor rejection, Eur Cytokine Netw, vol.9, issue.1, pp.61-69, 1998.

Z. Fridlender, J. Sun, S. Kim, V. Kapoor, G. Cheng et al., Polarization of Tumor-Associated Neutrophil Phenotype by TGF-??: ???N1??? versus ???N2??? TAN, Cancer Cell, vol.16, issue.3, pp.183-94, 2009.
DOI : 10.1016/j.ccr.2009.06.017

E. Becker, The cytotoxic action of neutrophils on mammalian cells in vitro, Prog Allergy, vol.40, pp.183-208, 1988.

F. Dallegri, L. Ottonello, A. Ballestrero, P. Dapino, F. Ferrando et al., Tumor cell lysis by activated human neutrophils: Analysis of neutrophil-delivered oxidative attack and role of leukocyte function-associated antigen 1, Inflammation, vol.136, issue.1, pp.15-30, 1991.
DOI : 10.1007/BF00917906

S. Weiss and A. Lobuglio, Phagocyte-generated oxygen metabolites and cellular injury, Lab Invest, vol.47, issue.1, pp.5-18, 1982.

A. Lichtenstein, Neutrophil-mediated nonoxidative tumor lysis stimulated by high concentrations of phorbol myristate acetate, Clinical Immunology and Immunopathology, vol.47, issue.3, 1988.
DOI : 10.1016/S0090-1229(88)80008-4

C. Elbim and G. Lizard, Flow cytometric investigation of neutrophil oxidative burst and apoptosis in physiological and pathological situations, Cytometry Part A, vol.25, issue.6, pp.475-81, 2009.
DOI : 10.1002/cyto.a.20726

B. Babior, Oxidants from phagocytes: agents of defense and destruction, Blood, vol.64, issue.5, pp.959-66, 1984.

R. Clark and S. Szot, The myeloperoxidase-hydrogen peroxide-halide system as effector of neutrophil-mediated tumor cell cytotoxicity, J Immunol, vol.126, issue.4, pp.1295-301, 1981.

D. English and J. Lukens, Regulation of neutrophil inflammatory mediator release: chemotactic peptide activation of stimulus-dependent cytotoxicity, J Immunol, 1983.

S. Weiss, R. Klein, A. Slivka, and M. Wei, Chlorination of Taurine by Human Neutrophils, Journal of Clinical Investigation, vol.70, issue.3, pp.598-607, 1982.
DOI : 10.1172/JCI110652

A. Kindzelskii and H. Petty, Early membrane rupture events during neutrophil-mediated antibody-dependent tumor cell cytolysis, J Immunol Mar, vol.15162, issue.6, pp.3188-92, 1999.

B. Kushner and N. Cheung, GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma, Blood, vol.73, issue.7, pp.1936-1977, 1989.

B. Kushner and N. Cheung, Absolute requirement of CD11/CD18 adhesion molecules, FcRII and the phosphatidylinositol-linked FcRIII for monoclonal antibody-mediated neutrophil antihuman tumor cytotoxicity, Blood, vol.79, issue.6, pp.1484-90, 1992.

P. Ragnhammar, J. Frodin, P. Trotta, and H. Mellstedt, Cytotoxicity of white blood cells activated by granulocyte-colony-stimulating factor, granulocyte/macrophage-colonystimulating factor and macrophage-colony-stimulating factor against tumor cells in the presence of various monoclonal antibodies, Cancer Immunol Immunother, 1994.

C. Wagner, S. Stegmaier, and G. Hansch, Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro, Molecular Immunology, vol.45, issue.6, pp.1761-1767, 2008.
DOI : 10.1016/j.molimm.2007.09.033

W. Grossman and T. Ley, Granzymes A and B are not expressed in human neutrophils, Blood, vol.104, issue.3, pp.906-913, 2004.
DOI : 10.1182/blood-2004-03-0858

S. Metkar and C. Froelich, Human neutrophils lack granzyme A, granzyme B, and perforin, Blood, vol.104, issue.3, pp.905-911, 2004.
DOI : 10.1182/blood-2004-03-0888

G. Nicoletti, G. De, P. Lollini, G. Bagnara, K. Scotlandi et al., In vivo and in vitro production of haemopoietic colony-stimulating activity by murine cell lines of different origin: a frequent finding, European Journal of Cancer and Clinical Oncology, vol.25, issue.9, pp.1281-1287, 1989.
DOI : 10.1016/0277-5379(89)90074-6

L. Pekarek, B. Starr, A. Toledano, and H. Schreiber, Inhibition of tumor growth by elimination of granulocytes, Journal of Experimental Medicine, vol.181, issue.1, pp.435-475, 1995.
DOI : 10.1084/jem.181.1.435

M. Keane, J. Belperio, Y. Xue, M. Burdick, and R. Strieter, Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer, The Journal of Immunology, vol.172, issue.5, pp.2853-60, 2004.
DOI : 10.4049/jimmunol.172.5.2853

H. Jensen, F. Donskov, N. Marcussen, M. Nordsmark, and F. Lundbeck, Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma, Journal of Clinical Oncology, vol.27, issue.28, pp.4709-4726, 2009.
DOI : 10.1200/JCO.2008.18.9498

M. Queen, R. Ryan, R. Holzer, C. Keller-peck, and C. Jorcyk, Breast Cancer Cells Stimulate Neutrophils to Produce Oncostatin M: Potential Implications for Tumor Progression, Cancer Research, vol.65, issue.19, pp.8896-904, 2005.
DOI : 10.1158/0008-5472.CAN-05-1734

Y. Imai, Y. Kubota, S. Yamamoto, K. Tsuji, M. Shimatani et al., Neutrophils enhance invasion activity of human cholangiocellular carcinoma and hepatocellular carcinoma cells: An in vitro study, Journal of Gastroenterology and Hepatology, vol.117, issue.2, pp.287-93, 2005.
DOI : 10.1046/j.1365-2141.1996.d01-1697.x

N. Gungor, A. Haegens, A. Knaapen, R. Godschalk, R. Chiu et al., Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo, Mutagenesis, vol.25, issue.1, pp.77-82, 2010.
DOI : 10.1093/mutage/gep049

S. Gordon, Alternative activation of macrophages, Nature Reviews Immunology, vol.3, issue.1, pp.23-35, 2003.
DOI : 10.1038/nri978

URL : https://hal.archives-ouvertes.fr/hal-00474829

A. Mantovani, A. Sica, S. Sozzani, P. Allavena, A. Vecchi et al., The chemokine system in diverse forms of macrophage activation and polarization, Trends in Immunology, vol.25, issue.12, pp.677-86, 2004.
DOI : 10.1016/j.it.2004.09.015

Z. Granot, E. Henke, E. Comen, T. King, L. Norton et al., Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell, pp.300-314, 2011.

P. Musiani, A. Allione, A. Modica, P. Lollini, M. Giovarelli et al., Role of neutrophils and lymphocytes in inhibition of a mouse mammary adenocarcinoma engineered to release IL-2, IL-4, IL-7, IL-10, IFN-alpha, IFN-gamma, and TNF-alpha, Lab Invest, vol.74, issue.1, pp.146-57, 1996.

B. Lippitz, Cytokine patterns in patients with cancer: a systematic review, The Lancet Oncology, vol.14, issue.6, pp.218-228, 2013.
DOI : 10.1016/S1470-2045(12)70582-X

D. Elsasser, T. Valerius, R. Repp, G. Weiner, Y. Deo et al., HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor, Blood, vol.87, issue.9, pp.3803-3815, 1996.

T. Valerius, R. Repp, T. De-wit, S. Berthold, E. Platzer et al., Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy, Blood, vol.82, issue.3, pp.931-940, 1993.

F. Valone, P. Kaufman, P. Guyre, L. Lewis, V. Memoli et al., Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu., Journal of Clinical Oncology, vol.13, issue.9, pp.2281-92, 1995.
DOI : 10.1200/JCO.1995.13.9.2281

J. Van-de-winkel, B. Bast, and G. De-gast, Immunotherapeutic potential of bispecific antibodies, Immunology Today, vol.18, issue.12, pp.562-566, 1997.
DOI : 10.1016/S0167-5699(97)01167-5

A. Ghosh, H. Dazzi, N. Thatcher, and M. Moore, Lack of correlation between peripheral blood lymphokine-activated killer (lak) cell function and clinical response in patients with advanced malignant melanoma receiving recombinant interleukin 2, International Journal of Cancer, vol.41, issue.3, pp.410-414, 1989.
DOI : 10.1002/ijc.2910430311

S. Huang, L. Mills, B. Mian, C. Tellez, M. Mccarty et al., Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma, The American Journal of Pathology, vol.161, issue.1, pp.125-159, 2002.
DOI : 10.1016/S0002-9440(10)64164-8

A. Houghton, D. Rzymkiewicz, J. H. Gregory, A. Egea, E. Metz et al., Neutrophil elastase???mediated degradation of IRS-1 accelerates lung tumor growth, Nature Medicine, vol.354, issue.2, pp.219-242, 2010.
DOI : 10.1038/nm.2084

T. Waldmann, Immunotherapy: past, present and future, Nature Medicine, vol.9, issue.3, pp.269-77, 2003.
DOI : 10.1038/nm0303-269

D. Lamm, B. Blumenstein, J. Crissman, J. Montie, J. Gottesman et al., MAINTENANCE BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY FOR RECURRENT TA, T1 AND CARCINOMA IN SITU TRANSITIONAL CELL CARCINOMA OF THE BLADDER: A RANDOMIZED SOUTHWEST ONCOLOGY GROUP STUDY, The Journal of Urology, vol.163, issue.4, pp.1124-1133, 2000.
DOI : 10.1016/S0022-5347(05)67707-5

W. Coley, The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus), Proc R Soc Med, vol.3, pp.1-48, 1910.

H. Brade, L. Brade, U. Schade, U. Zahringer, O. Holst et al., Structure, endotoxicity, immunogenicity and antigenicity of bacterial lipopolysaccharides (endotoxins, O-antigens), Prog Clin Biol Res, vol.272, pp.17-45, 1988.

C. Galanos, V. Lehmann, O. Luderitz, E. Rietschel, O. Westphal et al., Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A, European Journal of Biochemistry, vol.24, issue.2, pp.221-228, 1984.
DOI : 10.1007/BF00364907

S. Wolff, Biological Effects of Bacterial Endotoxins in Man, Journal of Infectious Diseases, vol.128, issue.Supplement 1, 1973.
DOI : 10.1093/infdis/128.Supplement_1.S259

J. Cavaillon, C. Fitting, N. Haeffner-cavaillon, S. Kirsch, and H. Warren, Cytokine response by monocytes and macrophages to free and lipoprotein-bound lipopolysaccharide, Infect Immun, vol.58, issue.7, pp.2375-82, 1990.

C. Blondiau, P. Lagadec, P. Lejeune, N. Onier, J. Cavaillon et al., Correlation between the capacity to activate macrophages in vitro and the antitumor activity in vivo of lipopolysaccharides from different bacterial species, Immunobiology, vol.190, issue.3, 1994.
DOI : 10.1016/S0171-2985(11)80272-X

R. Keller, R. Gehri, and R. Keist, The interaction of macrophages and bacteria: Escherichia coli species, bacterial lipopolysaccharide, and lipid A differ in their ability to induce tumoricidal activity and the secretion of reactive nitrogen intermediates in macrophages, Cellular Immunology, vol.141, issue.1, pp.47-58, 1992.
DOI : 10.1016/0008-8749(92)90126-A

J. Jeannin, R. Klein, D. Reisser, P. Lagadec, M. Vincent et al., Correlation between the synergistic effect of liposomes and endotoxins on the activation of macrophage tumoricidal activity and the effect of liposomes on the rough endoplasmic reticulum of macrophages, The Journal of Membrane Biology, vol.134, issue.2, pp.107-125, 1988.
DOI : 10.1007/BF01870923

J. Jeannin, N. Onier, P. Lagadec, J. Von, P. Stutz et al., Antitumor effect of synthetic derivatives of lipid A in an experimental model of colon cancer in the rat, Gastroenterology, vol.101, issue.3, pp.726-759, 1991.
DOI : 10.1016/0016-5085(91)90532-P

P. Lagadec, J. Jeannin, D. Reisser, H. Pelletier, and O. Olsson, Treatment with endotoxins of peritoneal carcinomatosis induced by colon tumor cells in the rat, Invasion Metastasis, vol.7, issue.2, pp.83-95, 1987.

F. Martin, A. Caignard, J. Jeannin, A. Leclerc, and M. Martin, Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors, International Journal of Cancer, vol.64, issue.5, pp.623-630, 1983.
DOI : 10.1002/ijc.2910320517

K. Miyamoto, R. Koshiura, T. Hasegawa, and N. Kato, Antitumor activity of Klebsiella 03 lipopolysaccharide in mice., The Japanese Journal of Pharmacology, vol.36, issue.1, pp.51-58, 1984.
DOI : 10.1254/jjp.36.51

E. Dye and R. North, Macrophage accumulation in murine ascites tumors. I. Cytoxaninduced dominance of macrophages over tumor cells and the anti-tumor effect of endotoxin, J Immunol, vol.125, issue.4, pp.1650-1657, 1980.

S. Abe, J. Tsubouchi, K. Takahashi, M. Yamazaki, and D. Mizuno, Combination therapy of murine tumors with lentinan plus lipopolysaccharide plus cyclophosphamide, Gann, 1982.

O. Westphal, O. Luderitz, E. Rietschel, and C. Galanos, Bacterial lipopolysaccharide and its lipid A component: some historical and some current aspects, Biochemical Society Transactions, vol.9, issue.3, 1981.
DOI : 10.1042/bst0090191

E. Rietschel, L. Brade, K. Brandenburg, H. Flad, J. De-jong-leuveninck et al., Chemical structure and biologic activity of bacterial and synthetic lipid A, Rev Infect Dis, vol.9, issue.5, pp.527-536, 1987.

A. Poltorak, X. He, I. Smirnova, M. Liu, H. Van et al., Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene, Science, vol.282, issue.5396, pp.2085-2093, 1998.
DOI : 10.1126/science.282.5396.2085

T. Ogawa, H. Uchida, and K. Amino, Immunobiological activities of chemically defined lipid A from lipopolysaccharides of Porphyromonas gingivalis, Microbiology, vol.140, issue.5, pp.1209-1225, 1994.
DOI : 10.1099/13500872-140-5-1209

M. Brunda, R. Wright, L. Luistro, M. Harbison, T. Anderson et al., Enhanced Antitumor Efficacy in Mice by Combination Treatment with Interleukin-1?? and Interferon-??, Journal of Immunotherapy, vol.15, issue.4, pp.233-274, 1994.
DOI : 10.1097/00002371-199405000-00001

S. Ukei, J. Iida, T. Shiba, S. Kusumoto, and I. Azuma, Adjuvant and antitumour activities of synthetic lipid A analogues, Vaccine, vol.4, issue.1, pp.21-25, 1986.
DOI : 10.1016/0264-410X(86)90093-9

K. Takayama, E. Ribi, and J. Cantrell, Isolation of a nontoxic lipid A fraction containing tumor regression activity, Cancer Res, vol.41, issue.7, pp.2654-2661, 1981.

M. Nakatsuka, Y. Kumazawa, S. Ikeda, A. Yamamoto, C. Nishimura et al., Antitumor and antimicrobial activities of lipid A-subunit analogue GLA-27, J Clin Lab Immunol, vol.26, issue.1, pp.43-50, 1988.

J. De-bono, A. Dalgleish, J. Carmichael, J. Diffley, F. Lofts et al., Phase I study of ONO-4007, a synthetic analogue of the lipid A moiety of bacterial lipopolysaccharide, Clin Cancer Res Feb, vol.6, issue.2, pp.397-405, 2000.

A. Kiani, A. Tschiersch, E. Gaboriau, F. Otto, A. Seiz et al., Downregulation of the proinflammatory cytokine response to endotoxin by pretreatment with the nontoxic lipid A analog SDZ MRL 953 in cancer patients, Blood, vol.90, issue.4, pp.1673-83, 1997.

G. Vosika, D. Cornelius, C. Gilbert, J. Sadlik, J. Bennek et al., Phase I Trial of ImmTher, a New Liposome-Incorporated Lipophilic Disaccharide Tripeptide, Journal of Immunotherapy, vol.10, issue.4, pp.256-66, 1991.
DOI : 10.1097/00002371-199108000-00004

K. Brandenburg, B. Lindner, A. Schromm, M. Koch, J. Bauer et al., Physicochemical characteristics of triacyl lipid???A partial structure OM-174 in relation to biological activity, European Journal of Biochemistry, vol.16, issue.11, pp.3370-3377, 2000.
DOI : 10.1046/j.1432-1327.2000.01370.x

N. Onier, S. Hilpert, L. Arnould, V. Saint-giorgio, J. Davies et al., Cure of colon cancer metastasis in rats with the new lipid A OM 174 Apoptosis of tumor cells and immunization of rats, Clinical & Experimental Metastasis, vol.17, issue.4, pp.299-306, 1999.
DOI : 10.1023/A:1006663017149

N. Onier, P. Lejeune, M. Martin, A. Hammann, J. Bauer et al., Involvement of T lymphocytes in curative effect of a new immunomodulator OM 163 on rat colon cancer metastases, European Journal of Cancer, vol.29, issue.14, pp.2003-2012, 1993.
DOI : 10.1016/0959-8049(93)90462-O

P. Rickham, Human experimentation Code of ethics of the World Medical Association. Declaration of Helsinki, Br Med J, vol.2, issue.5402, p.177, 1964.

P. Therasse, S. Arbuck, E. Eisenhauer, J. Wanders, R. Kaplan et al., New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada, J Natl Cancer Inst Feb, vol.292, issue.3, pp.205-221, 2000.

F. Lirussi, Z. Rakotoniaina, S. Madani, F. Goirand, M. Breuiller-fouche et al., ADRB3 Adrenergic Receptor Is a Key Regulator of Human Myometrial Apoptosis and Inflammation During Chorioamnionitis1, Biology of Reproduction, vol.78, issue.3, pp.497-505, 2008.
DOI : 10.1095/biolreprod.107.064444

C. Prunet, T. Montange, A. Vejux, A. Laubriet, J. Rohmer et al., Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients, Cytometry Part A, vol.61, issue.5, pp.359-73, 2006.
DOI : 10.1002/cyto.a.20272

D. Ducloux, M. Deschamps, M. Yannaraki, C. Ferrand, J. Bamoulid et al., Relevance of Toll-like receptor-4 polymorphisms in renal transplantation, Kidney International, vol.67, issue.6, pp.2454-61, 2005.
DOI : 10.1111/j.1523-1755.2005.00354.x

J. Chirgwin, A. Przybyla, R. Macdonald, and W. Rutter, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry, vol.18, issue.24, pp.5294-5303, 1979.
DOI : 10.1021/bi00591a005

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-410, 2001.
DOI : 10.1006/meth.2001.1262

A. Martin, C. Seignez, A. Scagliarini, C. Godard, N. Decologne et al., Antutumoral effect of granzyme B from tumor neutrophils, J Exp Med, 2013.

T. Schmidt, J. Zundorf, T. Gruger, K. Brandenburg, A. Reiners et al., CD66b overexpression and homotypic aggregation of human peripheral blood neutrophils after activation by a gram-positive stimulus, Journal of Leukocyte Biology, vol.91, issue.5, pp.791-802, 2012.
DOI : 10.1189/jlb.0911483

A. Carus, M. Ladekarl, H. Hager, B. Nedergaard, and F. Donskov, Tumour-associated CD66b+ neutrophil count is an independent prognostic factor for recurrence in localised cervical cancer, British Journal of Cancer, vol.280, issue.10, pp.2116-2138, 2013.
DOI : 10.1159/000127412

D. Goddard, K. Yamanaka, T. Kupper, and D. Jones, Activation of Neutrophils in Cutaneous T-Cell Lymphoma, Clinical Cancer Research, vol.11, issue.23, pp.8243-8252, 2005.
DOI : 10.1158/1078-0432.CCR-05-1434

A. Schroder, P. Uciechowski, D. Fleischer, and L. Rink, Crosslinking of CD66b on Peripheral Blood Neutrophils Mediates the Release of Interleukin-8 from Intracellular Storage, Human Immunology, vol.67, issue.9, pp.676-82, 2006.
DOI : 10.1016/j.humimm.2006.05.004

M. Ellegaard, L. Bastholt, A. Jakobsen, F. Donskov, and H. Schmidt, Interleukin-2-induced fever in relation to objective tumor response and survival in patients with metastatic melanoma., Journal of Clinical Oncology, vol.28, issue.15_suppl, p.15, 2010.
DOI : 10.1200/jco.2010.28.15_suppl.8569

C. Rockwell, D. Morison, and N. Qureshi, Lipid A-Mediated Tolerance and Cancer Therapy, In Cancer therapy Edited by Jeannin JF, pp.81-99, 2010.
DOI : 10.1007/978-1-4419-1603-7_8

A. Lichtenstein, M. Seelig, J. Berek, and J. Zighelboim, Human neutrophil-mediated lysis of ovarian cancer cells, Blood, vol.74, issue.2, pp.805-814, 1989.

M. Simons, W. Nauseef, and T. Griffith, Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer, Immunologic Research, vol.4, issue.1-3, pp.1-379, 2007.
DOI : 10.1007/s12026-007-0084-1

R. 1. Sylvester, R. Van-der, M. Ap, and D. Lamm, Intravesical Bacillus Calmette-Guerin Reduces the Risk of Progression in Patients with Superficial Bladder Cancer:, The Journal of Urology, vol.168, pp.1964-1970, 2002.
DOI : 10.1097/00005392-200211000-00016

K. Heldwein, M. Liang, and T. Andresen, TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG, Journal of Leukocyte Biology, vol.74, issue.2, pp.277-286, 2003.
DOI : 10.1189/jlb.0103026

R. Wang, Y. Miyahara, and H. Wang, Toll-like receptors and immune regulation: implications for cancer therapy, Oncogene, vol.61, issue.2, pp.181-189, 2008.
DOI : 10.1038/ni1488

O. Takeuchi, K. Hoshino, and T. Kawai, Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components, Immunity, vol.11, issue.4, pp.443-451, 1999.
DOI : 10.1016/S1074-7613(00)80119-3

I. Parr, E. Wheeler, and A. P. , Similarities of the Anti-tumour Actions of Endotoxin, Lipid A and Double-stranded RNA, British Journal of Cancer, vol.27, issue.5, pp.370-389, 1973.
DOI : 10.1038/bjc.1973.45

N. Isambert, P. Fumoleau, and C. Paul, Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors, BMC Cancer, vol.563, issue.1, p.172, 2013.
DOI : 10.1016/j.ejphar.2007.02.018

URL : https://hal.archives-ouvertes.fr/inserm-00813522

T. Gautier, C. Paul, and V. Deckert, Innate immune response triggered by triacyl lipid A is dependent on phospholipid transfer protein (PLTP) gene expression, The FASEB Journal, vol.24, issue.9, pp.3544-3554, 2010.
DOI : 10.1096/fj.09-152876

N. Onier, S. Hilpert, and L. Arnould, Cure of colon cancer metastasis in rats with the new lipid A OM 174 Apoptosis of tumor cells and immunization of rats, Clinical & Experimental Metastasis, vol.17, issue.4, pp.299-306, 1999.
DOI : 10.1023/A:1006663017149

N. Onier, S. Hilpert, and S. Reveneau, Expression of inducible nitric oxide synthase in tumors in relation with their regression induced by lipid A in rats, International Journal of Cancer, vol.45, issue.5, pp.755-760, 1999.
DOI : 10.1002/(SICI)1097-0215(19990531)81:5<755::AID-IJC15>3.0.CO;2-3

I. Afonina, S. Cullen, and S. Martin, Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B, Immunological Reviews, vol.56, issue.1, pp.105-116, 2010.
DOI : 10.1111/j.0105-2896.2010.00908.x

S. Cullen and S. Martin, Mechanisms of granule-dependent killing, Cell Death and Differentiation, vol.1996, issue.2, pp.251-262, 2008.
DOI : 10.1182/blood-2006-03-010348

K. Hochegger, P. Eller, and A. Rosenkranz, Granzyme A: an additional weapon of human polymorphonuclear neutrophils (PMNs) in innate immunity?, Blood, vol.103, issue.3, p.1176, 2004.
DOI : 10.1182/blood-2003-10-3708

C. Wagner, C. Iking-konert, and B. Denefleh, Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils, Blood, vol.103, issue.3, pp.1099-1104, 2004.
DOI : 10.1182/blood-2003-04-1069

C. Wagner, S. Stegmaier, and G. Hänsch, Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro, Molecular Immunology, vol.45, issue.6, pp.1761-1766, 2008.
DOI : 10.1016/j.molimm.2007.09.033

W. Grossman and T. Ley, Granzymes A and B are not expressed in human neutrophils, Blood, vol.104, issue.3, pp.906-907, 2004.
DOI : 10.1182/blood-2004-03-0858

S. Metkar and C. Froelich, Human neutrophils lack granzyme A, granzyme B, and perforin, Blood, vol.104, issue.3, pp.905-906, 2004.
DOI : 10.1182/blood-2004-03-0888

P. Martin, R. Wallich, and J. Pardo, Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes? Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis, Blood Proc Natl Acad Sci U S A, vol.106, issue.103, pp.2871-2878, 2005.

Z. Fridlender, J. Sun, and S. Kim, Polarization of Tumor-Associated Neutrophil Phenotype by TGF-??: ???N1??? versus ???N2??? TAN, Cancer Cell, vol.16, issue.3, pp.183-194, 2009.
DOI : 10.1016/j.ccr.2009.06.017

T. Kemp, A. Ludwig, and J. Earel, Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L, Blood, vol.106, issue.10, pp.3474-3482, 2005.
DOI : 10.1182/blood-2005-03-1327

H. Rosevear, A. Lightfoot, O. Donnell, and M. , The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette???Gu??rin (BCG) immunotherapy for urothelial carcinoma of the bladder, Cancer and Metastasis Reviews, vol.66, issue.Suppl 3, pp.345-353, 2009.
DOI : 10.1007/s10555-009-9195-6

H. Suttmann, J. Riemensberger, and G. Bentien, Neutrophil Granulocytes Are Required for Effective Bacillus Calmette-Guerin Immunotherapy of Bladder Cancer and Orchestrate Local Immune Responses, Cancer Research, vol.66, issue.16, pp.8250-8257, 2006.
DOI : 10.1158/0008-5472.CAN-06-1416

J. Jeannin, N. Onier, and P. Lagadec, Antitumor effect of synthetic derivatives of lipid A in an experimental model of colon cancer in the rat, Gastroenterology, vol.101, issue.3, pp.726-733, 1991.
DOI : 10.1016/0016-5085(91)90532-P

F. Martin, A. Caignard, and J. Jeannin, Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors, International Journal of Cancer, vol.64, issue.5, pp.623-627, 1983.
DOI : 10.1002/ijc.2910320517

L. Leon-bollotte, S. Subramaniam, and O. Cauvard, S-Nitrosylation of the Death Receptor Fas Promotes Fas Ligand???Mediated Apoptosis in Cancer Cells, Gastroenterology, vol.140, issue.7, 2001.
DOI : 10.1053/j.gastro.2011.02.053

URL : https://hal.archives-ouvertes.fr/hal-00680824

A. Mantovani, B. Savino, and M. Locati, The chemokine system in cancer biology and therapy, Cytokine & Growth Factor Reviews, vol.21, issue.1, pp.27-39, 2010.
DOI : 10.1016/j.cytogfr.2009.11.007

G. Lazennec and R. A. , Chemokines and chemokine receptors: new insights into cancer-related inflammation, Trends in Molecular Medicine, vol.16, issue.3, pp.133-144, 2010.
DOI : 10.1016/j.molmed.2010.01.003

D. Armstrong, J. Major, and A. Chudyk, Neutrophil chemoattractant genes KC and MIP-2 are expressed in different cell populations at sites of surgical injury, Journal of Leukocyte Biology, vol.75, issue.4, pp.641-648, 2004.
DOI : 10.1189/jlb.0803370

H. Rittner, S. Mousa, and D. Labuz, Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain, Journal of Leukocyte Biology, vol.79, issue.5, pp.1022-1032, 2006.
DOI : 10.1189/jlb.0805452

M. Mclean, G. Murray, and K. Stewart, The Inflammatory Microenvironment in Colorectal Neoplasia, PLoS ONE, vol.125, issue.1, p.15366, 2011.
DOI : 10.1371/journal.pone.0015366.s001

Y. Wen, S. Giardina, and D. Hamming, GRO?? Is Highly Expressed in Adenocarcinoma of the Colon and Down-Regulates Fibulin-1, Clinical Cancer Research, vol.12, issue.20, pp.5951-5959, 2006.
DOI : 10.1158/1078-0432.CCR-06-0736

S. Chiu, F. Hsieh, and S. Chen, Clinicopathologic Correlation of Up-regulated Genes Identified Using cDNA Microarray and Real-time Reverse Transcription-PCR in Human Colorectal Cancer, Cancer Epidemiology Biomarkers & Prevention, vol.14, issue.2, pp.437-443, 2005.
DOI : 10.1158/1055-9965.EPI-04-0396

S. Sharma, C. Karakousis, and H. Takita, Cytokines and Chemokines Are Expressed at Different Levels in Small and Large Murine Colon-26 Tumors Following Intratumoral Injections of CpG ODN, Neoplasia, vol.6, issue.5, pp.523-528, 2004.
DOI : 10.1593/neo.04166

L. Wang, L. Thomsen, and R. Sutherland, Neutrophil Influx and Chemokine Production during the Early Phases of the Antitumor Response to the Vascular Disrupting Agent DMXAA (ASA404), Neoplasia, vol.11, issue.8, pp.793-803, 2009.
DOI : 10.1593/neo.09506

J. Medina-echeverz, J. Fioravanti, and M. Zabala, Successful Colon Cancer Eradication after Chemoimmunotherapy Is Associated with Profound Phenotypic Change of Intratumoral Myeloid Cells, The Journal of Immunology, vol.186, issue.2, pp.807-815, 2011.
DOI : 10.4049/jimmunol.1001483

J. Reutershan, A. Basit, and E. Galkina, Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury, AJP: Lung Cellular and Molecular Physiology, vol.289, issue.5, pp.807-815, 2005.
DOI : 10.1152/ajplung.00477.2004

M. Guicciardi and G. Gores, Life and death by death receptors, The FASEB Journal, vol.23, issue.6, pp.1625-1637, 2009.
DOI : 10.1096/fj.08-111005

J. Brady, Y. Hayakawa, and M. Smyth, IL-21 Induces the Functional Maturation of Murine NK Cells, The Journal of Immunology, vol.172, issue.4, pp.2048-2058, 2004.
DOI : 10.4049/jimmunol.172.4.2048

T. Fehniger, S. Cai, and X. Cao, Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-existing Pool of??Granzyme B and Perforin mRNAs, Immunity, vol.26, issue.6, pp.798-811, 2007.
DOI : 10.1016/j.immuni.2007.04.010

B. Zhang, J. Zhang, and Z. Tian, Comparison in the effects of IL-2, IL-12, IL-15 and IFN?? on gene regulation of granzymes of human NK cell line NK-92, International Immunopharmacology, vol.8, issue.7, pp.989-996, 2008.
DOI : 10.1016/j.intimp.2008.03.001

R. Antibodies, Mouse antibody (Ab) HIS48 (Santa Cruz) was used to characterize tumor-infiltrating and purified neutrophils, Mouse anti-TCR D/E Ab (AbD Serotec)

N. Ab, (. Systems, and . Ab, AbD Serotec) were used to detect T lymphocytes, NK cells and JGT lymphocytes respectively in tumors. Tumor cells were characterized using a mouse anti cytokeratin antibody (DakoCytomation) The following Abs were also used: a mouse anti-arginase 1 Ab and a rabbit anti-iNOS Ab (BD Transduction Laboratories), a rabbit anti-cleaved caspase-3 Ab (Cell Signaling), a mouse anti-M30 fragment (Roche) and a rabbit anti-granzyme B Ab (Thermo Scientific)

F. Martin, A. Caignard, and J. Jeannin, Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors, International Journal of Cancer, vol.64, issue.5, pp.623-627, 1983.
DOI : 10.1002/ijc.2910320517

R. Kingston, C. Chen, and H. Okayama, Calcium phosphate transfection, Curr Protoc Immunol, vol.10, 2001.