V. C. Abraham, D. L. Taylor, and J. Haskins, High content screening applied to large-scale cell biology, Trends in Biotechnology, vol.22, issue.1, pp.15-22, 2004.
DOI : 10.1016/j.tibtech.2003.10.012

W. M. Ahmed, S. J. Leavesley, B. Rajwa, M. N. Ayyaz, A. Ghafoor et al., State of the Art in Information Extraction and Quantitative Analysis for Multimodality Biomolecular Imaging, Proceedings of the IEEE, vol.96, issue.3, pp.512-530, 2008.
DOI : 10.1109/JPROC.2007.913556

D. R. Albrecht, G. H. Underhill, J. Resnikoff, A. Mendelson, S. N. Bhatia et al., Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics, Integrative Biology, vol.7, issue.Pt 3, pp.278-287, 2010.
DOI : 10.1039/b923699f

J. W. Allen, S. R. Khetani, and S. Bhatia, In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor, Toxicological Sciences, vol.84, issue.1, pp.110-119, 2005.
DOI : 10.1093/toxsci/kfi052

H. Aly and O. Domenech, Cytotoxicity and mitochondrial dysfunction of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in isolated rat hepatocytes, Toxicology Letters, vol.191, issue.1, pp.79-87, 2009.
DOI : 10.1016/j.toxlet.2009.08.008

A. Antonsson and J. Persson, Induction of apoptosis by staurosporine involves the inhibition of expression of the major cell cycle proteins at the G(2)/M checkpoint accompanied by alterations in Erk and Akt kinase activities, Anticancer research, vol.29, pp.2893-98, 2009.

M. Andersen and D. Krewski, Toxicity Testing in the 21st Century: Bringing the Vision to Life, Toxicological Sciences, vol.107, issue.2, pp.324-330, 2009.
DOI : 10.1093/toxsci/kfn255

J. R. Anderson, D. T. Chiu, R. J. Jackman, O. Cherniavskaya, J. C. Mcdonald et al., Fabrication of Topologically Complex Three-Dimensional Microfluidic Systems in PDMS by Rapid Prototyping, Analytical Chemistry, vol.72, issue.14, pp.3158-64, 2000.
DOI : 10.1021/ac9912294

I. Antolino-lobo, J. Meulenbelt, S. M. Nijmeijer, R. F. Maas-bakker, I. Meijerman et al., 3,4-Methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition, Toxicology Letters, vol.203, issue.1, pp.4-82, 2011.
DOI : 10.1016/j.toxlet.2011.03.007

R. Baldock and J. Graham, Image Processing and Analysis. A Practical Approach, 2000.

R. Baudoin, L. Griscom, M. Monge, C. Legallais, and E. Leclerc, Development of a Renal Microchip for In Vitro Distal Tubule Models, Biotechnology Progress, vol.0, issue.0, pp.1245-1253, 2007.
DOI : 10.1021/bp0603513

URL : https://hal.archives-ouvertes.fr/hal-00196149

B. Régis, Développement et caractérisation d'une puce à cellules pour le criblage d'agents toxiques. 187p, Thèse : Bio-Ingénierie, 2008.

S. Benhamouche, T. Decaens, C. Godard, R. Chambrey, D. S. Rickman et al., Apc Tumor Suppressor Gene Is the ???Zonation-Keeper??? of Mouse Liver, Developmental Cell, vol.10, issue.6, pp.759-770, 2006.
DOI : 10.1016/j.devcel.2006.03.015

K. Bhadriraju and S. Chen, Engineering cellular microenvironments to improve cell-based drug testing, Drug Discovery Today, vol.7, issue.11, pp.612-620, 2002.
DOI : 10.1016/S1359-6446(02)02273-0

K. Bhadriraju, J. T. Elliott, M. Nguyen, and A. Plant, Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy, BMC Cell Biology, vol.8, issue.1, pp.43-56, 2007.
DOI : 10.1186/1471-2121-8-43

C. Bidault-godard, Rôle de la glutamine dans les foies prétumoraux présentant une singalisation ??Catérine Activée : Etude de la double invalidation génétique de la glutamine synthètase et du gene suppresseur de tumeur APC dans le foie murin, Mémoire : École Patrique des Hautes Études, p.2011

A. Blouin, R. P. Bolender, and E. Weibel, Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study, The Journal of Cell Biology, vol.72, issue.2, pp.441-455, 1977.
DOI : 10.1083/jcb.72.2.441

R. Booth and H. Kim, Characterization of a microfluidic in vitro model of the blood-brain barrier (??BBB), Lab on a Chip, vol.185, issue.S1, pp.1784-1792, 2012.
DOI : 10.1039/c2lc40094d

F. Briquet, A. Colas, and X. Thomas, Silicones à usage médical, pp.1-11, 1996.

A. Burgess, T. Lorca, and A. Castro, Quantitative Live Imaging of Endogenous DNA Replication in Mammalian Cells, PLoS ONE, vol.7, issue.9, p.45726, 2012.
DOI : 10.1371/journal.pone.0045726.s008

J. L. Campbell, R. A. Clewell, P. R. Gentry, M. E. Andersen, and H. J. Clewell, Physiologically Based Pharmacokinetic/Toxicokinetic Modeling, Methods Mol Biol, vol.929, pp.439-499, 2012.
DOI : 10.1007/978-1-62703-050-2_18

D. J. Carlile, N. Houston, and J. , Kinetics of drug metabolism in rat liver slices : IV : comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of Cytochrome P -450, Activity. Drug Metabolism And Disposition, vol.27, pp.526-558, 1999.

A. Carpenter, T. R. Jones, M. R. Lamprecht, C. Clarke, I. H. Kang et al., CellProfiler: image analysis software for identifying and quantifying cell phenotypes, Genome Biology, vol.7, issue.10, p.100, 2006.
DOI : 10.1186/gb-2006-7-10-r100

R. Carmona, D. Macías, J. Guadix, V. Portillo, J. M. Pérez-pomares et al., A simple technique of image analysis for specific nuclear immunolocalization of proteins, Journal of Microscopy, vol.4, issue.1, pp.96-99, 2007.
DOI : 10.1111/j.1600-0854.2005.00270.x

C. A. Carter and J. Hamm, Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells, Toxicology, vol.261, issue.3, pp.89-102, 2009.
DOI : 10.1016/j.tox.2009.04.039

A. Celli, F. G. Que, G. J. Gores, and F. Larusson, Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes, Am J Physiol, vol.275, pp.749-757, 1998.

P. Chao, T. Maguire, E. Novik, K. Cheng, and M. Yarmush, Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human, Biochemical Pharmacology, vol.78, issue.6, pp.625-632, 2009.
DOI : 10.1016/j.bcp.2009.05.013

S. Cheng, J. Prot, E. Leclerc, and F. Bois, Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions, BMC Genomics, vol.13, issue.1, pp.54-74, 2012.
DOI : 10.1186/1471-2164-13-54

URL : https://hal.archives-ouvertes.fr/ineris-00961774

J. S. Cho, D. Maysinger, M. Jain, B. Röder, S. Hackbarth et al., Long-Term Exposure to CdTe Quantum Dots Causes Functional Impairments in Live Cells, Langmuir, vol.23, issue.4, pp.1974-1980, 2007.
DOI : 10.1021/la060093j

L. Choucha-snouber, P. Chafey, C. Broussard, M. Monge, C. Legallais et al., Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip, Biotechnology Progress, vol.144, issue.2, pp.474-84, 2012.
DOI : 10.1002/btpr.743

L. Choucha-snouber, S. Jacques, M. Monge, C. Legallais, and E. Leclerc, Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips, Genomics, vol.100, issue.1, pp.27-34, 2012.
DOI : 10.1016/j.ygeno.2012.05.001

L. Choucha-snouber, C. Aninat, L. Griscom, G. Madalinski, C. Brochot et al., Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip, Biotechnology and Bioengineering, vol.37, issue.5, pp.597-603, 2013.
DOI : 10.1002/bit.24707

URL : https://hal.archives-ouvertes.fr/inserm-00864839

C. Sébastien, Génération de progéniteurs hépatiques dérivés de cellules souches : application à l'hypercholestérolémie familial. 224p, Thèse : Physiopathologie Moléculaire et Cellulaire : UNIVERSITÉ PARIS-SUD 11, 2011.

J. M. Custodio, C. Wu, and L. Benet, Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption, Advanced Drug Delivery Reviews, vol.60, issue.6, pp.717-733, 2008.
DOI : 10.1016/j.addr.2007.08.043

M. Darnell, T. Schreiter, K. Zeilinger, T. Urbaniak, T. So et al., Cytochrome P450-Dependent Metabolism in HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor, Drug Metabolism and Disposition, vol.39, issue.7, pp.1131-1138, 2011.
DOI : 10.1124/dmd.110.037721

E. P. Daskalopoulos, F. Malliou, G. Rentesi, M. Marselos, M. A. Lang et al., Stress is a critical player in CYP3A, CYP2C, and CYP2D regulation: role of adrenergic receptor signaling pathways, AJP: Endocrinology and Metabolism, vol.303, issue.1, pp.40-54, 2012.
DOI : 10.1152/ajpendo.00545.2011

D. Buck and C. Mackie, Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation. Expert opinion on drug metabolism & toxicology, pp.865-78, 2007.

S. Dertinger, D. T. Chiu, N. L. Jeon, and G. Whitesides, Generation of Gradients Having Complex Shapes Using Microfluidic Networks, Analytical Chemistry, vol.73, issue.6, pp.1240-1246, 2001.
DOI : 10.1021/ac001132d

D. Simone, V. , and C. R. , Transcription factors and liver-specific genes, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1132, issue.2, pp.119-126, 1992.
DOI : 10.1016/0167-4781(92)90001-G

T. Y. Doktorova, R. Yildirimman, M. Vinken, M. Vilardell, T. Vanhaecke et al., Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models, Carcinogenesis, vol.34, issue.6, pp.1393-402, 2013.
DOI : 10.1093/carcin/bgt054

K. Domansky, W. Inman, J. Serdy, A. Dash, M. Lim et al., Perfused multiwell plate for 3D liver tissue engineering, Lab Chip, vol.15, issue.1, pp.51-59, 2010.
DOI : 10.1039/B913221J

M. T. Donato, L. Tolosa, N. Jiménez, J. V. Castell, and M. J. Gómez-lechón, High-Content Imaging Technology for the Evaluation of Drug-Induced Steatosis Using a Multiparametric Cell-Based Assay, Journal of Biomolecular Screening, vol.19, issue.7, pp.394-400, 2012.
DOI : 10.1093/toxsci/kfn109

J. Doull, J. F. Borzelleca, R. Becker, G. Daston, J. Desesso et al., Framework for use of toxicity screening tools in context-based decision-making. Food and chemical toxicology, pp.759-796, 2007.

D. C. Duffy, J. C. Mcdonald, O. J. Schueller, and G. Whitesides, Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane) Analytical chemistry, pp.4974-4984, 1998.

S. Ekins, C. L. Waller, P. W. Swaan, G. Cruciani, S. Wrighton et al., Progress in predicting human ADME parameters in silico, Journal of Pharmacological and Toxicological Methods, vol.44, issue.1, pp.215-72, 2001.
DOI : 10.1016/S1056-8719(00)00109-X

S. L. Ellenberger and I. Young, Microscope image acquisition. Image Processing and Analysis : A Practical Approach, Par Baldock R. et Graham J, pp.1-36, 2000.

E. Yamani, M. Seret, and C. , La toxicologie diffuse par l'Afsset : agence française de sécurité sanitaire de l'environnement et du travail, pp.1-6, 2006.

E. Helena, Intestinal Barriers to Oral Drug Absorption, Cytochrome P450 3A and ABC-Transport Proteins. 62p, Thèse : Pharmacy, 2003.

S. J. Enoch, M. Cronin, T. W. Schultz, and J. Madden, An evaluation of global QSAR models for the prediction of the toxicity of phenols to Tetrahymena pyriformis, Chemosphere, vol.71, issue.7, pp.1225-1257, 2008.
DOI : 10.1016/j.chemosphere.2007.12.011

E. Eschbach, S. S. Chatterjee, M. Nöldner, E. Gottwald, H. Dertinger et al., Microstructured scaffolds for liver tissue cultures of high cell density: Morphological and biochemical characterization of tissue aggregates, Journal of Cellular Biochemistry, vol.90, issue.2, pp.243-255, 2005.
DOI : 10.1002/jcb.20360

D. Falconnet, G. Csucs, H. M. Grandin, and M. Textor, Surface engineering approaches to micropattern surfaces for cell-based assays, Biomaterials, vol.27, issue.16, pp.3044-63, 2006.
DOI : 10.1016/j.biomaterials.2005.12.024

Y. Feng, Z. Tian, and M. Wan, Bioeffects of Low-Intensity Ultrasound In Vitro, Journal of Ultrasound in Medicine, vol.29, issue.6, pp.963-974, 2010.
DOI : 10.7863/jum.2010.29.6.963

Z. Feng, X. Chu, N. Huang, M. K. Leach, G. Wang et al., Rat hepatocyte aggregate formation on discrete aligned nanofibers of type-I collagen

S. J. Fey and K. Wrzesinski, Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line, Toxicological Sciences, vol.127, issue.2, pp.403-414, 2012.
DOI : 10.1093/toxsci/kfs122

C. Filippi, S. Keatch, D. Rangar, L. J. Nelson, P. C. Hayes et al., Improvement of C3A cell metabolism for usage in bioartificial liver support systems, Journal of Hepatology, vol.41, issue.4, pp.599-605, 2004.
DOI : 10.1016/j.jhep.2004.06.012

R. Francis, X. Xu, H. Park, C. Wei, S. Chang et al., Connexin43 Modulates Cell Polarity and Directional Cell Migration by Regulating Microtubule Dynamics, PLoS ONE, vol.406, issue.Pt 3, p.26379, 2011.
DOI : 10.1371/journal.pone.0026379.s005

S. L. Friedman, Transcriptional regulation of stellate cell activation, Journal of Gastroenterology and Hepatology, vol.124, issue.s3, pp.79-83, 2006.
DOI : 10.1007/s10495-005-1877-0

J. Fukuda, Y. Sakai, and K. Nakazawa, Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing, Biomaterials, vol.27, issue.7, pp.1061-70, 2006.
DOI : 10.1016/j.biomaterials.2005.07.031

F. Gagné, J. Auclair, P. Turcotte, M. Fournier, C. Gagnon et al., Ecotoxicity of CdTe quantum dots to freshwater mussels: Impacts on immune system, oxidative stress and genotoxicity, Aquatic Toxicology, vol.86, issue.3, pp.333-373, 2008.
DOI : 10.1016/j.aquatox.2007.11.013

J. F. Galloway, A. Winter, K. H. Lee, P. J. , H. Dvoracek et al., Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications, Nanomedicine: Nanotechnology, Biology and Medicine, vol.8, issue.7
DOI : 10.1016/j.nano.2011.12.002

R. J. Giedt, D. R. Pfeiffer, A. Matzavinos, C. Kao, and B. Alevriadou, Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics, Annals of Biomedical Engineering, vol.6, issue.25, pp.1903-1919, 2012.
DOI : 10.1007/s10439-012-0568-6

S. S. Glaser, E. Gaudio, T. Miller, D. Alvaro, and G. Alpini, Cholangiocyte proliferation and liver fibrosis Expert reviews in molecular medicine, pp.1-20, 2009.

C. Hansch, A. Leo, S. B. Mekapati, A. Kurup, and A. Qsar, QSAR and ADME, Bioorganic & Medicinal Chemistry, vol.12, issue.12, pp.3391-3400, 2004.
DOI : 10.1016/j.bmc.2003.11.037

P. Godoy, J. G. Hengstler, I. Ilkavets, C. Meyer, A. Bachmann et al., Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor ??-induced apoptosis, Hepatology, vol.41, issue.6, pp.2031-2074, 2009.
DOI : 10.1002/hep.22880

M. J. Gómez-lechón, J. V. Castell, and M. Donato, Hepatocytes???the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo, Chemico-Biological Interactions, vol.168, issue.1, pp.30-50, 2007.
DOI : 10.1016/j.cbi.2006.10.013

C. A. Goubko and K. Cao, Patterning multiple cell types in co-cultures: A review, Materials Science and Engineering: C, vol.29, issue.6, pp.1855-1868, 2009.
DOI : 10.1016/j.msec.2009.02.016

Y. Gueguen, K. Mouzot, E. Ferrari, J. Lobaccaro, A. M. Batt et al., Les cytochromes P450 : metabolism des xénobiotiques, régulation et rôle en Clinique, Ann Biol Clin, vol.64, pp.535-583, 2006.

A. Guillouzo, A. Corlu, C. Aninat, D. Glaise, F. Morel et al., The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics, Chemico-Biological Interactions, vol.168, issue.1
DOI : 10.1016/j.cbi.2006.12.003

P. Gunness, D. Mueller, V. Shevchenko, E. Heinzle, M. Ingelman-sundberg et al., 3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies, Toxicological Sciences, vol.133, issue.1, pp.67-78, 2013.
DOI : 10.1093/toxsci/kft021

J. L. Hanslick, K. Laua, K. K. Noguchi, J. W. Olneya, C. F. Zorumski et al., Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system, Neurobiology of Disease, vol.34, issue.1, pp.1-10, 2009.
DOI : 10.1016/j.nbd.2008.11.006

Y. Harada, T. Matsumoto, S. Hirahara, A. Nakashima, S. Ueno et al., Characterization of a sperm factor for egg activation at fertilization of the newt Cynops pyrrhogaster, Developmental Biology, vol.306, issue.2, pp.797-808, 2007.
DOI : 10.1016/j.ydbio.2007.04.019

N. Hariparsad, B. A. Carr, R. Evers, and X. Chu, Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction, Drug Metabolism and Disposition, vol.36, issue.6, pp.1046-1055, 2008.
DOI : 10.1124/dmd.108.020677

K. Hazama, S. Asayama, and H. Kawakami, Up-Regulation of Gene Expression by Transfection to Hepatocyte Spheroids, Molecular Pharmaceutics, vol.9, issue.12, pp.3602-3607, 2012.
DOI : 10.1021/mp300519x

S. Higuchi, R. Wu, M. Zhou, T. S. Ravikumar, and P. Wang, Downregulation of Hepatic Cytochrome P-450 Isoforms and PPAR-??: Their Role in Hepatic Injury and Proinflammatory Responses in a Double-Hit Model of Hemorrhage and Sepsis, Journal of Surgical Research, vol.137, issue.1, pp.46-52, 2007.
DOI : 10.1016/j.jss.2006.04.019

R. W. Horobin, J. Stockert, and F. Rashid-doubell, Uptake and localisation of small-molecule fluorescent probes in living cells: a critical appraisal of QSAR models and a case study concerning probes for DNA and RNA, Histochemistry and Cell Biology, vol.164, issue.5, pp.623-660, 2013.
DOI : 10.1007/s00418-013-1090-0

M. Howarth, K. Takao, Y. Hayashi, and A. Ting, Targeting quantum dots to surface proteins in living cells with biotin ligase, Proceedings of the National Academy of Sciences, vol.102, issue.21, pp.7583-7588, 2005.
DOI : 10.1073/pnas.0503125102

B. Huang, H. Wu, D. Bhaya, A. Grossman, S. Granier et al., Counting Low-Copy Number Proteins in a Single Cell, Science, vol.315, issue.5808, pp.81-85, 2007.
DOI : 10.1126/science.1133992

M. Huang, S. Fan, W. Xing, and C. Liu, Microfluidic cell culture system studies and computational fluid dynamics, Mathematical and Computer Modelling, vol.52, issue.11-12, pp.2036-2042, 2010.
DOI : 10.1016/j.mcm.2010.01.024

URL : http://doi.org/10.1016/j.mcm.2010.01.024

D. Huh, G. A. Hamilton, and D. Ingber, From 3D cell culture to organs-on-chips, Trends in Cell Biology, vol.21, issue.12, pp.745-54, 2011.
DOI : 10.1016/j.tcb.2011.09.005

J. Huth, M. Buchholz, J. M. Kraus, K. Mølhave, C. Gradinaru et al., TimeLapseAnalyzer: Multi-target analysis for live-cell imaging and time-lapse microscopy, Computer Methods and Programs in Biomedicine, vol.104, issue.2, pp.227-234, 2011.
DOI : 10.1016/j.cmpb.2011.06.002

S. V. Iverson, K. M. Comstock, J. A. Kundert, and E. Schmidt, Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice, Hepatology, vol.35, issue.suppl 1, pp.655-63, 2011.
DOI : 10.1002/hep.24398

D. J. Jennen, C. Magkoufopoulou, H. B. Ketelslegers, M. Van-herwijnen, J. Kleinjans et al., Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification, Toxicological Sciences, vol.115, issue.1, pp.66-79, 2010.
DOI : 10.1093/toxsci/kfq026

I. A. Johnson, S. B. Kumar, and R. Malathi, De-intercalation of Ethidium Bromide and Acridine Orange by Xanthine Derivatives and Their Modulatory Effect on Anticancer Agents: A study of DNA-directed Toxicity Enlightened by Time Correlated Single Photon Counting, Journal of Biomolecular Structure and Dynamics, vol.1, issue.5, pp.677-685, 2003.
DOI : 10.1007/s002490100150

L. Ju, G. Zhang, C. Zhang, L. Sun, Y. Jiang et al., Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.753, issue.1, pp.54-64, 2013.
DOI : 10.1016/j.mrgentox.2013.01.006

L. Kamentsky, T. R. Jones, A. Fraser, M. A. Bray, D. J. Logan et al., Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software, Bioinformatics, vol.27, issue.8, pp.1179-1180, 2011.
DOI : 10.1093/bioinformatics/btr095

K. P. Kanebratt and T. Andersson, Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies, Drug Metabolism and Disposition, vol.36, issue.7, pp.1444-1452, 2008.
DOI : 10.1124/dmd.107.020016

J. M. Kelm, N. E. Timmins, C. J. Brown, M. Fussenegger, and L. Nielsen, Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types, Biotechnology and Bioengineering, vol.123, issue.2, pp.173-80, 2003.
DOI : 10.1002/bit.10655

R. Khan, J. E. Lee, Y. Yang, F. Liang, and P. Sehgal, Live-Cell Imaging of the Association of STAT6-GFP with Mitochondria, PLoS ONE, vol.224, issue.5, p.55426, 2013.
DOI : 10.1371/journal.pone.0055426.g009

S. R. Khetani and S. Bhatia, Microscale culture of human liver cells for drug development, Nature Biotechnology, vol.30, issue.1, pp.120-126, 2008.
DOI : 10.1038/nbt1361

J. Kikuta and M. Ishii, Recent Advances in Intravital Imaging of Dynamic Biological Systems, Journal of Pharmacological Sciences, vol.119, issue.3, pp.193-197, 2012.
DOI : 10.1254/jphs.12R03CP

H. J. Kim, D. Huh, G. Hamilton, and D. Ingber, Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow, Lab on a Chip, vol.94, issue.Pt 3, pp.2165-74, 2012.
DOI : 10.1039/c2lc40074j

S. Knasmüller, W. Parzefall, R. Sanyal, S. Ecker, C. Schwab et al., Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.402, issue.1-2, pp.185-202, 1998.
DOI : 10.1016/S0027-5107(97)00297-2

G. Kruh and M. Belinsky, The MRP family of drug efflux pumps, Oncogene, vol.22, issue.47, pp.7537-52, 2003.
DOI : 10.1038/sj.onc.1206953

D. V. Krysko, B. T. Vanden, D. Herde, K. Vandenabeele, and P. , Apoptosis and necrosis: Detection, discrimination and phagocytosis, Methods, vol.44, issue.3, pp.205-226, 2008.
DOI : 10.1016/j.ymeth.2007.12.001

L. Frédéric, Etude de la mort cellulaire par Cytométrie en Flux. Cours à l, 2013.

E. Leclerc, B. David, L. Griscom, B. Lepioufle, T. Fujii et al., Study of osteoblastic cells in a microfluidic environment, Biomaterials, vol.27, issue.4, pp.586-95, 2006.
DOI : 10.1016/j.biomaterials.2005.06.002

URL : https://hal.archives-ouvertes.fr/hal-00778216

E. L. Lecluyse, R. Witek, M. E. Andersen, and M. Powers, Organotypic liver culture models: Meeting current challenges in toxicity testing, Critical Reviews in Toxicology, vol.11, issue.1, pp.501-549, 2012.
DOI : 10.1126/science.1073502

P. J. Lee, P. J. Hung, and L. Lee, An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture, Biotechnology and Bioengineering, vol.27, issue.5, pp.1340-1346, 2007.
DOI : 10.1002/bit.21360

M. Lee, R. A. Kumar, S. M. Sukumaran, M. G. Hogg, D. S. Clark et al., Three-dimensional cellular microarray for high-throughput toxicology assays, Proceedings of the National Academy of Sciences, vol.105, issue.1, pp.59-63, 2008.
DOI : 10.1073/pnas.0708756105

A. Legendre, R. Baudoin, A. G. Paullier, P. Naudot, M. Bricks et al., Metabolic Characterization of Primary Rat Hepatocytes Cultivated in Parallel Microfluidic Biochips, Journal of Pharmaceutical Sciences, vol.102, issue.9, pp.3264-3276, 2013.
DOI : 10.1002/jps.23466

J. J. Lemasters, A. L. Nieminen, T. Qian, L. C. Trost, S. P. Elmore et al., The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1366, issue.1-2, pp.177-96, 1998.
DOI : 10.1016/S0005-2728(98)00112-1

S. Li and C. S. , Polydimethylsioxane Fluidic Interconnects for Microfluidic Systems, IEEE Transactions on advanced Packaging, vol.26, pp.242-247, 2003.

N. T. Lieggi, A. Edvardsson, and P. O-'brien, Translation of novel anti-cancer cytotoxicity biomarkers detected with high content analysis from an in vitro predictive model to an in vivo cell model, Toxicology in Vitro, vol.24, issue.8, pp.2063-71, 2010.
DOI : 10.1016/j.tiv.2010.07.014

Z. Lin, T. Cherng-wen, P. Roy, and D. Trau, In-situ measurement of cellular microenvironments in a microfluidic device, Lab Chip, vol.5, issue.17, pp.257-62, 2009.
DOI : 10.1039/B806907G

D. Lin, X. Zhuang, S. H. Wong, M. Kupnik, and B. Khuri-yakub, Encapsulation of Capacitive Micromachined Ultrasonic Transducers Using Viscoelastic Polymer, Journal of Microelectromechanical Systems, vol.19, issue.6, pp.1341-1351, 2010.
DOI : 10.1109/JMEMS.2010.2076786

V. Linder, H. Wu, X. Jiang, and G. Whitesides, Rapid Prototyping of 2D Structures with Feature Sizes Larger than 8 ??m, Analytical Chemistry, vol.75, issue.10, pp.2522-2529, 2003.
DOI : 10.1021/ac026441d

Q. Liu, L. Liu, Y. Lu, R. Tao, J. Huang et al., The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells, Toxicology and Applied Pharmacology, vol.244, issue.3, pp.374-84, 2010.
DOI : 10.1016/j.taap.2010.02.004

W. Liu, L. Li, J. Wang, Q. Tu, L. Ren et al., Dynamic trapping and high-throughput patterning of cells using pneumatic microstructures in an integrated microfluidic device, Lab on a Chip, vol.10, issue.9, pp.1702-1709, 2012.
DOI : 10.1039/c2lc00034b

C. Loichot and M. Grima, Chaptire 5 : Métabolisme des medicaments, 2004.

G. Luis and V. Jr, In silico toxicology for the pharmaceutical sciences, Toxicology and applied pharmacology, vol.241, pp.356-70, 2009.

O. M. Lukandu, T. Bredholt, E. Neppelberg, B. T. Gjertsen, A. C. Johannessen et al., Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells, Toxicology, vol.263, issue.2-3, pp.108-124, 2009.
DOI : 10.1016/j.tox.2009.06.024

M. J. Masson, L. D. Carpenter, M. L. Graf, and L. Pohl, Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide, Hepatology, vol.191, issue.3, pp.889-97, 2008.
DOI : 10.1002/hep.22400

A. Mata, A. J. Fleischman, and S. Roy, Characterization of Polydimethylsiloxane (PDMS) Properties for Biomedical Micro/Nanosystems, Biomedical Microdevices, vol.56, issue.535, pp.281-293, 2005.
DOI : 10.1007/s10544-005-6070-2

E. Meijering, O. Dzyubachyk, and I. Smal, Methods for Cell and Particle Tracking, Methods of enzymology, vol.504, pp.183-200, 2012.
DOI : 10.1016/B978-0-12-391857-4.00009-4

L. Meli, E. T. Jordan, D. S. Clark, R. J. Linhardt, and J. Dordick, Influence of a three-dimensional, microarray environment on human Cell culture in drug screening systems, Biomaterials, vol.33, issue.35, pp.9087-96, 2012.
DOI : 10.1016/j.biomaterials.2012.08.065

J. B. Mills, K. A. Rose, N. Sadagopan, J. Sahi, D. Morais et al., Induction of Drug Metabolism Enzymes and MDR1 Using a Novel Human Hepatocyte Cell Line, Journal of Pharmacology and Experimental Therapeutics, vol.309, issue.1, pp.303-309, 2004.
DOI : 10.1124/jpet.103.061713

E. Morgan, Impact of Infectious and Inflammatory Disease on Cytochrome P450???Mediated Drug Metabolism and Pharmacokinetics, Clinical Pharmacology & Therapeutics, vol.34, issue.4, pp.434-438, 2009.
DOI : 10.1038/clpt.2008.302

S. Nadanaciva, S. Lu, D. F. Gebhard, B. Jessen, W. D. Pennie et al., A high content screening assay for identifying lysosomotropic compounds, Toxicology in Vitro, vol.25, issue.3, pp.715-738, 2011.
DOI : 10.1016/j.tiv.2010.12.010

V. Nechyporuk-zloy, P. Dieterich, H. Oberleithner, C. Stock, and A. Schwab, Dynamics of single potassium channel proteins in the plasma membrane of migrating cells, AJP: Cell Physiology, vol.294, issue.4, pp.1096-102, 2008.
DOI : 10.1152/ajpcell.00252.2007

B. Neumann, M. Held, U. Liebel, H. Erfle, P. Rogers et al., High-throughput RNAi screening by time-lapse imaging of live human cells, Nature Methods, vol.5, issue.5, pp.385-390, 2006.
DOI : 10.1038/nmeth876

S. Ng, Y. Wu, Y. Zhou, Y. Toh, Z. Ho et al., Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the extra-cellular matrices, Biomaterials, vol.26, issue.16, pp.3153-63, 2005.
DOI : 10.1016/j.biomaterials.2004.08.017

T. Oh, J. H. Sung, D. Tatosian, M. L. Shuler, and D. Kim, Real-time fluorescence detection of multiple microscale cell culture analog devices in situ, Cytometry, vol.71, pp.857-65, 2007.

T. Ohta, S. Tokishita, and H. Yamagata, Ethidium bromide and SYBR Green I enhance the genotoxicity of UV-irradiation and chemical mutagens in E. coli, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.492, issue.1-2, pp.91-97, 2001.
DOI : 10.1016/S1383-5718(01)00155-3

S. Ong, C. Zhang, Y. Toh, S. H. Kim, H. L. Foo et al., A gel-free 3D microfluidic cell culture system, Biomaterials, vol.29, issue.22, pp.3237-3281, 2008.
DOI : 10.1016/j.biomaterials.2008.04.022

N. Otsu, A threshold selection method from grey scale histogram, IEEE Trans. on Syst. Man and Cyber, vol.1, pp.62-66, 1979.

Y. Pang, K. Montagne, M. Shinohara, K. Komori, and Y. Sakai, Liver tissue engineering based on aggregate assembly: efficient formation of endothelialized rat hepatocyte aggregates and their immobilization with biodegradable fibres, Biofabrication, vol.4, issue.4, p.45004, 2012.
DOI : 10.1088/1758-5082/4/4/045004

C. M. Pastor and P. Suter, Hepatic hemodynamics and cell functions in human and experimental sepsis, Anesthesia and analgesia, vol.89, pp.344-52, 1999.

J. Park, Z. Fan, and C. Deng, Effects of shear stress cultivation on cell membrane disruption and intracellular calcium concentration in sonoporation of endothelial cells, Journal of Biomechanics, vol.44, issue.1, pp.164-169, 2011.
DOI : 10.1016/j.jbiomech.2010.09.003

N. Pereira-rodrigues, Y. Sakai, and T. Fujii, Cell-Based Microfluidic Biochip for Electrochemical Real-Time Monitoring of Glucose and Oxygen, TRANSDUCERS 2007, 2007 International Solid-State Sensors, Actuators and Microsystems Conference, pp.608-613, 2008.
DOI : 10.1109/SENSOR.2007.4300262

Z. E. Perlman, M. D. Slack, Y. Feng, T. J. Mitchison, L. F. Wu et al., Multidimensional Drug Profiling By Automated Microscopy, Science, vol.306, issue.5699, pp.1194-1202, 2004.
DOI : 10.1126/science.1100709

M. Pool, J. Thiemann, A. Bar-or, and A. Fournier, NeuriteTracer: A novel ImageJ plugin for automated quantification of neurite outgrowth, Journal of Neuroscience Methods, vol.168, issue.1, pp.134-143, 2008.
DOI : 10.1016/j.jneumeth.2007.08.029

M. J. Powers, D. M. Janigian, K. E. Wack, C. S. Baker, D. B. Stolz et al., Functional Behavior of Primary Rat Liver Cells in a Three-Dimensional Perfused Microarray Bioreactor, Tissue Engineering, vol.8, issue.3, pp.499-513, 2002.
DOI : 10.1089/107632702760184745

J. Prot, C. Aninat, L. Griscom, F. Razan, C. Brochot et al., Improvement of HepG2/C3a cell functions in a microfluidic biochip, Biotechnology and Bioengineering, vol.2, issue.7, pp.1704-1715, 2011.
DOI : 10.1002/bit.23104

URL : https://hal.archives-ouvertes.fr/hal-00740224

W. Qi, D. Ding, and R. Salvi, Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures, Hearing Research, vol.236, issue.1-2, pp.52-60, 2008.
DOI : 10.1016/j.heares.2007.12.002

P. Rees, M. R. Brown, H. D. Summers, M. D. Holton, R. J. Errington et al., A transfer function approach to measuring cell inheritance, BMC Systems Biology, vol.5, issue.1, pp.32-38, 2011.
DOI : 10.1002/(SICI)1097-0320(19960901)25:1<1::AID-CYTO1>3.0.CO;2-N

S. Rieger, R. P. Kulkarni, D. Darcy, S. E. Fraser, and R. W. Köster, Quantum dots are powerful multipurpose vital labeling agents in zebrafish embryos, Developmental Dynamics, vol.21, issue.3, pp.670-81, 2005.
DOI : 10.1002/dvdy.20524

S. L. Ripp, J. B. Mills, O. A. Fahmi, K. A. Trevena, J. L. Liras et al., Use of Immortalized Human Hepatocytes to Predict the Magnitude of Clinical Drug-Drug Interactions Caused by CYP3A4 Induction, Drug Metabolism and Disposition, vol.34, issue.10, pp.1742-1790, 2006.
DOI : 10.1124/dmd.106.010132

F. Rizvi, T. Heimann, A. Herrnreiter, and W. O-'brien, Mitochondrial Dysfunction Links Ceramide Activated HRK Expression and Cell Death, PLoS ONE, vol.5, issue.3, p.18137, 2011.
DOI : 10.1371/journal.pone.0018137.s006

URL : http://doi.org/10.1371/journal.pone.0018137

R. M. Rodrigues, P. Macko, T. Palosaari, and M. Whelan, Autofluorescence microscopy: A non-destructive tool to monitor mitochondrial toxicity, Toxicology Letters, vol.206, issue.3, pp.281-289, 2011.
DOI : 10.1016/j.toxlet.2011.06.025

D. B. Schmolze, C. Standley, K. E. Fogarty, and A. Fischer, Advances in microscopy techniques, Archives of pathology & laboratory medicine, vol.135, pp.255-63, 2011.

S. Ehnert, L. Schyschka, A. Noss, D. Knobeloch, J. Kleeff et al., Further characterization of autologous NeoHepatocytes for in vitro toxicity testing, Toxicology in Vitro, vol.25, issue.6, pp.1203-1211, 2011.
DOI : 10.1016/j.tiv.2011.05.013

M. Shih, S. Tseng, Y. Weng, I. Chu, and C. Liu, A microfluidic device mimicking acinar concentration gradients across the liver acinus, Biomedical Microdevices, vol.7, issue.12, pp.767-780, 2013.
DOI : 10.1007/s10544-013-9762-z

Y. Shitara, T. Horie, and Y. Sugiyama, Transporters as a determinant of drug clearance and tissue distribution, European Journal of Pharmaceutical Sciences, vol.27, issue.5, pp.425-471, 2006.
DOI : 10.1016/j.ejps.2005.12.003

S. Silbernagl and A. Despopoulos, Atlas de poche de physiologie, 1992.

M. G. Soars, D. F. Mcginnity, K. Grime, and R. Riley, The pivotal role of hepatocytes in drug discovery, Chemico-Biological Interactions, vol.168, issue.1
DOI : 10.1016/j.cbi.2006.11.002

F. S. Sterrenburg, . Microscopy, and . Primer, Micscape Magazine (2002) disponible sur

M. Strazzabosco and L. Fabris, Functional Anatomy of Normal Bile Ducts, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, vol.35, issue.6, pp.653-660, 2008.
DOI : 10.1002/ar.20664

J. Sung and M. Shuler, In vitro microscale systems for systematic drug toxicity study, Bioprocess and Biosystems Engineering, vol.309, issue.1, pp.5-19, 2010.
DOI : 10.1007/s00449-009-0369-y

J. A. Sunman, R. L. Hawke, E. L. Lecluyse, and A. Kashuba, KUPFFER CELL-MEDIATED IL-2 SUPPRESSION OF CYP3A ACTIVITY IN HUMAN HEPATOCYTES, Drug Metabolism and Disposition, vol.32, issue.3, pp.359-363, 2004.
DOI : 10.1124/dmd.32.3.359

D. Tatosian and M. Shuler, A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers, Biotechnology and Bioengineering, vol.30, issue.4, pp.187-198, 2009.
DOI : 10.1002/bit.22219

C. Terryn, A. Bonnomet, J. Cutrona, C. Coraux, J. Tournier et al., Video-microscopic imaging of cell spatio-temporal dispersion and migration, Critical Reviews in Oncology/Hematology, vol.69, issue.2, pp.144-152, 2009.
DOI : 10.1016/j.critrevonc.2008.06.005

URL : https://hal.archives-ouvertes.fr/inserm-00289453

P. Thygesen, P. Macheras, and A. Van-peer, Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules, Pharmaceutical Research, vol.44, issue.12, pp.2543-50, 2009.
DOI : 10.1007/s11095-009-9990-3

R. M. Tostões, S. B. Leite, J. P. Miranda, M. Sousa, W. D. Carrondo et al., Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors, Biotechnology and Bioengineering, vol.28, issue.7, pp.41-49, 2011.
DOI : 10.1002/bit.22920

G. Tuschl, J. Hrach, Y. Walter, P. G. Hewitt, and S. Mueller, Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug???drug interaction studies, Chemico-Biological Interactions, vol.181, issue.1, pp.124-161, 2009.
DOI : 10.1016/j.cbi.2009.05.015

M. Ulvestad, M. Darnell, E. Molden, E. Ellis, A. Åsberg et al., Evaluation of Organic Anion-Transporting Polypeptide 1B1 and CYP3A4 Activities in Primary Human Hepatocytes and HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor System, Journal of Pharmacology and Experimental Therapeutics, vol.343, issue.1, pp.145-56, 2012.
DOI : 10.1124/jpet.112.195750

P. M. Van-midwoud, G. M. Groothuis, M. T. Merema, and E. Verpoorte, Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies, Biotechnology and Bioengineering, vol.12, issue.4, pp.184-94, 2010.
DOI : 10.1002/bit.22516

J. S. Verdaasdonk, A. D. Stephens, J. Haase, and K. Bloom, Bending the Rules: Widefield Microscopy and the Abbe Limit of Resolution, Journal of Cellular Physiology, vol.18, issue.2, 2013.
DOI : 10.1002/jcp.24439

M. Vermeir, P. Annaert, R. Mamidi, . Nvs, D. Roymans et al., Cell-based models to study hepatic drug metabolism and enzyme induction in humans, Expert Opinion on Drug Metabolism & Toxicology, vol.60, issue.6, pp.75-90, 2005.
DOI : 10.1124/dmd.104.001347

V. Claude and T. Robert, Chaptire 5 : Toxicologie. Environnement et santé publique ? Fondements et patrique, Par Gérin M, pp.119-143

Y. Wang, J. Shyy, and S. Chien, Fluorescence Proteins, Live-Cell Imaging, and Mechanobiology: Seeing Is Believing, Annual Review of Biomedical Engineering, vol.10, issue.1, pp.1-38, 2008.
DOI : 10.1146/annurev.bioeng.010308.161731

D. Warther, S. Gug, A. Specht, F. Bolze, J. Nicoud et al., Two-photon uncaging: New prospects in neuroscience and cellular biology, Bioorganic & Medicinal Chemistry, vol.18, issue.22, pp.7753-58, 2010.
DOI : 10.1016/j.bmc.2010.04.084

URL : https://hal.archives-ouvertes.fr/hal-00666923

J. Waters, Live???Cell Fluorescence Imaging, Methods in Cell, vol.81, pp.115-140, 2007.
DOI : 10.1016/S0091-679X(06)81007-1

C. M. Waters, M. R. Glucksberg, N. Depaola, J. Chang, and J. Grotberg, Shear stress alters pleural mesothelial cell permeability in culture, J Appl Physiol, vol.81, pp.448-458, 1996.

W. Westerink and W. Schoonen, Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells, Toxicology in Vitro, vol.21, issue.8, pp.1592-602, 2007.
DOI : 10.1016/j.tiv.2007.06.017

W. Westerink, T. Schirris, G. J. Horbach, and W. Schoonen, Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.724, issue.1-2, pp.7-21, 2011.
DOI : 10.1016/j.mrgentox.2011.05.007

S. Wilkening and A. Bader, Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2, Journal of Biochemical and Molecular Toxicology, vol.21, issue.4, pp.207-220, 2003.
DOI : 10.1002/jbt.10085

S. Wilkening, F. Stahl, and A. Bader, COMPARISON OF PRIMARY HUMAN HEPATOCYTES AND HEPATOMA CELL LINE HEPG2 WITH REGARD TO THEIR BIOTRANSFORMATION PROPERTIES, Drug Metabolism and Disposition, vol.31, issue.8, pp.1035-1042, 2003.
DOI : 10.1124/dmd.31.8.1035

G. Williams and M. J. Latropoulos, Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and Toxicity, Toxicologic Pathology, vol.32, issue.2, pp.41-53, 2002.
DOI : 10.1080/01926230252824699

R. Wu, X. Cui, W. Dong, M. Zhou, H. Simms et al., Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway : the central role of proinflammatory cytokines, Int J Mol Med, vol.18, pp.339-385, 2006.

C. Q. Xia and P. Smith, Drug Efflux Transporters and Multidrug Resistance in Acute Leukemia: Therapeutic Impact and Novel Approaches to Mediation, Molecular Pharmacology, vol.82, issue.6, pp.1008-1021, 2012.
DOI : 10.1124/mol.112.079129

J. J. Xu, P. V. Henstock, M. C. Dunn, A. R. Smith, J. R. Chabot et al., Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury, Toxicological Sciences, vol.105, issue.1, pp.97-105, 2008.
DOI : 10.1093/toxsci/kfn109

M. Yoon, J. L. Campbell, M. E. Andersen, and H. J. Clewell, extrapolation of cell-based toxicity assay results, Critical Reviews in Toxicology, vol.33, issue.2, pp.633-52, 2012.
DOI : 10.1124/dmd.111.042309

H. Youn, D. J. Mccanna, J. G. Sivak, and L. Jones, In vitro ultraviolet-induced damage in human corneal, lens, and retinal pigment epithelial cells, Molecular vision, vol.17, pp.237-283, 2011.

E. Young and D. Beebe, Fundamentals of microfluidic cell culture in controlled microenvironments, Chemical Society Reviews, vol.560, issue.3, pp.1036-1084, 2010.
DOI : 10.1039/b909900j

M. J. Zamek-gliszczynski, K. A. Hoffmaster, K. Nezasa, M. N. Tallman, and K. Brouwer, Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites, European Journal of Pharmaceutical Sciences, vol.27, issue.5, pp.447-86, 2006.
DOI : 10.1016/j.ejps.2005.12.007

S. Zhang, W. Tong, B. Zheng, T. Susanto, L. Xia et al., A robust high-throughput sandwich cell-based drug screening platform, Biomaterials, vol.32, issue.4, pp.1229-1270, 2011.
DOI : 10.1016/j.biomaterials.2010.09.064

L. Zhao, E. Y. Shang, and C. Sahajwalla, Application of pharmacokinetics???pharmacodynamics/clinical response modeling and simulation for biologics drug development, Journal of Pharmaceutical Sciences, vol.101, issue.12, pp.4367-4382, 2012.
DOI : 10.1002/jps.23330

G. Zheng, S. A. Lee, Y. Antebi, M. B. Elowitz, and C. Yang, The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM), Proceedings of the National Academy of Sciences, vol.108, issue.41, pp.16889-94, 2011.
DOI : 10.1073/pnas.1110681108

B. Ziaie, A. Baldi, M. Lei, Y. Gu, and R. Siegel, Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery, Advanced Drug Delivery Reviews, vol.56, issue.2, pp.145-172, 2004.
DOI : 10.1016/j.addr.2003.09.001